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CCDC105 Gene

protein-coding   GIFtS: 41
GCID: GC19P015121

Coiled-Coil Domain Containing 105

  Search for CCDC105
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coiled-Coil Domain Containing 1051 2
Coiled-Coil Domain-Containing Protein 1052

External Ids:    HGNC: 268661   Entrez Gene: 1264022   Ensembl: ENSG000001609947   UniProtKB: Q8IYK23   

Export aliases for CCDC105 gene to outside databases

Previous GC identifers: GC19P014983 GC19P014688


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCDC105 Gene:
CCDC105 (coiled-coil domain containing 105) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCDC105 gene promoter:
         Tal-1   CUTL1   NF-kappaB   E47   Max   deltaCREB   Chx10   NF-kappaB1   c-Myc   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC105 promoter sequence
   Search Chromatin IP Primers for CCDC105

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC105


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.12   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.12

CCDC105 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC105 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P015121:  view genomic region     (about GC identifiers)

Start:
15,121,539 bp from pter      End:
15,134,083 bp from pter
Size:
12,545 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CC105_HUMAN, Q8IYK2 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 105  
Size: 499 amino acids; 56909 Da
Secondary accessions: Q8N7T5 Q8NDL5

Explore the universe of human proteins at neXtProt for CCDC105: NX_Q8IYK2

Explore proteomics data for CCDC105 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCDC105 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775753.2  
    ENSEMBL proteins: 
     ENSP00000292574  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000435 Tektin

    Graphical View of Domain Structure for InterPro Entry Q8IYK2

    ProtoNet protein and cluster: Q8IYK2


    CCDC105 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         2 GenomeRNAi human phenotypes for CCDC105:
     Elongated cells with protrusio  Increased gamma-H2AX phosphory 

    Animal Models:
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    hsa-miR-1321 hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidCCDC105 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    cytosol2
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005874microtubule IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    CCDC105 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC105
    Interactions:

        Search GeneGlobe Interaction Network for CCDC105

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--

    CCDC105 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCDC105 (CC105)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCDC105 gene: 
    NM_173482.2  

    Unigene Cluster for CCDC105:

    Coiled-coil domain containing 105
    Hs.375985  [show with all ESTs]
    Unigene Representative Sequence: BC035678
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000292574(uc002nae.2)
    miRNA
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    hsa-miR-1321 hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidCCDC105 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat CCDC105

    Additional mRNA sequence: 

    AK097684.1 AL833847.1 BC035678.1 

    1 DOTS entry:

    DT.97767313 

    6 AceView cDNA sequences:

    AK097684 BC035678 NM_173482 BM552964 AL833847 CD300283 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCDC105 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTCCCTC
    CCDC105 Expression
    About this image

    CCDC105 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCDC105 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.375985
        Custom PCR Arrays for CCDC105
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC105

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCDC105 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc1051 , 5 coiled-coil domain containing 1051, 5 80.85(n)1
    79.96(a)1
      10 (39.72 cM)5
    709761  NM_027630.11  NP_081906.11 
     787469245 
    lizard
    (Anolis carolinensis)
    Reptilia CCDC1056
    coiled-coil domain containing 105
    40(a)
    1 ↔ 1
    2(189636546-189652076)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004871561 coiled-coil domain-containing protein 105-like 42.63(n)
    28.49(a)
      100487156  XM_002938674.2  XP_002938720.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5655701 coiled-coil domain-containing protein 105-like 42.7(n)
    29.2(a)
      565570  XM_688848.5  XP_693940.1 


    ENSEMBL Gene Tree for CCDC105 (if available)
    TreeFam Gene Tree for CCDC105 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCDC105 (see all 343)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20792501,2
    C,F,A--15050849(+) TGATTT/CCCCCC 1 -- us2k16Minor allele frequency- C:0.50NA WA CSA EA 364
    rs1169693821,2
    C,F--15123458(+) AGGAGA/TTGAGA 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1488361921,2
    --15123526(+) AGGGTA/GCAGCC 1 -- int10--------
    rs1434905331,2
    --15123577(+) CCCACA/CGCCCT 1 -- int10--------
    rs1480120901,2
    C--15123656(+) ACCCTC/TAGTGC 1 -- int10--------
    rs781557781,2
    C,F--15123672(+) TCCTAG/ATGAAA 1 -- int12Minor allele frequency- A:0.15WA NA 238
    rs129730191,2
    C,F--15123697(+) CCCAGC/TTGAGG 1 -- int114Minor allele frequency- T:0.27EA NA WA CSA 556
    rs1425090011,2
    C--15123708(+) AGAGCA/GGCTGA 1 -- int10--------
    rs360166071,2
    C--15123740(+) CCCCCC/-AGAAT 1 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs3695271651,2
    C--15123742(+) AACTCC/GCCCCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for CCDC105 (15121539 - 15134083 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CCDC105:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523277CNV Loss19592680
    nsv518179CNV Loss19592680
    dgv1058e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCDC105
    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC105

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    CCDC105 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CCDC105
    Human Genome Epidemiology (HuGE) Navigator: CCDC105 (1 document)

    Export disorders for CCDC105 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCDC105 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CCDC105)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 126402 HGNC: 26866 AceView: FLJ40365 Ensembl:ENSG00000160994 euGenes: HUgn126402
    ECgene: CCDC105 H-InvDB: CCDC105

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCDC105 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCDC105 gene:
    Search GeneIP for patents involving CCDC105

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Proteins for CCDC105
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     Browse ESI BIO Cell Lines and PureStem Progenitors for CCDC105
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC105
     SwitchGear 3'UTR luciferase reporter plasmids for CCDC105
     SwitchGear Promoter luciferase reporter plasmids for CCDC105
     ThermoFisher Antibodies for CCDC105
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC105
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCDC105
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCDC105
     Search LSBio for Antibodies for CCDC105
    Customized transgenic rodents for:
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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