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CCDC135 Gene

protein-coding   GIFtS: 45
GCID: GC16P057728

Coiled-Coil Domain Containing 135

(Previous name: chromosome 16 open reading frame 50)
(Previous symbol: C16orf50)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coiled-Coil Domain Containing 1351 2
C16orf501 2 3
Coiled-Coil Domain-Containing Protein 1352 3
Chromosome 16 Open Reading Frame 501
FAP502
Coiled-Coil Domain-Containing Protein Lobo Homolog2

External Ids:    HGNC: 252891   Entrez Gene: 842292   Ensembl: ENSG000001596257   UniProtKB: Q8IY823   

Export aliases for CCDC135 gene to outside databases

Previous GC identifers: GC16P056288 GC16P043596


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCDC135 Gene:
CCDC135 (coiled-coil domain containing 135) is a protein-coding gene. Diseases associated with CCDC135 include nephronophthisis, and bardet-biedl syndrome.

UniProtKB/Swiss-Prot: CC135_HUMAN, Q8IY82
Function: Plays a role in the regulation of germ cells differentiation during spermatogenesis, particularly during
meiosis and spermiogenesis. May be involved in sperm motility (By similarity)

Gene Wiki entry for CCDC135 (Coiled-coil domain-containing protein 135) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCDC135 gene promoter:
         Max1   ER-alpha   STAT1   AML1a   STAT1beta   STAT1alpha   RORalpha1   N-Myc   ATF6   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC135 promoter sequence
   Search Chromatin IP Primers for CCDC135

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC135


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q13

CCDC135 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC135 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P057728:  view genomic region     (about GC identifiers)

Start:
57,728,705 bp from pter      End:
57,765,717 bp from pter
Size:
37,013 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CC135_HUMAN, Q8IY82 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein lobo homolog  
Size: 874 amino acids; 103497 Da
Secondary accessions: A8K943 Q8NAA0 Q9H080
Alternative splicing: 2 isoforms:  Q8IY82-1   Q8IY82-2   

Explore the universe of human proteins at neXtProt for CCDC135: NX_Q8IY82

Explore proteomics data for CCDC135 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCDC135 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001276091.1  NP_001276092.1  NP_115645.4  

    ENSEMBL proteins: 
     ENSP00000456441   ENSP00000353942   ENSP00000455994   ENSP00000377869   ENSP00000457676  
     ENSP00000454722   ENSP00000338938   ENSP00000456374   ENSP00000456323  

    CCDC135 Human Recombinant Protein Products:

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    Novus Biologicals CCDC135 Lysate
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    Cloud-Clone Corp. Proteins for CCDC135

    CCDC135 Antibody Products:

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    Cloud-Clone Corp. CLIAs for CCDC135


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8IY82

    UniProtKB/Swiss-Prot: CC135_HUMAN, Q8IY82
    Similarity: Belongs to the CCDC135 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CC135_HUMAN, Q8IY82
    Function: Plays a role in the regulation of germ cells differentiation during spermatogenesis, particularly during
    meiosis and spermiogenesis. May be involved in sperm motility (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for CCDC135:

     Decreased TP53 protein express 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCDC135
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCDC135
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCDC135

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate CCDC135:
    hsa-miR-34a hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidCCDC135 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CCDC135

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for CCDC135 (see all 5)
    OriGene ORF clones in mouse, rat for CCDC135
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCDC135 (NM_032269)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC135
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC135

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CCDC135 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC135


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CC135_HUMAN, Q8IY82: Cell projection, cilium, flagellum (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005929cilium IEA--

    CCDC135 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC135
    Interactions:

        Search GeneGlobe Interaction Network for CCDC135

    3 Interacting proteins for CCDC135 (Q8IY823) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP6V1AP386063I2D: score=1 
    PHOSPHO2Q8TCD63I2D: score=1 
    RPS3AP612473I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001539cilium or flagellum-dependent cell motility IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--

    CCDC135 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCDC135 (CC135)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCDC135 gene (3 alternative transcripts): 
    NM_001289162.1  NM_001289163.1  NM_032269.5  

    Unigene Cluster for CCDC135:

    Coiled-coil domain containing 135
    Hs.513635  [show with all ESTs]
    Unigene Representative Sequence: BC030661
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000569375 ENST00000360716(uc002emi.3 uc002emj.3 uc002emk.3)
    ENST00000569167 ENST00000394337 ENST00000563126 ENST00000564297 ENST00000336825
    ENST00000564132 ENST00000562250 ENST00000565609
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCDC135 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CCDC135:
    hsa-miR-34a hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidCCDC135 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CCDC135
    Predesigned siRNA for gene silencing in human, mouse, rat CCDC135
    Clone
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    OriGene ORF clones in mouse, rat for CCDC135
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCDC135 (NM_032269)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC135
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC135
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCDC135
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCDC135
      QuantiTect SYBR Green Assays in human, mouse, rat CCDC135
      QuantiFast Probe-based Assays in human, mouse, rat CCDC135

    Additional mRNA sequence: 

