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Aliases for CCDC108 Gene

Aliases for CCDC108 Gene

  • Coiled-Coil Domain Containing 108 2 3

External Ids for CCDC108 Gene

Previous GeneCards Identifiers for CCDC108 Gene

  • GC02M219575
  • GC02M219869
  • GC02M211721

Summaries for CCDC108 Gene

GeneCards Summary for CCDC108 Gene

CCDC108 (Coiled-Coil Domain Containing 108) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC108 Gene

Genomics for CCDC108 Gene

Regulatory Elements for CCDC108 Gene

Genomic Location for CCDC108 Gene

Start:
219,002,846 bp from pter
End:
219,041,551 bp from pter
Size:
38,706 bases
Orientation:
Minus strand

Genomic View for CCDC108 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC108 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC108 Gene

Proteins for CCDC108 Gene

  • Protein details for CCDC108 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZU64-CC108_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 108
    Protein Accession:
    Q6ZU64
    Secondary Accessions:
    • A2BDD8
    • E9PCR1
    • E9PG25
    • E9PG72
    • Q6ZSR8
    • Q8N0T4
    • Q8NDJ3

    Protein attributes for CCDC108 Gene

    Size:
    1925 amino acids
    Molecular mass:
    217250 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86362.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86878.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC108 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC108 Gene

Proteomics data for CCDC108 Gene at MOPED

Post-translational modifications for CCDC108 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC108 Gene

Domains for CCDC108 Gene

Protein Domains for CCDC108 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC108 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZU64

UniProtKB/Swiss-Prot:

CC108_HUMAN :
  • Q6ZU64
Domain:
  • Contains 1 MSP domain.
genes like me logo Genes that share domains with CCDC108: view

No data available for Gene Families for CCDC108 Gene

Function for CCDC108 Gene

Gene Ontology (GO) - Molecular Function for CCDC108 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CCDC108: view

Phenotypes for CCDC108 Gene

GenomeRNAi human phenotypes for CCDC108:
genes like me logo Genes that share phenotypes with CCDC108: view

miRNA for CCDC108 Gene

miRTarBase miRNAs that target CCDC108

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCDC108 Gene

Localization for CCDC108 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC108 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC108 Gene COMPARTMENTS Subcellular localization image for CCDC108 gene
Compartment Confidence
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCDC108 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CCDC108: view

Pathways for CCDC108 Gene

SuperPathways for CCDC108 Gene

No Data Available

Interacting Proteins for CCDC108 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000340776%0d%0a9606.ENSP00000300213%0d%0a
Selected Interacting proteins: ENSP00000340776 Q6ZU64-CC108_HUMAN for CCDC108 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for CCDC108 Gene

None

No data available for Pathways by source for CCDC108 Gene

Transcripts for CCDC108 Gene

Unigene Clusters for CCDC108 Gene

Coiled-coil domain containing 108:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC108 Gene

No ASD Table

Relevant External Links for CCDC108 Gene

GeneLoc Exon Structure for
CCDC108
ECgene alternative splicing isoforms for
CCDC108

Expression for CCDC108 Gene

mRNA expression in normal human tissues for CCDC108 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC108 Gene

This gene is overexpressed in Testis (14.6), Fallopian Tube (6.2), Pituitary (4.8), and Cervix - Endocervix (4.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CCDC108 Gene

SOURCE GeneReport for Unigene cluster for CCDC108 Gene Hs.147762

genes like me logo Genes that share expressions with CCDC108: view

No data available for mRNA Expression by UniProt/SwissProt for CCDC108 Gene

Orthologs for CCDC108 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC108 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC108 35
  • 98.96 (n)
  • 98.49 (a)
CCDC108 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC108 35
  • 83.31 (n)
  • 77.35 (a)
CCDC108 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC108 35
  • 83.99 (n)
  • 79.16 (a)
CCDC108 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc108 35
  • 78.21 (n)
  • 73.04 (a)
Ccdc108 16
Ccdc108 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC108 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC108 36
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC301521 35
  • 79.06 (n)
  • 73.88 (a)
chicken
(Gallus gallus)
Aves CCDC108 35
  • 59.01 (n)
  • 49.33 (a)
CCDC108 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC108 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc108 35
  • 54.33 (n)
  • 45.86 (a)
zebrafish
(Danio rerio)
Actinopterygii CCDC108 36
  • 36 (a)
OneToOne
si:ch1073-349o24.2 35
  • 50.68 (n)
  • 39.28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5597 36
  • 36 (a)
OneToOne
Species with no ortholog for CCDC108:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC108 Gene

ENSEMBL:
Gene Tree for CCDC108 (if available)
TreeFam:
Gene Tree for CCDC108 (if available)

Paralogs for CCDC108 Gene

Selected SIMAP similar genes for CCDC108 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CCDC108: view

No data available for Paralogs for CCDC108 Gene

Variants for CCDC108 Gene

Sequence variations from dbSNP and Humsavar for CCDC108 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs359961 -- 219,042,844(-) AGAGG(C/T)TACAG upstream-variant-2KB
rs359962 -- 219,042,709(-) GCTGT(G/T)CTTCC upstream-variant-2KB
rs359976 -- 219,020,434(+) agcag(C/T)gacac intron-variant
rs359977 -- 219,022,959(+) ACACT(C/G)gttcc intron-variant
rs359978 -- 219,023,571(+) GTACC(A/G)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC108 Gene

Variant ID Type Subtype PubMed ID
nsv834542 CNV Gain 17160897

Relevant External Links for CCDC108 Gene

HapMap Linkage Disequilibrium report
CCDC108

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC108 Gene

Disorders for CCDC108 Gene

Relevant External Links for CCDC108

Genetic Association Database (GAD)
CCDC108
genes like me logo Genes that share disorders with CCDC108: view

No data available for UniProtKB/Swiss-Prot for CCDC108 Gene

Publications for CCDC108 Gene

  1. The Rose-comb mutation in chickens constitutes a structural rearrangement causing both altered comb morphology and defective sperm motility. (PMID: 22761584) Imsland F. … Andersson L. (PLoS Genet. 2012) 2 3
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4

Products for CCDC108 Gene

Sources for CCDC108 Gene

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