CCDC115 Gene
protein-coding GIFtS: 44
GCID: GC02M131095
|
|
coiled-coil domain containing 115
| |
Aliases
for CCDC115 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 1151 2 | | Ccp11 | | FLJ301311 | | MGC129811 | | Coiled-Coil Domain-Containing Protein 1152 | | CCP15 |
Export aliases for CCDC115 gene to outside databasesPrevious GC identifers: GC02M130814 GC02M123385 |
Summaries
for CCDC115 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CCDC115 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC115 gene promoter:
SRF MAZR SRF (504 AA) MyoD MIF-1 CREB PPAR-alpha deltaCREB Pax-4a ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC115
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC115 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q21.1 Ensembl cytogenetic band: 2q21.1 HGNC cytogenetic band: 2q21.1CCDC115 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M131095: view genomic region
(about GC identifiers)
Start:
|
131,095,814 bp from pter |
End:
|
131,099,922 bp from pter |
Size:
|
4,109 bases |
Orientation:
|
minus strand |
|
Proteins
for CCDC115 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CC115_HUMAN, Q96NT0 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 115 Size: 180 amino acids; 19761 Da
Subcellular location: Endosome (By similarity). Lysosome (By similarity)
Secondary accessions: Q9BR88Explore the universe of human proteins at neXtProt for CCDC115: NX_Q96NT0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96NT0
CCDC115 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115733.2
ENSEMBL proteins: ENSP00000259229 ENSP00000403480 ENSP00000387301 ENSP00000399756
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CCDC115 for ontologies About GeneDecksing
CCDC115 Antibody Products:
Assay Products for CCDC115: |
Protein
Domains /
Families
for CCDC115 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96NT0 |
Function
for CCDC115 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC115 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC115
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CCDC115 (NM_032357) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC115 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC115 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC115 |
|
Pathways & Interactions
for CCDC115 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC115
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/10 Interacting proteins for CCDC115 (Q96NT02, 3 ENSP000002592294) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
|
Drugs & Compounds
for CCDC115 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC115
Search CenterWatch for drugs/clinical trials and news about CCDC115 / CC115
|
Transcripts
for CCDC115 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC115 gene: NM_032357.2 Unigene Cluster for CCDC115: Coiled-coil domain containing 115 Hs.104203 [show with all ESTs]Unigene Representative Sequence: AK1244055 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000259229(uc002tqy.1) ENST00000442217(uc010zaf.1) ENST00000465315
ENST00000409127 ENST00000437688
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC115 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC115
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCDC115 (NM_032357) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC115 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC115 |
Additional cDNA sequence: AK054693.1 AK092196.1 AK124405.1 AK295922.1 BC006429.1 20 DOTS entries: DT.91948915 DT.450053 DT.100883153 DT.91968375 DT.100883132 DT.102839319 DT.99932817 DT.91767297 DT.100883138 DT.100883142 DT.120981512 DT.92445665 DT.100883146 DT.99952221 DT.100883152 DT.100883139 DT.120981107 DT.100883148 DT.120980765 DT.120981491 24/285 AceView cDNA sequences (see all 285): AA430499 AW467589 AA477058 BQ639247 AA476947 AW161045 AW261829 AI688838 CA748482 AW162612 W38853 CR621252 BQ575029 BI910807 AK124405 BI915411 BU622818 BQ059150 BQ692021 BM848242 BU856883 AI436004 BC006429 CA420264
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC115 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | | | | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for CCDC115
|
Expression
for CCDC115 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC115 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CCDC115 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC115
SOURCE GeneReport for Unigene cluster: Hs.104203
UniProtKB/Swiss-Prot: CC115_HUMAN, Q96NT0Tissue specificity: Expressed throughout the brain
SABiosciences Custom PCR Arrays for CCDC115
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC115
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC115 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC115 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC115 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC115 |
Orthologs
for CCDC115 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CCDC115 gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for CCDC115 (if available)
TreeFam Gene Tree for CCDC115 (if available) |
Paralogs
for CCDC115 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CCDC115 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC115 (131095814 - 131099922 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CCDC115
5 CNVs: 3393 9430 53632 2408 8387 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC115 |
|
Disorders
/ Diseases
for CCDC115 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCDC115 for disorders About GeneDecksing
OMIM gene information: 613734
OMIM disorders: --
3  diseases for CCDC115: About MalaCardsfungal meningitis meningitis measles
Export disorders for CCDC115 gene to outside databases
|
Publications
for CCDC115 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC115 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCDC115) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Regulation of cell proliferation and apoptosis in neu roblastoma cells by ccp1, a FGF2 downstream gene. (PubMed id 21118521)1, 3 Pellicano F....Iwata T. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Expression of coiled-coil protein 1, a novel gene downstream of FGF2, in the developing brain. (PubMed id 16378758)2 Pellicano F.... Iwata T. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for CCDC115 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC115 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC115 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC115 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC115 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC115 gene:
Search GeneIP for patents involving CCDC115
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC115 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC115 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC115 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC115 | | | OriGene Protein Over-expression Lysate for CCDC115 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC115 | | OriGene 3'-UTR Clone for CCDC115 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC115 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC115 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CCDC115 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CCDC115 | | OriGene Custom Protein Services for CCDC115 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC115 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC115 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC115 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC115 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC115 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC115 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CCDC115 |
| |  |  |  |  | | | | |
 |
 |
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 | | | CCDC115 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC115 |
|  |  |  | | | | Search ThermoFisher Antibodies for CCDC115 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC115 |
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