CCDC111 Gene
protein-coding GIFtS: 44
GCID: GC04P185570
|
|
coiled-coil domain containing 111
| |
Aliases
for CCDC111 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 1111 2 | | FLJ331671 | | Coiled-Coil Domain-Containing Protein 1112 |
Export aliases for CCDC111 gene to outside databasesPrevious GC identifers: GC04P185807 GC04P181325 |
Summaries
for CCDC111 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CCDC111 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC111 gene promoter:
Bach1 TBP FOXD3 IRF-1 CUTL1 POU3F2 AREB6 Nkx6-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC111
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC111 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q35.1 Ensembl cytogenetic band: 4q35.1 HGNC cytogenetic band: 4q35.1CCDC111 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P185570: view genomic region
(about GC identifiers)
Start:
|
185,570,767 bp from pter |
End:
|
185,616,117 bp from pter |
Size:
|
45,351 bases |
Orientation:
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plus strand |
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Proteins
for CCDC111 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CC111_HUMAN, Q96LW4 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 111 Size: 560 amino acids; 64383 Da
Secondary accessions: D3DP55 Q5HYJ9Explore the universe of human proteins at neXtProt for CCDC111: NX_Q96LW4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96LW4
CCDC111 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689896.1
ENSEMBL proteins: ENSP00000313816 ENSP00000421913 ENSP00000420860 ENSP00000425316 ENSP00000423353 ENSP00000423409 ENSP00000422199 ENSP00000424639
Human Recombinant Protein Products:
CCDC111 Antibody Products:
Assay Products for CCDC111: |
Protein
Domains /
Families
for CCDC111 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCDC111 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96LW4ProtoNet protein and cluster: Q96LW4 |
Function
for CCDC111 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC111 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC111
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CCDC111 (NM_152683) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC111 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC111 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC111 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003896 | DNA primase activity |
IEA | -- |
CCDC111 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for CCDC111:
|
Pathways & Interactions
for CCDC111 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC111
1 Interacting protein for CCDC111 (Q96LW43) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006260 | DNA replication |
-- | -- | | GO:0006269 | DNA replication, synthesis of RNA primer |
-- | -- |
CCDC111 for ontologies About GeneDecksing
|
Drugs & Compounds
for CCDC111 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC111
Search CenterWatch for drugs/clinical trials and news about CCDC111 / CC111
|
Transcripts
for CCDC111 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC111 gene: NM_152683.2 Unigene Cluster for CCDC111: Coiled-coil domain containing 111 Hs.481307 [show with all ESTs]Unigene Representative Sequence: NM_15268311 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000314970(uc010isd.1 uc003iwk.2 uc003iwj.2 uc003iwm.2 uc003iwn.2)
ENST00000515774 ENST00000503752 ENST00000512834 ENST00000509002 ENST00000509538
ENST00000506278 ENST00000515152 ENST00000508001 ENST00000512658 ENST00000510864
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC111 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC111
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCDC111 (NM_152683) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC111 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC111 |
Additional cDNA sequence: AK057729.1 AK307317.1 BC018930.2 BC047467.1 BC064600.1 BX647575.1 6 DOTS entries: DT.92435121 DT.97838908 DT.445649 DT.97844299 DT.99948701 DT.456398 24/78 AceView cDNA sequences (see all 78): AI983478 BG504811 CA312288 NM_152683 AI275986 BQ230773 AK057729 CR606183 AA931259 AA954268 AW675276 AA873626 AA687823 AW593220 BC064600 BX647575 BX956619 BC018930 AA532531 AI687165 BQ438097 BI755144 BG182311 AU252988
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC111 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CCDC111
|
Expression
for CCDC111 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC111 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCCTGTATG
About this image
See CCDC111 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC111
SOURCE GeneReport for Unigene cluster: Hs.481307
SABiosciences Custom PCR Arrays for CCDC111
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC111
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC111 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC111 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC111 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC111 |
Orthologs
for CCDC111 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CCDC111 gene from 8/20 species (see all 20) About this table
ENSEMBL Gene Tree for CCDC111 (if available)
TreeFam Gene Tree for CCDC111 (if available) |
Paralogs
for CCDC111 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CCDC111 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CCDC111
3 Indels: 12600 12601 41939 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC111 |
|
Disorders
/ Diseases
for CCDC111 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 CCDC111 for disorders About MalaCards
CCDC111 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: CCDC111 (1 document)
Export disorders for CCDC111 gene to outside databases
|
Publications
for CCDC111 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC111 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCDC111) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1 Hosgood H.D....Lan Q. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Origin and evolution of the archaeo-eukaryotic primase superfamily and related palm-domain proteins: structural insights and new membe rs. (PubMed id 16027112)1 Iyer L.M....Aravind L. (2005)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
|
External Searches for CCDC111 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC111 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC111 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC111 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC111 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC111 gene:
Search GeneIP for patents involving CCDC111
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC111 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC111 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC111 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC111 | | | OriGene Protein Over-expression Lysate for CCDC111 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC111 | | OriGene 3'-UTR Clone for CCDC111 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC111 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC111 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CCDC111 | | OriGene Custom Protein Services for CCDC111 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC111 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC111 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC111 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC111 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC111 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC111 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CCDC111 |
| |  |  |  |  | | | | |
 |
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 | | | CCDC111 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC111 |
|  |  |  | | | | Search ThermoFisher Antibodies for CCDC111 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC111 |
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