Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC12 Gene

Aliases for CCDC12 Gene

  • Coiled-Coil Domain Containing 12 2 3 5

External Ids for CCDC12 Gene

Summaries for CCDC12 Gene

GeneCards Summary for CCDC12 Gene

CCDC12 (Coiled-Coil Domain Containing 12) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC12 Gene

Genomics for CCDC12 Gene

Regulatory Elements for CCDC12 Gene

Enhancers for CCDC12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCDC12 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC12 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC12 Gene

Chromosome:
3
Start:
46,921,726 bp from pter
End:
46,982,018 bp from pter
Size:
60,293 bases
Orientation:
Minus strand

Genomic View for CCDC12 Gene

Genes around CCDC12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC12 Gene

Proteins for CCDC12 Gene

  • Protein details for CCDC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUD4-CCD12_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 12
    Protein Accession:
    Q8WUD4
    Secondary Accessions:
    • Q8N8I4

    Protein attributes for CCDC12 Gene

    Size:
    166 amino acids
    Molecular mass:
    19181 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC12 Gene

Proteomics data for CCDC12 Gene at MOPED

Post-translational modifications for CCDC12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC12 Gene

No data available for DME Specific Peptides for CCDC12 Gene

Domains & Families for CCDC12 Gene

Protein Domains for CCDC12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC12: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC12 Gene

Function for CCDC12 Gene

genes like me logo Genes that share phenotypes with CCDC12: view

Animal Model Products

miRNA for CCDC12 Gene

miRTarBase miRNAs that target CCDC12

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC12 Gene

Localization for CCDC12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC12 Gene COMPARTMENTS Subcellular localization image for CCDC12 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC12 Gene

Pathways & Interactions for CCDC12 Gene

SuperPathways for CCDC12 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with CCDC12: view

Pathways by source for CCDC12 Gene

1 KEGG pathway for CCDC12 Gene

Gene Ontology (GO) - Biological Process for CCDC12 Gene

None

No data available for SIGNOR curated interactions for CCDC12 Gene

Drugs & Compounds for CCDC12 Gene

No Compound Related Data Available

Transcripts for CCDC12 Gene

Unigene Clusters for CCDC12 Gene

Coiled-coil domain containing 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC12 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7: - - -
SP8: - - - - -

Relevant External Links for CCDC12 Gene

GeneLoc Exon Structure for
CCDC12
ECgene alternative splicing isoforms for
CCDC12

Expression for CCDC12 Gene

mRNA expression in normal human tissues for CCDC12 Gene

Protein differential expression in normal tissues from HIPED for CCDC12 Gene

This gene is overexpressed in NK cells (7.2) and Blymphocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCDC12 Gene



SOURCE GeneReport for Unigene cluster for CCDC12 Gene Hs.692157

genes like me logo Genes that share expression patterns with CCDC12: view

Protein tissue co-expression partners for CCDC12 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC12 Gene

Orthologs for CCDC12 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCDC12 35
  • 87.95 (n)
  • 91.57 (a)
CCDC12 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC12 35
  • 91.37 (n)
  • 93.98 (a)
CCDC12 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc12 35
  • 87.95 (n)
  • 90.36 (a)
Ccdc12 16
Ccdc12 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCDC12 35
  • 99.81 (n)
  • 100 (a)
CCDC12 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc12 35
  • 85.74 (n)
  • 90.36 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC12 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC12 35
  • 71.34 (n)
  • 71.34 (a)
CCDC12 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC12 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc12 35
  • 70.11 (n)
  • 77.42 (a)
Str.6452 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14414 35
zebrafish
(Danio rerio)
Actinopterygii ccdc12 35
  • 65.77 (n)
  • 69.13 (a)
ccdc12 36
  • 66 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10671 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004668 35
  • 53.29 (n)
  • 49.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15525 35
  • 53.9 (n)
  • 48.23 (a)
CG15525 36
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y69A2AR.21 36
  • 37 (a)
OneToOne
Species with no ortholog for CCDC12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC12 Gene

ENSEMBL:
Gene Tree for CCDC12 (if available)
TreeFam:
Gene Tree for CCDC12 (if available)

Paralogs for CCDC12 Gene

Pseudogenes.org Pseudogenes for CCDC12 Gene

genes like me logo Genes that share paralogs with CCDC12: view

No data available for Paralogs for CCDC12 Gene

Variants for CCDC12 Gene

Sequence variations from dbSNP and Humsavar for CCDC12 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs4587 -- 46,922,012(-) TGCAG(A/G)GGATG nc-transcript-variant, utr-variant-3-prime
rs1047628 -- 46,921,956(-) GGCTT(C/T)TGAGC nc-transcript-variant, utr-variant-3-prime
rs2290545 -- 46,925,550(-) TGTTC(C/T)CTCTA intron-variant
rs2290546 -- 46,923,707(-) AGCGC(A/C/G)TTTTC intron-variant
rs4289375 -- 46,944,839(-) TTGAG(C/T)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC12 Gene

Variant ID Type Subtype PubMed ID
dgv1455e1 CNV Complex 17122850
nsv428417 CNV Loss 18775914
essv8614 CNV CNV 17122850
dgv5130n71 CNV Loss 21882294
nsv876754 CNV Gain 21882294
nsv876755 CNV Loss 21882294
nsv460526 CNV Loss 19166990
nsv3800 CNV Loss 18451855
esv2657344 CNV Deletion 23128226
nsv876756 CNV Gain 21882294
esv25200 CNV Loss 19812545
nsv876757 CNV Loss 21882294

Variation tolerance for CCDC12 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.82% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCDC12 Gene

Disorders for CCDC12 Gene

Relevant External Links for CCDC12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC12

No disorders were found for CCDC12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC12 Gene

Publications for CCDC12 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for CCDC12 Gene

Sources for CCDC12 Gene

Content