Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC13 Gene

Aliases for CCDC13 Gene

  • Coiled-Coil Domain Containing 13 2 3 5

External Ids for CCDC13 Gene

Previous GeneCards Identifiers for CCDC13 Gene

  • GC03M042725

Summaries for CCDC13 Gene

GeneCards Summary for CCDC13 Gene

CCDC13 (Coiled-Coil Domain Containing 13) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC13 Gene

  • Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC13 Gene

Genomics for CCDC13 Gene

Regulatory Elements for CCDC13 Gene

Enhancers for CCDC13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCDC13 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC13 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC13 Gene

Chromosome:
3
Start:
42,692,663 bp from pter
End:
42,773,253 bp from pter
Size:
80,591 bases
Orientation:
Minus strand

Genomic View for CCDC13 Gene

Genes around CCDC13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC13 Gene

Proteins for CCDC13 Gene

  • Protein details for CCDC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYE1-CCD13_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 13
    Protein Accession:
    Q8IYE1

    Protein attributes for CCDC13 Gene

    Size:
    715 amino acids
    Molecular mass:
    80884 Da
    Quaternary structure:
    • Interacts with PCM1, CEP290 and PCNT.

neXtProt entry for CCDC13 Gene

Proteomics data for CCDC13 Gene at MOPED

Post-translational modifications for CCDC13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC13 Gene

Domains & Families for CCDC13 Gene

Protein Domains for CCDC13 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC13 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC13: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC13 Gene

Function for CCDC13 Gene

Molecular function for CCDC13 Gene

UniProtKB/Swiss-Prot Function:
Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC13 Gene

Localization for CCDC13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC13 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC13 Gene COMPARTMENTS Subcellular localization image for CCDC13 gene
Compartment Confidence
cytoskeleton 4
nucleus 3

Gene Ontology (GO) - Cellular Components for CCDC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with CCDC13: view

Pathways & Interactions for CCDC13 Gene

SuperPathways for CCDC13 Gene

No Data Available

Interacting Proteins for CCDC13 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309836%0d%0a9606.ENSP00000293217%0d%0a9606.ENSP00000307697%0d%0a
Selected Interacting proteins: ENSP00000309836 for CCDC13 Gene via STRING

Gene Ontology (GO) - Biological Process for CCDC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IMP 24816561
genes like me logo Genes that share ontologies with CCDC13: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC13 Gene

Drugs & Compounds for CCDC13 Gene

No Compound Related Data Available

Transcripts for CCDC13 Gene

Unigene Clusters for CCDC13 Gene

Coiled-coil domain containing 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC13 Gene

No ASD Table

Relevant External Links for CCDC13 Gene

GeneLoc Exon Structure for
CCDC13
ECgene alternative splicing isoforms for
CCDC13

Expression for CCDC13 Gene

mRNA expression in normal human tissues for CCDC13 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC13 Gene

This gene is overexpressed in Testis (x7.0).

Protein differential expression in normal tissues from HIPED for CCDC13 Gene

This gene is overexpressed in Prostate (18.0), Islet of Langerhans (18.0), Testis (17.3), and Blymphocyte (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCDC13 Gene



SOURCE GeneReport for Unigene cluster for CCDC13 Gene Hs.604182

genes like me logo Genes that share expression patterns with CCDC13: view

Protein tissue co-expression partners for CCDC13 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CCDC13 Gene

Orthologs for CCDC13 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCDC13 35
  • 87.19 (n)
  • 85.83 (a)
CCDC13 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC13 35
  • 86.97 (n)
  • 84.67 (a)
CCDC13 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc13 35
  • 80.84 (n)
  • 78.11 (a)
Ccdc13 16
Ccdc13 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCDC13 35
  • 99.25 (n)
  • 99.02 (a)
CCDC13 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc13 35
  • 81.85 (n)
  • 79.42 (a)
oppossum
(Monodelphis domestica)
Mammalia CCDC13 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC13 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC13 35
  • 62.15 (n)
  • 54.72 (a)
CCDC13 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC13 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc13 35
  • 60.75 (n)
  • 52.84 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC555345 35
  • 54.29 (n)
  • 46.63 (a)
CCDC13 36
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13032 36
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToOne
Species with no ortholog for CCDC13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC13 Gene

ENSEMBL:
Gene Tree for CCDC13 (if available)
TreeFam:
Gene Tree for CCDC13 (if available)

Paralogs for CCDC13 Gene

No data available for Paralogs for CCDC13 Gene

Variants for CCDC13 Gene

Sequence variations from dbSNP and Humsavar for CCDC13 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs12495805 - 42,730,546(+) CTCTG(A/T)CACTT intron-variant, nc-transcript-variant, reference, missense
rs17238798 - 42,758,273(+) TAACC(A/G)TTTGT nc-transcript-variant, reference, missense
VAR_055094 -
rs339661 -- 42,712,412(-) GCATC(C/T)TGTGG intron-variant
rs339662 -- 42,710,601(-) CCCCC(A/G)CTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC13 Gene

Variant ID Type Subtype PubMed ID
nsv3782 CNV Insertion 18451855

Variation tolerance for CCDC13 Gene

Residual Variation Intolerance Score: 81.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.76; 86.68% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCDC13 Gene

Disorders for CCDC13 Gene

Relevant External Links for CCDC13

Genetic Association Database (GAD)
CCDC13
Human Genome Epidemiology (HuGE) Navigator
CCDC13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC13

No disorders were found for CCDC13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC13 Gene

Publications for CCDC13 Gene

  1. Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability. (PMID: 24816561) Staples C.J. … Collis S.J. (J. Cell Sci. 2014) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein J.I. … Sullivan P.F. (Nat Commun 2014) 3
  4. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A. … Kocher T. (J. Clin. Periodontol. 2013) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for CCDC13 Gene

Sources for CCDC13 Gene

Content