Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCDC114 Gene

protein-coding GIFtS: 41
GCID: GC19M048799

coiled-coil domain containing 114

Search for CCDC114
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 114¹ ²
CILD20¹ ²
FLJ32926¹
Coiled-Coil Domain-Containing Protein 114²

External Ids:	HGNC: 26560¹	Entrez Gene: 93233²	Ensembl: ENSG00000105479⁷	OMIM: 615038⁵	UniProtKB: Q96M63³

Export aliases for CCDC114 gene to outside databases

Previous GC identifers: GC19M053492 GC19M045180

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CC114_HUMAN, Q96M63

Function: Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer

dynein arms (Probable)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCDC114 gene promoter:
COUP-TF1 STAT1 Bach2 RelA HNF-4alpha1 E47 AREB6 RORalpha1 HEN1 COUP-TF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCDC114 promoter sequence

Search SABiosciences Chromatin IP Primers for CCDC114

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC114

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.32

CCDC114 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC114 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M048799: view genomic region (about GC identifiers)

Start:	48,799,709 bp from pter	End:	48,825,130 bp from pter
Size:	25,422 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CC114_HUMAN, Q96M63 (See protein sequence)

Recommended Name: Coiled-coil domain-containing protein 114

Size: 670 amino acids; 75046 Da

Subcellular location: Cell projection, cilium

Caution: Although the CILD20 variant corresponding to dbSNP:rs147718607 could create a Ala to Thr substitution at

position 248, the variation causes an intronic insertion, resulting in a frameshift and premature truncation. It

should therefore not be considered as a single amino acid polymorphism (SAP) (PubMed:23261303)

Sequence caution: Sequence=BAB71448.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites;

Sequence=BAC87296.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites;

Secondary accessions: Q6ZRL4 Q96M06 Q9UFG8

Alternative splicing: 3 isoforms: Q96M63-1 Q96M63-4 Q96M63-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCDC114: NX_Q96M63

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96M63

CCDC114 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_653178.3

ENSEMBL proteins:

ENSP00000318429

Human Recombinant Protein Products for CCDC114:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CCDC114 OriGene Protein Over-expression Lysate: CCDC114 OriGene Custom Protein Services for CCDC114
	GenScript Custom Purified and Recombinant Proteins Services for CCDC114
	Novus Biologicals CCDC114 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CCDC114

CCDC114 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for CCDC114
	GenScript Custom Superior Antibodies Services for CCDC114
	Novus Biologicals CCDC114 Antibodies
	Abcam antibodies for CCDC114
	Uscn Antibodies for CCDC114
	ThermoFisher Antibodies for CCDC114

Assay Products for CCDC114:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CCDC114
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCDC114

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q96M63

UniProtKB/Swiss-Prot: CC114_HUMAN, Q96M63

Similarity: Belongs to the ODA1/DCC2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CC114_HUMAN, Q96M63

Function: Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer

dynein arms (Probable)

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CCDC114

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCDC114
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCDC114
		SwitchGear 3'UTR luciferase reporter plasmid: CCDC114 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC114 (see all 7) OriGene shRNA RFP: CCDC114 OriGene siRNA: CCDC114
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC114
		Sirion Biotech Custom design and validation of potent shRNA sequences against CCDC114

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CCDC114
			Sirion Biotech Customized adenovirus for overexpression of CCDC114 Sirion Biotech Customized adenovirus for potent knockdown of CCDC114

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC114 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC114 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCDC114 (NM_144577)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC114
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC114

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCDC114
		Search LifeMap BioReagents cell lines for CCDC114
		Sirion Biotech Customized stable knockdown cell line services for CCDC114 Sirion Biotech Customized inducible knockdown cell line services for CCDC114 Sirion Biotech Customized stable overexpressing cell line services for CCDC114 Sirion Biotech Customized inducible overexpressing cell line services for CCDC114

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC114

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CCDC114

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCDC114
Search CenterWatch for drugs/clinical trials and news about CCDC114 / CC114

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCDC114 gene (3 alternative transcripts):

NM_001135193.1 NM_001135194.1 NM_144577.3

Unigene Cluster for CCDC114:

Coiled-coil domain containing 114

Hs.112645 [show with all ESTs]

Unigene Representative Sequence: BC007730

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000315396(uc002piq.2 uc002pir.2) ENST00000474199(uc002pio.3 uc002pit.1 uc002piu.1)

ENST00000497273(uc002pis.1) ENST00000497803 ENST00000483610

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCDC114
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCDC114
		SwitchGear 3'UTR luciferase reporter plasmid: CCDC114 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC114 (see all 7) OriGene shRNA RFP: CCDC114 OriGene siRNA: CCDC114
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC114
		Sirion Biotech Custom design and validation of potent shRNA sequences against CCDC114

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC114 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC114 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCDC114 (NM_144577)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC114
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC114

