Aliases for CCDC137 Gene
Aliases for CCDC137 Gene
External Ids for CCDC137 Gene
- HGNC: 33451
- Entrez Gene: 339230
- Ensembl: ENSG00000185298
- OMIM: 614271
- UniProtKB: Q6PK04
Previous GeneCards Identifiers for CCDC137 Gene
- GC17U900828
- GC17P077245
- GC17P079633
- GC17P075079
Summaries for CCDC137 Gene
GeneCards Summary for CCDC137 Gene
CCDC137 (Coiled-Coil Domain Containing 137) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC137 Gene
Genomics for CCDC137 Gene
Regulatory Elements for CCDC137 Gene
Enhancers for CCDC137 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around CCDC137 on UCSC Golden Path with GeneCards custom track
Promoters for CCDC137 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around CCDC137 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CCDC137 gene promoter:
Regulatory Element Products
Genomic Location for CCDC137 Gene
- Chromosome:
- 17
- Start:
- 81,666,364 bp from pter
- End:
- 81,673,907 bp from pter
- Size:
- 7,544 bases
- Orientation:
- Plus strand
Genomic View for CCDC137 Gene
Genes around CCDC137 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by Ensembl
- 17q25.3 by Entrez Gene
- 17q25.3 by HGNC
CCDC137 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCDC137 Gene
Proteins for CCDC137 Gene
-
Protein details for CCDC137 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6PK04-CC137_HUMAN
- Recommended name:
- Coiled-coil domain-containing protein 137
- Protein Accession:
- Q6PK04
Protein attributes for CCDC137 Gene
- Size:
- 289 amino acids
- Molecular mass:
- 33231 Da
- Quaternary structure:
- No Data Available
Protein Expression for CCDC137 Gene
Post-translational modifications for CCDC137 Gene
Other Protein References for CCDC137 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CCDC137
- Novus Biologicals Antibodies for CCDC137
- GeneTex CCDC137 antibody for CCDC137
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCDC137
Protein Products
-
OriGene Purified Proteins for CCDC137
- Search Origene for MassSpec and Protein Over-expression Lysates for CCDC137
- Origene Custom Protein Services for CCDC137
- Novus Biologicals proteins for CCDC137
- Search GeneTex for Proteins for CCDC137
Assay Products
No data available for DME Specific Peptides for CCDC137 Gene
Domains & Families for CCDC137 Gene
Suggested Antigen Peptide Sequences for CCDC137 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC137 Gene
Function for CCDC137 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0044822 | poly(A) RNA binding | IDA | 22658674 |
Phenotypes for CCDC137 Gene
- MGI mutant phenotypes for CCDC137:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CCDC137:
Animal Models for CCDC137 Gene
- MGI Knock Outs for CCDC137:
-
- Ccdc137 tm1a(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for CCDC137 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC137 gene
- Search ViGene Biosciences for CCDC137
CRISPR Products
-
OriGene CRISPR knockouts for CCDC137
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC137
- GenScript: Design CRISPR guide RNA sequences for CCDC137
miRNA for CCDC137 Gene
- miRTarBase miRNAs that target CCDC137
-
- hsa-mir-155-5p (MIRT020508)
- hsa-mir-877-3p (MIRT037097)
- hsa-mir-615-3p (MIRT040105)
- hsa-mir-17-5p (MIRT079341)
- hsa-mir-19a-3p (MIRT079342)
- hsa-mir-19b-3p (MIRT079343)
- hsa-mir-20a-5p (MIRT079344)
- hsa-mir-93-5p (MIRT079345)
- hsa-mir-106a-5p (MIRT079346)
- hsa-mir-130a-3p (MIRT079347)
- hsa-mir-106b-5p (MIRT079348)
- hsa-mir-301a-3p (MIRT079349)
- hsa-mir-130b-3p (MIRT079350)
- hsa-mir-20b-5p (MIRT079352)
- hsa-mir-519c-3p (MIRT079353)
- hsa-mir-526b-3p (MIRT079354)
- hsa-mir-519b-3p (MIRT079355)
- hsa-mir-519d-3p (MIRT079356)
- hsa-mir-519a-3p (MIRT079357)
- hsa-mir-450a-2-3p (MIRT079359)
- hsa-mir-605-3p (MIRT079361)
- hsa-mir-454-3p (MIRT079362)
- hsa-mir-301b-3p (MIRT079363)
- hsa-mir-1910-3p (MIRT079364)
- hsa-mir-2110 (MIRT079365)
- hsa-mir-4295 (MIRT079366)
- hsa-mir-4271 (MIRT079367)
- hsa-mir-3666 (MIRT079368)
- hsa-mir-3714 (MIRT079369)
- hsa-mir-4725-3p (MIRT079370)
- hsa-mir-4747-5p (MIRT079371)
- hsa-mir-5196-5p (MIRT079373)
- hsa-mir-6511a-5p (MIRT079374)
- hsa-mir-6780b-5p (MIRT079375)
- hsa-mir-6763-5p (MIRT563864)
- hsa-mir-6857-5p (MIRT563865)
- hsa-mir-3150a-3p (MIRT563866)
- hsa-mir-6810-5p (MIRT563867)
- hsa-mir-513b-3p (MIRT571164)
- hsa-mir-4659b-3p (MIRT620006)
- hsa-mir-4659a-3p (MIRT620007)
- hsa-mir-6875-3p (MIRT620008)
- hsa-mir-223-5p (MIRT620009)
- hsa-mir-1208 (MIRT620010)
- hsa-mir-892c-3p (MIRT620011)
- hsa-mir-4676-3p (MIRT620012)
- hsa-mir-452-5p (MIRT620013)
miRNA Products
- Search ViGene Biosciences for CCDC137
Clone Products
- OriGene clones in human for CCDC137
- OriGene ORF clones in human,mouse,rat for CCDC137
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CCDC137 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CCDC137 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC137 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC137 Gene
Localization for CCDC137 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 2 |
| cytosol | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC137 Gene
Pathways & Interactions for CCDC137 Gene
More details on SuperPathways for CCDC137
No Data Available
Interacting Proteins for CCDC137 Gene
Selected Interacting proteins:
ENSP00000329360
Q6PK04-CC137_HUMAN
