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Aliases for CCDC140 Gene

Aliases for CCDC140 Gene

  • Coiled-Coil Domain Containing 140 2 3

External Ids for CCDC140 Gene

Previous GeneCards Identifiers for CCDC140 Gene

  • GC02P222872
  • GC02P223162
  • GC02P215016

Summaries for CCDC140 Gene

Entrez Gene Summary for CCDC140 Gene

  • This gene encodes a protein that appears to be restricted to select higher primate species. This protein contains a C-terminal coiled-coil domain, which is a versatile structural motif consisting of multiple amphipathic alpha-helices that twist around each other to form a supercoil. [provided by RefSeq, Aug 2011]

GeneCards Summary for CCDC140 Gene

CCDC140 (Coiled-Coil Domain Containing 140) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC140 Gene

Genomics for CCDC140 Gene

Regulatory Elements for CCDC140 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCDC140 Gene

Start:
222,298,147 bp from pter
End:
222,305,217 bp from pter
Size:
7,071 bases
Orientation:
Plus strand

Genomic View for CCDC140 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC140 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC140 Gene

Proteins for CCDC140 Gene

  • Protein details for CCDC140 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MF4-CC140_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 140
    Protein Accession:
    Q96MF4
    Secondary Accessions:

    Protein attributes for CCDC140 Gene

    Size:
    163 amino acids
    Molecular mass:
    18252 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC140 Gene

Proteomics data for CCDC140 Gene at MOPED

Post-translational modifications for CCDC140 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC140 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC140 Gene

Domains for CCDC140 Gene

Protein Domains for CCDC140 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC140 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC140: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC140 Gene

Function for CCDC140 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC140

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CCDC140 Gene

Localization for CCDC140 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC140 Gene COMPARTMENTS Subcellular localization image for CCDC140 gene
Compartment Confidence
nucleus 3
cytosol 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC140 Gene

Pathways for CCDC140 Gene

SuperPathways for CCDC140 Gene

No Data Available

Interacting Proteins for CCDC140 Gene

Gene Ontology (GO) - Biological Process for CCDC140 Gene

None

No data available for Pathways by source for CCDC140 Gene

Transcripts for CCDC140 Gene

mRNA/cDNA for CCDC140 Gene

(2) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC140 Gene

Coiled-coil domain containing 140:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC140

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC140 Gene

No ASD Table

Relevant External Links for CCDC140 Gene

GeneLoc Exon Structure for
CCDC140
ECgene alternative splicing isoforms for
CCDC140

Expression for CCDC140 Gene

mRNA expression in normal human tissues for CCDC140 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC140 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (8.4), Minor Salivary Gland (7.4), Muscle - Skeletal (6.8), and Brain - Cerebellum (5.6).

Protein differential expression in normal tissues for CCDC140 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CCDC140 Gene

SOURCE GeneReport for Unigene cluster for CCDC140 Gene Hs.350729

genes like me logo Genes that share expressions with CCDC140: view

Expression partners for CCDC140 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CCDC140 Gene

Orthologs for CCDC140 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CCDC140 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC140 35
  • 99.59 (n)
  • 98.77 (a)
CCDC140 36
  • 99 (a)
OneToOne
Species with no ortholog for CCDC140:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC140 Gene

ENSEMBL:
Gene Tree for CCDC140 (if available)
TreeFam:
Gene Tree for CCDC140 (if available)

Paralogs for CCDC140 Gene

No data available for Paralogs for CCDC140 Gene

Variants for CCDC140 Gene

Sequence variations from dbSNP and Humsavar for CCDC140 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs751576 -- 222,302,807(-) GGAGA(A/G)GAGCG intron-variant
rs751577 -- 222,302,900(-) CCACT(G/T)CGGCT intron-variant
rs6436310 -- 222,302,991(+) GGAAG(A/G)GAGAA intron-variant
rs6717451 -- 222,302,566(+) CGTGA(C/T)TCTCA intron-variant
rs7557746 -- 222,303,154(+) AGACA(A/G)GATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC140 Gene

Variant ID Type Subtype PubMed ID
nsv834550 CNV Gain 17160897

Relevant External Links for CCDC140 Gene

HapMap Linkage Disequilibrium report
CCDC140

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC140 Gene

Disorders for CCDC140 Gene

Relevant External Links for CCDC140

Genetic Association Database (GAD)
CCDC140

No disorders were found for CCDC140 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CCDC140 Gene

Publications for CCDC140 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Coiled coil domains: stability, specificity, and biological implications. (PMID: 14760737) Mason J.M. … Arndt K.M. (Chembiochem 2004) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4
  5. Alpha-helical coiled-coil oligomerization domains in extracellular proteins. (PMID: 9138288) Kammerer R.A. (Matrix Biol. 1997) 3

Products for CCDC140 Gene

Sources for CCDC140 Gene

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