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Aliases for CCDC124 Gene

Aliases for CCDC124 Gene

  • Coiled-Coil Domain Containing 124 2 3 5

External Ids for CCDC124 Gene

Previous GeneCards Identifiers for CCDC124 Gene

  • GC19P017911
  • GC19P018043
  • GC19P017608
  • GC19P017977
  • GC19P018178

Summaries for CCDC124 Gene

GeneCards Summary for CCDC124 Gene

CCDC124 (Coiled-Coil Domain Containing 124) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for CCDC124 Gene

  • Required for proper progression of late cytokinetic stages.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC124 Gene

Genomics for CCDC124 Gene

Regulatory Elements for CCDC124 Gene

Promoters for CCDC124 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC124 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC124 Gene

Chromosome:
19
Start:
17,933,015 bp from pter
End:
17,943,991 bp from pter
Size:
10,977 bases
Orientation:
Plus strand

Genomic View for CCDC124 Gene

Genes around CCDC124 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC124 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC124 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC124 Gene

Proteins for CCDC124 Gene

  • Protein details for CCDC124 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CT7-CC124_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 124
    Protein Accession:
    Q96CT7

    Protein attributes for CCDC124 Gene

    Size:
    223 amino acids
    Molecular mass:
    25835 Da
    Quaternary structure:
    • Interacts with RASGEF1B.

neXtProt entry for CCDC124 Gene

Proteomics data for CCDC124 Gene at MOPED

Post-translational modifications for CCDC124 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC124 Gene

Antibody Products

No data available for DME Specific Peptides for CCDC124 Gene

Domains & Families for CCDC124 Gene

Protein Domains for CCDC124 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC124 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96CT7

UniProtKB/Swiss-Prot:

CC124_HUMAN :
  • Belongs to the CCDC124 family.
Family:
  • Belongs to the CCDC124 family.
genes like me logo Genes that share domains with CCDC124: view

No data available for Gene Families for CCDC124 Gene

Function for CCDC124 Gene

Molecular function for CCDC124 Gene

UniProtKB/Swiss-Prot Function:
Required for proper progression of late cytokinetic stages.
genes like me logo Genes that share phenotypes with CCDC124: view

Animal Model Products

CRISPR Products

miRNA for CCDC124 Gene

miRTarBase miRNAs that target CCDC124

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC124 Gene

Localization for CCDC124 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC124 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Colocalizes with gamma-tubulin at interphase, prophase, metaphase, and anaphase. Relocates from centrosome to midbody at telophase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC124 Gene COMPARTMENTS Subcellular localization image for CCDC124 gene
Compartment Confidence
plasma membrane 5
cytosol 4
cytoskeleton 3
nucleus 3

Gene Ontology (GO) - Cellular Components for CCDC124 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0030496 midbody IEA --
genes like me logo Genes that share ontologies with CCDC124: view

Pathways & Interactions for CCDC124 Gene

SuperPathways for CCDC124 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC124 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC124 Gene

Drugs & Compounds for CCDC124 Gene

No Compound Related Data Available

Transcripts for CCDC124 Gene

mRNA/cDNA for CCDC124 Gene

Unigene Clusters for CCDC124 Gene

Coiled-coil domain containing 124:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC124 Gene

No ASD Table

Relevant External Links for CCDC124 Gene

GeneLoc Exon Structure for
CCDC124
ECgene alternative splicing isoforms for
CCDC124

Expression for CCDC124 Gene

mRNA expression in normal human tissues for CCDC124 Gene

Protein differential expression in normal tissues from HIPED for CCDC124 Gene

This gene is overexpressed in Bone marrow stromal cell (15.3), Peripheral blood mononuclear cells (8.4), and Bone (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCDC124 Gene



SOURCE GeneReport for Unigene cluster for CCDC124 Gene Hs.100043

mRNA Expression by UniProt/SwissProt for CCDC124 Gene

Q96CT7-CC124_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with CCDC124: view

Protein tissue co-expression partners for CCDC124 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CCDC124 Gene

Orthologs for CCDC124 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCDC124 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCDC124 35
  • 89.09 (n)
  • 93.72 (a)
CCDC124 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC124 35
  • 90.28 (n)
  • 95.52 (a)
-- 36
  • 68 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ccdc124 35
  • 84.33 (n)
  • 90.32 (a)
Ccdc124 16
Ccdc124 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCDC124 35
  • 99.7 (n)
  • 100 (a)
CCDC124 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc124 35
  • 84.02 (n)
  • 89.86 (a)
oppossum
(Monodelphis domestica)
Mammalia CCDC124 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC124 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC124 35
  • 76.92 (n)
  • 82.81 (a)
CCDC124 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc124 35
  • 69.44 (n)
  • 75.93 (a)
Str.3911 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3532 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
ccdc124 35
  • 68.99 (n)
  • 71.63 (a)
ccdc124 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004110 35
  • 60.07 (n)
  • 53.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6013 35
  • 56.09 (n)
  • 45.19 (a)
CG6013 36
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y73E7A.1 35
  • 55.45 (n)
  • 54.21 (a)
Y73E7A.1 36
  • 48 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G16210 35
  • 50.23 (n)
  • 36.15 (a)
rice
(Oryza sativa)
Liliopsida Os04g0561600 35
  • 55.77 (n)
  • 43.6 (a)
Species with no ortholog for CCDC124:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC124 Gene

ENSEMBL:
Gene Tree for CCDC124 (if available)
TreeFam:
Gene Tree for CCDC124 (if available)

Paralogs for CCDC124 Gene

No data available for Paralogs for CCDC124 Gene

Variants for CCDC124 Gene

Sequence variations from dbSNP and Humsavar for CCDC124 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs8104153 - 17,943,323(+) TGCTG(C/G)AGGAG reference, missense
rs1433126 -- 17,933,453(+) GGTCT(C/T)AATCC intron-variant, upstream-variant-2KB
rs1433127 -- 17,933,791(+) TCCCC(A/G)GCGCC intron-variant, upstream-variant-2KB
rs2302173 -- 17,942,713(+) AGCGC(C/T)TACTG reference, synonymous-codon
rs2302174 -- 17,943,460(+) TTTTC(C/G/T)GGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC124 Gene

Variant ID Type Subtype PubMed ID
nsv911214 CNV Loss 21882294
nsv833772 CNV Gain+Loss 17160897
nsv911226 CNV Loss 21882294
nsv911227 CNV Loss 21882294
dgv3767n71 CNV Loss 21882294
esv2232366 CNV Deletion 18987734
esv2667655 CNV Deletion 23128226
nsv470130 CNV Loss 18288195

Variation tolerance for CCDC124 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC124 Gene

HapMap Linkage Disequilibrium report
CCDC124

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC124 Gene

Disorders for CCDC124 Gene

Relevant External Links for CCDC124

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC124

No disorders were found for CCDC124 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC124 Gene

Publications for CCDC124 Gene

  1. Coiled-coil domain containing protein 124 is a novel centrosome and midbody protein that interacts with the ras-guanine nucleotide exchange factor 1B and is involved in cytokinesis. (PMID: 23894443) Telkoparan P. … Tazebay U.H. (PLoS ONE 2013) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  4. hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. (PMID: 25324306) Roy R. … Pardo O.E. (Nucleic Acids Res. 2014) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for CCDC124 Gene

Sources for CCDC124 Gene

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