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Aliases for CCDC14 Gene

Aliases for CCDC14 Gene

  • Coiled-Coil Domain Containing 14 2 3 5

External Ids for CCDC14 Gene

Previous GeneCards Identifiers for CCDC14 Gene

  • GC03M125116
  • GC03M123616
  • GC03M121005

Summaries for CCDC14 Gene

GeneCards Summary for CCDC14 Gene

CCDC14 (Coiled-Coil Domain Containing 14) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC14 Gene

  • Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC14 Gene

Genomics for CCDC14 Gene

Regulatory Elements for CCDC14 Gene

Enhancers for CCDC14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F123960 0.8 ENCODE 8.2 +0.4 386 1.9 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 GTF3C2 GLIS2 ELK1 ZNF143 ROPN1 UMPS SEC22A CCDC14 MYLK
GH03F123979 0.4 Ensembl 8.1 -18.8 -18759 0.9 CTCF MAZ ZNF654 REST RAD21 NR2F2 ZFP69B CBX8 ZNF692 MAFK CCDC14 ROPN1
GH03F123881 0.9 Ensembl ENCODE 6 +79.7 79703 1.0 CTCF KLF1 ZNF133 DPF2 ZNF644 RAD21 ARID1B ZNF366 ZNF512 SMC3 CCDC14 MYLK ENSG00000207002
GH03F123883 0.2 ENCODE 4.8 +77.4 77355 1.8 KLF1 ZNF223 CHD4 ZMYM3 E2F1 FOSL1 ZNF316 GLIS2 POLR2A PATZ1 CCDC14 MYLK ENSG00000207002
GH03F123949 0.6 ENCODE 0.4 +11.4 11443 0.8 ZNF146 ROPN1 CCDC14 MYLK
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CCDC14 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001372421 409 2001 ARID4B SIN3A DMAP1 ZNF48 YY1 GTF3C2 GLIS2 ELK1 ZNF143 SP3

Genomic Location for CCDC14 Gene

Chromosome:
3
Start:
123,887,353 bp from pter
End:
123,961,409 bp from pter
Size:
74,057 bases
Orientation:
Minus strand

Genomic View for CCDC14 Gene

Genes around CCDC14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC14 Gene

Proteins for CCDC14 Gene

  • Protein details for CCDC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49A88-CCD14_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 14
    Protein Accession:
    Q49A88
    Secondary Accessions:
    • B7Z2T2
    • B8ZZ41
    • B8ZZ58
    • D3DN98
    • Q7Z3N3
    • Q86T30
    • Q8IWF8
    • Q8WUJ8
    • Q96K47
    • Q9H9A3
    • Q9UFH0

    Protein attributes for CCDC14 Gene

    Size:
    953 amino acids
    Molecular mass:
    106302 Da
    Quaternary structure:
    • Interacts with CEP63.
    SequenceCaution:
    • Sequence=BAB14329.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55229.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC14 Gene

neXtProt entry for CCDC14 Gene

Post-translational modifications for CCDC14 Gene

  • Ubiquitination at Lys 291, Lys 389, Lys 551, Lys 606, Lys 649, and Lys 821
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCDC14 Gene

Domains & Families for CCDC14 Gene

Protein Domains for CCDC14 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC14: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC14 Gene

Function for CCDC14 Gene

Molecular function for CCDC14 Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization.

Gene Ontology (GO) - Molecular Function for CCDC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC14: view
genes like me logo Genes that share phenotypes with CCDC14: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC14 Gene

Localization for CCDC14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC14 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Colocalizes with PCM1 at centriolar satellites throughout the cell cycle. {ECO:0000269 PubMed:26297806}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC14 Gene COMPARTMENTS Subcellular localization image for CCDC14 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for CCDC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0034451 centriolar satellite IDA 26297806
genes like me logo Genes that share ontologies with CCDC14: view

Pathways & Interactions for CCDC14 Gene

SuperPathways for CCDC14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0021762 substantia nigra development IEP 22926577
GO:0071539 protein localization to centrosome IMP 26297806
genes like me logo Genes that share ontologies with CCDC14: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC14 Gene

