CCDC106 Gene
protein-coding GIFtS: 43
GCID: GC19P056158
|
|
coiled-coil domain containing 106
| |
Aliases
for CCDC106 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 1061 2 | | HSU793031 2 | | ZNF5812 | | Coiled-Coil Domain-Containing Protein 1062 | | Protein Predicted By Clone 238822 |
Export aliases for CCDC106 gene to outside databasesPrevious GC identifers: GC19P060850 GC19P052471 |
Summaries
for CCDC106 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CC106_HUMAN, Q9BWC9Function: Promotes the degradation of p53/TP53 protein and inhibits its transactivity
|
Genomic Views
for CCDC106 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC106 gene promoter:
E2F-4 E2F-3a E2F-5 ATF-2 Nkx2-5 E2F-2 FOXI1 E2F E2F-1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC106
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC106 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.42CCDC106 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P056158: view genomic region
(about GC identifiers)
Start:
|
56,152,428 bp from pter |
End:
|
56,164,527 bp from pter |
Size:
|
12,100 bases |
Orientation:
|
plus strand |
|
Proteins
for CCDC106 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CC106_HUMAN, Q9BWC9 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 106 Size: 280 amino acids; 32032 Da
Subunit: Interacts with p53/TP53
Subcellular location: Nucleus. Note=Colocalizes with p53/TP53
Sequence caution: Sequence=AAB50227.1; Type=Erroneous termination; Positions=154; Note=Translated as Gln;
Secondary accessions: B3KUF9 D3K183 Q99786Explore the universe of human proteins at neXtProt for CCDC106: NX_Q9BWC9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BWC9
CCDC106 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_037433.2
ENSEMBL proteins: ENSP00000466597 ENSP00000468521 ENSP00000309681 ENSP00000468077 ENSP00000465757 ENSP00000466870 ENSP00000468539 ENSP00000466521
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
CCDC106 for ontologies About GeneDecksing
CCDC106 Antibody Products:
Assay Products for CCDC106: |
Protein
Domains /
Families
for CCDC106 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9BWC9 |
Function
for CCDC106 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CC106_HUMAN, Q9BWC9Function: Promotes the degradation of p53/TP53 protein and inhibits its transactivity
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC106 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC106 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CCDC106 (NM_013301) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC106 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC106 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC106 |
|
Pathways & Interactions
for CCDC106 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC106
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/14 Interacting proteins for CCDC106 (Q9BWC92, 3 ENSP000003096814) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
|
Drugs & Compounds
for CCDC106 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC106
Search CenterWatch for drugs/clinical trials and news about CCDC106 / CC106
|
Transcripts
for CCDC106 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC106 gene: NM_013301.2 Unigene Cluster for CCDC106: Coiled-coil domain containing 106 Hs.82482 [show with all ESTs]Unigene Representative Sequence: AK0970959 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000592996 ENST00000593069 ENST00000308964(uc002qlr.3 uc021vcc.1 uc021vcd.1 uc002qls.3)
ENST00000587213 ENST00000586790 ENST00000591578 ENST00000588740 ENST00000586864
ENST00000591241
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC106 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC106 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCDC106 (NM_013301) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC106 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC106 |
Additional cDNA sequence: AF054984.1 AK097095.1 BC000412.2 BC008956.2 CR450308.1 GU354321.1 GU354322.1 GU354323.1 U79303.1 7 DOTS entries: DT.211863 DT.97855059 DT.100026821 DT.100790862 DT.92428129 DT.100790867 DT.40213797 24/374 AceView cDNA sequences (see all 374): AK123294 CD653037 CR610458 BQ774311 CF127611 BI907663 BI909057 AK026203 BC001219 AI864430 AI679440 AI679948 CR608870 CR622650 BQ673971 BM925190 BF058512 BC071845 NM_016202 BU625719 BM768406 BM931984 BF434836 AA809976
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC106 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CCDC106
|
Expression
for CCDC106 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC106 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCGCGGGCCT
About this image
See CCDC106 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC106
SOURCE GeneReport for Unigene cluster: Hs.82482
SABiosciences Custom PCR Arrays for CCDC106
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC106
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC106 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC106 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC106 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC106 |
Orthologs
for CCDC106 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CCDC106 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for CCDC106 (if available)
TreeFam Gene Tree for CCDC106 (if available) |
Paralogs
for CCDC106 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CCDC106 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC106 (56152428 - 56164527 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCDC106: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC106 |
|
Disorders
/ Diseases
for CCDC106 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 CCDC106 for disorders About MalaCards
CCDC106 for disorders About GeneDecksing
OMIM gene information: 613478
OMIM disorders: --
Export disorders for CCDC106 gene to outside databases
|
Publications
for CCDC106 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC106 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCDC106) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 2, 3 Yu W.... Gibbs R.A. (1997)
- Identification and characterization of the novel prot ein CCDC106 that interacts with p53 and promotes its degradation. (PubMed id 20159018)1, 2 Zhou J....Zhang J. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. (PubMed id 15790807)1 Cheng J....Gingeras T.R. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for CCDC106 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC106 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC106 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC106 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC106 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC106 gene:
Search GeneIP for patents involving CCDC106
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC106 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC106 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC106 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC106 | | | OriGene Protein Over-expression Lysate for CCDC106 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC106 | | OriGene 3'-UTR Clone for CCDC106 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC106 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC106 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CCDC106 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CCDC106 | | OriGene Custom Protein Services for CCDC106 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC106 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC106 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC106 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC106 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC106 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC106 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CCDC106 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CCDC106 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC106 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC106 |
|
|
|
|
