CCDC117 Gene
protein-coding GIFtS: 39
GCID: GC22P029168
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|
coiled-coil domain containing 117
| |
Aliases
for CCDC117 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 1171 2 | | FLJ338141 | | Coiled-Coil Domain-Containing Protein 1172 | | DJ366L4.11 |
Export aliases for CCDC117 gene to outside databasesPrevious GC identifers: GC22P027498 GC22P012133 |
Summaries
for CCDC117 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CCDC117 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC117 gene promoter:
NF-1 NF-1/L AML1a NF-kappaB HNF-1A C/EBPalpha NF-kappaB2 HNF-1 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC117
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC117 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q12.1 Ensembl cytogenetic band: 22q12.1 HGNC cytogenetic band: 22q12.1CCDC117 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P029168: view genomic region
(about GC identifiers)
Start:
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29,168,662 bp from pter |
End:
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29,185,283 bp from pter |
Size:
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16,622 bases |
Orientation:
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plus strand |
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Proteins
for CCDC117 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CC117_HUMAN, Q8IWD4 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 117 Size: 279 amino acids; 30541 Da
Secondary accessions: A8K0F1 Q6ICA7 Q8N278Alternative splicing: 2 isoforms: Q8IWD4-1 Q8IWD4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CCDC117: NX_Q8IWD4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IWD4
CCDC117 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775781.1
ENSEMBL proteins: ENSP00000249064 ENSP00000411668 ENSP00000399536 ENSP00000415728 ENSP00000389478 ENSP00000387827 ENSP00000399363
Human Recombinant Protein Products:
CCDC117 Antibody Products:
Assay Products for CCDC117: |
Protein
Domains /
Families
for CCDC117 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8IWD4 |
Function
for CCDC117 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC117 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC117
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CCDC117 (NM_173510) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC117 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC117 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC117 |
1 GenomeRNAi human phenotype for CCDC117:
|
Pathways & Interactions
for CCDC117 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC117
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for CCDC117 (Q8IWD43 ENSP000002490644) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CCDC117 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC117
Search CenterWatch for drugs/clinical trials and news about CCDC117 / CC117
|
Transcripts
for CCDC117 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC117 gene: NM_173510.2 Unigene Cluster for CCDC117: Coiled-coil domain containing 117 Hs.406460 [show with all ESTs]Unigene Representative Sequence: NM_1735107 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000249064(uc003aeb.3 uc011aki.2 uc011akj.2 uc011akk.2)
ENST00000453543 ENST00000444523 ENST00000432510 ENST00000448492 ENST00000421503
ENST00000443309
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC117 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC117
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCDC117 (NM_173510) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC117 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC117 |
Additional cDNA sequence: AK091133.1 AK092636.1 AK127794.1 AK289516.1 AK295140.1 AK302798.1 AK302925.1 BC040488.1 BC053874.1 BC065549.1 CR456461.1 9 DOTS entries: DT.213184 DT.100755200 DT.120629795 DT.100755199 DT.100755198 DT.120629812 DT.121616719 DT.65287234 DT.99934353 24/170 AceView cDNA sequences (see all 170): AI373370 AA453890 BU506786 CB850689 BM846250 AA426139 AI223864 AI800697 AA969156 BM829216 AV650620 CR456461 BF795360 AA422115 AA418230 BX478425 AI168645 AA453804 BQ639669 Z41665 AA741277 CD643560 AI093952 AA770192
GeneLoc Exon Structure
|
Expression
for CCDC117 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC117 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGCTGCTGG
About this image
See CCDC117 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC117
SOURCE GeneReport for Unigene cluster: Hs.406460
SABiosciences Custom PCR Arrays for CCDC117
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC117
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC117 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC117 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC117 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC117 |
Orthologs
for CCDC117 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CCDC117 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for CCDC117 (if available)
TreeFam Gene Tree for CCDC117 (if available) |
Paralogs
for CCDC117 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCDC117 gene
CCDC117 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CCDC117
PGOHUM00000259005
|
Genomic Variants
for CCDC117 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC117 (29168662 - 29185283 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CCDC117
5 Indels: 42189 27031 103148 61998 46217 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC117 |
|
Disorders
/ Diseases
for CCDC117 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CCDC117 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC117 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCDC117) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
|
External Searches for CCDC117 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC117 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC117 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC117 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC117 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC117 gene:
Search GeneIP for patents involving CCDC117
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC117 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC117 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC117 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC117 | | | OriGene Protein Over-expression Lysate for CCDC117 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC117 | | OriGene 3'-UTR Clone for CCDC117 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC117 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC117 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CCDC117 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CCDC117 | | OriGene Custom Protein Services for CCDC117 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC117 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC117 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC117 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC117 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC117 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC117 |
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 |  |  |  | |
| | | | Search Tocris compounds for CCDC117 |
| |  |  |  |  | | | | |
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 | | | CCDC117 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC117 |
|  |  |  | | | | Search ThermoFisher Antibodies for CCDC117 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC117 |
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