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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCDC103 Gene

protein-coding GIFtS: 44
GCID: GC17P042978

coiled-coil domain containing 103

Explore 2 diseases affiliated with
CCDC103 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 103¹ ²		FLJ34211¹
CILD17¹ ²		SMH²
PR46b¹ ²		Coiled-Coil Domain-Containing Protein 103²
FLJ13094¹

External Ids:	HGNC: 32700¹	Entrez Gene: 388389²	Ensembl: ENSG00000167131⁷	OMIM: 614677⁵	UniProtKB: Q8IW40³

Export aliases for CCDC103 gene to outside databases

Previous GC identifers: GC17P040333 GC17P038742

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCDC103:

This gene encodes a protein that contains a coiled-coil domain. (provided by RefSeq, Apr 2012)

UniProtKB/Swiss-Prot: CC103_HUMAN, Q8IW40

Function: Dynein-attachment factor required for cilia motility

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCDC103 gene promoter:
Bach1 Elk-1 AP-1 GCNF C/EBPalpha MEF-2A CHOP-10 GCNF-1 LyF-1 GCNF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCDC103 promoter sequence

Search SABiosciences Chromatin IP Primers for CCDC103

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC103

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31

CCDC103 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC103 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P042978: view genomic region (about GC identifiers)

Start:	42,976,510 bp from pter	End:	42,982,758 bp from pter
Size:	6,249 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CC103_HUMAN, Q8IW40 (See protein sequence)

Recommended Name: Coiled-coil domain-containing protein 103

Size: 242 amino acids; 27163 Da

Subunit: Homodimer

Subcellular location: Cytoplasm (By similarity). Cell projection, cilium, flagellum (By similarity)

Secondary accessions: A8K145 B8ZZU0

Alternative splicing: 2 isoforms: Q8IW40-1 Q8IW40-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCDC103: NX_Q8IW40

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IW40

CCDC103 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001245324.1 NP_001245325.1 NP_001245326.1 NP_001245327.1 NP_001245328.1 NP_998772.1

ENSEMBL proteins:

ENSP00000462450 ENSP00000387252 ENSP00000350420 ENSP00000386640 ENSP00000391692

Human Recombinant Protein Products for CCDC103:

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	Novus Biologicals CCDC103 Protein Novus Biologicals CCDC103 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CCDC103

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	ISS	--
GO:0035085	cilium axoneme	ISS	--

CCDC103 for ontologies About GeneDecksing

CCDC103 Antibody Products:

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	Novus Biologicals CCDC103 Antibody
	Abcam antibodies for CCDC103
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	Search ThermoFisher Antibodies for CCDC103

Assay Products for CCDC103:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CCDC103
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCDC103

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCDC103 for domains About GeneDecksing

1 InterPro domain/family:

IPR025986 RPAP3-like_C

Graphical View of Domain Structure for InterPro Entry Q8IW40

ProtoNet protein and cluster: Q8IW40

UniProtKB/Swiss-Prot: CC103_HUMAN, Q8IW40

Similarity: Belongs to the CCDC103/PR46b family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CC103_HUMAN, Q8IW40

Function: Dynein-attachment factor required for cilia motility

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0042803	protein homodimerization activity	IDA	--

CCDC103 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for CCDC103:

Decreased POU5F1-GFP protein e

Decreased viability with pacli

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CCDC103

miRNA Products:		OriGene 3'-UTR Clone: CCDC103 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCDC103
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate CCDC103:
		hsa-miR-146a* hsa-miR-92a-1* hsa-miR-3647-3p
		SwitchGear 3'UTR luciferase reporter plasmid: CCDC103 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC103 (see all 7) OriGene shRNA RFP: CCDC103 OriGene siRNA: CCDC103
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC103
		Sirion Biotech Custom design and validation of potent shRNA sequences against CCDC103

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CCDC103
			Sirion Biotech Customized adenovirus for overexpression of CCDC103 Sirion Biotech Customized adenovirus for potent knockdown of CCDC103

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC103 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC103 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCDC103 (NM_213607)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC103
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC103

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCDC103
		Search LifeMap BioReagents cell lines for CCDC103
		Sirion Biotech Customized stable knockdown cell line services for CCDC103 Sirion Biotech Customized inducible knockdown cell line services for CCDC103 Sirion Biotech Customized stable overexpressing cell line services for CCDC103 Sirion Biotech Customized inducible overexpressing cell line services for CCDC103

