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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCAR2 Gene

protein-coding   GIFtS: 41
GCID: GC08P022463

Cell Cycle And Apoptosis Regulator 2

(Previous name: KIAA1967)
(Previous symbol: KIAA1967)
  Search for CCAR2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cell Cycle And Apoptosis Regulator 21 2     DBIRD Complex Subunit KIAA19672
KIAA19671 2 5     Deleted In Breast Cancer 12
DBC12 3 5     P30 DBC Protein2
DBC-12 3     p30DBC2
P30 DBC2 3     DBC.13
Deleted In Breast Cancer1     Deleted In Breast Cancer Gene 1 Protein3
NET352     

External Ids:    HGNC: 233601   Entrez Gene: 578052   Ensembl: ENSG000001589417   OMIM: 6073595   UniProtKB: Q8N1633   
ORGUL members:         
NONCODE14:n409517      

Export aliases for CCAR2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CCAR2 Gene: 
CCAR2 (cell cycle and apoptosis regulator 2) is a protein-coding gene, and is affiliated with the lncRNA class. Among its related super-pathways are Cell Cycle / Checkpoint Control. An important paralog of this gene is CCAR1.

UniProtKB/Swiss-Prot: K1967_HUMAN, Q8N163
Function: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP
particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative
splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of
exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of
p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a
histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear
hormone receptors

Gene Wiki entry for CCAR2 (KIAA1967) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CCAR2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCAR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCAR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCAR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p22

CCAR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCAR2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P022463:  view genomic region     (about GC identifiers)

Start:
22,462,145 bp from pter      End:
22,479,027 bp from pter
Size:
16,883 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K1967_HUMAN, Q8N163 (See protein sequence)
Recommended Name: DBIRD complex subunit KIAA1967  
Size: 923 amino acids; 102902 Da
Subunit: Component of the DBIRD complex. Interacts with ZNF326/ZIRD; the interaction is direct. Interacts (via
N-terminus) with SIRT1. Interacts (via N-terminus) with SUV39H1; this interaction abolishes the interaction with
SIRT1. Part of a complex composed at least of ASCL2, C11orf30/EMSY, HCFC1, HSPA8, KIAA1967, MATR3, MKI67,RBBP5,
TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAG02472.1; Type=Frameshift; Positions=610, 622, 794, 810; Sequence=BAB85553.1;
Type=Erroneous initiation;
Secondary accessions: A6NL03 B2RB79 D3DSR6 Q6P0Q9 Q8N3G7 Q8N8M1 Q8TF34 Q9H9Q9 Q9HD12 Q9NT55
Alternative splicing: 2 isoforms:  Q8N163-1   Q8N163-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCAR2: NX_Q8N163

Explore proteomics data for CCAR2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N163

  • CCAR2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCAR2 Protein Expression
    REFSEQ proteins: NP_066997.3  
    ENSEMBL proteins: 
     ENSP00000310670   ENSP00000430974   ENSP00000429769   ENSP00000373930   ENSP00000430978  
     ENSP00000428843   ENSP00000431046   ENSP00000429773   ENSP00000429739   ENSP00000428549  

    Human Recombinant Protein Products for CCAR2: 
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    Novus Biologicals CCAR2 Proteins
    Novus Biologicals CCAR2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA--
    GO:0005634nucleus IDA--
    GO:0005681colocalizes with spliceosomal complex IDA--
    GO:0005737cytoplasm IDA15824730
    GO:0005759mitochondrial matrix IDA15824730

    CCAR2 for ontologies           About GeneDecksing



    CCAR2 Antibody Products: 
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    Novus Biologicals CCAR2 Antibodies
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    Browse Antibodies at Cloud-Clone Corp. 
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    Search LSBio for Antibodies for CCAR2 

    Assay Products for CCAR2: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR025223 S1-like_RNA-bd_dom
     IPR025954 DBC1/CARP1_inactive_NUDIX_dom
     IPR025224 DBC1/CARP1

