CCDC140 Gene
protein-coding GIFtS: 35
GCID: GC02P223162
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coiled-coil domain containing 140
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Aliases
for CCDC140 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 1401 2 | | FLJ324471 | | Coiled-Coil Domain-Containing Protein 1402 |
Export aliases for CCDC140 gene to outside databasesPrevious GC identifers: GC02P222872 GC02P215016 |
Summaries
for CCDC140 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CCDC140:
This gene encodes a protein that appears to be restricted to select higher primate species. This protein contains aC-terminal coiled-coil domain, which is a versatile structural motif consisting of multiple amphipathic alpha-helicesthat twist around each other to form a supercoil. (provided by RefSeq, Aug 2011)
|
Genomic Views
for CCDC140 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC140 gene promoter:
AP-2alpha isoform 3 AP-2alpha isoform 2 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC140
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC140 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q36.1 Ensembl cytogenetic band: 2q36.1 HGNC cytogenetic band: 2q36.1CCDC140 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P223162: view genomic region
(about GC identifiers)
Start:
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223,162,866 bp from pter |
End:
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223,169,936 bp from pter |
Size:
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7,071 bases |
Orientation:
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plus strand |
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Proteins
for CCDC140 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CC140_HUMAN, Q96MF4 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 140 Size: 163 amino acids; 18252 DaExplore the universe of human proteins at neXtProt for CCDC140: NX_Q96MF4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96MF4
CCDC140 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_694583.1
ENSEMBL proteins: ENSP00000295226 ENSP00000407652
Human Recombinant Protein Products for CCDC140:
CCDC140 Antibody Products:
Assay Products for CCDC140: |
Protein
Domains /
Families
for CCDC140 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96MF4 |
Function
for CCDC140 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC140
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC140
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CCDC140 (NM_153038) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC140 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC140 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC140 |
|
Pathways & Interactions
for CCDC140 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC140
|
Drugs & Compounds
for CCDC140 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC140
Search CenterWatch for drugs/clinical trials and news about CCDC140 / CC140
|
Transcripts
for CCDC140 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC140 gene: NM_153038.1 Unigene Cluster for CCDC140: Coiled-coil domain containing 140 Hs.350729 [show with all ESTs]Unigene Representative Sequence: AK0570092 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000295226(uc002vnb.1) ENST00000440903
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC140
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC140
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCDC140 (NM_153038) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC140 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC140 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC140
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CCDC140 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC140 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC140 |
Additional cDNA sequence: AK057009.1 BC109388.1 1 DOTS entry: DT.95325453 2 AceView cDNA sequences: AK057009 NM_153038
GeneLoc Exon Structure
|
Expression
for CCDC140 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC140 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGATATTG
About this image
See CCDC140 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC140
SOURCE GeneReport for Unigene cluster: Hs.350729
SABiosciences Custom PCR Arrays for CCDC140
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC140
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CCDC140 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC140 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC140 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC140 |
Orthologs
for CCDC140 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for CCDC140 (if available)
TreeFam Gene Tree for CCDC140 (if available) |
Paralogs
for CCDC140 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CCDC140 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC140 (223162866 - 223169936 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCDC140: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC140 |
|
Disorders
/ Diseases
for CCDC140 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CCDC140 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC140 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCDC140) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Coiled coil domains: stability, specificity, and biol ogical implications. (PubMed id 14760737)1 Mason J.M. and Arndt K.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Coiled coils: a highly versatile protein folding moti f. (PubMed id 11166216)1 Burkhard P....Strelkov S.V. (2001)
- Alpha-helical coiled-coil oligomerization domains in extracellular proteins. (PubMed id 9138288)1 Kammerer R.A. (1997)
|
External Searches for CCDC140 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC140 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC140 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC140 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC140 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC140 gene:
Search GeneIP for patents involving CCDC140
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC140 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC140 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC140 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC140 | | | OriGene Protein Over-expression Lysate for CCDC140 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC140 | | OriGene 3'-UTR Clone for CCDC140 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC140 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC140 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CCDC140 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for CCDC140 |
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 | | | CCDC140 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC140 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CCDC140 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC140 |
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