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Aliases for CCDC136 Gene

Aliases for CCDC136 Gene

  • Coiled-Coil Domain Containing 136 2 3 5
  • Nasopharyngeal Carcinoma-Associated Gene 6 Protein 3 4
  • KIAA1793 4
  • NAG6 3

External Ids for CCDC136 Gene

Previous GeneCards Identifiers for CCDC136 Gene

  • GC07P128219
  • GC07P128430
  • GC07P122792

Summaries for CCDC136 Gene

GeneCards Summary for CCDC136 Gene

CCDC136 (Coiled-Coil Domain Containing 136) is a Protein Coding gene. Diseases associated with CCDC136 include Gastric Cancer. An important paralog of this gene is SLMAP.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC136 Gene

Genomics for CCDC136 Gene

Regulatory Elements for CCDC136 Gene

Enhancers for CCDC136 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCDC136 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC136 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC136 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC136 Gene

Chromosome:
7
Start:
128,790,757 bp from pter
End:
128,822,133 bp from pter
Size:
31,377 bases
Orientation:
Plus strand

Genomic View for CCDC136 Gene

Genes around CCDC136 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC136 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC136 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC136 Gene

Proteins for CCDC136 Gene

  • Protein details for CCDC136 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JN2-CC136_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 136
    Protein Accession:
    Q96JN2
    Secondary Accessions:
    • A4D1K1
    • A7MCY7
    • A8MYA7
    • Q6ZVK7
    • Q9H8M3
    • Q9UFE1

    Protein attributes for CCDC136 Gene

    Size:
    1154 amino acids
    Molecular mass:
    134045 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Restriction fragment length polymorphisms (RFLPs) in gastric cancer showed loss of 5 kb fragment in comparison with the corresponding normal tissue.
    SequenceCaution:
    • Sequence=AF156971; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAB14590.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB47422.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC136 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC136 Gene

Proteomics data for CCDC136 Gene at MOPED

Post-translational modifications for CCDC136 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC136 Gene

Domains & Families for CCDC136 Gene

Protein Domains for CCDC136 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC136 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC136: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC136 Gene

Function for CCDC136 Gene

genes like me logo Genes that share phenotypes with CCDC136: view

Animal Model Products

CRISPR Products

miRNA for CCDC136 Gene

miRTarBase miRNAs that target CCDC136

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC136 Gene

Localization for CCDC136 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC136 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC136 Gene COMPARTMENTS Subcellular localization image for CCDC136 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 1
endoplasmic reticulum 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CCDC136 Gene

Pathways & Interactions for CCDC136 Gene

SuperPathways for CCDC136 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC136 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC136 Gene

Drugs & Compounds for CCDC136 Gene

No Compound Related Data Available

Transcripts for CCDC136 Gene

Unigene Clusters for CCDC136 Gene

Coiled-coil domain containing 136:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC136 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1: - -
SP2: - - - - - - - - - - - - - - - - -
SP3: - - - - -
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9: -

ExUns: 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CCDC136 Gene

GeneLoc Exon Structure for
CCDC136
ECgene alternative splicing isoforms for
CCDC136

Expression for CCDC136 Gene

mRNA expression in normal human tissues for CCDC136 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC136 Gene

This gene is overexpressed in Testis (x14.6) and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for CCDC136 Gene

This gene is overexpressed in Testis (14.1), Heart (12.8), Fetal ovary (12.7), Platelet (11.9), and Frontal cortex (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCDC136 Gene



SOURCE GeneReport for Unigene cluster for CCDC136 Gene Hs.521178

mRNA Expression by UniProt/SwissProt for CCDC136 Gene

Q96JN2-CC136_HUMAN
Tissue specificity: Expressed in gastric tissues. Down-regulated in gastric cancer.
genes like me logo Genes that share expression patterns with CCDC136: view

Protein tissue co-expression partners for CCDC136 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CCDC136 Gene

Orthologs for CCDC136 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC136 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCDC136 35
  • 83.2 (n)
  • 76.37 (a)
CCDC136 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC136 35
  • 85.58 (n)
  • 79.77 (a)
CCDC136 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc136 35
  • 80.79 (n)
  • 73.66 (a)
Ccdc136 16
Ccdc136 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCDC136 35
  • 98.66 (n)
  • 97.73 (a)
CCDC136 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc136 35
  • 80.44 (n)
  • 73.43 (a)
oppossum
(Monodelphis domestica)
Mammalia CCDC136 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC136 36
  • 31 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc136 35
  • 57.9 (n)
  • 50.32 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100330186 35
  • 56.68 (n)
  • 48.93 (a)
ccdc136b 36
  • 36 (a)
OneToMany
ccdc136b 36
  • 31 (a)
OneToMany
slmapb 36
  • 22 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17494 36
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M4.1 36
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8207 36
  • 15 (a)
OneToMany
Species with no ortholog for CCDC136:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC136 Gene

ENSEMBL:
Gene Tree for CCDC136 (if available)
TreeFam:
Gene Tree for CCDC136 (if available)

Paralogs for CCDC136 Gene

Paralogs for CCDC136 Gene

(1) SIMAP similar genes for CCDC136 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CCDC136: view

Variants for CCDC136 Gene

Sequence variations from dbSNP and Humsavar for CCDC136 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs3816887 - 128,801,491(-) GTAAT(C/G)TGAGA intron-variant, reference, missense
rs4728137 - 128,815,713(+) AAAAG(C/G)AAGTG intron-variant, reference, missense
rs902843 -- 128,795,541(+) GTAAG(C/G/T)GGGGA intron-variant
rs1565628 -- 128,809,333(-) AGTCA(C/T)CTTGG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1565629 -- 128,805,316(-) TTCTG(C/T)CTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC136 Gene

Variant ID Type Subtype PubMed ID
esv2735137 CNV Deletion 23290073
esv2670312 CNV Deletion 23128226
nsv831125 CNV Loss 17160897
esv22837 CNV Gain 19812545
nsv889192 CNV Loss 21882294
nsv512922 CNV Insertion 21212237
esv2642516 CNV Insertion 19546169
esv1249692 CNV Insertion 17803354
nsv819324 CNV Loss 19587683
nsv517923 CNV Gain 19592680
nsv464713 CNV Loss 19166990
nsv818553 CNV Gain 17921354
dgv7490n71 CNV Loss 21882294
nsv464715 CNV Loss 19166990

Variation tolerance for CCDC136 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.26; 70.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC136 Gene

Human Gene Mutation Database (HGMD)
CCDC136

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC136 Gene

Disorders for CCDC136 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCDC136 Gene - From: GeneCards

Disorder Aliases PubMed IDs
gastric cancer
  • stomach cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CCDC136

Genetic Association Database (GAD)
CCDC136
Human Genome Epidemiology (HuGE) Navigator
CCDC136
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC136
genes like me logo Genes that share disorders with CCDC136: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC136 Gene

Publications for CCDC136 Gene

  1. Expression of tumor related gene NAG6 in gastric cancer and restriction fragment length polymorphism analysis. (PMID: 15112360) Zhang X.-M. … Li G.-Y. (World J. Gastroenterol. 2004) 2 3 4 23 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  4. Genome-wide screening for DNA variants associated with reading and language traits. (PMID: 25065397) Gialluisi A. … Fisher S.E. (Genes Brain Behav. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for CCDC136 Gene

Sources for CCDC136 Gene

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