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC103

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CCDC103

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003341	cilium movement	IGI	--
GO:0030030	cell projection organization	IEA	--
GO:0036158	outer dynein arm assembly	IGI	--
GO:0036159	inner dynein arm assembly	IGI	--
GO:0070286	axonemal dynein complex assembly	IMP	--

CCDC103 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCDC103
Search CenterWatch for drugs/clinical trials and news about CCDC103 / CC103

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCDC103 gene (6 alternative transcripts):

NM_001258395.1 NM_001258396.1 NM_001258397.1 NM_001258398.1 NM_001258399.1 NM_213607.2

Unigene Cluster for CCDC103:

Coiled-coil domain containing 103

Hs.743398 [show with all ESTs]

Unigene Representative Sequence: AK023156

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000577339 ENST00000410006 ENST00000357776 ENST00000410027 ENST00000417826

miRNA Products:		OriGene 3'-UTR Clone: CCDC103 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCDC103
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate CCDC103:
		hsa-miR-146a* hsa-miR-92a-1* hsa-miR-3647-3p
		SwitchGear 3'UTR luciferase reporter plasmid: CCDC103 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC103 (see all 7) OriGene shRNA RFP: CCDC103 OriGene siRNA: CCDC103
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC103
		Sirion Biotech Custom design and validation of potent shRNA sequences against CCDC103

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC103 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC103 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCDC103 (NM_213607)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC103
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC103

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC103 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCDC103
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC103
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC103

Additional cDNA sequence:

AK023156.1 AK091530.1 AK289760.1 BC041060.1

12 DOTS entries:

DT.40109494 DT.121000812 DT.100026641 DT.100748923 DT.99976965 DT.100026640 DT.121000771 DT.101984856

DT.121000933 DT.408391 DT.87017319 DT.91710253

24/62 AceView cDNA sequences (see all 62):

BM673917 AK023156 AI206936 AI655404 BC041060 AU131199 BQ435149 BM712943

BE796577 AW013940 AI203333 CB852094 BF516604 BE888143 BM687000 NM_213607

BI829596 BI826937 BM454938 BI831532 AI962524 AA983856 BM982119 BM046826

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC103 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4a	·	4b
SP1:							-		-
SP2:
SP3:									-
SP4:

ECgene alternative splicing isoforms for CCDC103

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCDC103 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATCAAAAA

About this image

CCDC103 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CCDC103 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC103

SOURCE GeneReport for Unigene cluster: Hs.743398

SABiosciences Expression via Pathway-Focused PCR Arrays including CCDC103:

Necrosis in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Cell Death PathwayFinder in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC103 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCDC103
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC103
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC103

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC103

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCDC103 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ccdc103^{1 , 5}	coiled-coil domain containing 103^{1, 5}	82.77(n)¹ 80.51(a)¹		11 (66.48 cM)⁵ 73293¹ NM_028492.2¹ NP_082768.1¹ 102881204⁵
chicken (Gallus gallus)	Aves	CCDC103¹	coiled-coil domain containing 103	56.98(n) 55.56(a)		419970 XM_418092.3 XP_418092.1
lizard (Anolis carolinensis)	Reptilia	CCDC103⁶	--	49(a)	1 ↔ 1	6(64335569-64338743)
tropical clawed frog (Xenopus tropicalis)	Amphibia	137708681²	--	77.34(n)		137708681
zebrafish (Danio rerio)	Actinopterygii	ccdc103¹	coiled-coil domain containing 103	48.81(n) 45.61(a)		437026 NM_001002753.1 NP_001002753.1

ENSEMBL Gene Tree for CCDC103 (if available)
TreeFam Gene Tree for CCDC103 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142342712^1,2	C,F	--	42979019(+)	`CTCCCC/TGGTAG`	12	P L	mis¹		1		NA	4552
rs74349463^1,2	C,F	--	42979026(+)	`GTAGGT/CGAGGC`	6	--	int¹ spd¹		4		NA WA EU	1563
rs138353404^1,2	C	--	42979056(+)	`AGGATA/TCTCTG`	6	--	int¹		0	--	--	--	--
rs201769954^1,2		--	42979069(+)	`CTAAAA/GCTTCA`	6	--	int¹		0	--	--	--	--
rs185656902^1,2		--	42979087(+)	`TTTTTC/TATTTT`	6	--	int¹		0	--	--	--	--
rs140000541^1,2	C	--	42979089(+)	`TTTCA-/TTTTG TTTTG`	6	--	int¹		0	--	--	--	--
rs11079382^1,2	C,F,H	--	42979156(+)	`ACCAAC/TAGAGA`	6	--	int¹		21		EA NS NA WA	2616
rs189631619^1,2		--	42979533(+)	`ATGGCA/GTGGAT`	6	--	int¹		0	--	--	--	--
rs12451394^1,2	C,F,A,H	--	42979592(+)	`AGGCCG/ACCAAG`	6	--	int¹		15		NA NS EA WA	1246
rs8079610^1,2	C,F,A,H	--	42979670(+)	`CCCTCC/ACTGTC`	6	--	int¹ trp³		12		NA WA CSA EA EU	971