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC114 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCDC114
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC114
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC114

Additional cDNA sequence:

AK057488.1 BC007730.2

7 DOTS entries:

DT.95158637 DT.101980943 DT.65284543 DT.95309182 DT.121454765 DT.40121903 DT.121454761

18 AceView cDNA sequences:

CA440066 CD243987 AK057488 AK128144 BC025752 AI669605 NM_144577 AL122083

BC031619 AI801593 BM926487 BC007730 BG772128 AK057357 BI831110 BI766244

BF686049 BF852637

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC114 (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6a	·	6b	·	6c	·	6d	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16	^
SP1:																													-		-														-						-
SP2:																	-												-		-														-						-
SP3:													-				-												-		-
SP4:													-				-
SP5:							-										-

ExUns:	17	^	18	^	19	^	20
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CCDC114

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCDC114 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CCDC114 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Brain

Brain

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CCDC114 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC114

SOURCE GeneReport for Unigene cluster: Hs.112645

SABiosciences Custom PCR Arrays for CCDC114

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC114 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCDC114
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC114
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC114

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC114

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CCDC114 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ccdc114^{1 , 5}	coiled-coil domain containing 114^{1, 5}	73.27(n)¹ 65.13(a)¹		7 (29.60 cM)⁵ 211535¹ NM_001033243.2¹ NP_001028415.1¹ 45924072⁵
lizard (Anolis carolinensis)	Reptilia	CCDC114⁶	--	27(a)	1 ↔ 1	GL343329.1(230459-247675)
zebrafish (Danio rerio)	Actinopterygii	zgc:101737⁶	zgc:101737	25(a)	1 ↔ 1	11(42189798-42204454)
fruit fly (Drosophila melanogaster)	Insecta	CG14905⁶ CG17083⁶	--	21(a) 16(a)	possible ortholog possible ortholog	3R(12448457-12450439) 3R(19111815-19113773)

ENSEMBL Gene Tree for CCDC114 (if available)
TreeFam Gene Tree for CCDC114 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCDC114 gene

CCDC63²

CCDC114 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201130025^1,2	C	--	45203184(+)	`CAGGGG/TTTTTT`	1	--	int¹		0	--	--	--	--
rs190736321^1,2		--	48799386(+)	`AACATC/GGTGAA`	1	--	int¹		0	--	--	--	--
rs181512371^1,2		--	48799432(+)	`GCGTGC/GTAGTG`	1	--	int¹		0	--	--	--	--
rs184591758^1,2		--	48799469(+)	`AGGCTA/GAGGCA`	1	--	int¹		0	--	--	--	--
rs138915856^1,2		--	48799568(+)	`ATCTC-/AATA AATAA`	1	--	int¹		0	--	--	--	--
rs4572515^1,2	C,F	--	48799605(+)	`AAGAAC/TGCTGA`	1	--	int¹		6		NA WA CSA EA	363
rs77690484^1,2	C,F	--	48799621(+)	`TGAGTG/AAATGA`	1	--	int¹		1		NA	120
rs115478159^1,2	F	--	48799640(+)	`ATGAAT/CGAATG`	1	--	int¹		1		WA	118
rs2292112^1,2	C,F,H	--	48799716(+)	`AAGCCG/AGCTCT`	1	--	ut3¹		22		EA NS NA WA CSA	3838
rs188513042^1,2		--	48799726(+)	`TCCACA/CCATAT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCDC114 (48799709 - 48825130 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CCDC114
5 CNVs: 89276 47965 5106 78221 32261

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC114

DNA2.0 Custom Variant and Variant Library Synthesis for CCDC114

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCDC114 for disorders About MalaCards

CCDC114 for disorders About GeneDecksing

OMIM gene information: 615038 OMIM disorders: --

UniProtKB/Swiss-Prot: CC114_HUMAN, Q96M63

Defects in CCDC114 are the cause of primary ciliary dyskinesia 20 (CILD20) [MIM:615067]. A disorder

characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and

bronchiectasis are recurrent, due to defects in the respiratory cilia. Half of the patients exhibit randomization of

left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary

dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Unlike other forms of CILD, patients

with CILD20 do not appear to be infertile

1 disease from the University of Copenhagen DISEASES database for CCDC114:

Primary ciliary dyskinesia

Human Genome Epidemiology (HuGE) Navigator: CCDC114 (3 documents)

Export disorders for CCDC114 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCDC114 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCDC114)

Utopia: connect your pdf to the dynamic
world of online information

Splice-Site mutations in the axonemal outer dynein arm docking complex gene CCDC114 cause primary ciliary dyskinesia. (PubMed id 23261303)^{1, 2, 3} Onoufriadis A.... Mitchison H.M. (2013)
Exome sequencing identifies mutations in CCDC114 as a cause of primary ciliary dyskinesia. (PubMed id 23261302)^{1, 2, 3} Knowles M.R.... Zariwala M.A. (2013)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 93233	HGNC: 26560	AceView: FLJ32926	Ensembl:ENSG00000105479	euGenes: HUgn93233
ECgene: CCDC114	H-InvDB: CCDC114