Transcripts for CCDC14 Gene

Unigene Clusters for CCDC14 Gene

Coiled-coil domain containing 14:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC14 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e ·
SP1: - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - -
SP9: - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - -
SP12: -
SP13:
SP14: - - - - - - - - - - -
SP15: - - - - - - - -
SP16: - - - - - - - - - -
SP17: - - - - - - - - -
SP18:
SP19: -
SP20: - - - - - - - - - - - - - - - - - - - -
SP21:

ExUns: 10f ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b · 17c
SP1: -
SP2: - - -
SP3: -
SP4: -
SP5: - - -
SP6:
SP7:
SP8: - - - -
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: - - - - - - - - - -
SP21:

Relevant External Links for CCDC14 Gene

GeneLoc Exon Structure for
CCDC14
ECgene alternative splicing isoforms for
CCDC14

Expression for CCDC14 Gene

mRNA expression in normal human tissues for CCDC14 Gene

Protein differential expression in normal tissues from HIPED for CCDC14 Gene

This gene is overexpressed in Colon muscle (49.3) and Heart (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC14 Gene



Protein tissue co-expression partners for CCDC14 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC14 Gene:

CCDC14

SOURCE GeneReport for Unigene cluster for CCDC14 Gene:

Hs.645028
genes like me logo Genes that share expression patterns with CCDC14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC14 Gene

Orthologs for CCDC14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC14 34 35
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia CCDC14 34 35
  • 84.97 (n)
cow
(Bos Taurus)
Mammalia CCDC14 34 35
  • 84.45 (n)
mouse
(Mus musculus)
Mammalia Ccdc14 34 16 35
  • 76.96 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc14 34
  • 75.08 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 46 (a)
OneToMany
-- 35
  • 33 (a)
OneToMany
chicken
(Gallus gallus)
Aves CCDC14 34 35
  • 57.38 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC14 35
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491976 34
  • 50.42 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14290 34
zebrafish
(Danio rerio)
Actinopterygii ccdc14 35
  • 22 (a)
OneToOne
Species where no ortholog for CCDC14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC14 Gene

ENSEMBL:
Gene Tree for CCDC14 (if available)
TreeFam:
Gene Tree for CCDC14 (if available)

Paralogs for CCDC14 Gene

Pseudogenes.org Pseudogenes for CCDC14 Gene

genes like me logo Genes that share paralogs with CCDC14: view

No data available for Paralogs for CCDC14 Gene

Variants for CCDC14 Gene

Sequence variations from dbSNP and Humsavar for CCDC14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10573718 -- 123,931,601(+) TTCTT(-/AA)AAAAA intron-variant
rs1064236 -- 123,947,126(-) AGGAA(C/T)TCATA intron-variant, nc-transcript-variant, reference, missense
rs10675830 -- 123,898,899(+) TTTTT(-/T)GGTAG intron-variant
rs10934653 -- 123,892,637(+) cacag(A/G)ggaaa intron-variant
rs10934654 -- 123,892,690(+) caatt(C/T)gacat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC14 Gene

Variant ID Type Subtype PubMed ID
esv2725842 CNV deletion 23290073
esv2725843 CNV deletion 23290073
esv2725844 CNV deletion 23290073
esv2725845 CNV deletion 23290073
esv3597633 CNV gain 21293372
esv3597635 CNV gain 21293372
esv5313 CNV loss 18987735
nsv1007525 CNV loss 25217958
nsv460837 CNV gain 19166990
nsv520308 CNV gain 19592680
nsv591428 CNV gain 21841781
nsv591430 CNV loss 21841781

Variation tolerance for CCDC14 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC14 Gene

Human Gene Mutation Database (HGMD)
CCDC14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC14 Gene

Disorders for CCDC14 Gene

Relevant External Links for CCDC14

Genetic Association Database (GAD)
CCDC14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC14

No disorders were found for CCDC14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC14 Gene

Publications for CCDC14 Gene

  1. Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. (PMID: 26297806) Kodani A. … Reiter J.F. (Elife 2015) 3 4 64
  2. Proximity Interactions among Centrosome Components Identify Regulators of Centriole Duplication. (PMID: 24613305) Firat-Karalar E.N. … Stearns T. (Curr. Biol. 2014) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64

Products for CCDC14 Gene

Sources for CCDC14 Gene

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