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Aliases for CCDC105 Gene

Aliases for CCDC105 Gene

  • Coiled-Coil Domain Containing 105 2 3

External Ids for CCDC105 Gene

Previous GeneCards Identifiers for CCDC105 Gene

  • GC19P015121
  • GC19P014688

Summaries for CCDC105 Gene

GeneCards Summary for CCDC105 Gene

CCDC105 (Coiled-Coil Domain Containing 105) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC105 Gene

Genomics for CCDC105 Gene

Regulatory Elements for CCDC105 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCDC105 Gene

15,010,727 bp from pter
15,023,271 bp from pter
12,545 bases
Plus strand

Genomic View for CCDC105 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC105 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC105 Gene

Proteins for CCDC105 Gene

  • Protein details for CCDC105 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 105
    Protein Accession:
    Secondary Accessions:
    • Q8N7T5
    • Q8NDL5

    Protein attributes for CCDC105 Gene

    499 amino acids
    Molecular mass:
    56909 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC105 Gene

Proteomics data for CCDC105 Gene at MOPED

Post-translational modifications for CCDC105 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC105 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC105 Gene

Domains & Families for CCDC105 Gene

Protein Domains for CCDC105 Gene


Suggested Antigen Peptide Sequences for CCDC105 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC105: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC105 Gene

Function for CCDC105 Gene

genes like me logo Genes that share phenotypes with CCDC105: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC105

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC105 Gene

Localization for CCDC105 Gene

Subcellular locations from

Jensen Localization Image for CCDC105 Gene COMPARTMENTS Subcellular localization image for CCDC105 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CCDC105 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CCDC105: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCDC105 Gene

Pathways & Interactions for CCDC105 Gene

SuperPathways for CCDC105 Gene

No Data Available

Interacting Proteins for CCDC105 Gene

Gene Ontology (GO) - Biological Process for CCDC105 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC105 Gene

Drugs & Compounds for CCDC105 Gene

No Compound Related Data Available

Transcripts for CCDC105 Gene

mRNA/cDNA for CCDC105 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC105 Gene

Coiled-coil domain containing 105:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC105

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC105 Gene

No ASD Table

Relevant External Links for CCDC105 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC105 Gene

mRNA expression in normal human tissues for CCDC105 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC105 Gene

This gene is overexpressed in Testis (x51.6).

Protein differential expression in normal tissues from HIPED for CCDC105 Gene

This gene is overexpressed in Stomach (36.0), Tlymphocyte (17.5), and Heart (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC105 Gene

SOURCE GeneReport for Unigene cluster for CCDC105 Gene Hs.375985

genes like me logo Genes that share expression patterns with CCDC105: view

Protein tissue co-expression partners for CCDC105 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CCDC105 Gene

Orthologs for CCDC105 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC105 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCDC105 35
  • 85.72 (n)
  • 82.63 (a)
CCDC105 36
  • 81 (a)
(Canis familiaris)
Mammalia CCDC105 35
  • 85.85 (n)
  • 83.88 (a)
CCDC105 36
  • 83 (a)
(Mus musculus)
Mammalia Ccdc105 35
  • 80.85 (n)
  • 79.96 (a)
Ccdc105 16
Ccdc105 36
  • 79 (a)
(Pan troglodytes)
Mammalia CCDC105 35
  • 96.25 (n)
  • 94.76 (a)
CCDC105 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ccdc105 35
  • 79.57 (n)
  • 78.63 (a)
(Monodelphis domestica)
Mammalia CCDC105 36
  • 52 (a)
(Anolis carolinensis)
Reptilia CCDC105 36
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487156 35
  • 42.63 (n)
  • 28.49 (a)
(Danio rerio)
Actinopterygii LOC565570 35
  • 42.7 (n)
  • 29.2 (a)
CCDC105 36
  • 26 (a)
Species with no ortholog for CCDC105:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC105 Gene

Gene Tree for CCDC105 (if available)
Gene Tree for CCDC105 (if available)

Paralogs for CCDC105 Gene

No data available for Paralogs for CCDC105 Gene

Variants for CCDC105 Gene

Sequence variations from dbSNP and Humsavar for CCDC105 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs725461 -- 15,015,687(-) CTTGC(C/T)CTGTC intron-variant
rs736737 -- 15,021,733(+) GAGCC(C/T)TCGGG intron-variant
rs757463 -- 15,021,762(+) GGTGG(C/G)TGGAG intron-variant
rs757464 -- 15,022,217(+) CGTCA(A/G)CACCC intron-variant
rs2079251 -- 15,016,467(+) CAGGC(A/G)TGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC105 Gene

Variant ID Type Subtype PubMed ID
dgv1058e1 CNV Complex 17122850
nsv518179 CNV Loss 19592680
nsv523277 CNV Loss 19592680

Variation tolerance for CCDC105 Gene

Residual Variation Intolerance Score: 87.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.44; 88.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC105 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC105 Gene

Disorders for CCDC105 Gene

Relevant External Links for CCDC105

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CCDC105: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC105 Gene

Publications for CCDC105 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 67
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 67
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for CCDC105 Gene

Sources for CCDC105 Gene

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