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Aliases for CCDC121 Gene

Aliases for CCDC121 Gene

  • Coiled-Coil Domain Containing 121 2 3 5

External Ids for CCDC121 Gene

Previous GeneCards Identifiers for CCDC121 Gene

  • GC02M027702
  • GC02M027849
  • GC02M027590

Summaries for CCDC121 Gene

GeneCards Summary for CCDC121 Gene

CCDC121 (Coiled-Coil Domain Containing 121) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC121 Gene

Genomics for CCDC121 Gene

Regulatory Elements for CCDC121 Gene

Enhancers for CCDC121 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F027656 0.7 FANTOM5 11.9 -27.1 -27122 0.3 MAFK SLC4A1AP GPN1 CCDC121 ZNF512 IFT172 NRBP1 KRTCAP3 SLC5A6 SUPT7L GTF3C2
GH02F027662 0.4 ENCODE 11.3 -34.6 -34615 2.4 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 GPN1 NRBP1 GTF3C2 EMILIN1 ZNF512 SNX17 SLC4A1AP OST4 ENSG00000233438 ENSG00000206731
GH02F027655 0.2 ENCODE 10.8 -26.4 -26358 0.2 TGIF2 GPN1 CCDC121 ZNF512 IFT172 KRTCAP3 NRBP1 PIR62267 SLC4A1AP
GH02F027667 0.5 Ensembl 10.8 -38.4 -38370 0.4 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 KLF13 SP3 ENSG00000206731 GPN1 CCDC121 ZNF512 FNDC4 GCKR SUPT7L LOC105374378
GH02F027680 0.6 Ensembl ENCODE 10.5 -53.5 -53547 3.5 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF48 ZNF143 FOS DEK MXD4 LINC01460 SLC4A1AP CCDC121 GPN1 ZNF512 C2orf16 SUPT7L LOC105374378
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CCDC121 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC121 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000587118 31 1601 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for CCDC121 Gene

Chromosome:
2
Start:
27,625,638 bp from pter
End:
27,629,031 bp from pter
Size:
3,394 bases
Orientation:
Minus strand

Genomic View for CCDC121 Gene

Genes around CCDC121 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC121 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC121 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC121 Gene

Proteins for CCDC121 Gene

  • Protein details for CCDC121 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZUS5-CC121_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 121
    Protein Accession:
    Q6ZUS5
    Secondary Accessions:
    • B3KW66
    • J3KQZ8
    • Q9H8G6

    Protein attributes for CCDC121 Gene

    Size:
    278 amino acids
    Molecular mass:
    33061 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX93200.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14651.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC121 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC121 Gene

Post-translational modifications for CCDC121 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC121 Gene

No data available for DME Specific Peptides for CCDC121 Gene

Domains & Families for CCDC121 Gene

Protein Domains for CCDC121 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC121 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC121: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC121 Gene

Function for CCDC121 Gene

Gene Ontology (GO) - Molecular Function for CCDC121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with CCDC121: view
genes like me logo Genes that share phenotypes with CCDC121: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC121 Gene

Localization for CCDC121 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC121 Gene COMPARTMENTS Subcellular localization image for CCDC121 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC121 Gene

Pathways & Interactions for CCDC121 Gene

SuperPathways for CCDC121 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC121 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC121 Gene

Transcripts for CCDC121 Gene

Unigene Clusters for CCDC121 Gene

Coiled-coil domain containing 121:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC121 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c
SP1: - -
SP2:
SP3:

Relevant External Links for CCDC121 Gene

GeneLoc Exon Structure for
CCDC121
ECgene alternative splicing isoforms for
CCDC121

Expression for CCDC121 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC121 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC121 Gene

This gene is overexpressed in Testis (x5.3).

Protein differential expression in normal tissues from HIPED for CCDC121 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC121 Gene



Protein tissue co-expression partners for CCDC121 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC121 Gene:

CCDC121

SOURCE GeneReport for Unigene cluster for CCDC121 Gene:

Hs.21081
genes like me logo Genes that share expression patterns with CCDC121: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CCDC121 Gene

Orthologs for CCDC121 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCDC121 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC121 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 63 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ccdc121 34 16 35
  • 62.27 (n)
Gm6583 35
  • 27 (a)
OneToMany
4930548H24Rik 35
  • 26 (a)
OneToMany
Gm6588 35
  • 26 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ccdc121 34
  • 61.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC121 35
  • 35 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC121 35
  • 32 (a)
OneToOne
Species where no ortholog for CCDC121 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC121 Gene

ENSEMBL:
Gene Tree for CCDC121 (if available)
TreeFam:
Gene Tree for CCDC121 (if available)

Paralogs for CCDC121 Gene

Pseudogenes.org Pseudogenes for CCDC121 Gene

genes like me logo Genes that share paralogs with CCDC121: view

No data available for Paralogs for CCDC121 Gene

Variants for CCDC121 Gene

Sequence variations from dbSNP and Humsavar for CCDC121 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs113321834 -- 27,628,538(+) TAGTT(A/T)ATTCG intron-variant, upstream-variant-2KB, reference, stop-gained
rs113925459 -- 27,626,045(+) CATAT(A/G)GCACA utr-variant-3-prime
rs115359167 -- 27,629,397(+) TTACC(A/G)CGTTG intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs116747362 -- 27,629,604(+) TGGAG(A/G)AGATA intron-variant, upstream-variant-2KB
rs116756341 -- 27,629,522(+) TTGCA(C/T)GCCTG intron-variant, upstream-variant-2KB

Variation tolerance for CCDC121 Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC121 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC121

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCDC121 Gene

Disorders for CCDC121 Gene

Relevant External Links for CCDC121

Genetic Association Database (GAD)
CCDC121
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC121

No disorders were found for CCDC121 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC121 Gene

Publications for CCDC121 Gene

  1. A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. (PMID: 21386085) Kraja A.T. … Borecki I.B. (Diabetes 2011) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 64

Products for CCDC121 Gene

Sources for CCDC121 Gene

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