    AK093035.1 AK093822.1 AK292558.1 AL136907.1 BC030661.1 BC036667.1 

    7 DOTS entries:

    DT.120662349  DT.206925  DT.101979090  DT.100020840  DT.95299688  DT.120662346  DT.65286607 

    Selected AceView cDNA sequences (see all 31):

    AK093035 AI624796 BX099802 AL136907 BM985199 AX747872 AL046757 AK093822 
    AL039976 NM_032269 AX748325 BC030661 BU934453 BC036667 BM982846 AA889649 
    AW172303 BQ421215 AW182121 BQ027398 AA884996 BI465383 AI139000 AA724461 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC135    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20
    SP1:                                                                                                  -                           
    SP2:                                      -                                                           -                           
    SP3:                                                                                                                              
    SP4:                                                                                                                              


    ECgene alternative splicing isoforms for CCDC135

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCDC135 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTCCTGT
    CCDC135 Expression
    About this image

    CCDC135 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCDC135 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513635
        Custom PCR Arrays for CCDC135
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC135

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CCDC135 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc1351 , 5 coiled-coil domain containing 1351, 5 83.56(n)1
    83.18(a)1
      8 (47.12 cM)5
    3308301  NM_001042715.31  NP_001036180.21 
     950551035 
    chicken
    (Gallus gallus)
    Aves CCDC1351 coiled-coil domain containing 135 64.25(n)
    58.16(a)
      427527  XM_425101.4  XP_425101.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    66(a)
    64(a)
    many → 1
    many → 1
    GL344738.1(154-4708)
    GL343677.1(162565-171638)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.53242 Transcribed sequence with moderate similarity to protein more 80.65(n)    BQ522566.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5557821 coiled-coil domain-containing protein lobo homolog 54.63(n)
    47.44(a)
      555782  XM_678399.6  XP_683491.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta lobo1 lost boys 45.55(n)
    31.48(a)
      4379864  NM_001043292.1  NP_001036757.1 


    ENSEMBL Gene Tree for CCDC135 (if available)
    TreeFam Gene Tree for CCDC135 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCDC135 (see all 1125)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500191571,2
    C--57726906(+) ACTGCC/TCCAAA 1 -- us2k10--------
    rs756380161,2
    C,F--57726914(+) AAACCG/ATCAAG 1 -- us2k11Minor allele frequency- A:0.05EA 120
    rs74999581,2
    C,A--57726920(+) TCAAGA/CGGTAG 1 -- us2k1 tfbs35Minor allele frequency- C:0.21NA WA EA 362
    rs38867511,2
    C,F,A--57726922(-) CCCTAC/TCTCTT 1 -- us2k1 tfbs38Minor allele frequency- T:0.21NA WA EA 488
    rs20776121,2
    C,F,H--57726964(+) GCGCCG/AGGGTG 1 -- us2k112Minor allele frequency- A:0.20NA NS EA WA CSA 784
    rs20785531,2
    C,F,A--57726980(-) TTGGAT/CGGATA 1 -- us2k114Minor allele frequency- C:0.22NS NA WA EA 608
    rs1839527591,2
    --57727003(+) GGAAAC/TGTACA 1 -- us2k10--------
    rs604767051,2
    C--57727053(+) GGGAGA/GTGAGT 1 -- us2k12Minor allele frequency- G:0.10CSA WA 120
    rs42387971,2
    C--57727062(+) gtctgT/Ctcatc 1 -- us2k12Minor allele frequency- C:0.00NA 4
    rs42387991,2
    C,H--57727120(+) gttcaG/Tggctg 1 -- us2k16Minor allele frequency- T:0.00NS EA NA 420

    HapMap Linkage Disequilibrium report for CCDC135 (57728705 - 57765717 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CCDC135 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714539CNV Deletion23290073
    esv2676910CNV Deletion23128226
    esv2714543CNV Deletion23290073
    esv2661234CNV Deletion23128226
    esv2714542CNV Deletion23290073
    dgv407e201CNV Deletion23290073
    esv2714536CNV Deletion23290073
    esv2714538CNV Deletion23290073
    esv2714537CNV Deletion23290073
    nsv509622CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCDC135
    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC135

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for CCDC135:    
    About MalaCards
    nephronophthisis    bardet-biedl syndrome    malaria

    2 diseases from the University of Copenhagen DISEASES database for CCDC135:
    Nephronophthisis     Bardet-Biedl syndrome

    CCDC135 for disorders           About GeneDecksing


    Export disorders for CCDC135 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCDC135 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CCDC135)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of flagellar motility by the conserved flagellar protein CG34110/Ccdc135/FAP50. (PubMed id 21289096)1, 3 Yang Y....Lu X. (Mol. Biol. Cell 2011)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (EMBO Rep. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84229 HGNC: 25289 AceView: DKFZp434I099 Ensembl:ENSG00000159625 euGenes: HUgn84229
    ECgene: CCDC135 H-InvDB: CCDC135

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCDC135 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCDC135 gene:
    Search GeneIP for patents involving CCDC135

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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