CCDC134 Gene
protein-coding GIFtS: 46
GCID: GC22P042196
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coiled-coil domain containing 134
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Aliases
for CCDC134 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 1341 2 | | FLJ223491 | | Coiled-Coil Domain-Containing Protein 1342 | | DJ821D11.31 |
Export aliases for CCDC134 gene to outside databasesPrevious GC identifers: GC22P040526 GC22P025162 |
Summaries
for CCDC134 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CCDC134 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC134 gene promoter:
GR E2F-4 E2F-3a C/EBPbeta E2F-5 E2F-2 N-Myc E2F E2F-1 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC134
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC134 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.2 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.2CCDC134 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P042196: view genomic region
(about GC identifiers)
Start:
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42,196,678 bp from pter |
End:
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42,222,306 bp from pter |
Size:
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25,629 bases |
Orientation:
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plus strand |
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Proteins
for CCDC134 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CC134_HUMAN, Q9H6E4 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 134 precursor Size: 229 amino acids; 26561 Da
Subcellular location: Secreted (Potential)Explore the universe of human proteins at neXtProt for CCDC134: NX_Q9H6E4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H6E4
CCDC134 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079097.1
ENSEMBL proteins: ENSP00000385803 ENSP00000255784 ENSP00000394641
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
CCDC134 for ontologies About GeneDecksing
CCDC134 Antibody Products:
Assay Products for CCDC134: |
Protein
Domains /
Families
for CCDC134 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCDC134 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H6E4ProtoNet protein and cluster: Q9H6E4 UniProtKB/Swiss-Prot: CC134_HUMAN, Q9H6E4Similarity: Belongs to the UPF0388 family |
Function
for CCDC134 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC134 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC134
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CCDC134 (NM_024821) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC134 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC134 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC134 |
1 GenomeRNAi human phenotype for CCDC134:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Ccdc134):
CCDC134 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CCDC134 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC134
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for CCDC134 (Q9H6E42, 3 ENSP000002557844) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CCDC134 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC134
Search CenterWatch for drugs/clinical trials and news about CCDC134 / CC134
|
Transcripts
for CCDC134 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC134 gene: NM_024821.2 Unigene Cluster for CCDC134: Coiled-coil domain containing 134 Hs.474991 [show with all ESTs]Unigene Representative Sequence: BC0176933 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000402061 ENST00000255784(uc003bbh.1 uc011apg.1) ENST00000429249
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC134 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC134
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCDC134 (NM_024821) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC134 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC134 |
Additional cDNA sequence: AK026002.1 AK299311.1 BC017693.2 CR456484.1 2 DOTS entries: DT.97779162 DT.120645995 24/38 AceView cDNA sequences (see all 38): BC017693 BQ227811 AW297211 BM674759 CR456484 CB130635 BE907421 AI520706 AK026002 CB240942 BM982350 BX282466 BM046831 BQ919118 BQ437788 CA428472 BQ711220 NM_024821 BQ923086 AA476827 CF142800 BX473493 BU615489 CA426819
GeneLoc Exon Structure
|
Expression
for CCDC134 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC134 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCAAGGGGC
About this image
See CCDC134 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC134
SOURCE GeneReport for Unigene cluster: Hs.474991
SABiosciences Custom PCR Arrays for CCDC134
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC134
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC134 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC134 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC134 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC134 |
Orthologs
for CCDC134 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CCDC134 gene from 7/19 species (see all 19) About this table
ENSEMBL Gene Tree for CCDC134 (if available)
TreeFam Gene Tree for CCDC134 (if available) |
Paralogs
for CCDC134 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CCDC134 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC134 (42196678 - 42222306 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCDC134: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC134 |
|
Disorders
/ Diseases
for CCDC134 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCDC134 for disorders About GeneDecksing
1  disease for CCDC134: About MalaCardsataxia
Human Genome Epidemiology (HuGE) Navigator: CCDC134 (2 documents)
Export disorders for CCDC134 gene to outside databases
|
Publications
for CCDC134 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC134 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with CCDC134) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK. (PubMed id 18087676)1, 3 Huang J....Qiu X. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- CCDC134 interacts with hADA2a and functions as a regul ator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and c ell cycle arrest. (PubMed id 22644376)1 Huang J....Qiu X. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Genome-wide association study of CSF biomarkers Abeta 1-42, t-tau, and p-tau181p in the ADNI cohort. (PubMed id 21123754)1 Kim S....Saykin A.J. (2011)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
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External Searches for CCDC134 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC134 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC134 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC134 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC134 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CCDC134 gene:
Search GeneIP for patents involving CCDC134
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC134 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CCDC134 | | OriGene shRNA RFP for CCDC134 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC134 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC134 | | | OriGene Protein Over-expression Lysate for CCDC134 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC134 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC134 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC134 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CCDC134 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CCDC134 | | OriGene Custom Protein Services for CCDC134 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC134 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC134 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC134 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC134 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC134 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC134 |
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 |  |  |  | |
| | | | Search Tocris compounds for CCDC134 |
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 | | | CCDC134 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC134 |
|  |  |  | | | | ThermoFisher Antibodies for CCDC134 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC134 |
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