CCDC120 Gene
protein-coding GIFtS: 45
GCID: GC0XP048916
|
|
coiled-coil domain containing 120
| |
Aliases
for CCDC120 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Coiled-Coil Domain Containing 1201 2 | | JM111 | | Coiled-Coil Domain-Containing Protein 1202 |
| External Ids: | HGNC: 289101 | Entrez Gene: 900602 | Ensembl: ENSG000001471447 | UniProtKB: Q96HB53 | | ORGUL members: | |
|---|
| NONCODE:n337689 | |
Export aliases for CCDC120 gene to outside databasesPrevious GC identifers: GC0XP048803 GC0XP046573
|---|
Summaries
for CCDC120 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CCDC120:
This gene encodes a protein that contains a coiled-coil domain. Several alternatively spliced transcript variantsencoding multiple isoforms have been found for this gene. (provided by RefSeq, Nov 2012)
|
Genomic Views
for CCDC120 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_079573.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC120 gene promoter:
HOXA3 p53 ATF-2 Max CREB PPAR-gamma1 c-Jun PPAR-gamma2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC120
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC120 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23CCDC120 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP048916: view genomic region
(about GC identifiers)
Start:
|
48,916,514 bp from pter |
End:
|
48,927,510 bp from pter |
Size:
|
10,997 bases |
Orientation:
|
plus strand |
|
Proteins
for CCDC120 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CC120_HUMAN, Q96HB5 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 120 Size: 630 amino acids; 67567 Da
Secondary accessions: B4DTU2Alternative splicing: 2 isoforms: Q96HB5-1 Q96HB5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CCDC120: NX_Q96HB5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96HB5
CCDC120 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (6 alternative transcripts):
NP_001156793.2 NP_001156794.1 NP_001156795.1 NP_001258764.1 NP_001258765.1 NP_296375.1
ENSEMBL proteins: ENSP00000365577 ENSP00000416445 ENSP00000443351
Human Recombinant Protein Products:
CCDC120 Antibody Products:
Assay Products for CCDC120: |
Protein
Domains /
Families
for CCDC120 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCDC120 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96HB5ProtoNet protein and cluster: Q96HB5 1 Blocks protein family: IPB011072 Protein kinase PKN/PRK1
|
Function
for CCDC120 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC120 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC120 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): CCDC120 (NM_001163322) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC120 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC120 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC120 |
2 GenomeRNAi human phenotypes for CCDC120:
Animal Models:
1 MGI phenotypic allele  for Ccdc120 (no phenotypes)
CCDC120 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CCDC120 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC120
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/10 Interacting proteins for CCDC120 (Q96HB53 ENSP000003655774) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
|
Drugs & Compounds
for CCDC120 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC120
Search CenterWatch for drugs/clinical trials and news about CCDC120 / CC120
|
Transcripts
for CCDC120 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC120 gene (6 alternative transcripts): NM_001163321.2 NM_001163322.2 NM_001163323.2 NM_001271835.1 NM_001271836.1 NM_033626.3 Unigene Cluster for CCDC120: Coiled-coil domain containing 120 Hs.522643 [show with all ESTs]Unigene Representative Sequence: NM_0012718365 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000376396(uc004dmf.3) ENST00000482476(uc004dmg.1) ENST00000496529
ENST00000422185(uc011mmr.2) ENST00000536628(uc010nik.3 uc011mmq.2 uc010nil.3 uc011mms.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC120 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC120 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): CCDC120 (NM_001163322) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC120 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC120 |
Additional cDNA sequence: AK056290.1 AK125424.1 AK291370.1 AK293898.1 AK294024.1 AK300366.1 AK315837.1 BC008769.2 14 DOTS entries: DT.40197849 DT.40115393 DT.91955262 DT.121278375 DT.121278385 DT.121278389 DT.121278382 DT.121278383 DT.91737567 DT.91836373 DT.100682168 DT.450585 DT.91764542 DT.92422626 24/36 AceView cDNA sequences (see all 36): NM_033626 AI887768 BX281918 AK001937 AU136777 AI308943 CD244164 BQ689143 AW298300 BC008769 AW008062 AA133052 AK125424 AK056290 BG107898 AI668708 BF970152 BP357848 BE512643 BX117212 BI087144 BE138782 BM148872 N93943
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC120 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 |
|---|
|
| SP1: | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CCDC120
|
Expression
for CCDC120 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC120 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CCDC120 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC120
SOURCE GeneReport for Unigene cluster: Hs.522643
SABiosciences Custom PCR Arrays for CCDC120
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC120
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC120 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC120 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC120 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC120 |
Orthologs
for CCDC120 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CCDC120 gene from 4/11 species (see all 11) About this table
ENSEMBL Gene Tree for CCDC120 (if available)
TreeFam Gene Tree for CCDC120 (if available) |
Paralogs
for CCDC120 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CCDC120 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC120 (48916514 - 48927510 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CCDC120
1 CNV: 7789
Locus Specific Mutation Databases (LSDB): CCDC120
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC120 |
|
Disorders
/ Diseases
for CCDC120 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CCDC120 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC120 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with CCDC120) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PubMed id 19377476)1 Tarpey P.S.... Stratton M.R. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Shifted Transversal Design smart-pooling for high cov erage interactome mapping. (PubMed id 19447967)1 Xin X....Thierry-Mieg N. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for CCDC120 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC120 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC120 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC120 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC120 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC120 gene:
Search GeneIP for patents involving CCDC120
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC120 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC120 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC120 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC120 | | | OriGene Protein Over-expression Lysate for CCDC120 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC120 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC120 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC120 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CCDC120 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC120 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC120 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC120 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC120 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC120 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC120 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CCDC120 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CCDC120 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC120 |
|  |  |  | | | | Search ThermoFisher Antibodies for CCDC120 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC120 |
|
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