Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC125 Gene

Aliases for CCDC125 Gene

  • Coiled-Coil Domain Containing 125 2 3 5
  • Kenae 3 4
  • Protein Kenae 4

External Ids for CCDC125 Gene

Previous GeneCards Identifiers for CCDC125 Gene

  • GC05M068613
  • GC05M068576
  • GC05M065532

Summaries for CCDC125 Gene

GeneCards Summary for CCDC125 Gene

CCDC125 (Coiled-Coil Domain Containing 125) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC125 Gene

  • May be involved in the regulation of cell migration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC125 Gene

Genomics for CCDC125 Gene

Regulatory Elements for CCDC125 Gene

Promoters for CCDC125 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC125 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC125 Gene

Chromosome:
5
Start:
69,273,101 bp from pter
End:
69,332,852 bp from pter
Size:
59,752 bases
Orientation:
Minus strand

Genomic View for CCDC125 Gene

Genes around CCDC125 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC125 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC125 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC125 Gene

Proteins for CCDC125 Gene

  • Protein details for CCDC125 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Z20-CC125_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 125
    Protein Accession:
    Q86Z20
    Secondary Accessions:
    • Q86Z19

    Protein attributes for CCDC125 Gene

    Size:
    511 amino acids
    Molecular mass:
    58629 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC125 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC125 Gene

Proteomics data for CCDC125 Gene at MOPED

Post-translational modifications for CCDC125 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC125 Gene

No data available for DME Specific Peptides for CCDC125 Gene

Domains & Families for CCDC125 Gene

Protein Domains for CCDC125 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC125 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC125: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC125 Gene

Function for CCDC125 Gene

Molecular function for CCDC125 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of cell migration.
genes like me logo Genes that share phenotypes with CCDC125: view

Animal Model Products

CRISPR Products

miRNA for CCDC125 Gene

miRTarBase miRNAs that target CCDC125

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC125 Gene

Localization for CCDC125 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC125 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC125 Gene COMPARTMENTS Subcellular localization image for CCDC125 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for CCDC125 Gene

Pathways & Interactions for CCDC125 Gene

SuperPathways for CCDC125 Gene

No Data Available

Interacting Proteins for CCDC125 Gene

Gene Ontology (GO) - Biological Process for CCDC125 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC125 Gene

Drugs & Compounds for CCDC125 Gene

No Compound Related Data Available

Transcripts for CCDC125 Gene

Unigene Clusters for CCDC125 Gene

Coiled-coil domain containing 125:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC125 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: -
SP3:
SP4: - -

Relevant External Links for CCDC125 Gene

GeneLoc Exon Structure for
CCDC125
ECgene alternative splicing isoforms for
CCDC125

Expression for CCDC125 Gene

mRNA expression in normal human tissues for CCDC125 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCDC125 Gene

This gene is overexpressed in Plasma (28.7), Fetal heart (15.2), Stomach (11.4), and Breast (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC125 Gene



SOURCE GeneReport for Unigene cluster for CCDC125 Gene Hs.654850

genes like me logo Genes that share expression patterns with CCDC125: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCDC125 Gene

Orthologs for CCDC125 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC125 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC125 35
  • 99.59 (n)
  • 99.02 (a)
CCDC125 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC125 36
  • 76 (a)
OneToOne
CCDC125 35
  • 85.7 (n)
  • 77.36 (a)
dog
(Canis familiaris)
Mammalia CCDC125 35
  • 82.91 (n)
  • 74.16 (a)
CCDC125 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc125 16
Ccdc125 36
  • 74 (a)
OneToOne
Ccdc125 35
  • 79.25 (n)
  • 73.29 (a)
oppossum
(Monodelphis domestica)
Mammalia CCDC125 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC125 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc125 35
  • 78.35 (n)
  • 72.11 (a)
chicken
(Gallus gallus)
Aves CCDC125 35
  • 65.83 (n)
  • 57.56 (a)
CCDC125 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC125 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc125 35
  • 62.25 (n)
  • 54.46 (a)
zebrafish
(Danio rerio)
Actinopterygii ccdc125 36
  • 39 (a)
OneToOne
ccdc125 35
  • 54.42 (n)
  • 49.33 (a)
Species with no ortholog for CCDC125:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC125 Gene

ENSEMBL:
Gene Tree for CCDC125 (if available)
TreeFam:
Gene Tree for CCDC125 (if available)

Paralogs for CCDC125 Gene

No data available for Paralogs for CCDC125 Gene

Variants for CCDC125 Gene

Sequence variations from dbSNP and Humsavar for CCDC125 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_032505 -
rs7703720 -- 69,286,190(+) gtaaa(A/C)tatat intron-variant
rs11451510 -- 69,299,112(+) CTTTC(-/T)TTTTT intron-variant
rs11460860 -- 69,315,263(+) AAAAT(-/A)AAAAA intron-variant
rs34485198 -- 69,315,931(+) GCAGT(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC125 Gene

Variant ID Type Subtype PubMed ID
nsv821643 CNV Loss 15273396

Variation tolerance for CCDC125 Gene

Residual Variation Intolerance Score: 70.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.16; 90.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC125 Gene

HapMap Linkage Disequilibrium report
CCDC125

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC125 Gene

Disorders for CCDC125 Gene

Relevant External Links for CCDC125

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC125

No disorders were found for CCDC125 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC125 Gene

Publications for CCDC125 Gene

  1. Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase. (PMID: 19787194) Araya N. … Nakajima T. (Int. J. Mol. Med. 2009) 3 4 67
  2. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CCDC125 Gene

Sources for CCDC125 Gene

Back to Top

Content