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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCBP2 Gene

protein-coding   GIFtS: 62
GCID: GC03P042851

chemokine binding protein 2


(Previous symbol: CMKBR9)
 Explore 32 diseases affiliated with
CCBP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CCBP2    

Aliases
for CCBP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chemokine Binding Protein 21 2     C-C Chemokine Receptor D62 3
CCR101 2 3 5     CC-Chemokine-Binding Receptor JAB612
CMKBR91 2 3 5     Chemokine (C-C Motif) Receptor 92
CCR91 2 5     Chemokine (C-C) Receptor 92
D61 2 5     Chemokine Receptor D62
Chemokine Receptor CCR-102 3     Chemokine-Binding Protein 22
Chemokine Receptor CCR-92 3     HD61
Chemokine-Binding Protein D62 3     

External Ids:    HGNC: 15651   Entrez Gene: 12382   Ensembl: ENSG000001446487   OMIM: 6026485   UniProtKB: O005903   

Export aliases for CCBP2 gene to outside databases

Previous GC identifers: GC03P042155 GC03P042030 GC03P042665 GC03P042811 GC03P042825


Summaries
for CCBP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CCBP2:
This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G
protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment
of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells.
The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its
function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth
of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific
function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine
receptor genes. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCBP2_HUMAN, O00590
Function: Receptor for C-C type chemokines including SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3

Gene Wiki entry for CCBP2


Genomic Views
for CCBP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCBP2 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   MEF-2A   Nkx3-1 v2   E2F   E2F-1   Nkx3-1 v3   aMEF-2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCBP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCBP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p21.3

CCBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCBP2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P042851:  view genomic region     (about GC identifiers)

Start:
 42,846,244 bp from pter      End:
 42,949,597 bp from pter
Size:
 103,354 bases      Orientation:
 plus strand

Proteins
for CCBP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CCBP2_HUMAN, O00590 (See protein sequence)
Recommended Name: Chemokine-binding protein 2  
Size: 384 amino acids; 43443 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B2R8Y8 O00537 Q53YA1 Q86UN9 Q96A02

Explore the universe of human proteins at neXtProt for CCBP2: NX_O00590

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00590

    • CCBP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001287.2  
    ENSEMBL proteins: 
     ENSP00000396150   ENSP00000416996   ENSP00000273145  
    Reactome Protein details: O00590
    Human Recombinant Protein Products: 
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    Novus Biologicals CCBP2 Proteins
    Novus Biologicals CCBP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CCBP2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9364936


    CCBP2 for ontologies           About GeneDecksing



    CCBP2 Antibody Products: 
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    Uscn ELISAs and CLIAs for CCBP2

    Protein Domains /
    Families
    for CCBP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CCBP2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001277 Chemokine_CXCR4
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O00590

    ProtoNet protein and cluster: O00590

    1 Blocks protein family: IPB000355 Chemokine receptor signature

    UniProtKB/Swiss-Prot: CCBP2_HUMAN, O00590
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for CCBP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CCBP2_HUMAN, O00590
    Function: Receptor for C-C type chemokines including SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3

         Genatlas biochemistry entry for CCBP2:
    chemokin CC,binding protein 2,receptor 10,with affinity binding for monocyte chemoattractant protein 1 (SCYA2) and 2
    (SCYA8),primarily expressed in placenta and fetal liver,G protein coupled receptor superfamily

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CCBP2:
    hsa-miR-146a hsa-miR-146b-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CCBP2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCBP2 (see all 7)
    OriGene shRNA RFP: CCBP2
    OriGene siRNA: CCBP2
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004950chemokine receptor activity TAS9364936
    GO:0005515protein binding ----
    GO:0016493C-C chemokine receptor activity IEA--
    GO:0016494C-X-C chemokine receptor activity IEA--
    GO:0019957C-C chemokine binding IEA--


    CCBP2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Ccbp2tm1Gjg for CCBP2
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ccbp2):
     immune system  integument  mortality/aging  reproductive system 

    CCBP2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CCBP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		Peptide ligand-binding receptors0.61
    		GPCR ligand binding0.75
    		GPCRs, Class A Rhodopsin-like0.41
    2Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    3Chemokine receptors bind chemokines
    		Chemokine receptors bind chemokines1.00
    4Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    		Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CCBP2
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    1 BioSystems Pathway for CCBP2 
        GPCRs, Class A Rhodopsin-like

    5/6        Reactome Pathways for CCBP2 (see all 6)
        Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR
    GPCR ligand binding



