Aliases for CCAR2 Gene
External Ids for CCAR2 Gene
Previous Symbols for CCAR2 Gene
GeneCards Summary for CCAR2 Gene
CCAR2 (Cell Cycle And Apoptosis Regulator 2) is a Protein Coding gene. Diseases associated with CCAR2 include breast cancer. Among its related pathways are Chromatin Regulation / Acetylation and Cell Cycle / Checkpoint Control. GO annotations related to this gene include enzyme binding and RNA polymerase II core binding. An important paralog of this gene is CCAR1.
UniProtKB/Swiss-Prot for CCAR2 Gene
Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation.