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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCDC121 Gene

protein-coding   GIFtS: 39
GCID: GC02M027849

Coiled-Coil Domain Containing 121

  Search for CCDC121
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 1211 2
Coiled-Coil Domain-Containing Protein 1212

External Ids:    HGNC: 258331   Entrez Gene: 796352   Ensembl: ENSG000001767147   UniProtKB: Q6ZUS53   

Export aliases for CCDC121 gene to outside databases

Previous GC identifers: GC02M027702 GC02M027590


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CCDC121 Gene: 
CCDC121 (coiled-coil domain containing 121) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCDC121 gene promoter:
         HOXA9   AhR   Tal-1   Meis-1a   Arnt   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC121 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCDC121

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC121


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.2

CCDC121 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC121 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M027849:  view genomic region     (about GC identifiers)

Start:
27,848,506 bp from pter      End:
27,851,898 bp from pter
Size:
3,393 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CC121_HUMAN, Q6ZUS5 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 121  
Size: 278 amino acids; 33061 Da
Sequence caution: Sequence=AAX93200.1; Type=Erroneous initiation; Sequence=BAB14651.1; Type=Erroneous initiation;
Secondary accessions: B3KW66 J3KQZ8 Q9H8G6
Alternative splicing: 2 isoforms:  Q6ZUS5-1   Q6ZUS5-2   

Explore the universe of human proteins at neXtProt for CCDC121: NX_Q6ZUS5

Explore proteomics data for CCDC121 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZUS5

  • CCDC121 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCDC121 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001136155.1  NP_078860.2  

    ENSEMBL proteins: 
     ENSP00000339087   ENSP00000412150   ENSP00000428530  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6ZUS5


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCDC121 
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    SwitchGear 3'UTR luciferase reporter plasmidCCDC121 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC121

    2 Interacting proteins for CCDC121 (Q6ZUS53) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NECAB2Q7Z6G33I2D: score=1 
    NUP62P371983I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCDC121 (CC121)

    Search CenterWatch for drugs/clinical trials and news about CCDC121 / CC121

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCDC121 gene (3 alternative transcripts): 
    NM_001142682.1  NM_001142683.2  NM_024584.4  

    Unigene Cluster for CCDC121:

    Coiled-coil domain containing 121
    Hs.21081  [show with all ESTs]
    Unigene Representative Sequence: NM_001142683
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324364(uc002rld.3 uc002rle.3) ENST00000394775 ENST00000522876

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CCDC121:
    hsa-miR-3671 hsa-miR-548m hsa-miR-3679-5p hsa-miR-4310 hsa-miR-1185
    SwitchGear 3'UTR luciferase reporter plasmidCCDC121 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC121
    Sirion Biotech Customized lentivirus for stable overexpression of CCDC121 
                         Customized lentivirus expression plasmids for stable overexpression of CCDC121 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC121
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC121

    Additional mRNA sequence: 

    AK023708.1 AK125354.1 BC056244.1 BC066936.1 BC066969.1 

    5 DOTS entries:

    DT.111512  DT.100672702  DT.95135337  DT.99997829  DT.91854487 

    24/35 AceView cDNA sequences (see all 35):

    AK124337 AK125354 BC066969 CN483986 BC056244 AK023708 AU139784 NM_024584 
    BI481044 AA778728 BX095833 BC066936 BG772082 AA648537 AW148642 AI686937 
    BI559653 BF966257 BG771487 BI464992 BF037560 H12960 AI400634 H08083 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC121    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c
    SP1:        -     -                     
    SP2:                                    
    SP3:                                    


    ECgene alternative splicing isoforms for CCDC121

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCDC121 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAGTGAAT
    CCDC121 Expression
    About this image


    See CCDC121 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCDC121

    SOURCE GeneReport for Unigene cluster: Hs.21081
        SABiosciences Custom PCR Arrays for CCDC121
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC121

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for CCDC121 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc1211 , 5 coiled-coil domain containing 1211, 5 62.27(n)1
    43.56(a)1
      1 (84.69 cM)5
    4031801  NM_207280.21  NP_997163.21 
     1815096335 


    ENSEMBL Gene Tree for CCDC121 (if available)
    TreeFam Gene Tree for CCDC121 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCDC121 gene

    CCDC121 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCDC121
    PGOHUM00000241952


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/18 SNPs in CCDC121 are shown (see all 18)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs621389741,2
    C,F--27848068(+) CAAGCC/TCTCAC 2 -- ds50012Minor allele frequency- T:0.08NA 122
    rs1495083521,2
    C--27848198(+) CAGGAA/GGGGAA 2 -- ds50010--------
    rs1471731901,2
    --27848317(+) ATACCA/GTGCTT 2 -- ds50010--------
    rs46653841,2
    C,F,A,H--27848397(+) ATCCTG/AATTTC 2 -- ds500116Minor allele frequency- A:0.32NS EA NA WA CSA 792
    rs1815469631,2
    --27848460(+) TGGTAA/GCAGAA 2 -- ds50010--------
    rs1857088501,2
    --27848491(+) TGTTAC/TATTGG 2 -- ds50010--------
    rs46660031,2
    C,F,A,H--27848586(+) AAGCTC/ACAAGG 2 -- ut31 ese316Minor allele frequency- A:0.36NS NA WA CSA 1270
    rs1889515531,2
    --27848822(+) CTTCAA/GTGTCG 2 -- ut310--------
    rs2015954821,2
    C--27848844(+) AAAAA-/TATAAC 2 -- ut310--------
    rs2002398581,2
    C--27848877(+) AAAAT-/TAATT 
            
    AATTT
    2 -- ut310--------

    HapMap Linkage Disequilibrium report for CCDC121 (27848506 - 27851898 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCDC121: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CCDC121
    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC121

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CCDC121 for disorders           About MalaCards

    CCDC121 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CCDC121

    Export disorders for CCDC121 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCDC121 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CCDC121)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A bivariate genome-wide approach to metabolic syndrom e: STAMPEED consortium. (PubMed id 21386085)1, 4 Kraja A.T....Borecki I.B. (2011)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79635 HGNC: 25833 AceView: FLJ13646 Ensembl:ENSG00000176714 euGenes: HUgn79635
    ECgene: CCDC121 H-InvDB: CCDC121

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCDC121 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCDC121 gene:
    Search GeneIP for patents involving CCDC121

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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