Aliases for CCDC140 Gene
External Ids for CCDC140 Gene
- HGNC: 26514
- Entrez Gene: 151278
- Ensembl: ENSG00000163081
- UniProtKB: Q96MF4
Previous GeneCards Identifiers for CCDC140 Gene
- GC02P222872
- GC02P223162
- GC02P215016
Summaries for CCDC140 Gene
-
This gene encodes a protein that appears to be restricted to select higher primate species. This protein contains a C-terminal coiled-coil domain, which is a versatile structural motif consisting of multiple amphipathic alpha-helices that twist around each other to form a supercoil. [provided by RefSeq, Aug 2011]
GeneCards Summary for CCDC140 Gene
CCDC140 (Coiled-Coil Domain Containing 140) is a Protein Coding gene.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC140 Gene
Genomics for CCDC140 Gene
Regulatory Elements for CCDC140 Gene
Enhancers for CCDC140 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH02G222289 | 1 | FANTOM5 ENCODE | 4.2 | -7.1 | -7122 | 3.4 | CTCF RNF2 SUZ12 CHD1 CBX2 OSR2 CBX8 HDAC2 CTBP2 KDM1A | PAX3 CCDC140 GC02P222238 |
| GH02G222795 | 1.6 | FANTOM5 Ensembl ENCODE | 1.2 | +498.5 | 498459 | 3.1 | PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 FOS SP5 ZHX2 | SGPP2 CCDC140 LOC105373903 ACSL3 |
| GH02G222293 | 0.9 | ENCODE | 0.7 | -1.2 | -1202 | 5.9 | ZSCAN4 ZNF76 ZNF48 GLIS2 ZNF366 SCRT2 ZNF263 SP3 ZNF398 CBX8 | CCDC140 GC02P222238 |
| GH02G222269 | 1.5 | ENCODE | 0.3 | -28.8 | -28811 | 0.2 | CBX2 CHD7 EZH2 | CCDC140 GC02P222238 |
| GH02G222272 | 1.4 | ENCODE | 0.3 | -25.3 | -25311 | 0.1 | EZH2 | CCDC140 GC02P222238 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CCDC140 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CCDC140 gene promoter:
Regulatory Element Products
Genomic Location for CCDC140 Gene
- Chromosome:
- 2
- Start:
- 222,298,147 bp from pter
- End:
- 222,305,217 bp from pter
- Size:
- 7,071 bases
- Orientation:
- Plus strand
Genomic View for CCDC140 Gene
Genes around CCDC140 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q36.1 by Ensembl
- 2q36.1 by Entrez Gene
- 2q36.1 by HGNC
CCDC140 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCDC140 Gene
Proteins for CCDC140 Gene
-
Protein details for CCDC140 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96MF4-CC140_HUMAN
- Recommended name:
- Coiled-coil domain-containing protein 140
- Protein Accession:
- Q96MF4
Protein attributes for CCDC140 Gene
- Size:
- 163 amino acids
- Molecular mass:
- 18252 Da
- Quaternary structure:
- No Data Available
Protein Expression for CCDC140 Gene
Post-translational modifications for CCDC140 Gene
Other Protein References for CCDC140 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CCDC140
- Novus Biologicals Antibodies for CCDC140
-
Abcam antibodies for CCDC140
- Invitrogen Antibodies for CCDC140
- Search GeneTex for Antibodies for CCDC140
Protein Products
-
OriGene Purified Proteins for CCDC140
- Search Origene for MassSpec and Protein Over-expression Lysates for CCDC140
- Origene Custom Protein Services for CCDC140
- Novus Biologicals proteins for CCDC140
- Search GeneTex for Proteins for CCDC140
Assay Products
No data available for DME Specific Peptides for CCDC140 Gene
Domains & Families for CCDC140 Gene
Protein Domains for CCDC140 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for CCDC140 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC140 Gene
Function for CCDC140 Gene
Phenotypes for CCDC140 Gene
- GenomeRNAi human phenotypes for CCDC140:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCDC140
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CCDC140 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC140 gene
- Search ViGene Biosciences for CCDC140
CRISPR Products
-
OriGene CRISPR knockouts for CCDC140
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC140
- GenScript: Design CRISPR guide RNA sequences for CCDC140
miRNA for CCDC140 Gene
- miRTarBase miRNAs that target CCDC140
-
- hsa-mir-5706 (MIRT531083)
- hsa-mir-4782-5p (MIRT531084)
- hsa-mir-516b-5p (MIRT531085)
- hsa-mir-1299 (MIRT531086)
- hsa-mir-519e-5p (MIRT531087)
- hsa-mir-515-5p (MIRT531088)
- hsa-mir-152-5p (MIRT531089)
- hsa-mir-103a-2-5p (MIRT531090)
- hsa-mir-6839-5p (MIRT531091)
- hsa-mir-378j (MIRT531092)
- hsa-mir-5695 (MIRT531093)
- hsa-mir-519d-5p (MIRT531094)
- hsa-mir-136-5p (MIRT648550)
miRNA Products
- Search ViGene Biosciences for CCDC140
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCDC140
- Browse OriGene Inhibitory RNA Products For CCDC140
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC140 gene
Clone Products
-
OriGene ORF clones in human for CCDC140
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CCDC140
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC140
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CCDC140
-
ViGene Biosciences adenoviral particle packaged cDNA for CCDC140 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CCDC140 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC140 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC140 Gene
