Aliases for CCDC13 Gene
External Ids for CCDC13 Gene
- HGNC: 26358
- Entrez Gene: 152206
- Ensembl: ENSG00000244607
- UniProtKB: Q8IYE1
Previous GeneCards Identifiers for CCDC13 Gene
- GC03M042725
Summaries for CCDC13 Gene
GeneCards Summary for CCDC13 Gene
CCDC13 (Coiled-Coil Domain Containing 13) is a Protein Coding gene.
UniProtKB/Swiss-Prot for CCDC13 Gene
-
Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC13 Gene
Genomics for CCDC13 Gene
Regulatory Elements for CCDC13 Gene
Enhancers for CCDC13 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CCDC13 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for CCDC13 Gene
- Chromosome:
- 3
- Start:
- 42,692,663 bp from pter
- End:
- 42,773,253 bp from pter
- Size:
- 80,591 bases
- Orientation:
- Minus strand
Genomic View for CCDC13 Gene
Genes around CCDC13 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p22.1 by Ensembl
- 3p22.1 by Entrez Gene
- 3p22.1 by HGNC
CCDC13 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCDC13 Gene
Proteins for CCDC13 Gene
-
Protein details for CCDC13 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IYE1-CCD13_HUMAN
- Recommended name:
- Coiled-coil domain-containing protein 13
- Protein Accession:
- Q8IYE1
Protein attributes for CCDC13 Gene
- Size:
- 715 amino acids
- Molecular mass:
- 80884 Da
- Quaternary structure:
-
- Interacts with PCM1, CEP290 and PCNT.
Protein Expression for CCDC13 Gene
Post-translational modifications for CCDC13 Gene
Other Protein References for CCDC13 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CCDC13
- Novus Biologicals Antibodies for CCDC13
- Invitrogen Antibodies for CCDC13
- Search GeneTex for Antibodies for CCDC13
Protein Products
-
OriGene Purified Proteins for CCDC13
- Search Origene for MassSpec and Protein Over-expression Lysates for CCDC13
- Origene Custom Protein Services for CCDC13
- Search GeneTex for Proteins for CCDC13
Assay Products
No data available for DME Specific Peptides for CCDC13 Gene
Domains & Families for CCDC13 Gene
Protein Domains for CCDC13 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for CCDC13 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC13 Gene
Function for CCDC13 Gene
Molecular function for CCDC13 Gene
- UniProtKB/Swiss-Prot Function:
- Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 24816561 |
Phenotypes for CCDC13 Gene
- GenomeRNAi human phenotypes for CCDC13:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCDC13
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CCDC13 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC13 gene
- Search ViGene Biosciences for CCDC13
CRISPR Products
-
OriGene CRISPR knockouts for CCDC13
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC13
- GenScript: Design CRISPR guide RNA sequences for CCDC13
miRNA Products
- Search ViGene Biosciences for CCDC13
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCDC13
- Browse OriGene Inhibitory RNA Products For CCDC13
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC13 gene
Clone Products
-
OriGene ORF clones in human for CCDC13
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CCDC13
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC13
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CCDC13
-
ViGene Biosciences adenoviral particle packaged cDNA for CCDC13 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CCDC13 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC13 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC13 Gene
Localization for CCDC13 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCDC13 Gene
- Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 4 |
| cytosol | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | centrosome | IDA | 24816561 |
| GO:0005815 | microtubule organizing center | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for CCDC13 Gene
No Data Available
Interacting Proteins for CCDC13 Gene
Selected Interacting proteins:
ENSP00000309836
Q8IYE1-CCD13_HUMAN
for CCDC13 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006974 | cellular response to DNA damage stimulus | IMP | 24816561 |
| GO:0030030 | cell projection organization | IEA | -- |
| GO:0031122 | cytoplasmic microtubule organization | IMP | 24816561 |
| GO:1905515 | non-motile cilium assembly | IDA | 24816561 |
No data available for Pathways by source and SIGNOR curated interactions for CCDC13 Gene
Transcripts for CCDC13 Gene
mRNA/cDNA for CCDC13 Gene
- (8) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (115) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CCDC13 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCDC13
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC13
- GenScript: Design CRISPR guide RNA sequences for CCDC13
miRNA Products
- Search ViGene Biosciences for CCDC13
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCDC13
- Browse OriGene Inhibitory RNA Products For CCDC13
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC13 gene
Clone Products
-
OriGene ORF clones in human for CCDC13
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CCDC13
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC13
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CCDC13 Gene
mRNA differential expression in normal tissues according to GTEx for CCDC13 Gene
This gene is overexpressed in Testis (x7.0).