    Graphical View of Domain Structure for InterPro Entry Q8N163

    ProtoNet protein and cluster: Q8N163


    CCAR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: K1967_HUMAN, Q8N163
    Function: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP
    particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative
    splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of
    exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of
    p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a
    histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear
    hormone receptors

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000993RNA polymerase II core binding IDA--
    GO:0004857enzyme inhibitor activity IMP19218236
    GO:0005515protein binding IPI17314511
    GO:0019899enzyme binding IPI18235501
         
    CCAR2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCAR2:
     Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for 2610301G19Rik):
     immune system  liver/biliary system 

    CCAR2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCAR2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCAR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCAR2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCAR2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCAR2
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    SwitchGear 3'UTR luciferase reporter plasmidCCAR2 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCAR2

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CCAR2

    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of CCAR2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCAR2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCAR2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1DNA Damage
    DNA Damage0.32
    2TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    3Apoptosis and Autophagy
    Apoptosis and Autophagy
    4Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for CCAR2
        Chromatin Regulation / Acetylation
    Apoptosis and Autophagy
    DNA Damage

    1 BioSystems Pathway for CCAR2
        TNF-alpha/NF-kB Signaling Pathway



    CCAR2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCAR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/60 Interacting proteins for CCAR2 (Q8N1631, 2, 3 ENSP000003106704) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011061, 3, ENSP000003672074EBI-355410,EBI-447544 I2D: score=3 STRING: ENSP00000367207
    RELBQ012012, 3, ENSP000002214524MINT-49016 I2D: score=2 STRING: ENSP00000221452
    NFKB1P198382, 3, ENSP000002265744MINT-48675 I2D: score=1 STRING: ENSP00000226574
    SF3A2Q154282, 3, ENSP000002214944MINT-5206277 I2D: score=1 STRING: ENSP00000221494
    MAP3K3Q997592, 3MINT-48469 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0006915apoptotic process ----
    GO:0008380RNA splicing IMP--
    GO:0009411response to UV IMP--
    GO:0032784regulation of DNA-dependent transcription, elongation IMP--

    CCAR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCAR2 (K1967)

    Search CenterWatch for drugs/clinical trials and news about CCAR2 / K1967

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCAR2 gene (2 alternative transcripts): 
    NM_199205.1  NM_021174.5  

    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308511(uc003xch.3) ENST00000523801 ENST00000521301 ENST00000389279(uc003xci.3)
    ENST00000521837 ENST00000523349 ENST00000518989 ENST00000520861(uc003xcj.1)
    ENST00000522599 ENST00000521020 ENST00000520738 ENST00000521436 ENST00000520536

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCAR2
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCAR2

    24/408 AceView cDNA sequences (see all 408):

    CR595864 BU684981 NM_021174 BI820197 CR608004 BM456908 BM925200 BM788388 
    BE742364 AA911049 AI927868 F36914 AI685404 NM_021630 AA883927 BI760829 
    BX363112 AI674694 BU179002 T08526 BM715147 CR623059 NM_198042 AW501555 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CCAR2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                                -                 -                                                                                                   
    SP2:                                                                                                                                                      
    SP3:                                                  -                                                                                                   
    SP4:                                                                                                                                                      
    SP5:                                                  -                                                                                                   


    ECgene alternative splicing isoforms for CCAR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCAR2 expression in normal human tissues (normalized intensities)      CCAR2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CCAR2 Expression
    About this image


    CCAR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   

    See CCAR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCAR2

    UniProtKB/Swiss-Prot: K1967_HUMAN, Q8N163
    Tissue specificity: Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung,
    and colon tissues