    CCBP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCBP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/18 Interacting proteins for CCBP2 (O005903 ENSP000002731454) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL3L3P166193, ENSP000003676054I2D: score=3 STRING: ENSP00000367605
    CCL7P800983, ENSP000002003074I2D: score=4 STRING: ENSP00000200307
    CCL14Q166273, ENSP000004091974I2D: score=3 STRING: ENSP00000409197
    CCL2P135003, ENSP000002258314I2D: score=3 STRING: ENSP00000225831
    CCL3L1P166193I2D: score=3 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis TAS9364936
    GO:0006955immune response TAS9364936
    GO:0007165signal transduction ----
    GO:0007186G-protein coupled receptor signaling pathway TAS9364936
    GO:0007275multicellular organismal development TAS9364936


    CCBP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CCBP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCBP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCBP2
    4 Novoseek chemical compound relationships for CCBP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    teck 95.9 11 11493434 (2), 15833102 (1), 16839611 (1), 11046037 (1) (see all 9)
    ccl3 68.2 2 15818740 (1), 17011161 (1)
    rantes 47.3 2 15818740 (1), 9139699 (1)
    glycogen 0 3 11997671 (1), 11493434 (1)

    Search CenterWatch for drugs/clinical trials and news about CCBP2 

    Transcripts
    for CCBP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CCBP2 gene: 
    NM_001296.4  

    Unigene Cluster for CCBP2:

    Chemokine binding protein 2
    Hs.146346  [show with all ESTs]
    Unigene Representative Sequence: BC011588
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000565749(uc003cmc.1) ENST00000496604 ENST00000463699 ENST00000487368
    ENST00000460855 ENST00000498111 ENST00000442925(uc003cmf.3) ENST00000471537(uc003cmg.3)
    ENST00000480215 ENST00000422265(uc003cme.3) ENST00000497921 ENST00000492609
    ENST00000494619 ENST00000493193 ENST00000273145

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CCBP2:
    hsa-miR-146a hsa-miR-146b-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CCBP2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCBP2 (see all 7)
    OriGene shRNA RFP: CCBP2
    OriGene siRNA: CCBP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCBP2
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK313561.1 BC008816.2 BC011588.1 BC011631.2 BC018716.1 BC020558.1 BC101629.1 BC112045.1 
    BC118656.1 BT006800.1 DQ229109.1 U94888.1 Y12815.1 

    14 DOTS entries:

    DT.106799  DT.95362905  DT.120860164  DT.95121102  DT.91874383  DT.91974473  DT.92419189  DT.120860141 
    DT.120860231  DT.120860236  DT.95151377  DT.95153343  DT.40191441  DT.97824286 

    24/189 AceView cDNA sequences (see all 189):

    BM674860 AA399554 BC041820 CR610139 AA424410 AI700588 BC011631 BE466204 
    AI870497 AK054699 BC011588 AI570427 BF110494 W61299 AW771170 BX116130 
    AI306141 BE669583 AA610143 NM_001296 BC008816 BM726888 BC020558 BI056128 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CCBP2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:                                                                                    
    SP2:        -     -           -     -     -     -     -     -                           
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                  -     -                           


    ECgene alternative splicing isoforms for CCBP2

    Expression
    for CCBP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCBP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTTCCGGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CCBP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Syncytiotrophoblast-like cells (Generation of syncyt...)

    See CCBP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCBP2

    SOURCE GeneReport for Unigene cluster: Hs.146346

    UniProtKB/Swiss-Prot: CCBP2_HUMAN, O00590
    Tissue specificity: Expressed primarily in placenta and fetal liver, and found at very low levels in the lung and lymph
    node. Found in endothelial cells lining afferent lymphatics in dermis and lymph nodes. Also found in lymph nodes
    subcapsular and medullary sinuses, tonsillar lymphatic sinuses and lymphatics in mucosa and submucosa of small and
    large intestine and appendix. Also found in some malignant vascular tumors

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCBP2: 
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              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for CCBP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CCBP2 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CCBP21 chemokine binding protein 2 56.73(n)
    47.08(a)    		   420393  XM_418499.3  XP_418499.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CU633991.16
    		 --
    		 31(a)
    		 1 ↔ 1
    		 2(3922257-3923551)


    ENSEMBL Gene Tree for CCBP2 (if available)
    TreeFam Gene Tree for CCBP2 (if available) 

    Paralogs
    for CCBP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCBP2 gene
    CCR62  CCR52  CXCR62  CXCR32  XCR12  CCR92  CCRL22  CCR72  
    CX3CR12  CCR82  CXCR22  CCRL12  CCR42  CCR12  CXCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    18/32 SIMAP similar genes for CCBP2 using alignment to 2 protein entries:     CCBP2_HUMAN (see all proteins) (see all similar genes):
    CCR-5    CCR5    CCR4    CCR2    CXCR2    IL8RB
    CCR9    CCR3    CCR6    CCR7    CCRL2    CXCR1
    CXCR3    CX3CR1    CCR8    AGTR1    CCR1    CXCR6

