Aliases for CCAR2 Gene
External Ids for CCAR2 Gene
Previous HGNC Symbols for CCAR2 Gene
Previous GeneCards Identifiers for CCAR2 Gene
GeneCards Summary for CCAR2 Gene
CCAR2 (Cell Cycle And Apoptosis Regulator 2) is a Protein Coding gene. Diseases associated with CCAR2 include breast cancer. Among its related pathways are Chromatin Regulation / Acetylation and Cell Cycle / Checkpoint Control. GO annotations related to this gene include enzyme binding and RNA polymerase II core binding. An important paralog of this gene is CCAR1.
UniProtKB/Swiss-Prot for CCAR2 Gene
Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation.