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Aliases for CCDC101 Gene

Aliases for CCDC101 Gene

  • Coiled-Coil Domain Containing 101 2 3
  • Coiled-Coil Domain-Containing Protein 101 3 4
  • STAF36 3 6
  • SGF29 3 4
  • SAGA-Associated Factor 29 Homolog (Yeast) 2
  • SAGA-Associated Factor 29 Homolog 3

External Ids for CCDC101 Gene

Summaries for CCDC101 Gene

Entrez Gene Summary for CCDC101 Gene

  • CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]

GeneCards Summary for CCDC101 Gene

CCDC101 (Coiled-Coil Domain Containing 101) is a Protein Coding gene. Diseases associated with CCDC101 include diabetic macular edema. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include methylated histone binding. An important paralog of this gene is LOC388242.

UniProtKB/Swiss-Prot for CCDC101 Gene

  • Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated Lys-4 of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC101 Gene

Genomics for CCDC101 Gene

Genomic Location for CCDC101 Gene

Start:
28,553,915 bp from pter
End:
28,591,790 bp from pter
Size:
37,876 bases
Orientation:
Plus strand

Genomic View for CCDC101 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC101 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC101 Gene

Regulatory Elements for CCDC101 Gene

Proteins for CCDC101 Gene

  • Protein details for CCDC101 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ES7-SGF29_HUMAN
    Recommended name:
    SAGA-associated factor 29 homolog
    Protein Accession:
    Q96ES7
    Secondary Accessions:
    • Q96MF5

    Protein attributes for CCDC101 Gene

    Size:
    293 amino acids
    Molecular mass:
    33238 Da
    Quaternary structure:
    • Interacts with TADA3L, GCN5L2, SUPT3H and MYC (By similarity). Component of some SAGA-type complexes. Interacts with dimethylated and trimethylated Lys-4 of histone H3 (H3K4me2 and H3K4me3), with a preference for the trimethylated form (H3K4me3). Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.

    Three dimensional structures from OCA and Proteopedia for CCDC101 Gene

neXtProt entry for CCDC101 Gene

Proteomics data for CCDC101 Gene at MOPED

Post-translational modifications for CCDC101 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC101 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC101 Gene

Domains for CCDC101 Gene

Protein Domains for CCDC101 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SGF29_HUMAN
Domain:
  • The SGF29 tudor-like domain mediates binding to methylated Lys-4 of histone H3 (H3K4me).:
    • Q96ES7
  • Contains 1 SGF29 C-terminal domain.:
    • Q96ES7
Family:
  • Belongs to the SGF29 family.:
    • Q96ES7
genes like me logo Genes that share domains with CCDC101: view

No data available for Gene Families for CCDC101 Gene

Function for CCDC101 Gene

Molecular function for CCDC101 Gene

UniProtKB/Swiss-Prot Function: Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated Lys-4 of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation.

Gene Ontology (GO) - Molecular Function for CCDC101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0035064 methylated histone binding IDA 20850016
genes like me logo Genes that share ontologies with CCDC101: view

Phenotypes for CCDC101 Gene

MGI mutant phenotypes for CCDC101:
inferred from 1 alleles
GenomeRNAi human phenotypes for CCDC101:
genes like me logo Genes that share phenotypes with CCDC101: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CCDC101 Gene

Localization for CCDC101 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC101 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC101 Gene COMPARTMENTS Subcellular localization image for CCDC101 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CCDC101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
GO:0070461 SAGA-type complex IDA 18838386
genes like me logo Genes that share ontologies with CCDC101: view

Pathways for CCDC101 Gene

genes like me logo Genes that share pathways with CCDC101: view

Pathways by source for CCDC101 Gene

Interacting Proteins for CCDC101 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000316114%0d%0a9606.ENSP00000307684%0d%0a9606.ENSP00000360515%0d%0a9606.ENSP00000367406%0d%0a9606.ENSP00000252996%0d%0a9606.ENSP00000429986%0d%0a
Selected Interacting proteins: Q96ES7-SGF29_HUMAN ENSP00000316114 for CCDC101 Gene via MINT STRING UniProtKB I2D

Symbol External ID(s) Details
HIST1H3J
HIST1H3A
HIST1H3B
HIST1H3C
HIST1H3D

Gene Ontology (GO) - Biological Process for CCDC101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0043966 histone H3 acetylation IDA 18838386
GO:0071169 establishment of protein localization to chromatin TAS 20850016
genes like me logo Genes that share ontologies with CCDC101: view

Transcripts for CCDC101 Gene

mRNA/cDNA for CCDC101 Gene

Unigene Clusters for CCDC101 Gene

Coiled-coil domain containing 101:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC101 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1: - -
SP2: - -
SP3: -
SP4:

Relevant External Links for CCDC101 Gene

GeneLoc Exon Structure for
CCDC101
ECgene alternative splicing isoforms for
CCDC101

Expression for CCDC101 Gene

mRNA expression in normal human tissues for CCDC101 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCDC101 Gene

SOURCE GeneReport for Unigene cluster for CCDC101 Gene Hs.655476

genes like me logo Genes that share expressions with CCDC101: view

Orthologs for CCDC101 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC101 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC101 36
  • 99.2 (n)
  • 100 (a)
CCDC101 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 99 (a)
OneToMany
CCDC101 36
  • 92.61 (n)
  • 98.98 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 92 (a)
OneToMany
CCDC101 36
  • 93.06 (n)
  • 98.98 (a)
mouse
(Mus musculus)
Mammalia Ccdc101 36
  • 90.78 (n)
  • 98.29 (a)
Ccdc101 16
Ccdc101 37
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ccdc101 36
  • 89.8 (n)
  • 98.43 (a)
chicken
(Gallus gallus)
Aves CCDC101 36
  • 81 (n)
  • 94.54 (a)
CCDC101 37
  • 95 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 96 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc101 36
  • 81.34 (n)
  • 95.56 (a)
Str.1997 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11051 36
zebrafish
(Danio rerio)
Actinopterygii ccdc101 36
  • 76.04 (n)
  • 90.76 (a)
ccdc101 37
  • 91 (a)
OneToMany
Dr.13656 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005116 36
  • 58.18 (n)
  • 54.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sgf29 36
  • 54.74 (n)
  • 52.4 (a)
Sgf29 37
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T22B7.4 37
  • 14 (a)
ManyToMany
Y17G9B.8 36
  • 47.12 (n)
  • 41.83 (a)
Y17G9B.8 37
  • 35 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3192 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
OneToMany
Species with no ortholog for CCDC101:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC101 Gene

ENSEMBL:
Gene Tree for CCDC101 (if available)
TreeFam:
Gene Tree for CCDC101 (if available)

Paralogs for CCDC101 Gene

Paralogs for CCDC101 Gene

Selected SIMAP similar genes for CCDC101 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CCDC101 Gene

genes like me logo Genes that share paralogs with CCDC101: view

Variants for CCDC101 Gene

Sequence variations from dbSNP and Humsavar for CCDC101 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs149277 -- 28,554,189(-) CCTCA(G/T)GGAGG intron-variant
rs151229 -- 28,573,616(-) TTTCT(C/T)CTCTA intron-variant
rs151230 -- 28,571,894(-) AAGAA(C/T)GGAAA intron-variant
rs151231 -- 28,571,528(-) gaaac(C/T)tccac intron-variant
rs151232 -- 28,569,012(-) ctccc(A/G)ggttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC101 Gene

Variant ID Type Subtype PubMed ID
dgv842e1 CNV Complex 17122850
dgv843e1 CNV Complex 17122850
nsv833180 CNV Loss 17160897
nsv509608 CNV Insertion 20534489
nsv905689 CNV Loss 21882294
nsv833182 CNV Gain 17160897
nsv905690 CNV Gain 21882294
dgv2664n71 CNV Gain 21882294
nsv905694 CNV Loss 21882294
nsv9416 CNV Gain+Loss 18304495

Relevant External Links for CCDC101 Gene

HapMap Linkage Disequilibrium report
CCDC101

Disorders for CCDC101 Gene

(1) MalaCards Diseases for CCDC101 Gene

Search for CCDC101 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CCDC101 Gene

Relevant External Links for CCDC101

Genetic Association Database (GAD)
CCDC101
Human Genome Epidemiology (HuGE) Navigator
CCDC101
genes like me logo Genes that share disorders with CCDC101: view

No data available for UniProtKB/Swiss-Prot for CCDC101 Gene

Publications for CCDC101 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc. (PMID: 17334388) Kurabe N. … Tashiro F. (Oncogene 2007) 2 3
  4. Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. (PMID: 21685874) Bian C. … Min J. (EMBO J. 2011) 3 4
  5. Common variants at five new loci associated with early-onset inflammatory bowel disease. (PMID: 19915574) Imielinski M. … Hakonarson H. (Nat. Genet. 2009) 3 49

Products for CCDC101 Gene

Sources for CCDC101 Gene

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