Aliases for CCDC109B Gene
External Ids for CCDC109B Gene
Previous GeneCards Identifiers for CCDC109B Gene
GeneCards Summary for CCDC109B Gene
CCDC109B (Coiled-Coil Domain Containing 109B) is a Protein Coding gene. GO annotations related to this gene include ion channel activity and calcium channel inhibitor activity. An important paralog of this gene is MCU.
UniProtKB/Swiss-Prot for CCDC109B Gene
Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.