Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC127 Gene

Aliases for CCDC127 Gene

  • Coiled-Coil Domain Containing 127 2 3 5

External Ids for CCDC127 Gene

Previous GeneCards Identifiers for CCDC127 Gene

  • GC05M000258

Summaries for CCDC127 Gene

GeneCards Summary for CCDC127 Gene

CCDC127 (Coiled-Coil Domain Containing 127) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC127 Gene

Genomics for CCDC127 Gene

Regulatory Elements for CCDC127 Gene

Promoters for CCDC127 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC127 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC127 Gene

Chromosome:
5
Start:
196,871 bp from pter
End:
218,215 bp from pter
Size:
21,345 bases
Orientation:
Minus strand

Genomic View for CCDC127 Gene

Genes around CCDC127 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC127 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC127 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC127 Gene

Proteins for CCDC127 Gene

  • Protein details for CCDC127 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BQ5-CC127_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 127
    Protein Accession:
    Q96BQ5

    Protein attributes for CCDC127 Gene

    Size:
    260 amino acids
    Molecular mass:
    30834 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC127 Gene

Proteomics data for CCDC127 Gene at MOPED

Post-translational modifications for CCDC127 Gene

  • Ubiquitination at Lys 160
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC127 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC127 Gene

Domains & Families for CCDC127 Gene

Protein Domains for CCDC127 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC127 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC127: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC127 Gene

Function for CCDC127 Gene

genes like me logo Genes that share phenotypes with CCDC127: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CCDC127

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC127 Gene

Localization for CCDC127 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC127 Gene COMPARTMENTS Subcellular localization image for CCDC127 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC127 Gene

Pathways & Interactions for CCDC127 Gene

SuperPathways for CCDC127 Gene

No Data Available

Interacting Proteins for CCDC127 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296824%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000296824 Q96BQ5-CC127_HUMAN for CCDC127 Gene via STRING I2D MINT

Gene Ontology (GO) - Biological Process for CCDC127 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC127 Gene

Drugs & Compounds for CCDC127 Gene

No Compound Related Data Available

Transcripts for CCDC127 Gene

mRNA/cDNA for CCDC127 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(108) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC127 Gene

Coiled-coil domain containing 127:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC127 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP1: - -
SP2: -

Relevant External Links for CCDC127 Gene

GeneLoc Exon Structure for
CCDC127
ECgene alternative splicing isoforms for
CCDC127

Expression for CCDC127 Gene

mRNA expression in normal human tissues for CCDC127 Gene

Protein differential expression in normal tissues from HIPED for CCDC127 Gene

This gene is overexpressed in Adrenal (12.3) and Testis (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CCDC127 Gene



SOURCE GeneReport for Unigene cluster for CCDC127 Gene Hs.294145

genes like me logo Genes that share expression patterns with CCDC127: view

Protein tissue co-expression partners for CCDC127 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC127 Gene

Orthologs for CCDC127 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC127 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC127 35
  • 99.49 (n)
  • 99.62 (a)
CCDC127 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC127 36
  • 88 (a)
OneToOne
CCDC127 35
  • 82.04 (n)
  • 87.98 (a)
dog
(Canis familiaris)
Mammalia CCDC127 35
  • 82.46 (n)
  • 82.71 (a)
CCDC127 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc127 16
Ccdc127 35
  • 81.15 (n)
  • 82.69 (a)
Ccdc127 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC127 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC127 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc127 35
  • 80.29 (n)
  • 81.35 (a)
chicken
(Gallus gallus)
Aves CCDC127 35
  • 67.44 (n)
  • 65.12 (a)
CCDC127 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC127 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc127 35
  • 64.97 (n)
  • 62.11 (a)
zebrafish
(Danio rerio)
Actinopterygii ccdc127a 36
  • 49 (a)
OneToMany
ccdc127b 36
  • 49 (a)
OneToMany
ccdc127a 35
  • 57.65 (n)
  • 52.55 (a)
Species with no ortholog for CCDC127:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC127 Gene

ENSEMBL:
Gene Tree for CCDC127 (if available)
TreeFam:
Gene Tree for CCDC127 (if available)

Paralogs for CCDC127 Gene

Pseudogenes.org Pseudogenes for CCDC127 Gene

genes like me logo Genes that share paralogs with CCDC127: view

No data available for Paralogs for CCDC127 Gene

Variants for CCDC127 Gene

Sequence variations from dbSNP and Humsavar for CCDC127 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs11557427 - 205,901(-) CTACC(A/G)TCGGA reference, missense
rs13474 -- 204,962(-) CCTTA(C/G)CACAA utr-variant-3-prime
rs371751 -- 210,718(+) CATCA(C/G)GATGG intron-variant
rs822194 -- 213,313(-) CCATC(C/G)TGATG intron-variant
rs1651342 -- 213,094(-) GTGTG(C/T)GATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC127 Gene

Variant ID Type Subtype PubMed ID
essv22552 CNV CNV 17122850
dgv1733e1 CNV Complex 17122850
esv2752083 CNV Gain 17911159
dgv1734e1 CNV Complex 17122850
nsv428458 CNV Loss 18775914
dgv5878n71 CNV Loss 21882294
nsv880815 CNV Loss 21882294
nsv518607 CNV Gain 19592680
nsv523382 CNV Loss 19592680
dgv5879n71 CNV Loss 21882294
nsv881455 CNV Loss 21882294
nsv10644 CNV Gain+Loss 18304495
esv2630858 CNV Deletion 19546169
esv993161 CNV Deletion 20482838
esv29543 CNV Gain+Loss 19812545
esv1005832 CNV Deletion 20482838
esv1572597 CNV Deletion 17803354
esv1179194 CNV Deletion 17803354

Variation tolerance for CCDC127 Gene

Residual Variation Intolerance Score: 70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC127 Gene

HapMap Linkage Disequilibrium report
CCDC127

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC127 Gene

Disorders for CCDC127 Gene

Relevant External Links for CCDC127

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC127

No disorders were found for CCDC127 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC127 Gene

Publications for CCDC127 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3

Products for CCDC127 Gene

Sources for CCDC127 Gene

Back to Top

Content