    CCBP2 for paralogs           About GeneDecksing



    Genomic Variants
    for CCBP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/988 NCBI SNPs in CCBP2 are shown (see all 988)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1508037411,2
    		--42849084(+) TTTAAA/TCCAAT 1 -- us2k10--------
    rs1932133871,2
    		--42849106(+) CTCCCA/TATCCA 1 -- us2k10--------
    rs67771691,2
    		C,A,H,--42849148(+) AAGAAA/GTAATT 1 -- us2k112Minor allele frequency- G:0.06WA NA CSA EA 374
    rs1826311941,2
    		--42849193(+) TTATTA/GGAAAA 1 -- us2k10--------
    rs1877487801,2
    		--42849359(+) GCCATA/GGCATT 1 -- us2k10--------
    rs1913332201,2
    		--42849477(+) CTGTTG/TTATCA 1 -- us2k10--------
    rs1842877251,2
    		--42849519(+) ATCTCC/TCATGT 1 -- us2k10--------
    rs1380683261,2
    		--42849578(+) GAATGC/GCTAAC 1 -- us2k10--------
    rs1495321371,2
    		--42849630(+) CTAGCC/TCCTAT 1 -- us2k10--------
    rs1886721641,2
    		--42849745(+) GATTCC/TGCTAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCBP2 (42846244 - 42949597 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CCBP2
         2 Indels: 63455 91295

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    Disorders / Diseases
    for CCBP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CCBP2 for disorders           About GeneDecksing

    OMIM gene information: 602648    OMIM disorders: --

    20/32 diseases for CCBP2 (see all 32):    About MalaCards
    graft versus host disease    papillary cystadenoma    b-cell lymphomas    cystadenoma
    lymphocytic leukemia    inflammatory bowel disease    adult t-cell leukemia    chronic lymphocytic leukemia
    acute lymphocytic leukemia    leukemia/lymphoma    t-cell leukemia    mediastinitis
    hepatitis c    leukemia    skin disease    crohn's disease
    hepatitis b    sinusitis    melanoma    hepatocellular carcinoma

    7 Novoseek disease relationships for CCBP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 36.9 9 18822328 (2), 18708360 (1), 15306587 (1), 16785557 (1) (see all 5)
    t-all 35.5 1 14656893 (1)
    metastasis 35.3 3 19283928 (1), 15086589 (1)
    melanoma 13.7 4 19283928 (1), 15086589 (1), 16638848 (1)
    lymphoma 4.02 1 17071491 (1)
    tumors 2.15 8 19056145 (3), 11238036 (2)
    immunodeficiency 0 1 16014924 (1)

    Human Genome Epidemiology (HuGE) Navigator: CCBP2 (5 documents)

    Export disorders for CCBP2 gene to outside databases

    Publications
    for CCBP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCBP2 gene, integrated from 9 sources (see all 122):
    (articles sorted by number of sources associating them with CCBP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6. (PubMed id 9405404)1, 2, 3 Nibbs R.J....Graham G.J. (1997)
    2. Cloning, expression, and chromosomal mapping of a novel human CC- chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3. (PubMed id 9364936)1, 2, 3 Bonini J.A....Steiner D.F. (1997)
    3. The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors. (PubMed id 11238036)1, 2, 9 Nibbs R.J.B....Rot A. (2001)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. [AH8165, a new muscle relaxant]. (PubMed id 16148)1, 3 Iwatsuki K....Shima T. (1977)
    6. Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. (PubMed id 9139699)1, 9 Nibbs R.J....Graham G.J. (1997)
    7. CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. (PubMed id 12671049)1, 9 Kunkel E.J....Butcher E.C. (2003)
    8. Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome. (PubMed id 10702689)1, 9 Maho A....Parmentier M. (1999)
    9. Genetic variations of the chemokine scavenger receptor D6 are associated with liver inflammation in chronic hepatitis C. (PubMed id 18822328)1, 9 Wiederholt T....Wasmuth H.E. (2008)
    10. The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes. (PubMed id 16014924)1, 9 Neil S.J....Weiss R.A. (2005)

    External Searches for CCBP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing CCBP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1238 HGNC: 1565 AceView: FLJ45880andDKFZP434B172andLOC339903 Ensembl:ENSG00000144648 euGenes: HUgn1238
    ECgene: CCBP2 H-InvDB: CCBP2

    Other Databases showing CCBP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CCBP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCBP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCBP2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CCBP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCBP2 gene:
    Search GeneIP for patents involving CCBP2

    GeneCards and IP:
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