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Aliases for CCDC134 Gene

Aliases for CCDC134 Gene

  • Coiled-Coil Domain Containing 134 2 3 5

External Ids for CCDC134 Gene

Previous GeneCards Identifiers for CCDC134 Gene

  • GC22P040526
  • GC22P042196
  • GC22P025162

Summaries for CCDC134 Gene

GeneCards Summary for CCDC134 Gene

CCDC134 (Coiled-Coil Domain Containing 134) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC134 Gene

Genomics for CCDC134 Gene

Regulatory Elements for CCDC134 Gene

Enhancers for CCDC134 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCDC134 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC134 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC134 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC134 Gene

41,800,622 bp from pter
41,832,164 bp from pter
31,543 bases
Plus strand

Genomic View for CCDC134 Gene

Genes around CCDC134 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC134 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC134 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC134 Gene

Proteins for CCDC134 Gene

  • Protein details for CCDC134 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 134
    Protein Accession:

    Protein attributes for CCDC134 Gene

    229 amino acids
    Molecular mass:
    26561 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC134 Gene

Proteomics data for CCDC134 Gene at MOPED

Post-translational modifications for CCDC134 Gene

  • Ubiquitination at Lys 51
  • Glycosylation at Ser 192 and Thr 193
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC134 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCDC134 Gene

Domains & Families for CCDC134 Gene

Protein Domains for CCDC134 Gene


Suggested Antigen Peptide Sequences for CCDC134 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0388 family.
  • Belongs to the UPF0388 family.
genes like me logo Genes that share domains with CCDC134: view

No data available for Gene Families for CCDC134 Gene

Function for CCDC134 Gene

genes like me logo Genes that share phenotypes with CCDC134: view

Animal Models for CCDC134 Gene

MGI Knock Outs for CCDC134:

Animal Model Products

  • Taconic Biosciences Mouse Models for CCDC134

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC134 Gene

Localization for CCDC134 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC134 Gene


Subcellular locations from

Jensen Localization Image for CCDC134 Gene COMPARTMENTS Subcellular localization image for CCDC134 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCDC134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CCDC134: view

Pathways & Interactions for CCDC134 Gene

SuperPathways for CCDC134 Gene

No Data Available

Interacting Proteins for CCDC134 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9H6E4-CC134_HUMAN ENSP00000255784 for CCDC134 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for CCDC134 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC134 Gene

Drugs & Compounds for CCDC134 Gene

No Compound Related Data Available

Transcripts for CCDC134 Gene

mRNA/cDNA for CCDC134 Gene

Unigene Clusters for CCDC134 Gene

Coiled-coil domain containing 134:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC134 Gene

No ASD Table

Relevant External Links for CCDC134 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC134 Gene

mRNA expression in normal human tissues for CCDC134 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC134 Gene

This gene is overexpressed in Adrenal Gland (x4.7).

Protein differential expression in normal tissues from HIPED for CCDC134 Gene

This gene is overexpressed in Bone (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CCDC134 Gene

SOURCE GeneReport for Unigene cluster for CCDC134 Gene Hs.474991

genes like me logo Genes that share expression patterns with CCDC134: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCDC134 Gene

Orthologs for CCDC134 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC134 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCDC134 35
  • 91.99 (n)
  • 92.58 (a)
CCDC134 36
  • 93 (a)
(Canis familiaris)
Mammalia CCDC134 35
  • 91.12 (n)
  • 93.46 (a)
CCDC134 36
  • 60 (a)
(Mus musculus)
Mammalia Ccdc134 35
  • 88.26 (n)
  • 91.08 (a)
Ccdc134 16
Ccdc134 36
  • 90 (a)
(Pan troglodytes)
Mammalia CCDC134 35
  • 99.56 (n)
  • 99.13 (a)
CCDC134 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ccdc134 35
  • 88.58 (n)
  • 92.49 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC134 36
  • 68 (a)
(Gallus gallus)
Aves CCDC134 35
  • 77.72 (n)
  • 79.51 (a)
CCDC134 36
  • 73 (a)
(Anolis carolinensis)
Reptilia CCDC134 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc134 35
  • 70.48 (n)
  • 73.13 (a)
Str.6128 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398726 35
(Danio rerio)
Actinopterygii LOC100536187 35
  • 69.76 (n)
  • 66.34 (a)
CCDC134 (1 of 2) 36
  • 62 (a)
CCDC134 (2 of 2) 36
  • 61 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7625 35
(Caenorhabditis elegans)
Secernentea F56A8.9 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6343 36
  • 32 (a)
Species with no ortholog for CCDC134:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC134 Gene

Gene Tree for CCDC134 (if available)
Gene Tree for CCDC134 (if available)

Paralogs for CCDC134 Gene

No data available for Paralogs for CCDC134 Gene

Variants for CCDC134 Gene

Sequence variations from dbSNP and Humsavar for CCDC134 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs4512 -- 41,810,080(+) CTAAC(C/G)GGTTG intron-variant
rs7288832 -- 41,817,739(+) ataaa(C/T)aaata intron-variant
rs7290899 -- 41,821,528(+) ctcat(C/T)gttca intron-variant
rs7292782 -- 41,804,320(+) cttgt(A/C)cctta intron-variant
rs7292894 -- 41,818,715(+) aatga(C/T)gcATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC134 Gene

Variant ID Type Subtype PubMed ID
nsv915155 CNV Loss 21882294
nsv3640 CNV Insertion 18451855

Variation tolerance for CCDC134 Gene

Residual Variation Intolerance Score: 30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCDC134 Gene

Disorders for CCDC134 Gene

Relevant External Links for CCDC134

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC134 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC134 Gene

Publications for CCDC134 Gene

  1. Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort. (PMID: 21123754) Kim S. … Saykin A.J. (Neurology 2011) 3 48 67
  2. CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK. (PMID: 18087676) Huang J. … Qiu X. (Cell. Mol. Life Sci. 2008) 2 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. Cytokine-like molecule CCDC134 contributes to CD8a8_ T-cell effector functions in cancer immunotherapy. (PMID: 25125657) Huang J. … Qiu X. (Cancer Res. 2014) 3
  5. CCDC134 is down-regulated in gastric cancer and its silencing promotes cell migration and invasion of GES-1 and AGS cells via the MAPK pathway. (PMID: 23070808) Zhong J. … Huang C. (Mol. Cell. Biochem. 2013) 3

Products for CCDC134 Gene

Sources for CCDC134 Gene