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Aliases for CCDC105 Gene

Aliases for CCDC105 Gene

  • Coiled-Coil Domain Containing 105 2 3 5

External Ids for CCDC105 Gene

Previous GeneCards Identifiers for CCDC105 Gene

  • GC19P015121
  • GC19P014688

Summaries for CCDC105 Gene

GeneCards Summary for CCDC105 Gene

CCDC105 (Coiled-Coil Domain Containing 105) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC105 Gene

Genomics for CCDC105 Gene

Regulatory Elements for CCDC105 Gene

Enhancers for CCDC105 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F015137 0.4 ENCODE 10.3 +127.7 127666 2.2 BHLHE40 NR2F2 JUND GATA3 ZFHX2 HNF4G ZBTB33 FOS PRDM10 ZNF600 SYDE1 EPHX3 SLC1A6 CCDC105 OR7A10 OR7C1 ILVBL OR10B1P
GH19F015135 0.5 ENCODE 10.3 +125.4 125368 1.9 JUN ZFP64 RAD21 GATA3 CTBP1 POLR2A RCOR1 NR2F6 FOSL2 FOS SYDE1 EPHX3 SLC1A6 CCDC105 OR7A10 OR7C1 ILVBL OR10B1P
GH19F015010 0.8 ENCODE 0.8 -0.2 -249 0.0 CCDC105 OR7C2
GH19F015011 0.4 ENCODE 0.8 0.0 -24 0.2 RFX1 TEAD4 CCDC105 OR7C2
GH19F015012 0.2 ENCODE 0.8 +0.3 317 0.2 POLR2A CCDC105 SLC1A6
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CCDC105 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC105 Gene

15,010,727 bp from pter
15,023,271 bp from pter
12,545 bases
Plus strand

Genomic View for CCDC105 Gene

Genes around CCDC105 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC105 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC105 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC105 Gene

Proteins for CCDC105 Gene

  • Protein details for CCDC105 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 105
    Protein Accession:
    Secondary Accessions:
    • Q8N7T5
    • Q8NDL5

    Protein attributes for CCDC105 Gene

    499 amino acids
    Molecular mass:
    56909 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC105 Gene

Post-translational modifications for CCDC105 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC105 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC105 Gene

Domains & Families for CCDC105 Gene

Protein Domains for CCDC105 Gene


Suggested Antigen Peptide Sequences for CCDC105 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC105: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC105 Gene

Function for CCDC105 Gene

genes like me logo Genes that share phenotypes with CCDC105: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC105 Gene

Localization for CCDC105 Gene

Subcellular locations from

Jensen Localization Image for CCDC105 Gene COMPARTMENTS Subcellular localization image for CCDC105 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CCDC105 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CCDC105: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCDC105 Gene

Pathways & Interactions for CCDC105 Gene

SuperPathways for CCDC105 Gene

No Data Available

Interacting Proteins for CCDC105 Gene

Selected Interacting proteins: Q8IYK2-CC105_HUMAN for CCDC105 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CCDC105 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC105 Gene

Transcripts for CCDC105 Gene

mRNA/cDNA for CCDC105 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC105 Gene

Coiled-coil domain containing 105:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC105 Gene

No ASD Table

Relevant External Links for CCDC105 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC105 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC105 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC105 Gene

This gene is overexpressed in Testis (x51.6).

Protein differential expression in normal tissues from HIPED for CCDC105 Gene

This gene is overexpressed in Stomach (36.0), Tlymphocyte (17.5), and Heart (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC105 Gene

Protein tissue co-expression partners for CCDC105 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC105 Gene:


SOURCE GeneReport for Unigene cluster for CCDC105 Gene:

genes like me logo Genes that share expression patterns with CCDC105: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CCDC105 Gene

Orthologs for CCDC105 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC105 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC105 34 35
  • 96.25 (n)
(Canis familiaris)
Mammalia CCDC105 34 35
  • 85.85 (n)
(Bos Taurus)
Mammalia CCDC105 34 35
  • 85.72 (n)
(Mus musculus)
Mammalia Ccdc105 34 16 35
  • 80.85 (n)
(Rattus norvegicus)
Mammalia Ccdc105 34
  • 79.57 (n)
(Monodelphis domestica)
Mammalia CCDC105 35
  • 52 (a)
(Anolis carolinensis)
Reptilia CCDC105 35
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487156 34
  • 42.63 (n)
(Danio rerio)
Actinopterygii LOC565570 34
  • 42.7 (n)
CCDC105 35
  • 26 (a)
Species where no ortholog for CCDC105 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC105 Gene

Gene Tree for CCDC105 (if available)
Gene Tree for CCDC105 (if available)

Paralogs for CCDC105 Gene

No data available for Paralogs for CCDC105 Gene

Variants for CCDC105 Gene

Sequence variations from dbSNP and Humsavar for CCDC105 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10402309 -- 15,019,962(+) caaaa(C/G)aaaaa intron-variant
rs10408703 -- 15,021,166(+) TACAG(C/G)CTCTG intron-variant
rs10408908 -- 15,011,754(+) AAAAT(A/C)TTTCC intron-variant, upstream-variant-2KB
rs10414534 -- 15,011,757(+) aTATT(C/T)CCATA intron-variant, upstream-variant-2KB
rs10419689 -- 15,009,292(+) atata(C/T)gctct intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC105 Gene

Variant ID Type Subtype PubMed ID
esv2758746 CNV gain 17122850
nsv518179 CNV loss 19592680
nsv523277 CNV loss 19592680

Variation tolerance for CCDC105 Gene

Residual Variation Intolerance Score: 87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.44; 88.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC105 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC105 Gene

Disorders for CCDC105 Gene

Relevant External Links for CCDC105

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC105 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC105 Gene

Publications for CCDC105 Gene

  1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Interactome of the negative regulator of nuclear import BRCA1-binding protein 2. (PMID: 25820252) Fatima S. … Jans D.A. (Sci. Rep. 2015) 3 64
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3 64

Products for CCDC105 Gene

Sources for CCDC105 Gene

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