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Aliases for CCDC126 Gene

Aliases for CCDC126 Gene

  • Coiled-Coil Domain Containing 126 2 3 5

External Ids for CCDC126 Gene

Previous GeneCards Identifiers for CCDC126 Gene

  • GC07P023603
  • GC07P023522

Summaries for CCDC126 Gene

GeneCards Summary for CCDC126 Gene

CCDC126 (Coiled-Coil Domain Containing 126) is a Protein Coding gene. GO annotations related to this gene include alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC126 Gene

Genomics for CCDC126 Gene

Regulatory Elements for CCDC126 Gene

Enhancers for CCDC126 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F023597 1.1 ENCODE 18.9 +0.7 749 2.7 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 SP5 CCDC126 ENSG00000228649 FAM221A FCF1P1
GH07F023628 0.8 ENCODE 16.9 +31.2 31150 0.7 SOX13 TBP SAP130 ZNF384 DMAP1 TEAD3 HOMEZ SOX5 GATAD2A TEAD1 CCDC126 FCF1P1 ENSG00000279448
GH07F023570 1 Ensembl ENCODE 12.9 -26.4 -26428 0.5 CTCF ETV1 RAD21 ETS1 ZNF143 SMC3 DEK CHD2 ELK4 ZNF263 CCDC126 FAM221A LOC442517 CLK2P1
GH07F023430 1.4 Ensembl ENCODE 5.8 -165.9 -165862 2.6 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 CCDC126 GC07M023312 RNU7-143P
GH07F023462 1.6 FANTOM5 ENCODE 4.7 -128.0 -128010 13.3 CREB3L1 MLX FEZF1 DMAP1 ZNF263 SP3 NFYC TBX21 MEF2D SSRP1 ENSG00000227930 EEF1A1P6 STK31 TRA2A IGF2BP3 CCDC126 KLHL7-AS1 NUPL2 MALSU1 GC07P023450
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC126 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC126 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001558022 621 2001 CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 SP5 NFYC

Genomic Location for CCDC126 Gene

Chromosome:
7
Start:
23,597,379 bp from pter
End:
23,644,708 bp from pter
Size:
47,330 bases
Orientation:
Plus strand

Genomic View for CCDC126 Gene

Genes around CCDC126 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC126 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC126 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC126 Gene

Proteins for CCDC126 Gene

  • Protein details for CCDC126 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EE4-CC126_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 126
    Protein Accession:
    Q96EE4
    Secondary Accessions:
    • A8K1J6
    • Q6UWP1
    • Q75MQ6

    Protein attributes for CCDC126 Gene

    Size:
    140 amino acids
    Molecular mass:
    15668 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ96871.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CCDC126 Gene

Post-translational modifications for CCDC126 Gene

  • Glycosylation at Asn 110 and Asn 134
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC126 Gene

No data available for DME Specific Peptides for CCDC126 Gene

Domains & Families for CCDC126 Gene

Protein Domains for CCDC126 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC126 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC126: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC126 Gene

Function for CCDC126 Gene

Gene Ontology (GO) - Molecular Function for CCDC126 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity IEA --
genes like me logo Genes that share ontologies with CCDC126: view
genes like me logo Genes that share phenotypes with CCDC126: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CCDC126

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC126 Gene

Localization for CCDC126 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC126 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC126 gene
Compartment Confidence
extracellular 5
golgi apparatus 3
plasma membrane 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CCDC126 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CCDC126: view

Pathways & Interactions for CCDC126 Gene

SuperPathways for CCDC126 Gene

No Data Available

Interacting Proteins for CCDC126 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000304355%0d%0a9606.ENSP00000347184%0d%0a
Selected Interacting proteins: ENSP00000304355 Q96EE4-CC126_HUMAN for CCDC126 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CCDC126 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006487 protein N-linked glycosylation IEA --
genes like me logo Genes that share ontologies with CCDC126: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC126 Gene

Transcripts for CCDC126 Gene

Unigene Clusters for CCDC126 Gene

Coiled-coil domain containing 126:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC126 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5:
SP6: - - - - - -
SP7: - - - -

Relevant External Links for CCDC126 Gene

GeneLoc Exon Structure for
CCDC126
ECgene alternative splicing isoforms for
CCDC126

Expression for CCDC126 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC126 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCDC126 Gene

This gene is overexpressed in Serum (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC126 Gene



Protein tissue co-expression partners for CCDC126 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC126 Gene:

CCDC126

SOURCE GeneReport for Unigene cluster for CCDC126 Gene:

Hs.232296
genes like me logo Genes that share expression patterns with CCDC126: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC126 Gene

Orthologs for CCDC126 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC126 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC126 34 35
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia CCDC126 34 35
  • 92.14 (n)
cow
(Bos Taurus)
Mammalia CCDC126 34 35
  • 90 (n)
mouse
(Mus musculus)
Mammalia Ccdc126 34 16 35
  • 81.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC126 35
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc126 34
  • 80.71 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC126 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC126 34 35
  • 76.02 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC126 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc126 34
  • 71.9 (n)
zebrafish
(Danio rerio)
Actinopterygii ccdc126 34 35
  • 63.06 (n)
worm
(Caenorhabditis elegans)
Secernentea gly-2 35
  • 4 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 2 (a)
OneToOne
Species where no ortholog for CCDC126 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC126 Gene

ENSEMBL:
Gene Tree for CCDC126 (if available)
TreeFam:
Gene Tree for CCDC126 (if available)

Paralogs for CCDC126 Gene

(1) SIMAP similar genes for CCDC126 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CCDC126: view

No data available for Paralogs for CCDC126 Gene

Variants for CCDC126 Gene

Sequence variations from dbSNP and Humsavar for CCDC126 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1010499 -- 23,635,461(+) ATGTC(A/G)TCTCA intron-variant
rs10225172 -- 23,638,661(+) ATTGT(C/T)CTATG intron-variant
rs10240396 -- 23,638,417(+) ttatc(C/T)ccaac intron-variant
rs10241204 -- 23,642,034(+) TGAGA(C/G)GGAGT intron-variant
rs10241321 -- 23,642,153(+) ACCAC(A/G)GGCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC126 Gene

Variant ID Type Subtype PubMed ID
esv2734130 CNV deletion 23290073
nsv5663 CNV insertion 18451855
nsv7393 OTHER inversion 18451855

Variation tolerance for CCDC126 Gene

Residual Variation Intolerance Score: 38.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC126 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC126

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC126 Gene

Disorders for CCDC126 Gene

Relevant External Links for CCDC126

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC126

No disorders were found for CCDC126 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC126 Gene

Publications for CCDC126 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B. … Wanker E.E. (Nucleic Acids Res. 2013) 3 64

Products for CCDC126 Gene

Sources for CCDC126 Gene

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