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Aliases for CCDC106 Gene

Aliases for CCDC106 Gene

  • Coiled-Coil Domain Containing 106 2 3
  • Coiled-Coil Domain-Containing Protein 106 3
  • Protein Predicted By Clone 23882 3
  • HSU79303 3
  • ZNF581 3

External Ids for CCDC106 Gene

Previous GeneCards Identifiers for CCDC106 Gene

  • GC19P060850
  • GC19P056158
  • GC19P052471

Summaries for CCDC106 Gene

GeneCards Summary for CCDC106 Gene

CCDC106 (Coiled-Coil Domain Containing 106) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC106 Gene

  • Promotes the degradation of p53/TP53 protein and inhibits its transactivity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC106 Gene

Genomics for CCDC106 Gene

Regulatory Elements for CCDC106 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCDC106 Gene

Start:
55,641,062 bp from pter
End:
55,653,161 bp from pter
Size:
12,100 bases
Orientation:
Plus strand

Genomic View for CCDC106 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC106 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC106 Gene

Proteins for CCDC106 Gene

  • Protein details for CCDC106 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWC9-CC106_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 106
    Protein Accession:
    Q9BWC9
    Secondary Accessions:
    • B3KUF9
    • D3K183
    • Q99786

    Protein attributes for CCDC106 Gene

    Size:
    280 amino acids
    Molecular mass:
    32032 Da
    Quaternary structure:
    • Interacts with p53/TP53.
    SequenceCaution:
    • Sequence=AAB50227.1; Type=Erroneous termination; Positions=154; Note=Translated as Gln.; Evidence={ECO:0000305};

neXtProt entry for CCDC106 Gene

Proteomics data for CCDC106 Gene at MOPED

Post-translational modifications for CCDC106 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC106 Gene

Domains for CCDC106 Gene

Protein Domains for CCDC106 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC106 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC106: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC106 Gene

Function for CCDC106 Gene

Molecular function for CCDC106 Gene

UniProtKB/Swiss-Prot Function: Promotes the degradation of p53/TP53 protein and inhibits its transactivity.

Gene Ontology (GO) - Molecular Function for CCDC106 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with CCDC106: view

Animal Model Products

CRISPR Products

miRNA for CCDC106 Gene

miRTarBase miRNAs that target CCDC106

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC106

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCDC106 Gene

Localization for CCDC106 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC106 Gene

Nucleus. Note=Colocalizes with p53/TP53.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC106 Gene COMPARTMENTS Subcellular localization image for CCDC106 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CCDC106 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CCDC106: view

Pathways for CCDC106 Gene

SuperPathways for CCDC106 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC106 Gene

None

No data available for Pathways by source for CCDC106 Gene

Transcripts for CCDC106 Gene

Unigene Clusters for CCDC106 Gene

Coiled-coil domain containing 106:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC106

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CCDC106

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC106 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6
SP1: - - - - -
SP2: - - - -
SP3:
SP4: - - - - -
SP5: - -
SP6:
SP7: - -
SP8: -

Relevant External Links for CCDC106 Gene

GeneLoc Exon Structure for
CCDC106
ECgene alternative splicing isoforms for
CCDC106

Expression for CCDC106 Gene

mRNA expression in normal human tissues for CCDC106 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CCDC106 Gene

SOURCE GeneReport for Unigene cluster for CCDC106 Gene Hs.82482

genes like me logo Genes that share expressions with CCDC106: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC106 Gene

Orthologs for CCDC106 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC106 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC106 35
  • 99.52 (n)
  • 99.29 (a)
CCDC106 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC106 35
  • 87.41 (n)
  • 89.21 (a)
CCDC106 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC106 35
  • 89.05 (n)
  • 91.43 (a)
CCDC106 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc106 35
  • 87.57 (n)
  • 89.96 (a)
Ccdc106 16
Ccdc106 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC106 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC106 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc106 35
  • 87.26 (n)
  • 93.21 (a)
lizard
(Anolis carolinensis)
Reptilia CCDC106 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc106 35
  • 63.67 (n)
  • 66.19 (a)
zebrafish
(Danio rerio)
Actinopterygii CCDC106 (2 of 3) 36
  • 36 (a)
OneToMany
ccdc106a 35
  • 63.73 (n)
  • 67.13 (a)
ccdc106a 36
  • 39 (a)
OneToMany
ccdc106b 36
  • 38 (a)
OneToMany
Species with no ortholog for CCDC106:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC106 Gene

ENSEMBL:
Gene Tree for CCDC106 (if available)
TreeFam:
Gene Tree for CCDC106 (if available)

Paralogs for CCDC106 Gene

No data available for Paralogs for CCDC106 Gene

Variants for CCDC106 Gene

Sequence variations from dbSNP and Humsavar for CCDC106 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs310470 -- 55,650,615(-) GGGAA(A/G)GCCAG intron-variant
rs310471 -- 55,647,354(-) AAAAA(C/G)AGGTC upstream-variant-2KB
rs310472 -- 55,646,582(-) tactc(A/G)ggagg upstream-variant-2KB
rs310473 -- 55,646,387(-) agttc(A/G)agacc upstream-variant-2KB
rs519856 -- 55,651,515(-) CGCCC(A/G)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC106 Gene

Variant ID Type Subtype PubMed ID
dgv4025n71 CNV Loss 21882294
nsv912500 CNV Loss 21882294
nsv912501 CNV Loss 21882294
nsv2553 CNV Insertion 18451855
nsv912503 CNV Loss 21882294
nsv912504 CNV Loss 21882294
nsv833882 CNV Loss 17160897

Relevant External Links for CCDC106 Gene

HapMap Linkage Disequilibrium report
CCDC106

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC106 Gene

Disorders for CCDC106 Gene

No disorders were found for CCDC106 Gene.

No data available for UniProtKB/Swiss-Prot for CCDC106 Gene

Publications for CCDC106 Gene

  1. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3 4
  2. Identification and characterization of the novel protein CCDC106 that interacts with p53 and promotes its degradation. (PMID: 20159018) Zhou J. … Zhang J. (FEBS Lett. 2010) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3

Products for CCDC106 Gene

Sources for CCDC106 Gene

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