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Aliases for CCDC138 Gene

Aliases for CCDC138 Gene

  • Coiled-Coil Domain Containing 138 2 3 5

External Ids for CCDC138 Gene

Previous GeneCards Identifiers for CCDC138 Gene

  • GC02P109403
  • GC02P103001

Summaries for CCDC138 Gene

GeneCards Summary for CCDC138 Gene

CCDC138 (Coiled-Coil Domain Containing 138) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC138 Gene

Genomics for CCDC138 Gene

Regulatory Elements for CCDC138 Gene

Enhancers for CCDC138 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G108923 0.7 ENCODE dbSUPER 4.2 +136.5 136480 0.1 PKNOX1 JUND CCDC138 GC02M108928 PIR56059
GH02G108916 0.5 dbSUPER 5 +130.3 130278 2.0 SOX5 SOX13 POLR2A HLF GCC2 CCDC138 GC02M108928 PIR56059
GH02G108785 1.1 ENCODE 0.7 +0.0 44 2.3 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 GCC2 LIMS1 CCDC138 RPL39P16
GH02G108890 0.3 FANTOM5 2.4 +103.4 103401 0.2 EDAR CCDC138 LIMS1 PIR52808 RPL39P16
GH02G108775 0.8 ENCODE 0.4 -10.2 -10227 2.3 TBL1XR1 ZMYM3 BMI1 RELA ARID3A EED RELB IKZF2 CREM MAFK GCC2 CCDC138 RANBP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC138 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC138 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000121423 150 1801 PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for CCDC138 Gene

Chromosome:
2
Start:
108,786,750 bp from pter
End:
108,885,477 bp from pter
Size:
98,728 bases
Orientation:
Plus strand

Genomic View for CCDC138 Gene

Genes around CCDC138 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC138 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC138 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC138 Gene

Proteins for CCDC138 Gene

  • Protein details for CCDC138 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M89-CC138_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 138
    Protein Accession:
    Q96M89
    Secondary Accessions:
    • Q05DF1
    • Q4ZG07
    • Q53TE1
    • Q6ZUY5
    • Q86VL7

    Protein attributes for CCDC138 Gene

    Size:
    665 amino acids
    Molecular mass:
    76219 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC138 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC138 Gene

Post-translational modifications for CCDC138 Gene

  • Ubiquitination at Lys19, posLast=4141, posLast=200200, posLast=230230, Lys295, posLast=313313, Lys399, and posLast=463463
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCDC138 Gene

Domains & Families for CCDC138 Gene

Protein Domains for CCDC138 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC138 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC138: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC138 Gene

Function for CCDC138 Gene

Phenotypes for CCDC138 Gene

genes like me logo Genes that share phenotypes with CCDC138: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC138 Gene

Localization for CCDC138 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC138 gene
Compartment Confidence
cytosol 4
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC138 Gene

Pathways & Interactions for CCDC138 Gene

SuperPathways for CCDC138 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC138 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC138 Gene

Drugs & Compounds for CCDC138 Gene

No Compound Related Data Available

Transcripts for CCDC138 Gene

Unigene Clusters for CCDC138 Gene

Coiled-coil domain containing 138:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC138 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d
SP1: -
SP2: -
SP3: - -
SP4: -
SP5: - -

Relevant External Links for CCDC138 Gene

GeneLoc Exon Structure for
CCDC138
ECgene alternative splicing isoforms for
CCDC138

Expression for CCDC138 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC138 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC138 Gene

This gene is overexpressed in Testis (x5.8).

Protein differential expression in normal tissues from HIPED for CCDC138 Gene

This gene is overexpressed in Lung (59.1) and Testis (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC138 Gene



Protein tissue co-expression partners for CCDC138 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC138 Gene:

CCDC138

SOURCE GeneReport for Unigene cluster for CCDC138 Gene:

Hs.731709
genes like me logo Genes that share expression patterns with CCDC138: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC138 Gene

Orthologs for CCDC138 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC138 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC138 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia CCDC138 34 35
  • 88.35 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc138 34
  • 82.9 (n)
mouse
(Mus musculus)
Mammalia Ccdc138 34 16 35
  • 81.67 (n)
cow
(Bos Taurus)
Mammalia CCDC138 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC138 35
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC138 35
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC138 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc138 34
  • 64.07 (n)
Str.4317 34
zebrafish
(Danio rerio)
Actinopterygii CCDC138 35
  • 42 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2655 35
  • 37 (a)
OneToOne
Species where no ortholog for CCDC138 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC138 Gene

ENSEMBL:
Gene Tree for CCDC138 (if available)
TreeFam:
Gene Tree for CCDC138 (if available)

Paralogs for CCDC138 Gene

No data available for Paralogs for CCDC138 Gene

Variants for CCDC138 Gene

Sequence variations from dbSNP and Humsavar for CCDC138 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000014844 -- 108,840,757(+) ATTGA(C/T)CTTTC intron-variant
rs1000028371 -- 108,833,257(+) TAATC(A/T)TAGTA intron-variant
rs1000029304 -- 108,815,569(+) CAGGT(A/G)ATTCT intron-variant
rs1000059657 -- 108,840,998(+) GTGTG(C/T)GTGTT intron-variant
rs1000083705 -- 108,805,789(+) AGTTT(C/T)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC138 Gene

Variant ID Type Subtype PubMed ID
nsv1149522 OTHER inversion 26484159
nsv1153528 CNV deletion 26484159
nsv2872 CNV insertion 18451855

Variation tolerance for CCDC138 Gene

Residual Variation Intolerance Score: 27.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.77; 86.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC138 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC138

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC138 Gene

Disorders for CCDC138 Gene

Relevant External Links for CCDC138

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC138

No disorders were found for CCDC138 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC138 Gene

Publications for CCDC138 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for CCDC138 Gene

Sources for CCDC138 Gene

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