Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC107 Gene

Aliases for CCDC107 Gene

  • Coiled-Coil Domain Containing 107 2 3 5
  • Coiled-Coil Domain-Containing Protein 107 3
  • PSEC0222 3

External Ids for CCDC107 Gene

Previous GeneCards Identifiers for CCDC107 Gene

  • GC09P035649
  • GC09P035613

Summaries for CCDC107 Gene

Entrez Gene Summary for CCDC107 Gene

  • This gene encodes a membrane protein which contains a coiled-coil domain in the central region. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

GeneCards Summary for CCDC107 Gene

CCDC107 (Coiled-Coil Domain Containing 107) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC107 Gene

Genomics for CCDC107 Gene

Regulatory Elements for CCDC107 Gene

Enhancers for CCDC107 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F035679 0.6 Ensembl ENCODE 18.5 +27.8 27836 12.8 PKNOX1 ARID4B SIN3A GLIS2 ELK1 FOS ZNF263 SP3 SMARCB1 MBD2 TPM2 GBA2 TMEM8B TLN1 NPR2 CCDC107 SIT1 CREB3 MIR6852 RGP1
GH09F035025 0.9 Ensembl ENCODE 17.9 -631.0 -631010 4.1 ATF1 CBX3 PKNOX1 PTRF ZNF766 CREM JUNB ZEB2 REST HDAC8 FANCG CCDC107 PIGO TPM2 DNAJB5 SPAG8 PHF24 STOML2 ENSG00000234181 CREB3
GH09F035694 0.2 ENCODE 12.4 +37.8 37805 2.6 CTCF ARID4B RAD21 ZBTB48 POLR2A ZNF143 SMC3 FOS THAP11 TRIM22 TPM2 ARHGEF39 RN7SL22P CCDC107 SIT1 CA9 CREB3 TLN1 MIR6852 GBA2
GH09F035616 0.4 ENCODE 12.2 -39.0 -39028 6.4 HDGF ATF1 PKNOX1 WRNIP1 ZBTB40 ETS1 RFX5 EGR1 SCRT2 ZNF143 CCDC107 RN7SL22P ARHGEF39 SIT1 CA9 FAM166B TLN1 CREB3 MIR6852 GBA2
GH09F035611 0.5 Ensembl ENCODE 12.1 -46.9 -46925 0.3 CTCF PKNOX1 TRIM22 ZNF143 RAD21 ZNF18 CCDC107 RN7SL22P ARHGEF39 SIT1 FAM166B CA9 CREB3 MIR6852 TLN1 GBA2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CCDC107 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC107 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001470325 18 2201 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for CCDC107 Gene

Chromosome:
9
Start:
35,658,282 bp from pter
End:
35,661,511 bp from pter
Size:
3,230 bases
Orientation:
Plus strand

Genomic View for CCDC107 Gene

Genes around CCDC107 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC107 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC107 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC107 Gene

Proteins for CCDC107 Gene

  • Protein details for CCDC107 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV48-CC107_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 107
    Protein Accession:
    Q8WV48
    Secondary Accessions:
    • A6XND6
    • Q5T4R5
    • Q5T4R8
    • Q5T4R9
    • Q86VB6
    • Q8N2E4

    Protein attributes for CCDC107 Gene

    Size:
    283 amino acids
    Molecular mass:
    30509 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI13448.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC107 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC107 Gene

Post-translational modifications for CCDC107 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC107 Gene

Domains & Families for CCDC107 Gene

Protein Domains for CCDC107 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC107 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC107: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC107 Gene

Function for CCDC107 Gene

genes like me logo Genes that share phenotypes with CCDC107: view

Animal Model Products

miRNA for CCDC107 Gene

miRTarBase miRNAs that target CCDC107

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC107 Gene

Localization for CCDC107 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC107 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC107 Gene COMPARTMENTS Subcellular localization image for CCDC107 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CCDC107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CCDC107: view

Pathways & Interactions for CCDC107 Gene

SuperPathways for CCDC107 Gene

No Data Available

Interacting Proteins for CCDC107 Gene

Gene Ontology (GO) - Biological Process for CCDC107 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC107 Gene

Transcripts for CCDC107 Gene

Unigene Clusters for CCDC107 Gene

Coiled-coil domain containing 107:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC107 Gene

No ASD Table

Relevant External Links for CCDC107 Gene

GeneLoc Exon Structure for
CCDC107
ECgene alternative splicing isoforms for
CCDC107

Expression for CCDC107 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC107 Gene

Protein differential expression in normal tissues from HIPED for CCDC107 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC107 Gene



Protein tissue co-expression partners for CCDC107 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC107 Gene:

CCDC107

SOURCE GeneReport for Unigene cluster for CCDC107 Gene:

Hs.745107
genes like me logo Genes that share expression patterns with CCDC107: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC107 Gene

Orthologs for CCDC107 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCDC107 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC107 34 35
  • 98.7 (n)
dog
(Canis familiaris)
Mammalia CCDC107 34 35
  • 85.19 (n)
cow
(Bos Taurus)
Mammalia CCDC107 34 35
  • 81.7 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc107 34
  • 76.98 (n)
mouse
(Mus musculus)
Mammalia Ccdc107 34 16 35
  • 76.68 (n)
Species where no ortholog for CCDC107 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC107 Gene

ENSEMBL:
Gene Tree for CCDC107 (if available)
TreeFam:
Gene Tree for CCDC107 (if available)

Paralogs for CCDC107 Gene

Pseudogenes.org Pseudogenes for CCDC107 Gene

genes like me logo Genes that share paralogs with CCDC107: view

No data available for Paralogs for CCDC107 Gene

Variants for CCDC107 Gene

Sequence variations from dbSNP and Humsavar for CCDC107 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs199476103 Pathogenic 35,657,948(-) AGGGG(A/G)AAGTC nc-transcript-variant, upstream-variant-2KB
rs727502774 Pathogenic 35,657,756(-) AGCGC(G/T)GCTGT nc-transcript-variant, upstream-variant-2KB
rs727502775 Pathogenic 35,658,030(-) ATACT(-/TACTCTGTGA)AAGCT upstream-variant-2KB
rs727502776 Pathogenic 35,658,027(-) AAATA(-/ACTACTCTGTGAAGC)CTGAG upstream-variant-2KB
rs727502777 Pathogenic 35,658,023(-) CTGAG(-/CCTGAG/TACTCTGTGAAGCTGAG)GACGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC107 Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259

Variation tolerance for CCDC107 Gene

Residual Variation Intolerance Score: 84.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.44; 71.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC107 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC107

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC107 Gene

Disorders for CCDC107 Gene

Relevant External Links for CCDC107

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC107

No disorders were found for CCDC107 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC107 Gene

Publications for CCDC107 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64

Products for CCDC107 Gene

Sources for CCDC107 Gene

Content
Loading form....