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Aliases for CCDC134 Gene

Aliases for CCDC134 Gene

  • Coiled-Coil Domain Containing 134 2 3 5

External Ids for CCDC134 Gene

Previous GeneCards Identifiers for CCDC134 Gene

  • GC22P040526
  • GC22P042196
  • GC22P025162

Summaries for CCDC134 Gene

GeneCards Summary for CCDC134 Gene

CCDC134 (Coiled-Coil Domain Containing 134) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC134 Gene

Genomics for CCDC134 Gene

Regulatory Elements for CCDC134 Gene

Enhancers for CCDC134 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G041379 1.7 FANTOM5 ENCODE dbSUPER 10 -418.7 -418659 4.0 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A YY1 FOS SP3 SP5 EP300 MEI1 POLR3H EP300-AS1 ENSG00000272834 XRCC6 PHF5A LOC100313968 ENSG00000227413 ENSG00000232754
GH22G041666 1.4 Ensembl ENCODE 10 -133.2 -133179 2.5 HDGF PKNOX1 FOXA2 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 RN7SKP80 EP300 PHF5A RRP7BP MEI1 EP300-AS1 XRCC6 LOC100313968 ENSG00000232754 SNU13
GH22G042751 1.4 FANTOM5 Ensembl ENCODE 9.9 +952.0 952020 2.1 ELF3 THRB RARA GTF3C2 RELB IKZF2 CREM CBFB MIER2 NR2F2 RN7SKP80 A4GALT ENSG00000273366 RPL5P34 ENSG00000233903 CCDC134 OGFRP1 GC22M042763 ENSG00000200448
GH22G042753 1.3 Ensembl ENCODE 9.9 +954.5 954532 2.5 PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B ZNF2 FOS ZNF263 SP5 A4GALT RN7SKP80 ENSG00000273366 RPL5P34 ENSG00000233903 CCDC134 OGFRP1 NAGA GC22M042763 ENSG00000200448
GH22G042551 1.2 Ensembl ENCODE 9.9 +751.3 751305 1.7 PKNOX1 FOXA2 ARID4B ZNF2 ZNF121 GTF3C2 ZNF143 ZNF207 FOS ZHX2 RRP7BP XRCC6 RN7SKP80 ENSG00000273366 RPL5P34 ENSG00000233903 CCDC134 OGFRP1 CYB5R3 GC22M042540
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC134 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC134 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000146665 78 1401 HDGF PKNOX1 MLX DMAP1 ZNF143 ZNF207 ZNF263 SP3 MXD4 NFYC

Genomic Location for CCDC134 Gene

Chromosome:
22
Start:
41,800,622 bp from pter
End:
41,832,164 bp from pter
Size:
31,543 bases
Orientation:
Plus strand

Genomic View for CCDC134 Gene

Genes around CCDC134 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC134 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC134 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC134 Gene

Proteins for CCDC134 Gene

  • Protein details for CCDC134 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6E4-CC134_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 134
    Protein Accession:
    Q9H6E4

    Protein attributes for CCDC134 Gene

    Size:
    229 amino acids
    Molecular mass:
    26561 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC134 Gene

Post-translational modifications for CCDC134 Gene

  • Ubiquitination at Lys51
  • Glycosylation at Ser192 and posLast=193193
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC134 Gene

Antibody Products

No data available for DME Specific Peptides for CCDC134 Gene

Domains & Families for CCDC134 Gene

Protein Domains for CCDC134 Gene

Suggested Antigen Peptide Sequences for CCDC134 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6E4

UniProtKB/Swiss-Prot:

CC134_HUMAN :
  • Belongs to the UPF0388 family.
Family:
  • Belongs to the UPF0388 family.
genes like me logo Genes that share domains with CCDC134: view

No data available for Gene Families for CCDC134 Gene

Function for CCDC134 Gene

genes like me logo Genes that share phenotypes with CCDC134: view

Animal Models for CCDC134 Gene

MGI Knock Outs for CCDC134:

