Aliases for CCBL1 Gene
- Cysteine Conjugate-Beta Lyase, Cytoplasmic 2 3
- Glutamine Transaminase K 2 3 4
- Cysteine Conjugate-Beta Lyase; Cytoplasmic (Glutamine Transaminase K, Kyneurenine Aminotransferase) 2 3
- Kynurenine--Oxoglutarate Transaminase I 3 4
- Glutamine--Phenylpyruvate Transaminase 3 4
- Cysteine-S-Conjugate Beta-Lyase 3 4
- Kynurenine Aminotransferase I 3 4
- Kyneurenine Aminotransferase 2 3
- KATI 3 4
External Ids for CCBL1 Gene
This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for CCBL1 Gene
CCBL1 (Cysteine Conjugate-Beta Lyase, Cytoplasmic) is a Protein Coding gene. Diseases associated with CCBL1 include schizophrenia. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include protein homodimerization activity and transaminase activity. An important paralog of this gene is TAT.
UniProtKB/Swiss-Prot for CCBL1 Gene
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.