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Aliases for CCDC137 Gene

Aliases for CCDC137 Gene

  • Coiled-Coil Domain Containing 137 2 3
  • Hepatocellular Carcinoma Related Protein 2 3
  • Coiled-Coil Domain-Containing Protein 137 3
  • Retinoic Acid Resistance Factor 3
  • RaRF 3

External Ids for CCDC137 Gene

Previous GeneCards Identifiers for CCDC137 Gene

  • GC17U900828
  • GC17P077245
  • GC17P079633
  • GC17P075079

Summaries for CCDC137 Gene

GeneCards Summary for CCDC137 Gene

CCDC137 (Coiled-Coil Domain Containing 137) is a Protein Coding gene.

Gene Wiki entry for CCDC137 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC137 Gene

Genomics for CCDC137 Gene

Regulatory Elements for CCDC137 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCDC137 Gene

Start:
81,666,364 bp from pter
End:
81,673,907 bp from pter
Size:
7,544 bases
Orientation:
Plus strand

Genomic View for CCDC137 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC137 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC137 Gene

Proteins for CCDC137 Gene

  • Protein details for CCDC137 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PK04-CC137_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 137
    Protein Accession:
    Q6PK04
    Secondary Accessions:

    Protein attributes for CCDC137 Gene

    Size:
    289 amino acids
    Molecular mass:
    33231 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC137 Gene

Proteomics data for CCDC137 Gene at MOPED

Post-translational modifications for CCDC137 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC137 Gene

No data available for DME Specific Peptides for CCDC137 Gene

Domains for CCDC137 Gene

Protein Domains for CCDC137 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC137 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC137: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC137 Gene

Function for CCDC137 Gene

Gene Ontology (GO) - Molecular Function for CCDC137 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CCDC137: view

Phenotypes for CCDC137 Gene

MGI mutant phenotypes for CCDC137:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CCDC137: view

Animal Model Products

CRISPR Products

miRNA for CCDC137 Gene

miRTarBase miRNAs that target CCDC137

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCDC137 Gene

Localization for CCDC137 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC137 Gene COMPARTMENTS Subcellular localization image for CCDC137 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CCDC137 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with CCDC137: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCDC137 Gene

Pathways for CCDC137 Gene

SuperPathways for CCDC137 Gene

No Data Available

Interacting Proteins for CCDC137 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000329360%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000254942%0d%0a
Selected Interacting proteins: ENSP00000329360 Q6PK04-CC137_HUMAN for CCDC137 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CCDC137 Gene

None

No data available for Pathways by source for CCDC137 Gene

Transcripts for CCDC137 Gene

mRNA/cDNA for CCDC137 Gene

Unigene Clusters for CCDC137 Gene

Coiled-coil domain containing 137:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC137

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CCDC137
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC137 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: -
SP2: - -
SP3: -

Relevant External Links for CCDC137 Gene

GeneLoc Exon Structure for
CCDC137
ECgene alternative splicing isoforms for
CCDC137

Expression for CCDC137 Gene

mRNA expression in normal human tissues for CCDC137 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCDC137 Gene

SOURCE GeneReport for Unigene cluster for CCDC137 Gene Hs.744125

genes like me logo Genes that share expressions with CCDC137: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC137 Gene

Orthologs for CCDC137 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC137 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC137 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC137 35
  • 83.71 (n)
  • 80.6 (a)
CCDC137 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC137 35
  • 83.77 (n)
  • 77.15 (a)
CCDC137 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc137 35
  • 76.87 (n)
  • 74.25 (a)
Ccdc137 16
Ccdc137 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC137 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC137 36
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc137 35
  • 75.17 (n)
  • 71.68 (a)
chicken
(Gallus gallus)
Aves CCDC137 35
  • 60.52 (n)
  • 47.93 (a)
CCDC137 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC137 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485278 35
  • 59.03 (n)
  • 50.93 (a)
zebrafish
(Danio rerio)
Actinopterygii ccdc137 35
  • 54.29 (n)
  • 44.29 (a)
ccdc137 36
  • 38 (a)
OneToOne
Species with no ortholog for CCDC137:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC137 Gene

ENSEMBL:
Gene Tree for CCDC137 (if available)
TreeFam:
Gene Tree for CCDC137 (if available)

Paralogs for CCDC137 Gene

Pseudogenes.org Pseudogenes for CCDC137 Gene

genes like me logo Genes that share paralogs with CCDC137: view

No data available for Paralogs for CCDC137 Gene

Variants for CCDC137 Gene

Sequence variations from dbSNP and Humsavar for CCDC137 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1137357 -- 81,672,986(+) ACCTT(A/G)GGAAG utr-variant-3-prime
rs1137358 -- 81,673,090(+) GCGTA(C/T)AGTGC utr-variant-3-prime
rs1137360 -- 81,673,189(+) CCCCT(A/G)CAGAG utr-variant-3-prime
rs3088016 -- 81,673,019(-) CGGTA(G/T)TTGGT utr-variant-3-prime
rs3201131 -- 81,673,728(+) ACCGT(C/G)TGGAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCDC137 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV Gain+Loss 19812545
nsv828128 CNV Loss 20364138
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
nsv909109 CNV Loss 21882294
nsv909111 CNV Loss 21882294
dgv3333n71 CNV Loss 21882294

Relevant External Links for CCDC137 Gene

HapMap Linkage Disequilibrium report
CCDC137

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC137 Gene

Disorders for CCDC137 Gene

No disorders were found for CCDC137 Gene.

No data available for UniProtKB/Swiss-Prot for CCDC137 Gene

Publications for CCDC137 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee O.H. … Songyang Z. (Mol. Cell Proteomics 2011) 3
  5. Negative regulation of ERRI+ by a novel nucleolar protein. (PMID: 22266318) Um S.J. … Kim E.J. (Biochem. Biophys. Res. Commun. 2012) 3

Products for CCDC137 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CCDC137
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC137
    • Block miRNA regulation of CCDC137 using miScript Target Protectors

    Sources for CCDC137 Gene

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