Animal Model Products

  • Taconic Biosciences Mouse Models for CCDC134

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC134 Gene

Localization for CCDC134 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC134 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC134 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCDC134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CCDC134: view

Pathways & Interactions for CCDC134 Gene

SuperPathways for CCDC134 Gene

No Data Available

Interacting Proteins for CCDC134 Gene

Selected Interacting proteins: Q9H6E4-CC134_HUMAN for CCDC134 Gene via IID

Gene Ontology (GO) - Biological Process for CCDC134 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC134 Gene

Transcripts for CCDC134 Gene

mRNA/cDNA for CCDC134 Gene

Unigene Clusters for CCDC134 Gene

Coiled-coil domain containing 134:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC134 Gene

No ASD Table

Relevant External Links for CCDC134 Gene

GeneLoc Exon Structure for
CCDC134
ECgene alternative splicing isoforms for
CCDC134

Expression for CCDC134 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC134 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC134 Gene

This gene is overexpressed in Adrenal Gland (x4.7).

Protein differential expression in normal tissues from HIPED for CCDC134 Gene

This gene is overexpressed in Bone (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC134 Gene



NURSA nuclear receptor signaling pathways regulating expression of CCDC134 Gene:

CCDC134

SOURCE GeneReport for Unigene cluster for CCDC134 Gene:

Hs.474991

Evidence on tissue expression from TISSUES for CCDC134 Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with CCDC134: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC134 Gene

Orthologs for CCDC134 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC134 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC134 34 35
  • 99.56 (n)
cow
(Bos Taurus)
Mammalia CCDC134 34 35
  • 91.99 (n)
dog
(Canis familiaris)
Mammalia CCDC134 34 35
  • 91.12 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc134 34
  • 88.58 (n)
mouse
(Mus musculus)
Mammalia Ccdc134 34 16 35
  • 88.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC134 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC134 34 35
  • 77.72 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC134 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc134 34
  • 70.48 (n)
Str.6128 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398726 34
zebrafish
(Danio rerio)
Actinopterygii LOC100536187 34
  • 69.76 (n)
CCDC134 (1 of 2) 35
  • 62 (a)
OneToMany
CCDC134 (2 of 2) 35
  • 61 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7625 34
worm
(Caenorhabditis elegans)
Secernentea F56A8.9 35
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6343 35
  • 32 (a)
OneToOne
Species where no ortholog for CCDC134 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC134 Gene

ENSEMBL:
Gene Tree for CCDC134 (if available)
TreeFam:
Gene Tree for CCDC134 (if available)

Paralogs for CCDC134 Gene

No data available for Paralogs for CCDC134 Gene

Variants for CCDC134 Gene

Sequence variations from dbSNP and Humsavar for CCDC134 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000095886 -- 41,820,059(+) GGCGC(A/G)ATCTT intron-variant
rs1000126741 -- 41,831,969(+) TGAGG(C/T)TTAGA upstream-variant-2KB, utr-variant-3-prime
rs1000177249 -- 41,801,113(+) TCCCG(C/T)AGGCT intron-variant
rs1000243786 -- 41,813,124(+) GATTG(A/G)CAGCC intron-variant
rs1000296970 -- 41,806,688(+) TTTCA(C/T)CAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC134 Gene

Variant ID Type Subtype PubMed ID
dgv8111n54 CNV gain 21841781
esv3647804 CNV loss 21293372
nsv3640 CNV insertion 18451855

Variation tolerance for CCDC134 Gene

Residual Variation Intolerance Score: 30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC134 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC134

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC134 Gene

Disorders for CCDC134 Gene

Relevant External Links for CCDC134

Genetic Association Database (GAD)
CCDC134
Human Genome Epidemiology (HuGE) Navigator
CCDC134
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC134

No disorders were found for CCDC134 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC134 Gene

Publications for CCDC134 Gene

  1. Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort. (PMID: 21123754) Kim S. … Saykin A.J. (Neurology 2011) 3 46 64
  2. CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK. (PMID: 18087676) Huang J. … Qiu X. (Cell. Mol. Life Sci. 2008) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CCDC134 Gene

Sources for CCDC134 Gene

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