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Aliases for CCDC137 Gene

Aliases for CCDC137 Gene

  • Coiled-Coil Domain Containing 137 2 3 5
  • Hepatocellular Carcinoma Related Protein 2 3
  • Retinoic Acid Resistance Factor 3
  • RaRF 3

External Ids for CCDC137 Gene

Previous GeneCards Identifiers for CCDC137 Gene

  • GC17U900828
  • GC17P077245
  • GC17P079633
  • GC17P075079

Summaries for CCDC137 Gene

GeneCards Summary for CCDC137 Gene

CCDC137 (Coiled-Coil Domain Containing 137) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

Gene Wiki entry for CCDC137 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC137 Gene

Genomics for CCDC137 Gene

Regulatory Elements for CCDC137 Gene

Enhancers for CCDC137 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCDC137 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC137 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC137 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC137 Gene

81,666,364 bp from pter
81,673,907 bp from pter
7,544 bases
Plus strand

Genomic View for CCDC137 Gene

Genes around CCDC137 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC137 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC137 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC137 Gene

Proteins for CCDC137 Gene

  • Protein details for CCDC137 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 137
    Protein Accession:

    Protein attributes for CCDC137 Gene

    289 amino acids
    Molecular mass:
    33231 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC137 Gene

Proteomics data for CCDC137 Gene at MOPED

Post-translational modifications for CCDC137 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC137 Gene

No data available for DME Specific Peptides for CCDC137 Gene

Domains & Families for CCDC137 Gene

Protein Domains for CCDC137 Gene


Suggested Antigen Peptide Sequences for CCDC137 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC137: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC137 Gene

Function for CCDC137 Gene

Gene Ontology (GO) - Molecular Function for CCDC137 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CCDC137: view

Phenotypes for CCDC137 Gene

MGI mutant phenotypes for CCDC137:
inferred from 1 alleles
GenomeRNAi human phenotypes for CCDC137:
genes like me logo Genes that share phenotypes with CCDC137: view

Animal Models for CCDC137 Gene

MGI Knock Outs for CCDC137:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC137 Gene

Localization for CCDC137 Gene

Subcellular locations from

Jensen Localization Image for CCDC137 Gene COMPARTMENTS Subcellular localization image for CCDC137 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC137 Gene

Pathways & Interactions for CCDC137 Gene

SuperPathways for CCDC137 Gene

No Data Available

Interacting Proteins for CCDC137 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000329360 Q6PK04-CC137_HUMAN for CCDC137 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for CCDC137 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC137 Gene

Drugs & Compounds for CCDC137 Gene

No Compound Related Data Available

Transcripts for CCDC137 Gene

Unigene Clusters for CCDC137 Gene

Coiled-coil domain containing 137:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC137 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: -
SP2: - -
SP3: -

Relevant External Links for CCDC137 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC137 Gene

mRNA expression in normal human tissues for CCDC137 Gene

Protein differential expression in normal tissues from HIPED for CCDC137 Gene

This gene is overexpressed in Lung (56.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CCDC137 Gene

SOURCE GeneReport for Unigene cluster for CCDC137 Gene Hs.744125

genes like me logo Genes that share expression patterns with CCDC137: view

Protein tissue co-expression partners for CCDC137 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC137 Gene

Orthologs for CCDC137 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC137 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCDC137 35
  • 83.71 (n)
  • 80.6 (a)
CCDC137 36
  • 75 (a)
(Canis familiaris)
Mammalia CCDC137 35
  • 83.77 (n)
  • 77.15 (a)
CCDC137 36
  • 70 (a)
(Mus musculus)
Mammalia Ccdc137 35
  • 76.87 (n)
  • 74.25 (a)
Ccdc137 16
Ccdc137 36
  • 68 (a)
(Rattus norvegicus)
Mammalia Ccdc137 35
  • 75.17 (n)
  • 71.68 (a)
(Monodelphis domestica)
Mammalia CCDC137 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC137 36
  • 47 (a)
(Pan troglodytes)
Mammalia CCDC137 36
  • 96 (a)
(Gallus gallus)
Aves CCDC137 35
  • 60.52 (n)
  • 47.93 (a)
CCDC137 36
  • 36 (a)
(Anolis carolinensis)
Reptilia CCDC137 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485278 35
  • 59.03 (n)
  • 50.93 (a)
(Danio rerio)
Actinopterygii ccdc137 35
  • 54.29 (n)
  • 44.29 (a)
ccdc137 36
  • 38 (a)
Species with no ortholog for CCDC137:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC137 Gene

Gene Tree for CCDC137 (if available)
Gene Tree for CCDC137 (if available)

Paralogs for CCDC137 Gene Pseudogenes for CCDC137 Gene

genes like me logo Genes that share paralogs with CCDC137: view

No data available for Paralogs for CCDC137 Gene

Variants for CCDC137 Gene

Sequence variations from dbSNP and Humsavar for CCDC137 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs7226091 - 81,670,337(+) ATCCA(C/G)CGCAT reference, missense, utr-variant-5-prime
rs11150805 - 81,671,775(+) TCCGA(C/T)GGAAA reference, missense
rs11546630 - 81,672,520(+) GCTGC(A/G)GATGC reference, missense
rs11546631 - 81,672,678(+) CTTCC(C/T)GGAAG reference, missense
rs1137357 -- 81,672,986(+) ACCTT(A/G)GGAAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCDC137 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV Gain+Loss 19812545
nsv828128 CNV Loss 20364138
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
nsv909109 CNV Loss 21882294
nsv909111 CNV Loss 21882294
dgv3333n71 CNV Loss 21882294

Variation tolerance for CCDC137 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.30; 90.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCDC137 Gene

Disorders for CCDC137 Gene

Relevant External Links for CCDC137

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC137 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC137 Gene

Publications for CCDC137 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 67
  2. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  5. Negative regulation of ERRI+ by a novel nucleolar protein. (PMID: 22266318) Um S.J. … Kim E.J. (Biochem. Biophys. Res. Commun. 2012) 3

Products for CCDC137 Gene

Sources for CCDC137 Gene