HapMap Linkage Disequilibrium report for CCDC103 (42976510 - 42982758 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCDC103: --
Human Gene Mutation Database (HGMD): CCDC103

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC103

DNA2.0 Custom Variant and Variant Library Synthesis for CCDC103

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCDC103 for disorders About GeneDecksing

OMIM gene information: 614677 OMIM disorders: --

UniProtKB/Swiss-Prot: CC103_HUMAN, Q8IW40

Defects in CCDC103 are the cause of primary ciliary dyskinesia type 17 (CILD17) [MIM:614679]. A disorder

characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and

bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male

patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry

and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with

situs inversus is referred to as Kartagener syndrome

2 diseases for CCDC103: About MalaCards

primary ciliary dyskinesia ciliary dyskinesia

1 disease from the University of Copenhagen DISEASES database for CCDC103:

Primary ciliary dyskinesia

Export disorders for CCDC103 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCDC103 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCDC103)

Utopia: connect your pdf to the dynamic
world of online information

CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms. (PubMed id 22581229)^{1, 2, 3} Panizzi J.R....Drummond I.A. (2012)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)² Zody M.C.... Nusbaum C. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Primary Ciliary Dyskinesia (PubMed id 20301301)¹ Zariwala M.A....Leigh M.W. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 388389	HGNC: 32700	AceView: LOC388389	Ensembl:ENSG00000167131	euGenes: HUgn388389
ECgene: CCDC103	H-InvDB: CCDC103

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCDC103	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CCDC103 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CCDC103 gene:
Search GeneIP for patents involving CCDC103

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Browse OriGene Antibodies		OriGene shRNA RFP for CCDC103
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC103		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC103
	OriGene Protein Over-expression Lysate for CCDC103		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CCDC103		OriGene 3'-UTR Clone for CCDC103
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC103
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC103
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC103
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC103
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC103
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC103

	GenScript Custom Purified and Recombinant Proteins Services for CCDC103		GenScript cDNA clones with any tag delivered in your preferred vector for CCDC103
	GenScript Custom Assay Services for CCDC103		GenScript Custom Superior Antibodies Services for CCDC103
	GenScript Custom overexpressing Cell Line Services for CCDC103		CloneReady with Over 120,000 Genes
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC103

	SwitchGear 3'UTR luciferase reporter plasmids for CCDC103
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Search ThermoFisher Antibodies for CCDC103

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC103

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CCDC103

Sirion Biotech Customized:

	stable knockdown cell line services for CCDC103
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	design and validation of potent shRNA sequences against CCDC103
	adenovirus for potent knockdown of CCDC103
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CCDC103 gene at Home site.

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CCDC103 Gene

coiled-coil domain containing 103

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CCDC103 Gene

coiled-coil domain containing 103

Aliasesfor CCDC103 gene

Summariesfor CCDC103 gene

Genomic Viewsfor CCDC103 gene

Proteinsfor CCDC103 gene

Protein Domains /Familiesfor CCDC103 gene

Functionfor CCDC103 gene

Pathways & Interactionsfor CCDC103 gene

Drugs & Compoundsfor CCDC103 gene

Transcriptsfor CCDC103 gene

Expression for CCDC103 gene

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Genomic Variantsfor CCDC103 gene

Disorders / Diseasesfor CCDC103 gene

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Genome Databases showing CCDC103 gene

Other Databases showing CCDC103 gene

Specialized Databases showing CCDC103 gene

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Summaries
for CCDC103 gene

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for CCDC103 gene

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for CCDC103 gene

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Families
for CCDC103 gene

Function
for CCDC103 gene

Pathways & Interactions
for CCDC103 gene

Drugs & Compounds
for CCDC103 gene

Transcripts
for CCDC103 gene

Expression
for CCDC103 gene

Orthologs
for CCDC103 gene

Paralogs
for CCDC103 gene

Genomic Variants
for CCDC103 gene

Disorders / Diseases
for CCDC103 gene

Publications
for CCDC103 gene

Intellectual Property
for CCDC103 gene

Products
for CCDC103 gene