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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCDC140 Gene

protein-coding   GIFtS: 37
GCID: GC02P223162

Coiled-Coil Domain Containing 140

  Search for CCDC140
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 1401 2
Coiled-Coil Domain-Containing Protein 1402

External Ids:    HGNC: 265141   Entrez Gene: 1512782   Ensembl: ENSG000001630817   UniProtKB: Q96MF43   

Export aliases for CCDC140 gene to outside databases

Previous GC identifers: GC02P222872 GC02P215016


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCDC140 Gene:
This gene encodes a protein that appears to be restricted to select higher primate species. This protein contains
a C-terminal coiled-coil domain, which is a versatile structural motif consisting of multiple amphipathic
alpha-helices that twist around each other to form a supercoil. (provided by RefSeq, Aug 2011)

GeneCards Summary for CCDC140 Gene: 
CCDC140 (coiled-coil domain containing 140) is a protein-coding gene.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCDC140 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC140 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCDC140

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC140


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.1   Ensembl cytogenetic band:  2q36.1   HGNC cytogenetic band: 2q36.1

CCDC140 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC140 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P223162:  view genomic region     (about GC identifiers)

Start:
223,162,866 bp from pter      End:
223,169,936 bp from pter
Size:
7,071 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CC140_HUMAN, Q96MF4 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 140  
Size: 163 amino acids; 18252 Da

Explore the universe of human proteins at neXtProt for CCDC140: NX_Q96MF4

Explore proteomics data for CCDC140 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96MF4

  • CCDC140 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCDC140 Protein Expression
    REFSEQ proteins: NP_694583.1  
    ENSEMBL proteins: 
     ENSP00000295226   ENSP00000407652  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96MF4


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC140

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCDC140 (CC140)

    Search CenterWatch for drugs/clinical trials and news about CCDC140 / CC140

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCDC140 gene: 
    NM_153038.1  

    Unigene Cluster for CCDC140:

    Coiled-coil domain containing 140
    Hs.350729  [show with all ESTs]
    Unigene Representative Sequence: AK057009
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295226(uc002vnb.1) ENST00000440903
    miRNA
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    Additional mRNA sequence: 

    AK057009.1 BC109388.1 

    1 DOTS entry:

    DT.95325453 

    2 AceView cDNA sequences:

    AK057009 NM_153038 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCDC140 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGATATTG
    CCDC140 Expression
    About this image


    See CCDC140 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCDC140

    SOURCE GeneReport for Unigene cluster: Hs.350729
        SABiosciences Custom PCR Arrays for CCDC140
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC140

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for CCDC140 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia CCDC1401 coiled-coil domain containing 140 99.59(n)
    98.77(a)
      744142  XM_003309477.1  XP_003309525.1 


    ENSEMBL Gene Tree for CCDC140 (if available)
    TreeFam Gene Tree for CCDC140 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/123 SNPs in CCDC140 are shown (see all 123)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1850910251,2
    C--222549406(+) GGCAAC/GAGGCT 2 Q E mis10--------
    rs2011940851,2
    C--222549461(+) CCTGGG/TGCCAG 2 G V mis10--------
    rs1406267931,2
    C,F--222549477(+) GCACAG/ACCAAC 2 /Q syn11Minor allele frequency- A:0.00NA 4494
    rs1500274321,2
    C--222549506(+) CAGGTG/AGAGGA 2 /* /W stg11Minor allele frequency- A:0.00NA 4502
    rs2020567481,2
    --222549518(+) GCAGAC/GTTGTC 2 T S mis10--------
    rs1408563991,2
    C,F--222549529(+) AGGGGC/TCAAGC 2 P S mis11Minor allele frequency- T:0.00NA 4506
    rs1434571021,2
    C,F--222549589(+) GAGGCG/ATTTTG 2 /I /V mis12Minor allele frequency- A:0.01NA EU 5481
    rs2020847451,2
    F--222549850(+) GCGGGG/AGAGAG 1 -- ut311Minor allele frequency- A:0.01EU 563
    rs102102191,2
    C,F--222549853(+) GGGGAG/TAGAAG 1 -- ut31 ese3 trp37Minor allele frequency- T:0.13WA NA EA EU 914
    rs1415491281,2
    --222549893(+) AGCAGA/GAGGCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CCDC140 (223162866 - 223169936 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCDC140:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834550CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC140

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CCDC140 for disorders           About MalaCards

    CCDC140 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CCDC140

    Export disorders for CCDC140 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCDC140 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CCDC140)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    3. Coiled coil domains: stability, specificity, and biol ogical implications. (PubMed id 14760737)1 Mason J.M. and Arndt K.M. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Coiled coils: a highly versatile protein folding moti f. (PubMed id 11166216)1 Burkhard P....Strelkov S.V. (2001)
    7. Alpha-helical coiled-coil oligomerization domains in extracellular proteins. (PubMed id 9138288)1 Kammerer R.A. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 151278 HGNC: 26514 AceView: FLJ32447 Ensembl:ENSG00000163081 euGenes: HUgn151278
    ECgene: CCDC140 H-InvDB: CCDC140

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCDC140 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCDC140 gene:
    Search GeneIP for patents involving CCDC140

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     inGenious Targeting Laboratory - Custom generated mouse model solutions for CCDC140
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCDC140
    Customized:
     lentivirus for stable overexpression of CCDC140
     lentivirus expression plasmids for stable overexpression of CCDC140
     adenovirus for overexpression of CCDC140
     LSBio Antibodies in human, mouse, rat for CCDC140
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
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     Tissue-specific gene expresssion
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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