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Aliases for CCDC127 Gene

Aliases for CCDC127 Gene

  • Coiled-Coil Domain Containing 127 2 3 5

External Ids for CCDC127 Gene

Previous GeneCards Identifiers for CCDC127 Gene

  • GC05M000258

Summaries for CCDC127 Gene

GeneCards Summary for CCDC127 Gene

CCDC127 (Coiled-Coil Domain Containing 127) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC127 Gene

Genomics for CCDC127 Gene

Regulatory Elements for CCDC127 Gene

Enhancers for CCDC127 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F000187 1.6 FANTOM5 Ensembl ENCODE 10.9 +27.9 27903 5.6 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZNF48 YY1 GLIS2 ZNF143 KLF7 LRRC14B LOC100288152 HRAT5 SDHA CCDC127 PLEKHG4B EXOC3 PDCD6 PIR34013
GH05F000390 1.7 FANTOM5 Ensembl ENCODE 9.4 -178.2 -178199 11.7 HDGF PKNOX1 FEZF1 ZNF2 ZNF121 GLIS2 FOS DEK ZNF263 SP3 EXOC3 CCDC127 SDHA PDCD6 HRAT5 LOC100310782 GC05M000376
GH05F000367 1.6 FANTOM5 Ensembl ENCODE 9.4 -155.2 -155195 13.5 HDGF PKNOX1 WRNIP1 GLIS2 ZNF207 FOS ZNF263 JUNB REST TBX21 PDCD6 AHRR CCDC127 SDHA HRAT5 EXOC3 EXOC3-AS1 GC05M000376
GH05F000217 1 ENCODE 13.8 -0.9 -902 3.7 MLX CREB3L1 ARID4B SIN3A ZNF48 SLC30A9 GLIS2 ZNF143 ZNF207 KLF13 SDHA HRAT5 CCDC127 PDCD6 PIR59029
GH05F000317 1.2 Ensembl ENCODE 11 -99.1 -99061 1.1 HDGF PKNOX1 KLF17 SIN3A ZNF2 RAD21 ZNF121 GLIS2 EGR1 ZNF143 SDHA CCDC127 LOC100288152 AHRR GC05M000376
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC127 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC127 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001273906 -685 3401 MLX CREB3L1 ARID4B SIN3A ZNF48 SLC30A9 GLIS2 ZNF143 ZNF207 KLF13

Genomic Location for CCDC127 Gene

196,871 bp from pter
218,215 bp from pter
21,345 bases
Minus strand

Genomic View for CCDC127 Gene

Genes around CCDC127 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC127 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC127 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC127 Gene

Proteins for CCDC127 Gene

  • Protein details for CCDC127 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 127
    Protein Accession:

    Protein attributes for CCDC127 Gene

    260 amino acids
    Molecular mass:
    30834 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC127 Gene

Post-translational modifications for CCDC127 Gene

  • Ubiquitination at Lys 160
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC127 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC127 Gene

Domains & Families for CCDC127 Gene

Protein Domains for CCDC127 Gene


Suggested Antigen Peptide Sequences for CCDC127 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC127: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC127 Gene

Function for CCDC127 Gene

genes like me logo Genes that share phenotypes with CCDC127: view

Animal Models for CCDC127 Gene

MGI Knock Outs for CCDC127:

Animal Model Products

  • Taconic Biosciences Mouse Models for CCDC127

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC127 Gene

Localization for CCDC127 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC127 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CCDC127 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CCDC127: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCDC127 Gene

Pathways & Interactions for CCDC127 Gene

SuperPathways for CCDC127 Gene

No Data Available

Interacting Proteins for CCDC127 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q96BQ5-CC127_HUMAN ENSP00000296824 for CCDC127 Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for CCDC127 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC127 Gene

Transcripts for CCDC127 Gene

mRNA/cDNA for CCDC127 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(108) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC127 Gene

Coiled-coil domain containing 127:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC127 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP1: - -
SP2: -