for CCDC137 Gene via
STRING
UniProtKB
I2D
No data available for Pathways by source and SIGNOR curated interactions for CCDC137 Gene
Transcripts for CCDC137 Gene
mRNA/cDNA for CCDC137 Gene
- (2) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (154) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CCDC137 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCDC137
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC137
- GenScript: Design CRISPR guide RNA sequences for CCDC137
miRNA Products
- Search ViGene Biosciences for CCDC137
Clone Products
- OriGene clones in human for CCDC137
- OriGene ORF clones in human,mouse,rat for CCDC137
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||
| SP3: | - |
Expression for CCDC137 Gene
This gene is overexpressed in Lung (56.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CCDC137 Gene
SOURCE GeneReport for Unigene cluster for CCDC137 Gene Hs.744125
Primer Products
-
OriGene qPCR primer pairs for CCDC137
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC137 Gene
Orthologs for CCDC137 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | CCDC137 35 |
|
||
| CCDC137 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | CCDC137 35 |
|
||
| CCDC137 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Ccdc137 35 |
|
||
| Ccdc137 16 |
|
||||
| Ccdc137 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Ccdc137 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CCDC137 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CCDC137 36 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | CCDC137 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CCDC137 35 |
|
||
| CCDC137 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | CCDC137 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100485278 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ccdc137 35 |
|
||
| ccdc137 36 |
|
OneToOne |
- Species with no ortholog for CCDC137:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CCDC137 Gene
Pseudogenes.org Pseudogenes for CCDC137 Gene
No data available for Paralogs for CCDC137 Gene
Variants for CCDC137 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs7226091 | - | 81,670,337(+) | ATCCA(C/G)CGCAT | reference, missense, utr-variant-5-prime | |
| rs11150805 | - | 81,671,775(+) | TCCGA(C/T)GGAAA | reference, missense | |
| rs11546630 | - | 81,672,520(+) | GCTGC(A/G)GATGC | reference, missense | |
| rs11546631 | - | 81,672,678(+) | CTTCC(C/T)GGAAG | reference, missense | |
| rs1137357 | -- | 81,672,986(+) | ACCTT(A/G)GGAAG | utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv26223 | CNV | Gain+Loss | 19812545 |
| nsv828128 | CNV | Loss | 20364138 |
| nsv909052 | CNV | Loss | 21882294 |
| nsv428351 | CNV | Gain | 18775914 |
| dgv3330n71 | CNV | Loss | 21882294 |
| dgv3332n71 | CNV | Loss | 21882294 |
| nsv470620 | CNV | Loss | 18288195 |
| nsv909109 | CNV | Loss | 21882294 |
| nsv909111 | CNV | Loss | 21882294 |
| dgv3333n71 | CNV | Loss | 21882294 |
Residual Variation Intolerance Score:
92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.30;
90.66% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCDC137 Gene
Disorders for CCDC137 Gene
Relevant External Links for CCDC137
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CCDC137
No disorders were found for CCDC137 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC137 Gene
Publications for CCDC137 Gene
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 67
- Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
- The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
- Negative regulation of ERRI+ by a novel nucleolar protein. (PMID: 22266318) Um S.J. … Kim E.J. (Biochem. Biophys. Res. Commun. 2012) 3
Products for CCDC137 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CCDC137
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CCDC137
- Search Origene for MassSpec and Protein Over-expression Lysates for CCDC137
- Origene Custom Protein Services for CCDC137
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for CCDC137
- Browse OriGene Inhibitory RNA Products For CCDC137
- OriGene qPCR primer pairs for CCDC137
- OriGene CRISPR knockouts for CCDC137
- OriGene clones in human for CCDC137
- OriGene ORF clones in human,mouse,rat for CCDC137
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for CCDC137
- GenScript Custom Assay Services for CCDC137
- GenScript Custom overexpressing Cell Line Services for CCDC137
- GenScript: Design CRISPR guide RNA sequences for CCDC137
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CCDC137
- Novus Biologicals Antibodies for CCDC137
- Novus Biologicals proteins for CCDC137
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for CCDC137 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CCDC137 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CCDC137 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CCDC137 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CCDC137 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CCDC137 gene
- Search ViGene Biosciences for CCDC137
- Search ViGene Biosciences for CCDC137
- Santa Cruz Biotechnology (SCBT) Antibodies for CCDC137
- Search Santa Cruz Biotechnology (SCBT) for CCDC137 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CCDC137
Sources for CCDC137 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon