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CCDC109B Gene

protein-coding   GIFtS: 51
GCID: GC04P110481

Coiled-Coil Domain Containing 109B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coiled-Coil Domain Containing 109B1 2     MCUb2 3
Coiled-Coil Domain-Containing Protein 109B2 3     Mitochondrial Calcium Uniporter Regulatory Subunit MCUb2
Essential MCU Regulator2 3     MCUB3
EMRE2 3     

External Ids:    HGNC: 260761   Entrez Gene: 550132   Ensembl: ENSG000000050597   UniProtKB: Q9NWR83   

Export aliases for CCDC109B gene to outside databases

Previous GC identifers: GC04P110700 GC04P106215


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCDC109B Gene:
CCDC109B (coiled-coil domain containing 109B) is a protein-coding gene. GO annotations related to this gene include ion channel activity and calcium channel inhibitor activity. An important paralog of this gene is MCU.

UniProtKB/Swiss-Prot: MCUB_HUMAN, Q9NWR8
Function: Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and
thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself.
Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics,
cytoplasmic calcium signals and activation of cell death pathways (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCDC109B gene promoter:
         Nkx2-2   p300   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   HNF-1A   GATA-1   HNF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC109B promoter sequence
   Search Chromatin IP Primers for CCDC109B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC109B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

CCDC109B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC109B gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P110481:  view genomic region     (about GC identifiers)

Start:
110,481,355 bp from pter      End:
110,609,874 bp from pter
Size:
128,520 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MCUB_HUMAN, Q9NWR8 (See protein sequence)
Recommended Name: Mitochondrial calcium uniporter regulatory subunit MCUb  
Size: 336 amino acids; 39082 Da
Subunit: Heterotetramer with MCU; this reduces MCU channel activity. Homooligomer (By similarity). Component of
the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1
Sequence caution: Sequence=AAH02633.1; Type=Erroneous initiation; Sequence=BAA91309.1; Type=Erroneous initiation;
Secondary accessions: A8K4Y3 Q6IAC1

Explore the universe of human proteins at neXtProt for CCDC109B: NX_Q9NWR8

Explore proteomics data for CCDC109B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCDC109B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060388.2  
    ENSEMBL proteins: 
     ENSP00000378145   ENSP00000414591  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR006769 Coiled-coil-dom_prot_109_C

    Graphical View of Domain Structure for InterPro Entry Q9NWR8

    ProtoNet protein and cluster: Q9NWR8

    UniProtKB/Swiss-Prot: MCUB_HUMAN, Q9NWR8
    Similarity: Belongs to the MCU family


    Find genes that share domains with CCDC109B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCUB_HUMAN, Q9NWR8
    Function: Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and
    thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself.
    Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics,
    cytoplasmic calcium signals and activation of cell death pathways (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216NOT ion channel activity ISS--
    GO:0019855calcium channel inhibitor activity ISS--
         
    Find genes that share ontologies with CCDC109B           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CCDC109B:
     Increased G1 DNA content  Increased cell size 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCDC109B
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    hsa-mir-324-3p (MIRT042978), hsa-mir-26b-5p (MIRT029347)

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    1 qRT-PCR Assays for microRNA that regulate CCDC109B:
    hsa-miR-3613-3p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MCUB_HUMAN, Q9NWR8: Mitochondrion inner membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    cytosol1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS--
    GO:0005743mitochondrial inner membrane ----
    GO:0031224intrinsic component of membrane ISS--
    GO:0031305integral component of mitochondrial inner membrane IDA--
    GO:0034704calcium channel complex ISS--

    Find genes that share ontologies with CCDC109B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC109B
    Interactions:

        Search GeneGlobe Interaction Network for CCDC109B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for CCDC109B (Q9NWR82, 3 ENSP000003781454) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZBTB16Q055162, 3, ENSP000003381574MINT-64609 I2D: score=5 STRING: ENSP00000338157
    SECISBP2Q96T213I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006851mitochondrial calcium ion transport ISS--
    GO:0051560mitochondrial calcium ion homeostasis ISS--

    Find genes that share ontologies with CCDC109B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCDC109B (MCUB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCDC109B gene: 
    NM_017918.4  

    Unigene Cluster for CCDC109B:

    Coiled-coil domain containing 109B
    Hs.234149  [show with all ESTs]
    Unigene Representative Sequence: AK095936
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394650(uc011cfs.2) ENST00000472310(uc010imf.2) ENST00000515114
    ENST00000452915 ENST00000494604
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CCDC109B:
    hsa-miR-3613-3p
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    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CCDC109B
      QuantiFast Probe-based Assays in human, mouse, rat CCDC109B

    Additional mRNA sequence: 

    AK000654.1 AK095936.1 AK291098.1 AK311030.1 AL832311.1 BC002633.2 CR457234.1 

    8 DOTS entries:

    DT.113656  DT.100783987  DT.453087  DT.100664942  DT.100784784  DT.121269728  DT.92422713  DT.97844039 

    Selected AceView cDNA sequences (see all 153):

    CA424607 BM830891 BU681769 AI308770 BM842055 AI094458 BM671226 AA282437 
    BQ549355 BC002633 AI097009 AA234937 AI523829 CD742907 AU186053 NM_017918 
    AW768513 AI571324 AI524155 BE910430 BU632672 BU619554 AA280609 AI479430 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCDC109B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCATTTTG
    CCDC109B Expression
    About this image


    CCDC109B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Hair (Integumentary System)
             Fetal Matrix Cells Hair Follicle
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
    CCDC109B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCDC109B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.234149
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CCDC109B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc109b1 , 5 coiled-coil domain containing 109B1, 5 77.48(n)1
    73.51(a)1
      3 (59.56 cM)5
    668151  NM_025779.31  NP_080055.21 
     1299149605 
    chicken
    (Gallus gallus)
    Aves CCDC109B1 coiled-coil domain containing 109B 68.97(n)
    62.07(a)
      422698  XM_420651.4  XP_420651.4 
    lizard
    (Anolis carolinensis)
    Reptilia CCDC109B6
    coiled-coil domain containing 109B
    52(a)
    1 ↔ 1
    5(144468183-144548333)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.214022 Xenopus laevis transcribed sequence with weak similarity more 72.73(n)    CF548459.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG187696
    --
    23(a)
    1 → many
    3L(6543838-6587040)
    worm
    (Caenorhabditis elegans)
    Secernentea mcu-16
    Protein MCU-1 (mcu-1) mRNA, complete cds
    29(a)
    1 → many
    IV(5937445-5939230) WBGene00019296


    ENSEMBL Gene Tree for CCDC109B (if available)
    TreeFam Gene Tree for CCDC109B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCDC109B gene
    MCU2  
    1 SIMAP similar gene for CCDC109B using alignment to 2 protein entries:     MCUB_HUMAN (see all proteins):
    MCU

    Find genes that share paralogs with CCDC109B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCDC109B (see all 2842)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs346461421,2
    C,F--106319096(+) CTTGT-/A/AA  
            
    AAAAA
    1 -- int13NA CSA 6
    rs1413740171,2
    --110479373(+) CTCTGC/TATCTA 1 -- us2k10--------
    rs1873366631,2
    --110479402(+) CATCAA/GTCAGC 1 -- us2k10--------
    rs131472101,2
    C,F--110479474(+) gggccA/Ggatgg 1 -- us2k13Minor allele frequency- G:0.11NA 124
    rs1451038021,2
    --110479476(+) GCCAGA/GTGGGG 1 -- us2k10--------
    rs1124724601,2
    C,F--110479484(+) GGGGAA/CTAAAA 1 -- us2k13Minor allele frequency- C:0.07WA NA EA 358
    rs1144438621,2
    F--110479490(+) TAAAAG/ACAGGC 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1468334341,2
    --110479535(+) CGTGCC/TACGCT 1 -- us2k10--------
    rs567616401,2
    C,F--110479537(+) TGCCAT/CGCTCT 1 -- us2k11Minor allele frequency- C:0.48WA 118
    rs131474391,2
    C,F--110479548(+) agaagC/Gtttgt 1 -- us2k14Minor allele frequency- G:0.09NA 126

    HapMap Linkage Disequilibrium report for CCDC109B (110481355 - 110609874 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CCDC109B (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658349CNV Deletion23128226
    esv2518482CNV Deletion19546169
    esv3474CNV Deletion18987735
    esv2728129CNV Deletion23290073
    esv2350206CNV Deletion18987734
    esv272340CNV Insertion20981092
    esv7767CNV Loss19470904
    nsv292142CNV Loss16902084
    nsv508303CNV Loss20534489
    nsv461613CNV Gain19166990

    Human Gene Mutation Database (HGMD): CCDC109B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCDC109B
    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC109B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with CCDC109B           About GenesLikeMe

    Genetic Association Database (GAD): CCDC109B
    Human Genome Epidemiology (HuGE) Navigator: CCDC109B (2 documents)

    Export disorders for CCDC109B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCDC109B gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with CCDC109B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. EMRE is an essential component of the mitochondrial calcium uniporter complex. (PubMed id 24231807)1, 2 Sancak Y.... Mootha V.K. (Science 2013)
    2. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    3. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Seven new loci associated with age-related macular degeneration. (PubMed id 23455636)1 Fritsche L.G....Abecasis G.R. (Nat. Genet. 2013)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55013 HGNC: 26076 AceView: FLJ20647 Ensembl:ENSG00000005059 euGenes: HUgn55013
    ECgene: CCDC109B H-InvDB: CCDC109B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCDC109B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CCDC109B gene:
    Search GeneIP for patents involving CCDC109B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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