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Aliases for CCDC110 Gene

Aliases for CCDC110 Gene

  • Coiled-Coil Domain Containing 110 2 3
  • Cancer/Testis Antigen 52 2 3 4
  • KMHN1 3 4 6
  • Cancer/Testis Antigen KM-HN-1 3 4
  • CT52 3 4
  • Coiled-Coil Domain-Containing Protein 110 3
  • KM-HN-1 3

External Ids for CCDC110 Gene

Previous GeneCards Identifiers for CCDC110 Gene

  • GC04M186604
  • GC04M186366
  • GC04M182120

Summaries for CCDC110 Gene

GeneCards Summary for CCDC110 Gene

CCDC110 (Coiled-Coil Domain Containing 110) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC110 Gene

Genomics for CCDC110 Gene

Regulatory Elements for CCDC110 Gene

Genomic Location for CCDC110 Gene

Start:
185,445,182 bp from pter
End:
185,471,759 bp from pter
Size:
26,578 bases
Orientation:
Minus strand

Genomic View for CCDC110 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC110 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC110 Gene

Proteins for CCDC110 Gene

  • Protein details for CCDC110 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBZ0-CC110_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 110
    Protein Accession:
    Q8TBZ0
    Secondary Accessions:
    • Q86YI9
    • Q8N7W0

    Protein attributes for CCDC110 Gene

    Size:
    833 amino acids
    Molecular mass:
    96726 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC110 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC110 Gene

Proteomics data for CCDC110 Gene at MOPED

Post-translational modifications for CCDC110 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC110 Gene

Domains for CCDC110 Gene

Protein Domains for CCDC110 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC110 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC110: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC110 Gene

Function for CCDC110 Gene

Gene Ontology (GO) - Molecular Function for CCDC110 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC110: view

Phenotypes for CCDC110 Gene

GenomeRNAi human phenotypes for CCDC110:
genes like me logo Genes that share phenotypes with CCDC110: view

miRNA for CCDC110 Gene

miRTarBase miRNAs that target CCDC110

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCDC110 Gene

Localization for CCDC110 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC110 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC110 Gene COMPARTMENTS Subcellular localization image for CCDC110 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
plasma membrane 4
cytosol 3

Gene Ontology (GO) - Cellular Components for CCDC110 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with CCDC110: view

Pathways for CCDC110 Gene

SuperPathways for CCDC110 Gene

No Data Available

Interacting Proteins for CCDC110 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000306776%0d%0a9606.ENSP00000286234%0d%0a
Selected Interacting proteins: ENSP00000306776 Q8TBZ0-CC110_HUMAN for CCDC110 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for CCDC110 Gene

None

No data available for Pathways by source for CCDC110 Gene

Transcripts for CCDC110 Gene

Unigene Clusters for CCDC110 Gene

Coiled-coil domain containing 110:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC110 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3:
SP4: - -
SP5:
SP6: -
SP7: -

Relevant External Links for CCDC110 Gene

GeneLoc Exon Structure for
CCDC110
ECgene alternative splicing isoforms for
CCDC110

Expression for CCDC110 Gene

mRNA expression in normal human tissues for CCDC110 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC110 Gene

This gene is overexpressed in Testis (26.5) and Pancreas (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CCDC110 Gene

SOURCE GeneReport for Unigene cluster for CCDC110 Gene Hs.41101

mRNA Expression by UniProt/SwissProt for CCDC110 Gene

Q8TBZ0-CC110_HUMAN
Tissue specificity: Expressed specifically in testis. Also expressed in tumors of different origins.
genes like me logo Genes that share expressions with CCDC110: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CCDC110 Gene

Orthologs for CCDC110 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC110 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC110 35
  • 99.07 (n)
  • 98.05 (a)
CCDC110 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC110 35
  • 87.05 (n)
  • 80.76 (a)
CCDC110 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC110 35
  • 88.63 (n)
  • 81.77 (a)
CCDC110 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc110 35
  • 75.04 (n)
  • 70.17 (a)
Ccdc110 16
Ccdc110 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC110 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC110 36
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc110 35
  • 74.79 (n)
  • 68.18 (a)
chicken
(Gallus gallus)
Aves CCDC110 35
  • 56.15 (n)
  • 36.93 (a)
lizard
(Anolis carolinensis)
Reptilia CCDC110 36
  • 26 (a)
OneToOne
Species with no ortholog for CCDC110:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC110 Gene

ENSEMBL:
Gene Tree for CCDC110 (if available)
TreeFam:
Gene Tree for CCDC110 (if available)

Paralogs for CCDC110 Gene

Selected SIMAP similar genes for CCDC110 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CCDC110: view

No data available for Paralogs for CCDC110 Gene

Variants for CCDC110 Gene

Sequence variations from dbSNP and Humsavar for CCDC110 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4279261 -- 185,457,636(+) TATAC(C/T)TAATT intron-variant, downstream-variant-500B
rs4286574 -- 185,462,033(+) gcaga(A/G)gtcgc intron-variant
rs4309881 -- 185,462,011(+) gagaa(A/T)tgctt intron-variant
rs4314326 -- 185,462,261(+) gatca(C/T)gtgga intron-variant
rs4488974 -- 185,468,214(+) CCTGC(C/T)GCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC110 Gene

Variant ID Type Subtype PubMed ID
nsv428456 CNV Gain+Loss 18775914
nsv881506 CNV Gain 21882294
dgv1724e1 CNV Complex 17122850
nsv527026 CNV Gain 19592680
nsv4638 CNV Insertion 18451855
nsv517035 CNV Gain+Loss 19592680
esv2575908 CNV Insertion 19546169
esv272660 CNV Insertion 20981092
esv267647 CNV Insertion 20981092

Relevant External Links for CCDC110 Gene

HapMap Linkage Disequilibrium report
CCDC110

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC110 Gene

Disorders for CCDC110 Gene

No disorders were found for CCDC110 Gene.

No data available for UniProtKB/Swiss-Prot for CCDC110 Gene

Publications for CCDC110 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Identification of a novel human cancer/testis antigen, KM-HN-1, recognized by cellular and humoral immune responses. (PMID: 15447989) Monji M. … Nishimura Y. (Clin. Cancer Res. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The centrosomal localization of KM-HN-1 (MGC33607) depends on the leucine zipper motif and the C-terminal coiled-coil domain. (PMID: 18160854) Park H.J. … Seong Y.S. (Exp. Mol. Med. 2007) 2 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for CCDC110 Gene

Sources for CCDC110 Gene

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