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Aliases for CCDC124 Gene

Aliases for CCDC124 Gene

  • Coiled-Coil Domain Containing 124 2 3

External Ids for CCDC124 Gene

Summaries for CCDC124 Gene

GeneCards Summary for CCDC124 Gene

CCDC124 (Coiled-Coil Domain Containing 124) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC124 Gene

  • Required for proper progression of late cytokinetic stages.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC124 Gene

Genomics for CCDC124 Gene

Genomic Location for CCDC124 Gene

Start:
17,933,015 bp from pter
End:
17,943,991 bp from pter
Size:
10,977 bases
Orientation:
Plus strand

Genomic View for CCDC124 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC124 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC124 Gene

Regulatory Elements for CCDC124 Gene

Proteins for CCDC124 Gene

  • Protein details for CCDC124 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CT7-CC124_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 124
    Protein Accession:
    Q96CT7
    Secondary Accessions:

    Protein attributes for CCDC124 Gene

    Size:
    223 amino acids
    Molecular mass:
    25835 Da
    Quaternary structure:
    • Interacts with RASGEF1B.

neXtProt entry for CCDC124 Gene

Proteomics data for CCDC124 Gene at MOPED

Post-translational modifications for CCDC124 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC124 Gene

No data available for DME Specific Peptides for CCDC124 Gene

Domains for CCDC124 Gene

Protein Domains for CCDC124 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC124 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96CT7

UniProtKB/Swiss-Prot:

CC124_HUMAN
Family:
  • Belongs to the CCDC124 family.:
    • Q96CT7
genes like me logo Genes that share domains with CCDC124: view

No data available for Gene Families for CCDC124 Gene

Function for CCDC124 Gene

Molecular function for CCDC124 Gene

UniProtKB/Swiss-Prot Function: Required for proper progression of late cytokinetic stages.

Gene Ontology (GO) - Molecular Function for CCDC124 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CCDC124: view

Phenotypes for CCDC124 Gene

GenomeRNAi human phenotypes for CCDC124:
genes like me logo Genes that share phenotypes with CCDC124: view

miRNA for CCDC124 Gene

miRTarBase miRNAs that target CCDC124

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCDC124 Gene

Localization for CCDC124 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC124 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Colocalizes with gamma-tubulin at interphase, prophase, metaphase, and anaphase. Relocates from centrosome to midbody at telophase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC124 Gene COMPARTMENTS Subcellular localization image for CCDC124 gene
Compartment Confidence
cytosol 4
plasma membrane 4
nucleus 3

Gene Ontology (GO) - Cellular Components for CCDC124 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton --
GO:0005886 plasma membrane IDA --
GO:0030496 midbody IEA --
genes like me logo Genes that share ontologies with CCDC124: view

Pathways for CCDC124 Gene

SuperPathways for CCDC124 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC124 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CCDC124: view

No data available for Pathways by source for CCDC124 Gene

Transcripts for CCDC124 Gene

mRNA/cDNA for CCDC124 Gene

Unigene Clusters for CCDC124 Gene

Coiled-coil domain containing 124:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC124 Gene

No ASD Table

Relevant External Links for CCDC124 Gene

GeneLoc Exon Structure for
CCDC124
ECgene alternative splicing isoforms for
CCDC124

Expression for CCDC124 Gene

mRNA expression in normal human tissues for CCDC124 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCDC124 Gene

SOURCE GeneReport for Unigene cluster for CCDC124 Gene Hs.100043

mRNA Expression by UniProt/SwissProt for CCDC124 Gene

Q96CT7-CC124_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with CCDC124: view

No data available for mRNA differential expression in normal tissues for CCDC124 Gene

Orthologs for CCDC124 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCDC124 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC124 35
  • 99.7 (n)
  • 100 (a)
CCDC124 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC124 35
  • 89.09 (n)
  • 93.72 (a)
CCDC124 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
CCDC124 35
  • 90.28 (n)
  • 95.52 (a)
mouse
(Mus musculus)
Mammalia Ccdc124 35
  • 84.33 (n)
  • 90.32 (a)
Ccdc124 16
Ccdc124 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC124 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC124 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc124 35
  • 84.02 (n)
  • 89.86 (a)
chicken
(Gallus gallus)
Aves CCDC124 35
  • 76.92 (n)
  • 82.81 (a)
CCDC124 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3532 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc124 35
  • 69.44 (n)
  • 75.93 (a)
Str.3911 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
ccdc124 35
  • 68.99 (n)
  • 71.63 (a)
ccdc124 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004110 35
  • 60.07 (n)
  • 53.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6013 35
  • 56.09 (n)
  • 45.19 (a)
CG6013 36
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y73E7A.1 35
  • 55.45 (n)
  • 54.21 (a)
Y73E7A.1 36
  • 48 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G16210 35
  • 50.23 (n)
  • 36.15 (a)
rice
(Oryza sativa)
Liliopsida Os04g0561600 35
  • 55.77 (n)
  • 43.6 (a)
Species with no ortholog for CCDC124:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC124 Gene

ENSEMBL:
Gene Tree for CCDC124 (if available)
TreeFam:
Gene Tree for CCDC124 (if available)

Paralogs for CCDC124 Gene

No data available for Paralogs for CCDC124 Gene

Variants for CCDC124 Gene

Sequence variations from dbSNP and Humsavar for CCDC124 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1052564 -- 17,943,834(+) GGCCC(C/T)GGGGC utr-variant-3-prime
rs1052575 -- 17,943,921(+) CCCGG(C/G)GCGTG utr-variant-3-prime
rs1052577 -- 17,943,923(+) CGGCG(C/G)GTGTG utr-variant-3-prime
rs1433126 -- 17,933,453(+) GGTCT(C/T)AATCC intron-variant, upstream-variant-2KB
rs1433127 -- 17,933,791(+) TCCCC(A/G)GCGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC124 Gene

Variant ID Type Subtype PubMed ID
nsv911214 CNV Loss 21882294
nsv833772 CNV Gain+Loss 17160897
nsv911226 CNV Loss 21882294
nsv911227 CNV Loss 21882294
dgv3767n71 CNV Loss 21882294
esv2232366 CNV Deletion 18987734
esv2667655 CNV Deletion 23128226
nsv470130 CNV Loss 18288195

Relevant External Links for CCDC124 Gene

HapMap Linkage Disequilibrium report
CCDC124

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC124 Gene

Disorders for CCDC124 Gene

No disorders were found for CCDC124 Gene.

No data available for UniProtKB/Swiss-Prot for CCDC124 Gene

Publications for CCDC124 Gene

  1. Coiled-coil domain containing protein 124 is a novel centrosome and midbody protein that interacts with the ras-guanine nucleotide exchange factor 1B and is involved in cytokinesis. (PMID: 23894443) Telkoparan P. … Tazebay U.H. (PLoS ONE 2013) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for CCDC124 Gene

Sources for CCDC124 Gene

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