        SABiosciences Custom PCR Arrays for CCAR2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCAR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CCAR2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2610301G19Rik1 , 5 RIKEN cDNA 2610301G19 gene1, 5 87.92(n)1
    91.54(a)1
      14 (36.24 cM)5
    2191581  NM_146055.31  NP_666167.31 
     701381685 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA19676
    KIAA1967
    57(a)
    1 ↔ 1
    GL343443.1(564698-588394)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-24n17.56
    si:dkey-24n17.5
    30(a)
    1 ↔ 1
    10(2903212-2925111)
    worm
    (Caenorhabditis elegans)
    Secernentea lst-36
    Protein LST-3, isoform a
    16(a)
    1 → many
    IV(14071373-14076744)


    ENSEMBL Gene Tree for CCAR2 (if available)
    TreeFam Gene Tree for CCAR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCAR2 gene
    CCAR12  

    CCAR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/885 SNPs in CCAR2 are shown (see all 885)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115555431,2
    C--22462346(+) TGCCCG/TGGCCC 2 -- us2k1 nc-transcript-variant0--------
    rs37359011,2
    C,A--22462374(-) GCGGCA/GGGGGG 2 -- us2k1 int15Minor allele frequency- G:0.31NA WA EA 362
    rs1422863161,2
    C--22462542(+) GGAGAA/GACCGC 2 -- ut51 int10--------
    rs1180072351,2
    C,F--22462579(+) CGCCGC/G/TGGCTC 3 -- ut51 int11EA 120
    rs1167656171,2
    C,F--22462672(+) GGTTTC/TGCGTT 2 -- ut51 int12Minor allele frequency- T:0.06WA EA 238
    rs117778081,2
    C,F,A,H--22462755(+) CACACA/C/GGTCTC 3 -- ut51 int122NS EA NA WA CSA 2124
    rs795501391,2
    C,F--22462758(+) ACAGTC/GTCCTC 2 -- ut51 int11Minor allele frequency- G:0.14WA 118
    rs750912321,2
    C--22462835(+) AAGGAA/GTGTCA 2 -- ut51 int10--------
    rs117786931,2
    C,F,A,H--22462852(+) CTCTCT/CCGAGC 2 -- ut51 int125Minor allele frequency- C:0.30NS EA NA WA CSA 2357
    rs1456196741,2
    C--22462963(+) GTTATA/GTGGCC 2 -- int10--------

    HapMap Linkage Disequilibrium report for CCAR2 (22462145 - 22479027 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCAR2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CCAR2
    DNA2.0 Custom Variant and Variant Library Synthesis for CCAR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CCAR2 for disorders           About MalaCards
    OMIM gene information: 607359    OMIM disorders: --


    CCAR2 for disorders           About GeneDecksing


    Export disorders for CCAR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCAR2 gene, integrated from 9 sources (see all 78):
    (articles sorted by number of sources associating them with CCAR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DBC2, a candidate for a tumor suppressor gene involved in breast cancer. (PubMed id 12370419)1, 2, 3 Hamaguchi M.... Wigler M.H. (2002)
    2. DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. (PubMed id 22446626)1, 2 Close P.... Svejstrup J.Q. (2012)
    3. Inhibition of SUV39H1 methyltransferase activity by DBC1. (PubMed id 19218236)1, 2 Li Z.... Chen J. (2009)
    4. Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. (PubMed id 19131338)1, 2 Garapaty S....Samuels H.H. (2009)
    5. DBC1 is a negative regulator of SIRT1. (PubMed id 18235501)1, 2 Kim J.-E.... Lou Z. (2008)
    6. Negative regulation of the deacetylase SIRT1 by DBC1. (PubMed id 18235502)1, 2 Zhao W.... Gu W. (2008)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2 Nagase T.... Ohara O. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57805 HGNC: 23360 AceView: DBC-1andPDLIM2 Ensembl:ENSG00000158941 euGenes: HUgn57805
    ECgene: CCAR2 H-InvDB: CCAR2

    (According to HUGE)
    About This Section
    HUGE: KIAA1967

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCAR2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCAR2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCAR2 gene:
    Search GeneIP for patents involving CCAR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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