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCDC114	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CCDC114 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CCDC114 gene:
Search GeneIP for patents involving CCDC114

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for CCDC114
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC114		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC114
	OriGene Protein Over-expression Lysate for CCDC114		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CCDC114		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC114		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC114
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for CCDC114		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CCDC114		OriGene Custom Protein Services for CCDC114
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC114
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC114
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC114
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC114
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC114
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC114

	GenScript Custom Purified and Recombinant Proteins Services for CCDC114		GenScript cDNA clones with any tag delivered in your preferred vector for CCDC114
	GenScript Custom Assay Services for CCDC114		GenScript Custom Superior Antibodies Services for CCDC114
	GenScript Custom overexpressing Cell Line Services for CCDC114		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CCDC114 promoter
	Search Chromatin IP Primers for CCDC114
	RT² qPCR Primer Assay in human, mouse, rat CCDC114
	Search GNC Networks for CCDC114
	SABiosciences Custom PCR Arrays for CCDC114

Search Tocris compounds for CCDC114

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CCDC114 antibodies
	CCDC114 lysates

	Antibodies for CCDC114
	See all of Abcam's Antibodies, Kits and Proteins for CCDC114
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

CCDC114 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CCDC114

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC114

	SwitchGear 3'UTR luciferase reporter plasmids for CCDC114
	SwitchGear Promoter luciferase reporter plasmids for CCDC114

ThermoFisher Antibodies for CCDC114

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC114

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CCDC114

Sirion Biotech Customized:

	stable knockdown cell line services for CCDC114
	inducible knockdown cell line services for CCDC114
	design and validation of potent shRNA sequences against CCDC114
	adenovirus for potent knockdown of CCDC114
	adenovirus for overexpression of CCDC114
	stable overexpressing cell line services for CCDC114
	inducible overexpressing cell line services for CCDC114

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CCDC114 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

CCDC114 Gene

coiled-coil domain containing 114

Aliases
for CCDC114 gene

Summaries
for CCDC114 gene

Genomic Views
for CCDC114 gene

Proteins
for CCDC114 gene

Protein Domains /
Families
for CCDC114 gene

Function
for CCDC114 gene

Pathways & Interactions
for CCDC114 gene

Drugs & Compounds
for CCDC114 gene

Transcripts
for CCDC114 gene

Expression
for CCDC114 gene

Orthologs
for CCDC114 gene

Paralogs
for CCDC114 gene

Genomic Variants
for CCDC114 gene

Disorders / Diseases
for CCDC114 gene

Publications
for CCDC114 gene

External Searches for CCDC114 gene

Genome Databases showing CCDC114 gene

Other Databases showing CCDC114 gene

Specialized Databases showing CCDC114 gene

Intellectual Property
for CCDC114 gene

Products
for CCDC114 gene

View Random Gene

Advanced Search

Export list of displayed genes

CCDC114 Gene

coiled-coil domain containing 114

Aliasesfor CCDC114 gene

Summariesfor CCDC114 gene

Genomic Viewsfor CCDC114 gene

Proteinsfor CCDC114 gene

Protein Domains /Familiesfor CCDC114 gene

Functionfor CCDC114 gene

Pathways & Interactionsfor CCDC114 gene

Drugs & Compoundsfor CCDC114 gene

Transcriptsfor CCDC114 gene

Expression for CCDC114 gene

Orthologsfor CCDC114 gene

Paralogsfor CCDC114 gene

Genomic Variantsfor CCDC114 gene

Disorders / Diseasesfor CCDC114 gene

Publicationsfor CCDC114 gene

External Searches for CCDC114 gene

Genome Databases showing CCDC114 gene

Other Databases showing CCDC114 gene

Specialized Databases showing CCDC114 gene

Intellectual Propertyfor CCDC114 gene

Productsfor CCDC114 gene

View Random Gene

Aliases
for CCDC114 gene

Summaries
for CCDC114 gene

Genomic Views
for CCDC114 gene

Proteins
for CCDC114 gene

Protein Domains /
Families
for CCDC114 gene

Function
for CCDC114 gene

Pathways & Interactions
for CCDC114 gene

Drugs & Compounds
for CCDC114 gene

Transcripts
for CCDC114 gene

Expression
for CCDC114 gene

Orthologs
for CCDC114 gene

Paralogs
for CCDC114 gene

Genomic Variants
for CCDC114 gene

Disorders / Diseases
for CCDC114 gene

Publications
for CCDC114 gene

Intellectual Property
for CCDC114 gene

Products
for CCDC114 gene