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Aliases for CCDC13 Gene

Aliases for CCDC13 Gene

  • Coiled-Coil Domain Containing 13 2 3 5

External Ids for CCDC13 Gene

Previous GeneCards Identifiers for CCDC13 Gene

  • GC03M042725

Summaries for CCDC13 Gene

GeneCards Summary for CCDC13 Gene

CCDC13 (Coiled-Coil Domain Containing 13) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC13 Gene

  • Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC13 Gene

Genomics for CCDC13 Gene

Regulatory Elements for CCDC13 Gene

Enhancers for CCDC13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F042759 1.4 Ensembl ENCODE 23.6 +10.9 10931 5.0 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CCDC13-AS1 CCDC13 SEC22C RN7SL567P RPL36P20 GEMIN2P2 POMGNT2 HIGD1A LOC729083
GH03F042880 1.6 FANTOM5 Ensembl ENCODE 10.8 -107.8 -107848 1.4 ATF1 PKNOX1 ARID4B DMAP1 ZNF48 ZNF2 ETS1 GLIS2 ELK1 ZNF143 HIGD1A ENSG00000235288 ACKR2 ZNF662 CCDC13 LOC729083 KRBOX1 CYP8B1 POMGNT2 HNRNPA1P22
GH03F042802 1.1 ENCODE 11.5 -30.9 -30871 3.1 HDGF PKNOX1 MLX ZFP64 SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 RN7SL567P RPL36P20 GEMIN2P2 CCDC13 LOC729083 SEC22C ACKR2 NKTR ENSG00000280571 GC03M042803
GH03F042744 1.1 Ensembl ENCODE 11.1 +28.7 28653 1.2 HDAC1 TBP PKNOX1 TBL1XR1 SIN3A ZNF2 RAD21 ZNF121 GATA2 POLR3A CCDC13-AS1 LOC729083 CCDC13 HHATL
GH03F042539 1.2 Ensembl ENCODE 9.6 +233.3 233253 0.8 ATF1 SIN3A ZNF48 ZNF143 KLF13 SP3 ZHX2 KAT8 MBD2 MXD3 NKTR SS18L2 SEC22C VIPR1 CCDC13 CCDC13-AS1 VIPR1-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC13 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001362155 53 1201 ATF1 PKNOX1 SIN3A FEZF1 YY1 GATA2 ZNF143 ZNF207 FOS ZNF263

Genomic Location for CCDC13 Gene

Chromosome:
3
Start:
42,692,663 bp from pter
End:
42,773,253 bp from pter
Size:
80,591 bases
Orientation:
Minus strand

Genomic View for CCDC13 Gene

Genes around CCDC13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC13 Gene

Proteins for CCDC13 Gene

  • Protein details for CCDC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYE1-CCD13_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 13
    Protein Accession:
    Q8IYE1

    Protein attributes for CCDC13 Gene

    Size:
    715 amino acids
    Molecular mass:
    80884 Da
    Quaternary structure:
    • Interacts with PCM1, CEP290 and PCNT.

neXtProt entry for CCDC13 Gene

Post-translational modifications for CCDC13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC13 Gene

No data available for DME Specific Peptides for CCDC13 Gene

Domains & Families for CCDC13 Gene

Protein Domains for CCDC13 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC13 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC13: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC13 Gene

Function for CCDC13 Gene

Molecular function for CCDC13 Gene

UniProtKB/Swiss-Prot Function:
Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia.

