CCDC137 Gene
protein-coding GIFtS: 42
GCID: GC17P079633
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Coiled-Coil Domain Containing 137
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Aliases
for CCDC137 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 1371 2 | | Coiled-Coil Domain-Containing Protein 1372 | | Hepatocellular Carcinoma Related Protein 22 |
Export aliases for CCDC137 gene to outside databasesPrevious GC identifers: GC17U900828 GC17P077245 GC17P075079 |
Summaries
for CCDC137 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for CCDC137 Gene: 
CCDC137 (coiled-coil domain containing 137) is a protein-coding gene.
Gene Wiki entry for CCDC137 Gene
|
Genomic Views
for CCDC137 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.2 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC137 gene promoter:
HFH-3 HTF SREBP-1c SREBP-1b C/EBPalpha FOXI1 SREBP-1a ATF6 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC137
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC137 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3CCDC137 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P079633: view genomic region
(about GC identifiers)
Start:
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79,633,394 bp from pter |
End:
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79,640,937 bp from pter |
Size:
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7,544 bases |
Orientation:
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plus strand |
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Proteins
for CCDC137 gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
|
UniProtKB/Swiss-Prot: CC137_HUMAN, Q6PK04 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 137 Size: 289 amino acids; 33231 DaExplore the universe of human proteins at neXtProt for CCDC137: NX_Q6PK04
Explore proteomics data for CCDC137 at MOPED
Post-translational modifications:
View modification sites using PhosphoSitePlusView neXtProt modification sites for NX_Q6PK04
CCDC137 Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins: NP_954981.1
ENSEMBL proteins: ENSP00000329360 ENSP00000458884 ENSP00000458350 ENSP00000461207 ENSP00000460261
Human Recombinant Protein Products for CCDC137:
CCDC137 Antibody Products:
Assay Products for CCDC137: |
Protein
Domains /
Families
for CCDC137 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| 1 InterPro protein domain:Graphical View of Domain Structure for InterPro Entry Q6PK04 ProtoNet protein and cluster: Q6PK04
CCDC137 for domains About GeneDecksing
|
Function
for CCDC137 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
Vector BioLabs,
and Sirion Biotech,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Ccdc137):
CCDC137 for phenotypes About GeneDecksing
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for CCDC137 | |  | Search LifeMap BioReagents cell lines for CCDC137 | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC137 |
Pathways & Interactions
for CCDC137 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC137
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5 Interacting proteins for CCDC137 (Q6PK043 ENSP000003293604) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CCDC137 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC137 (CC137)
Search CenterWatch for drugs/clinical trials and news about CCDC137 / CC137
|
Transcripts
for CCDC137 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Sirion Biotech,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC137 gene: NM_199287.2 Unigene Cluster for CCDC137: Coiled-coil domain containing 137 Hs.744125 [show with all ESTs]Unigene Representative Sequence: FJ6496456 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000329214(uc002kbc.4) ENST00000575223 ENST00000574107 ENST00000574200
ENST00000571916 ENST00000572531
Primer
Products: |  | OriGene qSTAR qPCR primer pairs in human, mouse for CCDC137
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC137 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC137 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC137 |
Additional mRNA sequence: BC009369.2 BC052272.1 FJ649645.1 17 DOTS entries: DT.91828799 DT.95173536 DT.91665014 DT.115093 DT.100023589 DT.100812851 DT.95273536 DT.120892522 DT.100777399 DT.100812853 DT.100812854 DT.92414326 DT.100023591 DT.120892587 DT.91737208 DT.95255977 DT.100713426 24/154 AceView cDNA sequences (see all 154): CR606833 N56867 AI201901 BG056094 AW445033 BF195200 BU738073 BG056095 BG230563 AI093140 BM548065 AI991334 CA422682 BM701908 AA554311 BG056030 AA598792 BQ575236 CR596466 BF115231 AI278136 BC052272 BG055723 AI870937
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC137 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 |
|---|
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| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CCDC137
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Expression
for CCDC137 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC137 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTGAAACTGC
About this image
See CCDC137 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC137
SOURCE GeneReport for Unigene cluster: Hs.744125
SABiosciences Custom PCR Arrays for CCDC137
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for CCDC137
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC137 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC137 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC137 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC137 |
Orthologs
for CCDC137 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CCDC137 gene from 4/9 species (see all 9) About this table
ENSEMBL Gene Tree for CCDC137 (if available)
TreeFam Gene Tree for CCDC137 (if available) |
Paralogs
for CCDC137 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCDC137 gene
CCDC137 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for CCDC137
PGOHUM00000238060 PGOHUM00000238061
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Genomic Variants
for CCDC137 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC137 (79633394 - 79640937 bp)
Structural Variations
Database of Genomic Variants (DGV) 10 variations for CCDC137: About this table
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC137 |
|
Disorders
/ Diseases
for CCDC137 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 CCDC137 for disorders About MalaCards
OMIM gene information: 614271
OMIM disorders: --
CCDC137 for disorders About GeneDecksing
Export disorders for CCDC137 gene to outside databases
|
Publications
for CCDC137 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC137 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with CCDC137) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
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External Searches for CCDC137 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC137 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC137 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC137 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC137 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CCDC137 gene:
Search GeneIP for patents involving CCDC137
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC137 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
|
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 |
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC137 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC137 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC137 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC137 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC137 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC137 |
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 |
 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC137 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CCDC137 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC137 |
| |  |  |  | | | | LSBio Antibodies in human, mouse, rat for CCDC137 |
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