This gene is overexpressed in Prostate (18.0), Islet of Langerhans (18.0), Testis (17.3), and Blymphocyte (14.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCDC13 Gene
NURSA nuclear receptor signaling pathways regulating expression of CCDC13 Gene:
CCDC13SOURCE GeneReport for Unigene cluster for CCDC13 Gene:
Hs.604182Primer Products
-
OriGene qPCR primer pairs and template standards for CCDC13
-
OriGene qPCR primer pairs for CCDC13
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC13 Gene
Orthologs for CCDC13 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCDC13 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CCDC13 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CCDC13 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ccdc13 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ccdc13 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CCDC13 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CCDC13 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CCDC13 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CCDC13 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ccdc13 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC555345 34 |
|
||
| CCDC13 35 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG13032 35 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for CCDC13 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CCDC13 Gene
No data available for Paralogs for CCDC13 Gene
Variants for CCDC13 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000022688 | -- | 42,713,388(+) | TCAGG(C/T)CCTTA | intron-variant | |
| rs1000043507 | -- | 42,770,634(+) | GTTGA(A/G)GCTTT | intron-variant, nc-transcript-variant | |
| rs1000117738 | -- | 42,716,757(+) | GCAGC(C/T)ATTGT | intron-variant | |
| rs1000127617 | -- | 42,732,241(+) | TTTTC(A/G)GGGAT | intron-variant, upstream-variant-2KB | |
| rs1000191977 | -- | 42,716,278(+) | TCAAG(A/G)AAGTT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4728n100 | CNV | loss | 25217958 |
| esv3596003 | CNV | loss | 21293372 |
| nsv3782 | CNV | insertion | 18451855 |
| nsv954472 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
81.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.76;
86.68% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CCDC13 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCDC13
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC13 Gene
Disorders for CCDC13 Gene
Relevant External Links for CCDC13
No disorders were found for CCDC13 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC13 Gene
Publications for CCDC13 Gene
- Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability. (PMID: 24816561) Staples C.J. … Collis S.J. (J. Cell Sci. 2014) 3 4 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein J.I. … Sullivan P.F. (Nat Commun 2014) 3 64
Products for CCDC13 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CCDC13
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CCDC13
- Search Origene for MassSpec and Protein Over-expression Lysates for CCDC13
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCDC13
- Browse OriGene Inhibitory RNA Products For CCDC13
- OriGene qPCR primer pairs and template standards for CCDC13
- OriGene qPCR primer pairs for CCDC13
- OriGene CRISPR knockouts for CCDC13
- OriGene ORF clones in human for CCDC13
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCDC13
- GenScript: Next-day shipping cDNA ORF clone for CCDC13 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CCDC13
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- GenScript: Design CRISPR guide RNA sequences for CCDC13
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- CloneReady with Over 120,000 Genes
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- Browse Sino Biological cDNA Clones
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CCDC13
- Novus Biologicals proteins and lysates for CCDC13
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for CCDC13 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CCDC13 gene
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- Search ViGene Biosciences for CCDC13
- Horizon Cell Lines for CCDC13
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCDC13
- VectorBuilder custom plasmid, inducible vectors for CCDC13
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC13
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CCDC13 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer