CCDC135 Gene
protein-coding GIFtS : 46
GCID: GC16 P057728
coiled-coil domain containing 135 (Previous name: chromosome 16 open reading frame 50 ) (Previous symbol: C16orf50 )
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Aliasesfor CCDC135 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Coiled-Coil Domain Containing 135 1 2 DKFZp434I0991 C16orf501 2 3 Chromosome 16 Open Reading Frame 501 FAP501 2 Coiled-Coil Domain-Containing Protein Lobo Homolog2 Coiled-Coil Domain-Containing Protein 1352 3
Export aliases for CCDC135 gene to outside databases Previous GC identifers: GC16P056288 GC16P043596
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Summariesfor CCDC135 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: CC135_HUMAN, Q8IY82 Function : Plays a role in the regulation of germ cells differentiation during spermatogenesis, particularly duringmeiosis and spermiogenesis. May be involved in sperm motility (By similarity) Gene Wiki entry for CCDC135 (Coiled-coil domain-containing protein 135)
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Genomic Viewsfor CCDC135 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000016.9 NC_018927.1 NT_010498.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CCDC135 gene promoter: Max1 ER-alpha STAT1 AML1a STAT1beta STAT1alpha RORalpha1 N-Myc ATF6 c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for CCDC135 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC135
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 16q21 Ensembl cytogenetic band: 16q21 HGNC cytogenetic band: 16q13 CCDC135 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16P057728: view genomic region
(about GC identifiers )
Start:
57,728,705 bp from pter
End:
57,765,717 bp from pter
Size:
37,013 bases
Orientation:
plus strand
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Proteinsfor CCDC135 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CC135_HUMAN, Q8IY82 (See
protein sequence )Recommended Name: Coiled-coil domain-containing protein lobo homolog Size : 874 amino acids; 103497 Da
Subcellular location : Cell projection, cilium, flagellum (By similarity)
Secondary accessions : A8K943 Q8NAA0 Q9H080Alternative splicing : 2 isoforms : Q8IY82-1 Q8IY82-2 Explore the universe of human proteins at neXtProt for CCDC135: NX_Q8IY82 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8IY82 CCDC135 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_115645.4 ENSEMBL proteins: ENSP00000456441 ENSP00000353942 ENSP00000455994 ENSP00000377869 ENSP00000457676 ENSP00000454722 ENSP00000338938 ENSP00000456374 ENSP00000456323 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
CCDC135 for ontologies About GeneDecksing CCDC135 Antibody Products: Assay Products for CCDC135:
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Protein
Domains / Familiesfor CCDC135 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q8IY82
UniProtKB/Swiss-Prot: CC135_HUMAN, Q8IY82 Similarity : Belongs to the CCDC135 family
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Functionfor CCDC135 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: CC135_HUMAN, Q8IY82 Function : Plays a role in the regulation of germ cells differentiation during spermatogenesis, particularly duringmeiosis and spermiogenesis. May be involved in sperm motility (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC135 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC135OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CCDC135 (NM_032269 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC135 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCDC135
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC135
1 GenomeRNAi human phenotype for CCDC135 :
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Pathways & Interactionsfor CCDC135 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC135 3 Interacting proteins for CCDC135 (Q8IY82 3 ) via UniProtKB, MINT, STRING, and/or I2D About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0001539 ciliary or flagellar motility
IEA -- GO:0007283 spermatogenesis
IEA -- GO:0030154 cell differentiation
IEA --
CCDC135 for ontologies About GeneDecksing
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Drugs & Compoundsfor CCDC135 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CCDC135 Search CenterWatch for drugs/clinical trials and news about CCDC135 / CC135
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Transcriptsfor CCDC135 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CCDC135 gene: NM_032269.5 Unigene Cluster for CCDC135:
Coiled-coil domain containing 135 Hs.513635 [show with all ESTs ] Unigene Representative Sequence: BC030661 10 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000569375 ENST00000360716 (uc002emi.3 uc002emj.3 uc002emk.3 )ENST00000569167 ENST00000394337 ENST00000563126 ENST00000564297 ENST00000336825 ENST00000564132 ENST00000562250 ENST00000565609 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC135 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC135OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CCDC135 (NM_032269 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC135 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCDC135
Additional cDNA sequence: AK093035.1 AK093822.1 AK292558.1 AL136907.1 BC030661.1 BC036667.1
7 DOTS entries : DT.120662349 DT.206925
DT.101979090 DT.100020840 DT.95299688 DT.120662346 DT.65286607 24/31 AceView cDNA sequences (see all 31 ):
AL136907 AX747872 AK093035 AL046757 BM985199 AI624796 BX099802 AA889649 BU934453 BM982846 BQ421215 BC030661 AW172303 NM_032269 AK093822 AL039976 BC036667 AX748325 AA724461 BQ027398 AI139000 AW182121 BI465383 AA884996 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC135 About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 SP1 :                                 -           SP2 :             -                     -           SP3 :                                           SP4 :                                          
ECgene alternative splicing isoforms for CCDC135
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Expression for CCDC135 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CCDC135 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATTTTCCTGT
About this image CCDC135 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Posterior foregut-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See CCDC135 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CCDC135 SOURCE GeneReport for Unigene cluster: Hs.513635 SABiosciences Custom PCR Arrays for CCDC135 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CCDC135Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CCDC135 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CCDC135 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CCDC135 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC135
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Orthologsfor CCDC135 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for CCDC135 gene from 6/21 species (see all 21 ) About this table
ENSEMBL Gene Tree for CCDC135 (if available)TreeFam Gene Tree for CCDC135 (if available)
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Paralogsfor CCDC135 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor CCDC135 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 16 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CCDC135 (57728705 - 57765717 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for CCDC135 1 CNV : 4958
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CCDC135
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Disorders
/ Diseasesfor CCDC135 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CCDC135 for disorders About GeneDecksing 1 disease for CCDC135 : About MalaCards malaria 1 disease from the University of Copenhagen DISEASES database for CCDC135 :Nephronophthisis Export disorders for CCDC135 gene to outside databases
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Publicationsfor CCDC135 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CCDC135 gene integrated from 9 sources : (articles sorted by number of sources associating them with CCDC135) Utopia : connect your pdf to the dynamic world of online information
Regulation of flagellar motility by the conserved flag ellar protein CG34110/Ccdc135/FAP50. (PubMed id 21289096) 1 , 3 Yang Y....Lu X. (2011) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 1 , 2 Wiemann S.... Poustka A. (2001) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553) 2 Martin J.... Pennacchio L.A. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614) 1 Simpson J.C.... Wiemann S. (2000)
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External Searches for CCDC135 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CCDC135 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CCDC135 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CCDC135 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CCDC135 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CCDC135 gene: Search GeneIP for patents involving CCDC135 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CCDC135 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CCDC135 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CCDC135 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CCDC135 OriGene Protein Over-expression Lysate for CCDC135 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CCDC135 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC135 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC135 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for CCDC135 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CCDC135 OriGene Custom Protein Services for CCDC135 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC135 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CCDC135 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC135 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CCDC135 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CCDC135 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CCDC135
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CCDC135 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC135
ThermoFisher Antibodies for CCDC135
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCDC135
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