CCDC12 Gene
protein-coding GIFtS: 47
GCID: GC03M046939
|
|
coiled-coil domain containing 12
| |
Aliases
for CCDC12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 121 2 | | MGC239181 | | Coiled-Coil Domain-Containing Protein 122 |
Export aliases for CCDC12 gene to outside databases |
Summaries
for CCDC12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CCDC12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC12 gene promoter:
CREB NF-1 CP2 HOXA5 Lmo2 Nkx2-5 ZID NF-kappaB NF-kappaB1 c-Ets-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.31 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.31CCDC12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M046939: view genomic region
(about GC identifiers)
Start:
|
46,963,216 bp from pter |
End:
|
47,023,500 bp from pter |
Size:
|
60,285 bases |
Orientation:
|
minus strand |
|
Proteins
for CCDC12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CCD12_HUMAN, Q8WUD4 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 12 Size: 166 amino acids; 19181 Da
Secondary accessions: Q8N8I4Explore the universe of human proteins at neXtProt for CCDC12: NX_Q8WUD4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WUD4
CCDC12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653317.2
ENSEMBL proteins: ENSP00000416263 ENSP00000387490 ENSP00000292314 ENSP00000441327
Human Recombinant Protein Products:
CCDC12 Antibody Products:
Assay Products for CCDC12: |
Protein
Domains /
Families
for CCDC12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCDC12 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WUD4ProtoNet protein and cluster: Q8WUD4 |
Function
for CCDC12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC12 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC12 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CCDC12 (NM_024584) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC12 |
2 GenomeRNAi human phenotypes for CCDC12:
|
Pathways & Interactions
for CCDC12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for CCDC12):
CCDC12 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC12
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/9 Interacting proteins for CCDC12 (Q8WUD42, 3 ENSP000002923144) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
|
Drugs & Compounds
for CCDC12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC12
Search CenterWatch for drugs/clinical trials and news about CCDC12 / CCD12
|
Transcripts
for CCDC12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC12 gene: NM_144716.4 Unigene Clusters for CCDC12: Coiled-coil domain containing 12 Hs.631918 [show with all ESTs], Hs.692157 [show with all ESTs]Unigene Representative Sequences: BM546625, AK2955328 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000425441(uc003cqo.2) ENST00000488069(uc011baq.2) ENST00000446836
ENST00000494655(uc011bar.1) ENST00000460035 ENST00000492819 ENST00000292314
ENST00000546280
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC12 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC12 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CCDC12 (NM_024584) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC12 |
Additional cDNA sequence: AK295532.1 11 DOTS entries: DT.95130304 DT.114842 DT.97854154 DT.100683664 DT.120841724 DT.120841687 DT.75114384 DT.75184413 DT.97854156 DT.92043352 DT.99935624 24/145 AceView cDNA sequences (see all 145): BM830766 CD108843 BM718147 BM712682 C02159 BM769733 W72343 AK098120 W19909 BM676030 BM768997 BQ574648 BU684888 BM828367 BM831811 N91255 BQ020908 BQ642425 AW613821 D31084 BQ642957 CB853809 BM803652 BG107767
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC12 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | - | | - | | | | - | | | | - | | - | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | | | - | | | | - | | - | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | - | | | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CCDC12
|
Expression
for CCDC12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGTGGGAAC
About this image
See CCDC12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC12
SOURCE GeneReport for Unigene clusters: Hs.631918 Hs.692157
SABiosciences Custom PCR Arrays for CCDC12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC12 |
Orthologs
for CCDC12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CCDC12 gene from 9/26 species (see all 26) About this table
ENSEMBL Gene Tree for CCDC12 (if available)
TreeFam Gene Tree for CCDC12 (if available) |
Paralogs
for CCDC12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCDC12 gene
CCDC12 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CCDC12
PGOHUM00000240042
|
Genomic Variants
for CCDC12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC12 (46963216 - 47023500 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CCDC12
1 CNV: 3428
1 Indel: 63461 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC12 |
|
Disorders
/ Diseases
for CCDC12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CCDC12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC12 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with CCDC12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Isolation of siRNA target by biotinylated siRNA reveal s that human CCDC12 promotes early erythroid differentiation. (PubMed id 22269669)1 Fan C....Chen M. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
|
External Searches for CCDC12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC12 gene:
Search GeneIP for patents involving CCDC12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC12 | | | OriGene Protein Over-expression Lysate for CCDC12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC12 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CCDC12 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC12 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CCDC12 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CCDC12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC12 |
|  |  |  | | | | Search ThermoFisher Antibodies for CCDC12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC12 |
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