Aliases
for CCDC137 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Coiled-Coil Domain Containing 1371 2 | | Coiled-Coil Domain-Containing Protein 1372 | | Hepatocellular Carcinoma Related Protein 22 |
| External Ids: | HGNC: 334511 | Entrez Gene: 3392302 | Ensembl: ENSG000001852987 | OMIM: 6142715 | UniProtKB: Q6PK043 |
|---|
|
Export aliases for CCDC137 gene to outside databasesPrevious GC identifers: GC17U900828 GC17P077245 GC17P075079
Summaries
for CCDC137 gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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GeneCards Summary for CCDC137 Gene:
CCDC137 (coiled-coil domain containing 137) is a protein-coding gene.
Gene Wiki entry for CCDC137 Gene
|
Genomic Views
for CCDC137 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | Regulatory elements:
 Regulatory transcription factor binding sites in the CCDC137 gene promoter:
HFH-3 HTF SREBP-1c SREBP-1b C/EBPalpha FOXI1 SREBP-1a ATF6 RSRFC4
Other transcription factors
Search Chromatin IP Primers for CCDC137
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC137 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3CCDC137 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P079633: view genomic region
(about GC identifiers)
Start:
|
79,633,394 bp from pter |
End:
|
79,640,937 bp from pter |
Size:
|
7,544 bases |
Orientation:
|
plus strand |
|
Proteins
for CCDC137 gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
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UniProtKB/Swiss-Prot: CC137_HUMAN, Q6PK04 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 137 Size: 289 amino acids; 33231 DaExplore the universe of human proteins at neXtProt for CCDC137: NX_Q6PK04
Explore proteomics data for CCDC137 at MOPED
Post-translational modifications:  Modification sites at neXtProt Modification sites at PhosphoSitePlus
See CCDC137 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB
REFSEQ proteins: NP_954981.1
ENSEMBL proteins: ENSP00000329360 ENSP00000458884 ENSP00000458350 ENSP00000461207 ENSP00000460261
CCDC137 Human Recombinant
Protein Products:CCDC137 Antibody
Products:CCDC137 Assay Products: |
Domains /
Families
for CCDC137 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | 1 InterPro protein domain:Graphical View of Domain Structure for InterPro Entry Q6PK04 ProtoNet protein and cluster: Q6PK04
CCDC137 for domains About GeneDecksing
|
Function
for CCDC137 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
About This Section
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Gene Ontology (GO): 1 molecular function term: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0044822 | poly(A) RNA binding |
IDA | -- |
CCDC137 for ontologies About GeneDecksing
Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ccdc137):
CCDC137 for phenotypes About GeneDecksing
Animal Models:
Inhib. RNA
Products: |  | OriGene RNAi products in human, mouse, rat for CCDC137
| | | Predesigned siRNA for gene silencing in human, mouse, rat CCDC137 |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for CCDC137 | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for CCDC137  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC137 |
Localization
for CCDC137 gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
About This Section
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Subcellular locations from COMPARTMENTS:
| Compartment | Confidence |
|---|
|
| nucleus | 3 | | mitochondrion | 2 | | cytosol | 1 |
|
Pathways & Interactions
for CCDC137 gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
About This Section
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC137
Interactions:
Search GeneGlobe Interaction Network for CCDC137
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5 Interacting proteins for CCDC137 (Q6PK043 ENSP000003293604) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CCDC137 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
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 Browse compounds at ApexBio
 Browse Tocris compounds for CCDC137 (CC137)
|
Transcripts
for CCDC137 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for CCDC137 gene: NM_199287.2 6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000329214(uc002kbc.4) ENST00000575223 ENST00000574107 ENST00000574200
ENST00000571916 ENST00000572531
Inhib. RNA
Products: | | OriGene RNAi products in human, mouse, rat for CCDC137
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat CCDC137 |
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for CCDC137
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCDC137 | | | QuantiTect SYBR Green Assays in human, mouse, rat CCDC137 | | | QuantiFast Probe-based Assays in human, mouse, rat CCDC137 |
Selected AceView cDNA sequences (see all 154): BG056095 BM798021 N56867 AW445033 CA422682 AI991334 CR596466 BG056030 BM798403 BC052272 BM548065 BG055723 AI093140 BF115231 AA554311 BG230563 BQ575236 CR606833 AI278136 AA598792 BF195200 AI201901 BG056094 BM701908
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC137 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CCDC137
|
Expression
for CCDC137 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
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CCDC137 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTGAAACTGC
About this image CCDC137 Protein expression data from MOPED1, PaxDb2 and
MaxQB3: About this image
Custom PCR Arrays for CCDC137
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for CCDC137
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCDC137 | | | QuantiTect SYBR Green Assays in human, mouse, rat CCDC137 | | | QuantiFast Probe-based Assays in human, mouse, rat CCDC137 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC137 |
Orthologs
for CCDC137 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for CCDC137 gene from Selected species (see all 11) About this table
ENSEMBL Gene Tree for CCDC137 (if available)
TreeFam Gene Tree for CCDC137 (if available) |
Paralogs
for CCDC137 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | Paralogs for CCDC137 gene
CCDC137 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for CCDC137
PGOHUM00000238060 PGOHUM00000238061
|
Genomic Variants
for CCDC137 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC137 (79633394 - 79640937 bp)
Structural Variations
Database of Genomic Variants (DGV) 10 variations for CCDC137: About this table
| | Site Specific Mutation Identification with PCR Assays |
| | SeqTarget long-range PCR primers for resequencing CCDC137 |
|
Disorders
/ Diseases
for CCDC137 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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OMIM gene information: 614271
OMIM disorders: --
CCDC137 for disorders About GeneDecksing
Export disorders for CCDC137 gene to outside databases
|
Publications
for CCDC137 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for CCDC137 gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with CCDC137) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
- Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
- Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (J. Proteome Res. 2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
|
External Searches for CCDC137 gene (in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing CCDC137 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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|
Other Databases showing CCDC137 gene
(According to HUGE)
About This Section
TryGeneCards Plus | -- |
Specialized Databases showing CCDC137 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for CCDC137 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
TryGeneCards Plus | Patent Information for CCDC137 gene:
Search GeneIP for patents involving CCDC137
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC137 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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 | |
 |
| | | | |
 |
 |
|  | Block miRNA regulation of human, mouse, rat CCDC137 using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing CCDC137 | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC137 | | Predesigned siRNA for gene silencing in human, mouse, rat CCDC137 | | | QuantiFast Probe-based Assays in human, mouse, rat CCDC137 | | QuantiTect SYBR Green Assays in human, mouse, rat CCDC137 | | | Custom PCR Arrays for CCDC137 | | Search Chromatin IP Primers for CCDC137 | | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCDC137 | | Search GeneGlobe Interaction Network for CCDC137 | | | Regulatory tfbs in CCDC137 promoter |
| |
 |  |  |  | |
| | | |  |  |  |
 | | | | |
 |
 |
 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC137 |
| |  |  |  |  | | | Search ThermoFisher Antibodies for CCDC137 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC137 |
| | | | LSBio Antibodies in human, mouse, rat for CCDC137 |
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