CCDC110 Gene
protein-coding GIFtS: 43
GCID: GC04M186366
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|
coiled-coil domain containing 110
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Aliases
for CCDC110 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 1101 2 | | Cancer/Testis Antigen 522 3 | | CT521 2 3 | | Cancer/Testis Antigen KM-HN-12 3 | | KMHN12 3 5 | | MGC336071 | | KM-HN-11 2 | | Coiled-Coil Domain-Containing Protein 1102 |
Export aliases for CCDC110 gene to outside databasesPrevious GC identifers: GC04M186604 GC04M182120 |
Summaries
for CCDC110 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CCDC110 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC110 gene promoter:
MEF-2A FAC1 AML1a Sox9 aMEF-2 GATA-1 Gfi-1 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC110
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC110 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q35.1 Ensembl cytogenetic band: 4q35.1 HGNC cytogenetic band: 4q35.1CCDC110 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M186366: view genomic region
(about GC identifiers)
Start:
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186,366,336 bp from pter |
End:
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186,392,913 bp from pter |
Size:
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26,578 bases |
Orientation:
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minus strand |
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Proteins
for CCDC110 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CC110_HUMAN, Q8TBZ0 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 110 Size: 833 amino acids; 96726 Da
Subcellular location: Nucleus
Secondary accessions: Q86YI9 Q8N7W0Alternative splicing: 2 isoforms: Q8TBZ0-1 Q8TBZ0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CCDC110: NX_Q8TBZ0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TBZ0
CCDC110 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001138883.1 NP_689988.1
ENSEMBL proteins: ENSP00000377172 ENSP00000306776 ENSP00000424878 ENSP00000427246 ENSP00000424520 ENSP00000425276 ENSP00000425547
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
CCDC110 for ontologies About GeneDecksing
CCDC110 Antibody Products:
Assay Products for CCDC110: |
Protein
Domains /
Families
for CCDC110 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8TBZ0 |
Function
for CCDC110 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC110 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC110 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CCDC110 (NM_152775) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC110 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC110 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC110 |
1 GenomeRNAi human phenotype for CCDC110:
|
Pathways & Interactions
for CCDC110 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC110
|
Drugs & Compounds
for CCDC110 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC110
Search CenterWatch for drugs/clinical trials and news about CCDC110 / CC110
|
Transcripts
for CCDC110 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC110 gene (2 alternative transcripts): NM_001145411.1 NM_152775.3 Unigene Cluster for CCDC110: Coiled-coil domain containing 110 Hs.41101 [show with all ESTs]Unigene Representative Sequence: AL8333379 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000393540 ENST00000307588(uc003ixu.4 uc003ixv.4) ENST00000508538
ENST00000510617(uc011ckt.1) ENST00000510481 ENST00000506876 ENST00000507501
ENST00000506962 ENST00000504020
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC110 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC110 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CCDC110 (NM_152775) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC110 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC110 |
Additional cDNA sequence: AB080722.1 AK097605.1 AK302815.1 AL833337.1 BC028419.1 BC038515.1 BX641119.1 6 DOTS entries: DT.208954 DT.95156887 DT.100751661 DT.97800405 DT.99984503 DT.208953 24/63 AceView cDNA sequences (see all 63): AK097605 AI201289 BU561479 BU853586 CD557413 AI139838 BU854677 BU567268 BQ286758 AW303582 BI464244 BQ438408 BU854088 BU561083 BX641119 AA416708 BG200170 AI126130 AW959242 AA416613 BI459630 AA295198 AI949455 BU160051
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC110 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b |
|---|
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| SP1: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CCDC110
|
Expression
for CCDC110 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC110 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGGAGCTG
About this image
See CCDC110 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC110
SOURCE GeneReport for Unigene cluster: Hs.41101
UniProtKB/Swiss-Prot: CC110_HUMAN, Q8TBZ0Tissue specificity: Expressed specifically in testis. Also expressed in tumors of different origins
SABiosciences Custom PCR Arrays for CCDC110
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC110
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC110 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC110 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC110 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC110 |
Orthologs
for CCDC110 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CCDC110 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for CCDC110 (if available)
TreeFam Gene Tree for CCDC110 (if available) |
Paralogs
for CCDC110 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CCDC110 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CCDC110
2 CNVs: 3530 98993 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC110 |
|
Disorders
/ Diseases
for CCDC110 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCDC110 for disorders About GeneDecksing
OMIM gene information: 609488
OMIM disorders: --
1  disease for CCDC110: About MalaCardsdiverticulitis
Export disorders for CCDC110 gene to outside databases
|
Publications
for CCDC110 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC110 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCDC110) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The centrosomal localization of KM-HN-1 (MGC33607) de pends on the leucine zipper motif and the C-terminal coiled-coil domain. (PubMed id 18160854)1, 3 Park H.J....Seong Y.S. (2007)
- Identification of a novel human cancer/testis antigen, KM-HN-1, recognized by cellular and humoral immune responses. (PubMed id 15447989)1, 2 Monji M.... Nishimura Y. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CCDC110 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC110 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC110 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC110 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC110 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC110 gene:
Search GeneIP for patents involving CCDC110
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC110 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC110 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC110 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC110 | | | OriGene Protein Over-expression Lysate for CCDC110 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC110 | | OriGene 3'-UTR Clone for CCDC110 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC110 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC110 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for CCDC110 |
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 | | | CCDC110 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC110 |
|  |  |  | | | | Search ThermoFisher Antibodies for CCDC110 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC110 |
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