CCDC102B Gene
protein-coding GIFtS: 41
GCID: GC18P066382
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|
coiled-coil domain containing 102B(Previous names: chromosome 18 open reading frame 14, aminoacylase 1-like...)
(Previous symbols: C18orf14, ACY1L)
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Aliases
for CCDC102B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 102B1 2 | | FLJ235941 | | C18orf141 2 3 | | Aminoacylase 1-Like1 | | ACY1L1 2 | | Chromosome 18 Open Reading Frame 141 | | AN1 2 | | Coiled-Coil Domain-Containing Protein 102B2 | | HsT17311 2 | | |
Export aliases for CCDC102B gene to outside databasesPrevious GC identifers: GC18P064616 GC18P064533 GC18P063100 |
Summaries
for CCDC102B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CCDC102B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_025028.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC102B gene promoter:
FOXF2 FOXO3 NF-kappaB FOXO3b FOXL1 GCNF-1 NF-kappaB2 FOXO3a NF-kappaB1 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC102B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC102B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q22.1 Ensembl cytogenetic band: 18q22.1 HGNC cytogenetic band: 18q22.1CCDC102B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P066382: view genomic region
(about GC identifiers)
Start:
|
66,382,446 bp from pter |
End:
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66,722,426 bp from pter |
Size:
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339,981 bases |
Orientation:
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plus strand |
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Proteins
for CCDC102B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: C102B_HUMAN, Q68D86 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 102B Size: 513 amino acids; 60448 Da
Sequence caution: Sequence=AAH56269.1; Type=Miscellaneous discrepancy; Note=wrong intron-exon boundaries;Sequence=BAB15706.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAD38721.2;Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAD38721.2; Type=Frameshift;Positions=200;
Secondary accessions: Q7Z467 Q8NDK7 Q9H5C1Alternative splicing: 2 isoforms: Q68D86-1 Q68D86-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CCDC102B: NX_Q68D86
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q68D86
CCDC102B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001087198.1 NP_079057.2
ENSEMBL proteins: ENSP00000461987 ENSP00000463399 ENSP00000463538 ENSP00000353377 ENSP00000462150 ENSP00000463111 ENSP00000316237 ENSP00000351479
Human Recombinant Protein Products:
CCDC102B Antibody Products:
Assay Products for CCDC102B: |
Protein
Domains /
Families
for CCDC102B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q68D86 |
Function
for CCDC102B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC102B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC102B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CCDC102B (NM_001093729) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC102B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC102B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC102B |
1 GenomeRNAi human phenotype for CCDC102B:
|
Pathways & Interactions
for CCDC102B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC102B
|
Drugs & Compounds
for CCDC102B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC102B
Search CenterWatch for drugs/clinical trials and news about CCDC102B / C102B
|
Transcripts
for CCDC102B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC102B gene (2 alternative transcripts): NM_001093729.1 NM_024781.2 Unigene Cluster for CCDC102B: Coiled-coil domain containing 102B Hs.280781 [show with all ESTs]Unigene Representative Sequence: NM_00109372913 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000582077 ENST00000578970 ENST00000582371 ENST00000584775 ENST00000580292(uc002lkh.2)
ENST00000360242(uc002lki.2) ENST00000581520 ENST00000577772(uc002lkj.1)
ENST00000584156 ENST00000577800 ENST00000581103 ENST00000319445(uc002lkk.2)
ENST00000358653
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC102B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC102B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CCDC102B (NM_001093729) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC102B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC102B |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC102B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CCDC102B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC102B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC102B |
Additional cDNA sequence: AK027247.1 AK057282.1 AK091108.1 AK225597.1 AK308114.1 AL833863.1 BC056269.1 BC126448.1 BC126450.1 CR749520.1 8 DOTS entries: DT.439815 DT.95356889 DT.40295818 DT.101977780 DT.111940 DT.40126678 DT.91754828 DT.91675477 24 AceView cDNA sequences: BQ003970 CK823962 AA994548 AA436734 AI337113 AK027247 BX091569 AL833863 AA932364 AV682652 AW964249 CR749520 BC056269 NM_024781 BX102568 AI262120 AK057282 BG541131 BI523645 BM875518 BI524799 CD358365 BM875267 BF091438
GeneLoc Exon Structure
|
Expression
for CCDC102B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC102B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGGGAGAAG
About this image
See CCDC102B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC102B
SOURCE GeneReport for Unigene cluster: Hs.280781
SABiosciences Custom PCR Arrays for CCDC102B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC102B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CCDC102B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC102B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC102B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC102B |
Orthologs
for CCDC102B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CCDC102B gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CCDC102B6 |
Uncharacterized protein |
44(a) |
1 ↔ 1 |
2(96556375-96586300) |
lizard
(Anolis carolinensis) |
Reptilia |
CCDC102B6 |
-- |
41(a) |
1 ↔ 1 |
4(46475319-46480460) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG316386 |
-- |
23(a) |
1 → many |
2L(6491122-6496986) |
worm
(Caenorhabditis elegans) |
Secernentea |
F53F10.16 |
Protein F53F10.1 |
27(a) |
1 → many |
I(3834120-3837768) |
ENSEMBL Gene Tree for CCDC102B (if available)
TreeFam Gene Tree for CCDC102B (if available) |
Paralogs
for CCDC102B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCDC102B gene
- CGN2 CCDC102A2 CGNL12
1 SIMAP similar gene for CCDC102B using alignment to 7 protein entries: C102B_HUMAN (see all proteins):CCDC102A
CCDC102B for paralogs About GeneDecksing
|
Genomic Variants
for CCDC102B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC102B (66382446 - 66632446 bp, first 250kb of CCDC102B)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for CCDC102B
7 CNVs: 29680 50034 102701 4061 29681 88917 102700
1 Indel: 60267 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC102B |
|
Disorders
/ Diseases
for CCDC102B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCDC102B for disorders About GeneDecksing
3  diseases for CCDC102B: About MalaCardscongenital diaphragmatic hernia hernia microphthalmia
Human Genome Epidemiology (HuGE) Navigator: CCDC102B (1 document)
Export disorders for CCDC102B gene to outside databases
|
Publications
for CCDC102B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC102B gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCDC102B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
- Human aminoacylase-1: cloning, regional assignment to distal chromosome 3p21.1, and identification of a cross-hybridizing sequence on chromosome 18. (PubMed id 1707030)1 Miller Y.E....Fisher J.H. (1990)
|
External Searches for CCDC102B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC102B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC102B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC102B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC102B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC102B gene:
Search GeneIP for patents involving CCDC102B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC102B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for CCDC102B | | OriGene Custom Protein Services for CCDC102B | | | OriGene Custom Immunoassay Development | | |
| |
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 | | | CCDC102B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC102B |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC102B |
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