Relevant External Links for CCDC127 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC127 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC127 Gene

Protein differential expression in normal tissues from HIPED for CCDC127 Gene

This gene is overexpressed in Adrenal (12.3) and Testis (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC127 Gene

Protein tissue co-expression partners for CCDC127 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC127 Gene:


SOURCE GeneReport for Unigene cluster for CCDC127 Gene:

genes like me logo Genes that share expression patterns with CCDC127: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC127 Gene

Orthologs for CCDC127 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC127 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC127 34 35
  • 99.49 (n)
(Canis familiaris)
Mammalia CCDC127 34 35
  • 82.46 (n)
(Bos Taurus)
Mammalia CCDC127 34 35
  • 82.04 (n)
(Mus musculus)
Mammalia Ccdc127 34 16 35
  • 81.15 (n)
(Rattus norvegicus)
Mammalia Ccdc127 34
  • 80.29 (n)
(Monodelphis domestica)
Mammalia CCDC127 35
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC127 35
  • 73 (a)
(Gallus gallus)
Aves CCDC127 34 35
  • 67.44 (n)
(Anolis carolinensis)
Reptilia CCDC127 35
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc127 34
  • 64.97 (n)
(Danio rerio)
Actinopterygii ccdc127a 34 35
  • 57.65 (n)
ccdc127b 35
  • 49 (a)
Species where no ortholog for CCDC127 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC127 Gene

Gene Tree for CCDC127 (if available)
Gene Tree for CCDC127 (if available)

Paralogs for CCDC127 Gene Pseudogenes for CCDC127 Gene

genes like me logo Genes that share paralogs with CCDC127: view

No data available for Paralogs for CCDC127 Gene

Variants for CCDC127 Gene

Sequence variations from dbSNP and Humsavar for CCDC127 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1061517 Pathogenic 218,356(+) CAGAC(A/C/G)TGTCG upstream-variant-2KB, reference, missense
rs749948037 Likely benign 218,412(+) CTGGC(C/G)AAGGC upstream-variant-2KB, reference, synonymous-codon
rs766358430 Likely benign 218,426(+) GAGTC(C/T)GTGCC intron-variant, upstream-variant-2KB
rs587781942 Uncertain significance 218,418(+) AAGGC(A/G)GTGAG upstream-variant-2KB, reference, synonymous-codon
rs878854631 Uncertain significance 218,378(+) CCTGT(C/G)GCGGC upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CCDC127 Gene

Variant ID Type Subtype PubMed ID
nsv596611 CNV loss 21841781
nsv523382 CNV loss 19592680
nsv518607 CNV gain 19592680
nsv428458 CNV loss 18775914
nsv1109667 CNV deletion 24896259
nsv10644 CNV gain+loss 18304495
nsv1030767 CNV gain 25217958
nsv1028658 CNV gain 25217958
nsv1018482 CNV loss 25217958
nsv1018481 CNV gain 25217958
esv993161 CNV deletion 20482838
esv3894107 CNV gain 25118596
esv3569901 CNV loss 25503493
esv3569900 CNV loss 25503493
esv3569895 CNV loss 25503493
esv3569892 CNV loss 25503493
esv29543 CNV gain+loss 19812545
esv2763907 CNV gain+loss 21179565
esv2759315 CNV loss 17122850
esv2752083 CNV gain 17911159
esv2630858 CNV deletion 19546169
esv1572597 CNV deletion 17803354
esv1179194 CNV deletion 17803354
esv1005832 CNV deletion 20482838
dgv3181e59 CNV duplication 20981092

Variation tolerance for CCDC127 Gene

Residual Variation Intolerance Score: 70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC127 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC127 Gene

Disorders for CCDC127 Gene

Relevant External Links for CCDC127

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC127 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC127 Gene

Publications for CCDC127 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64

Products for CCDC127 Gene

Sources for CCDC127 Gene

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