Localization for CCDC140 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC140 Gene
Transcripts for CCDC140 Gene
mRNA/cDNA for CCDC140 Gene
- (2) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (2) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CCDC140 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCDC140
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC140
- GenScript: Design CRISPR guide RNA sequences for CCDC140
miRNA Products
- Search ViGene Biosciences for CCDC140
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCDC140
- Browse OriGene Inhibitory RNA Products For CCDC140
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC140 gene
Clone Products
-
OriGene ORF clones in human for CCDC140
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CCDC140
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC140
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CCDC140 Gene
mRNA differential expression in normal tissues according to GTEx for CCDC140 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.4), Minor Salivary Gland (x7.4), Muscle - Skeletal (x6.8), and Brain - Cerebellum (x5.6).
This gene is overexpressed in Platelet (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC140 Gene
NURSA nuclear receptor signaling pathways regulating expression of CCDC140 Gene:
CCDC140SOURCE GeneReport for Unigene cluster for CCDC140 Gene:
Hs.350729Primer Products
-
OriGene qPCR primer pairs and template standards for CCDC140
-
OriGene qPCR primer pairs for CCDC140
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC140 Gene
Orthologs for CCDC140 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCDC140 34 35 |
|
- Species where no ortholog for CCDC140 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CCDC140 Gene
No data available for Paralogs for CCDC140 Gene
Variants for CCDC140 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs104893650 | Pathogenic | 222,297,150(-) | CAGGC(C/T)GCTGC | upstream-variant-2KB, reference, missense | |
| rs104893651 | Pathogenic | 222,297,048(-) | CGTCT(C/T)CAAGA | upstream-variant-2KB, reference, missense | |
| rs104893652 | Pathogenic | 222,297,158(-) | ATCAA(C/G)GGCAG | upstream-variant-2KB, reference, missense | |
| rs104893653 | Pathogenic | 222,297,160(-) | TTATC(A/C)ACGGC | upstream-variant-2KB, reference, missense | |
| rs104893654 | Pathogenic | 222,297,031(-) | GCAGG(C/T)ACCAG | upstream-variant-2KB, reference, missense |
Residual Variation Intolerance Score:
55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.20;
24.08% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CCDC140 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCDC140
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC140 Gene
Disorders for CCDC140 Gene
Relevant External Links for CCDC140
No disorders were found for CCDC140 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC140 Gene
Publications for CCDC140 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
- Coiled coil domains: stability, specificity, and biological implications. (PMID: 14760737) Mason J.M. … Arndt K.M. (Chembiochem 2004) 3 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
Products for CCDC140 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CCDC140
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CCDC140
- Search Origene for MassSpec and Protein Over-expression Lysates for CCDC140
- Origene Custom Protein Services for CCDC140
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCDC140
- Browse OriGene Inhibitory RNA Products For CCDC140
- OriGene qPCR primer pairs and template standards for CCDC140
- OriGene qPCR primer pairs for CCDC140
- OriGene CRISPR knockouts for CCDC140
- OriGene ORF clones in human for CCDC140
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCDC140
- GenScript: Next-day shipping cDNA ORF clone for CCDC140 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CCDC140
- GenScript Custom Assay Services for CCDC140
- GenScript Custom overexpressing Cell Line Services for CCDC140
- GenScript: Design CRISPR guide RNA sequences for CCDC140
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CCDC140
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CCDC140
- Novus Biologicals proteins for CCDC140
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for CCDC140 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CCDC140 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CCDC140 gene
- Search ViGene Biosciences for CCDC140
- Horizon Cell Lines for CCDC140
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCDC140
- VectorBuilder custom plasmid, inducible vectors for CCDC140
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC140
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CCDC140 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer