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Aliases for CCDC113 Gene

Aliases for CCDC113 Gene

  • Coiled-Coil Domain Containing 113 2 3 5
  • Coiled-Coil Domain-Containing Protein 113 3
  • HSPC065 3

External Ids for CCDC113 Gene

Previous GeneCards Identifiers for CCDC113 Gene

  • GC16P056842
  • GC16P058283
  • GC16P044152

Summaries for CCDC113 Gene

GeneCards Summary for CCDC113 Gene

CCDC113 (Coiled-Coil Domain Containing 113) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC113 Gene

  • Component of centriolar satellites contributing to primary cilium formation.

Gene Wiki entry for CCDC113 Gene

Additional gene information for CCDC113 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC113 Gene

Genomics for CCDC113 Gene

Regulatory Elements for CCDC113 Gene

Enhancers for CCDC113 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H058280 0.6 ENCODE 18.5 +84.1 84051 1 IKZF1 FEZF1 PRDM10 ZNF518A RFX5 SP7 CCDC113 CFAP20 GC16P058281 PIR34447
GH16H058264 1.6 FANTOM5 Ensembl ENCODE 6.7 +68.3 68295 2 PKNOX1 ATF1 TCF12 ZNF766 GATA2 ELK1 ATF7 FOS CAVIN1 SMARCB1 PRSS54 SETD6 CCDC113 GC16P058267 GC16M058249
GH16H057626 1.6 Ensembl ENCODE dbSUPER 4.9 -568.2 -568180 4 HDGF PKNOX1 SIN3A YBX1 ZNF2 ZNF766 ZNF302 ZNF416 ZNF207 ZNF548 RSPRY1 LOC101927556 POLR2C NUP93 LOC105371286 SETD6 LOC100421594 LOC100125393 ENSG00000260148 RN7SL645P
GH16H058249 1 ENCODE 4.6 +53.0 52976 1 PKNOX1 ATF1 ZFP64 ARID4B SIN3A BRCA1 ETS1 GLIS2 ELK1 ZNF143 CNOT1 CCDC113 LOC105371293 GC16M058249
GH16H058317 0.4 ENCODE 11.1 +120.9 120910 0 JUN PRSS54 CCDC113 CNGB1 CFAP20 CSNK2A2 GINS3 GC16P058353
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC113 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC113 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000086548 936 1401 HDGF PKNOX1 GLIS2 ZNF143 KLF7 ZNF548 SP3 SP5 YY2 ZNF592

Genomic Location for CCDC113 Gene

Chromosome:
16
Start:
58,196,964 bp from pter
End:
58,283,836 bp from pter
Size:
86,873 bases
Orientation:
Plus strand

Genomic View for CCDC113 Gene

Genes around CCDC113 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC113 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC113 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC113 Gene

Proteins for CCDC113 Gene

  • Protein details for CCDC113 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0I3-CC113_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 113
    Protein Accession:
    Q9H0I3
    Secondary Accessions:
    • B2RAQ7
    • B4DR20
    • Q9NZX2

    Protein attributes for CCDC113 Gene

    Size:
    377 amino acids
    Molecular mass:
    44220 Da
    Quaternary structure:
    • Interacts with HAP1 and PCM1.
    SequenceCaution:
    • Sequence=AAF29037.1; Type=Frameshift; Positions=187; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC113 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC113 Gene

Post-translational modifications for CCDC113 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC113 Gene

Domains & Families for CCDC113 Gene

Gene Families for CCDC113 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC113 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC113 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC113: view

No data available for UniProtKB/Swiss-Prot for CCDC113 Gene

Function for CCDC113 Gene

Molecular function for CCDC113 Gene

UniProtKB/Swiss-Prot Function:
Component of centriolar satellites contributing to primary cilium formation.

Phenotypes From GWAS Catalog for CCDC113 Gene

Gene Ontology (GO) - Molecular Function for CCDC113 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25074808
genes like me logo Genes that share ontologies with CCDC113: view
genes like me logo Genes that share phenotypes with CCDC113: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCDC113
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC113 Gene

Localization for CCDC113 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC113 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Colocalized with HAP1 at centriolar satellites. Centriolar satellite localization requires PCM1. {ECO:0000269 PubMed:25074808}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC113 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 3
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC113 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0034451 centriolar satellite IMP 25074808
GO:0043234 protein complex IDA 25074808
genes like me logo Genes that share ontologies with CCDC113: view

Pathways & Interactions for CCDC113 Gene

SuperPathways for CCDC113 Gene

No Data Available

Interacting Proteins for CCDC113 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000219299%0d%0a9606.ENSP00000228918%0d%0a
Selected Interacting proteins: Q9H0I3-CC113_HUMAN ENSP00000219299 for CCDC113 Gene via IID STRING MINT

Gene Ontology (GO) - Biological Process for CCDC113 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
GO:0060271 cilium assembly IMP 25074808
genes like me logo Genes that share ontologies with CCDC113: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC113 Gene

Drugs & Compounds for CCDC113 Gene

No Compound Related Data Available

Transcripts for CCDC113 Gene

Unigene Clusters for CCDC113 Gene

Coiled-coil domain containing 113:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCDC113
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC113 Gene

No ASD Table

Relevant External Links for CCDC113 Gene

GeneLoc Exon Structure for
CCDC113
ECgene alternative splicing isoforms for
CCDC113

Expression for CCDC113 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC113 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC113 Gene

This gene is overexpressed in Testis (x8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC113 Gene



NURSA nuclear receptor signaling pathways regulating expression of CCDC113 Gene:

CCDC113

SOURCE GeneReport for Unigene cluster for CCDC113 Gene:

Hs.11614

Evidence on tissue expression from TISSUES for CCDC113 Gene

  • Nervous system(4.4)
  • Blood(4)
genes like me logo Genes that share expression patterns with CCDC113: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC113 Gene

Orthologs for CCDC113 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC113 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC113 33 34
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia CCDC113 33 34
  • 87.57 (n)
cow
(Bos Taurus)
Mammalia CCDC113 33 34
  • 83.02 (n)
mouse
(Mus musculus)
Mammalia Ccdc113 33 16 34
  • 81.79 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc113 33
  • 77.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC113 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC113 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC113 33 34
  • 57.85 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC113 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc113 33
  • 59.09 (n)
Str.12836 33
zebrafish
(Danio rerio)
Actinopterygii ccdc113 33 34
  • 51.11 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
OneToOne
Species where no ortholog for CCDC113 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC113 Gene

ENSEMBL:
Gene Tree for CCDC113 (if available)
TreeFam:
Gene Tree for CCDC113 (if available)

Paralogs for CCDC113 Gene

No data available for Paralogs for CCDC113 Gene

Variants for CCDC113 Gene

Sequence variations from dbSNP and Humsavar for CCDC113 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000003641 -- 58,280,355(+) TAAGG(A/G)TTGTA reference, missense, utr-variant-3-prime
rs1000022059 -- 58,196,472(+) TTAAA(A/G)ATAGC intron-variant, upstream-variant-2KB
rs1000057731 -- 58,229,251(+) TTATT(A/C)ATATG intron-variant
rs1000075756 -- 58,280,128(+) CCAGT(G/T)TGCAA utr-variant-3-prime
rs1000108314 -- 58,229,570(+) ACCTG(A/G)TCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC113 Gene

Variant ID Type Subtype PubMed ID
esv2672427 CNV deletion 23128226
esv2714548 CNV deletion 23290073
esv3553490 CNV deletion 23714750
esv6424 CNV loss 19470904
nsv474315 CNV novel sequence insertion 20440878

Variation tolerance for CCDC113 Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC113 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC113

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC113 Gene

Disorders for CCDC113 Gene

Relevant External Links for CCDC113

Genetic Association Database (GAD)
CCDC113
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC113

No disorders were found for CCDC113 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC113 Gene

Publications for CCDC113 Gene

  1. Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. (PMID: 25074808) Firat-Karalar EN … Stearns T (Journal of cell science 2014) 2 3 4 60
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 60
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for CCDC113 Gene

Sources for CCDC113 Gene

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