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Aliases for CCDC14 Gene

Aliases for CCDC14 Gene

  • Coiled-Coil Domain Containing 14 2 3 5

External Ids for CCDC14 Gene

Previous GeneCards Identifiers for CCDC14 Gene

  • GC03M125116
  • GC03M123616
  • GC03M121005

Summaries for CCDC14 Gene

GeneCards Summary for CCDC14 Gene

CCDC14 (Coiled-Coil Domain Containing 14) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC14 Gene

  • Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC14 Gene

Genomics for CCDC14 Gene

Regulatory Elements for CCDC14 Gene

Promoters for CCDC14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC14 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC14 Gene

Chromosome:
3
Start:
123,887,353 bp from pter
End:
123,961,409 bp from pter
Size:
74,057 bases
Orientation:
Minus strand

Genomic View for CCDC14 Gene

Genes around CCDC14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC14 Gene

Proteins for CCDC14 Gene

  • Protein details for CCDC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49A88-CCD14_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 14
    Protein Accession:
    Q49A88
    Secondary Accessions:
    • B7Z2T2
    • B8ZZ41
    • B8ZZ58
    • D3DN98
    • Q7Z3N3
    • Q86T30
    • Q8IWF8
    • Q8WUJ8
    • Q96K47
    • Q9H9A3
    • Q9UFH0

    Protein attributes for CCDC14 Gene

    Size:
    953 amino acids
    Molecular mass:
    106302 Da
    Quaternary structure:
    • Interacts with CEP63.
    SequenceCaution:
    • Sequence=BAB14329.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55229.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC14 Gene

neXtProt entry for CCDC14 Gene

Proteomics data for CCDC14 Gene at MOPED

Post-translational modifications for CCDC14 Gene

  • Ubiquitination at Lys 291, Lys 389, Lys 551, Lys 606, Lys 649, and Lys 821
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCDC14 Gene

Domains & Families for CCDC14 Gene

Protein Domains for CCDC14 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC14: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC14 Gene

Function for CCDC14 Gene

Molecular function for CCDC14 Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization.
genes like me logo Genes that share phenotypes with CCDC14: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC14 Gene

Localization for CCDC14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC14 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Colocalizes with PCM1 at centriolar satellites throughout the cell cycle. {ECO:0000269 PubMed:26297806}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC14 Gene COMPARTMENTS Subcellular localization image for CCDC14 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for CCDC14 Gene

Pathways & Interactions for CCDC14 Gene

SuperPathways for CCDC14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0021762 substantia nigra development IEP 22926577
genes like me logo Genes that share ontologies with CCDC14: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC14 Gene

Drugs & Compounds for CCDC14 Gene

No Compound Related Data Available

Transcripts for CCDC14 Gene

Unigene Clusters for CCDC14 Gene

Coiled-coil domain containing 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC14 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e ·
SP1: - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - -
SP9: - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - -
SP12: -
SP13:
SP14: - - - - - - - - - - -
SP15: - - - - - - - -
SP16: - - - - - - - - - -
SP17: - - - - - - - - -
SP18:
SP19: -
SP20: - - - - - - - - - - - - - - - - - - - -
SP21:

ExUns: 10f ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b · 17c
SP1: -
SP2: - - -
SP3: -
SP4: -
SP5: - - -
SP6:
SP7:
SP8: - - - -
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: - - - - - - - - - -
SP21:

Relevant External Links for CCDC14 Gene

GeneLoc Exon Structure for
CCDC14
ECgene alternative splicing isoforms for
CCDC14

Expression for CCDC14 Gene

mRNA expression in normal human tissues for CCDC14 Gene

Protein differential expression in normal tissues from HIPED for CCDC14 Gene

This gene is overexpressed in Colon muscle (49.3) and Heart (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CCDC14 Gene



SOURCE GeneReport for Unigene cluster for CCDC14 Gene Hs.645028

genes like me logo Genes that share expression patterns with CCDC14: view

Protein tissue co-expression partners for CCDC14 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC14 Gene

Orthologs for CCDC14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC14 35
  • 99.12 (n)
  • 98.46 (a)
CCDC14 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC14 36
  • 72 (a)
OneToOne
CCDC14 35
  • 84.45 (n)
  • 75.39 (a)
dog
(Canis familiaris)
Mammalia CCDC14 35
  • 84.97 (n)
  • 77.45 (a)
CCDC14 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc14 36
  • 63 (a)
OneToOne
Ccdc14 16
Ccdc14 35
  • 76.96 (n)
  • 66.44 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 46 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ccdc14 35
  • 75.08 (n)
  • 64.19 (a)
chicken
(Gallus gallus)
Aves CCDC14 36
  • 39 (a)
OneToOne
CCDC14 35
  • 57.38 (n)
  • 45.45 (a)
lizard
(Anolis carolinensis)
Reptilia CCDC14 36
  • 36 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14290 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491976 35
  • 50.42 (n)
  • 43.56 (a)
zebrafish
(Danio rerio)
Actinopterygii ccdc14 36
  • 22 (a)
OneToOne
Species with no ortholog for CCDC14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC14 Gene

ENSEMBL:
Gene Tree for CCDC14 (if available)
TreeFam:
Gene Tree for CCDC14 (if available)

Paralogs for CCDC14 Gene

Pseudogenes.org Pseudogenes for CCDC14 Gene

genes like me logo Genes that share paralogs with CCDC14: view

No data available for Paralogs for CCDC14 Gene

Variants for CCDC14 Gene

Sequence variations from dbSNP and Humsavar for CCDC14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs17310144 - 123,947,055(+) ATGCG(G/T)TTCTT intron-variant, reference, missense
rs1064236 -- 123,947,126(-) AGGAA(C/T)TCATA intron-variant, reference, missense
rs1814975 -- 123,959,722(+) TGGTA(C/T)GTGGA intron-variant
rs1996681 -- 123,941,803(+) TAAAA(C/T)AGTAA intron-variant
rs1920213 -- 123,895,354(+) AAGAC(A/G)GTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC14 Gene

Variant ID Type Subtype PubMed ID
nsv460837 CNV Gain 19166990
nsv520308 CNV Gain 19592680
nsv877397 CNV Gain 21882294
esv2725842 CNV Deletion 23290073
esv5313 CNV Deletion 18987735
esv2725843 CNV Deletion 23290073
esv2725844 CNV Deletion 23290073
esv2725845 CNV Deletion 23290073

Variation tolerance for CCDC14 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC14 Gene

HapMap Linkage Disequilibrium report
CCDC14
Human Gene Mutation Database (HGMD)
CCDC14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC14 Gene

Disorders for CCDC14 Gene

Relevant External Links for CCDC14

Genetic Association Database (GAD)
CCDC14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC14

No disorders were found for CCDC14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC14 Gene

Publications for CCDC14 Gene

  1. Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. (PMID: 26297806) Kodani A. … Reiter J.F. (Elife 2015) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Proximity Interactions among Centrosome Components Identify Regulators of Centriole Duplication. (PMID: 24613305) Firat-Karalar E.N. … Stearns T. (Curr. Biol. 2014) 3

Products for CCDC14 Gene

Sources for CCDC14 Gene

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