Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC134 Gene

Aliases for CCDC134 Gene

  • Coiled-Coil Domain Containing 134 2 3

External Ids for CCDC134 Gene

Summaries for CCDC134 Gene

GeneCards Summary for CCDC134 Gene

CCDC134 (Coiled-Coil Domain Containing 134) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC134 Gene

Genomics for CCDC134 Gene

Genomic Location for CCDC134 Gene

Start:
41,800,632 bp from pter
End:
41,826,302 bp from pter
Size:
25,671 bases
Orientation:
Plus strand

Genomic View for CCDC134 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC134 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC134 Gene

Regulatory Elements for CCDC134 Gene

Proteins for CCDC134 Gene

  • Protein details for CCDC134 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6E4-CC134_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 134
    Protein Accession:
    Q9H6E4
    Secondary Accessions:

    Protein attributes for CCDC134 Gene

    Size:
    229 amino acids
    Molecular mass:
    26561 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC134 Gene

Proteomics data for CCDC134 Gene at MOPED

Post-translational modifications for CCDC134 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys51

Other Protein References for CCDC134 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC134 Gene

Domains for CCDC134 Gene

Protein Domains for CCDC134 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CC134_HUMAN
Family:
  • Belongs to the UPF0388 family.:
    • Q9H6E4
genes like me logo Genes that share domains with CCDC134: view

No data available for Gene Families for CCDC134 Gene

Function for CCDC134 Gene

genes like me logo Genes that share phenotypes with CCDC134: view

miRNA for CCDC134 Gene

miRTarBase miRNAs that target CCDC134

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCDC134 Gene

Localization for CCDC134 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC134 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC134 Gene COMPARTMENTS Subcellular localization image for CCDC134 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 2
cytosol 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CCDC134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CCDC134: view

Pathways for CCDC134 Gene

SuperPathways for CCDC134 Gene

No Data Available

Interacting Proteins for CCDC134 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000255784%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000357292%0d%0a
Selected Interacting proteins: Q9H6E4-CC134_HUMAN ENSP00000255784 for CCDC134 Gene via I2D STRING MINT

Gene Ontology (GO) - Biological Process for CCDC134 Gene

None

No data available for Pathways by source for CCDC134 Gene

Transcripts for CCDC134 Gene

mRNA/cDNA for CCDC134 Gene

Unigene Clusters for CCDC134 Gene

Coiled-coil domain containing 134:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC134 Gene

No ASD Table

Relevant External Links for CCDC134 Gene

GeneLoc Exon Structure for
CCDC134
ECgene alternative splicing isoforms for
CCDC134

Expression for CCDC134 Gene

mRNA expression in normal human tissues for CCDC134 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC134 Gene

This gene is overexpressed in Adrenal Gland (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCDC134 Gene

SOURCE GeneReport for Unigene cluster for CCDC134 Gene Hs.474991

genes like me logo Genes that share expressions with CCDC134: view

Orthologs for CCDC134 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC134 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC134 36
  • 99.56 (n)
  • 99.13 (a)
CCDC134 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC134 36
  • 91.99 (n)
  • 92.58 (a)
CCDC134 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC134 36
  • 91.12 (n)
  • 93.46 (a)
CCDC134 37
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc134 36
  • 88.26 (n)
  • 91.08 (a)
Ccdc134 16
Ccdc134 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC134 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc134 36
  • 88.58 (n)
  • 92.49 (a)
chicken
(Gallus gallus)
Aves CCDC134 36
  • 77.72 (n)
  • 79.51 (a)
CCDC134 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC134 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398726 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc134 36
  • 70.48 (n)
  • 73.13 (a)
Str.6128 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7625 36
zebrafish
(Danio rerio)
Actinopterygii CCDC134 (1 of 2) 37
  • 62 (a)
OneToMany
CCDC134 (2 of 2) 37
  • 61 (a)
OneToMany
LOC100536187 36
  • 69.76 (n)
  • 66.34 (a)
worm
(Caenorhabditis elegans)
Secernentea F56A8.9 37
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6343 37
  • 32 (a)
OneToOne
Species with no ortholog for CCDC134:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC134 Gene

ENSEMBL:
Gene Tree for CCDC134 (if available)
TreeFam:
Gene Tree for CCDC134 (if available)

Paralogs for CCDC134 Gene

No data available for Paralogs for CCDC134 Gene

Variants for CCDC134 Gene

Sequence variations from dbSNP and Humsavar for CCDC134 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs4512 -- 41,810,080(+) CTAAC(C/G)GGTTG intron-variant
rs139562 -- 41,800,680(+) TTTCA(C/G)TTGCT utr-variant-5-prime
rs139564 -- 41,802,892(+) ctggg(C/T)gacag intron-variant
rs139565 -- 41,803,043(+) tggga(A/G)gtgga intron-variant
rs139566 -- 41,803,273(+) ACCCC(A/G)AATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC134 Gene

Variant ID Type Subtype PubMed ID
nsv915155 CNV Loss 21882294
nsv3640 CNV Insertion 18451855

Relevant External Links for CCDC134 Gene

HapMap Linkage Disequilibrium report
CCDC134

Disorders for CCDC134 Gene

Relevant External Links for CCDC134

Genetic Association Database (GAD)
CCDC134
Human Genome Epidemiology (HuGE) Navigator
CCDC134
genes like me logo Genes that share disorders with CCDC134: view

No data available for UniProtKB/Swiss-Prot for CCDC134 Gene

Publications for CCDC134 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  5. CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK. (PMID: 18087676) Huang J. … Qiu X. (Cell. Mol. Life Sci. 2008) 2 3

Products for CCDC134 Gene

Sources for CCDC134 Gene

Back to Top

Content