Gene Ontology (GO) - Molecular Function for CCDC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24816561
genes like me logo Genes that share ontologies with CCDC13: view

Phenotypes for CCDC13 Gene

GenomeRNAi human phenotypes for CCDC13:
genes like me logo Genes that share phenotypes with CCDC13: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC13 Gene

Localization for CCDC13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC13 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC13 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 4

Gene Ontology (GO) - Cellular Components for CCDC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 24816561
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0034451 centriolar satellite IDA 24816561
genes like me logo Genes that share ontologies with CCDC13: view

Pathways & Interactions for CCDC13 Gene

SuperPathways for CCDC13 Gene

No Data Available

Interacting Proteins for CCDC13 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309836%0d%0a9606.ENSP00000293217%0d%0a9606.ENSP00000307697%0d%0a
Selected Interacting proteins: ENSP00000309836 Q8IYE1-CCD13_HUMAN for CCDC13 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CCDC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IMP 24816561
GO:0030030 cell projection organization IEA --
GO:0031122 cytoplasmic microtubule organization IMP 24816561
GO:1905515 non-motile cilium assembly IDA 24816561
genes like me logo Genes that share ontologies with CCDC13: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC13 Gene

Transcripts for CCDC13 Gene

Unigene Clusters for CCDC13 Gene

Coiled-coil domain containing 13:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC13 Gene

No ASD Table

Relevant External Links for CCDC13 Gene

GeneLoc Exon Structure for
CCDC13
ECgene alternative splicing isoforms for
CCDC13

Expression for CCDC13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC13 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC13 Gene

This gene is overexpressed in Testis (x7.0).

Protein differential expression in normal tissues from HIPED for CCDC13 Gene

This gene is overexpressed in Prostate (18.0), Islet of Langerhans (18.0), Testis (17.3), and Blymphocyte (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCDC13 Gene



Protein tissue co-expression partners for CCDC13 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC13 Gene:

CCDC13

SOURCE GeneReport for Unigene cluster for CCDC13 Gene:

Hs.604182
genes like me logo Genes that share expression patterns with CCDC13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CCDC13 Gene

Orthologs for CCDC13 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC13 34 35
  • 99.25 (n)
cow
(Bos Taurus)
Mammalia CCDC13 34 35
  • 87.19 (n)
dog
(Canis familiaris)
Mammalia CCDC13 34 35
  • 86.97 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc13 34
  • 81.85 (n)
mouse
(Mus musculus)
Mammalia Ccdc13 34 16 35
  • 80.84 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC13 35
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC13 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC13 34 35
  • 62.15 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC13 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc13 34
  • 60.75 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC555345 34
  • 54.29 (n)
CCDC13 35
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13032 35
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToOne
Species where no ortholog for CCDC13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC13 Gene

ENSEMBL:
Gene Tree for CCDC13 (if available)
TreeFam:
Gene Tree for CCDC13 (if available)

Paralogs for CCDC13 Gene

No data available for Paralogs for CCDC13 Gene

Variants for CCDC13 Gene

Sequence variations from dbSNP and Humsavar for CCDC13 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10461012 -- 42,705,282(+) GGGGT(C/G)CAGAG nc-transcript-variant, utr-variant-3-prime
rs10490793 -- 42,761,788(-) TAGAA(G/T)TTAGC intron-variant
rs10490794 -- 42,711,380(-) GGTCT(G/T)CTGAT intron-variant
rs10605371 -- 42,773,911(+) TTCTT(-/TCTA)TCTAT downstream-variant-500B, upstream-variant-2KB
rs10678747 -- 42,753,489(+) ATTCA(-/GTG)GTGGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC13 Gene

Variant ID Type Subtype PubMed ID
nsv954472 CNV deletion 24416366
nsv3782 CNV insertion 18451855
esv3596003 CNV loss 21293372
dgv4728n100 CNV loss 25217958

Variation tolerance for CCDC13 Gene

Residual Variation Intolerance Score: 81.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.76; 86.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC13 Gene

Disorders for CCDC13 Gene

Relevant External Links for CCDC13

Genetic Association Database (GAD)
CCDC13
Human Genome Epidemiology (HuGE) Navigator
CCDC13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC13

No disorders were found for CCDC13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC13 Gene

Publications for CCDC13 Gene

  1. Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability. (PMID: 24816561) Staples C.J. … Collis S.J. (J. Cell Sci. 2014) 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein J.I. … Sullivan P.F. (Nat Commun 2014) 3 64

Products for CCDC13 Gene

Sources for CCDC13 Gene

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