Aliases for CCAR2 Gene
Aliases for CCAR2 Gene
External Ids for CCAR2 Gene
- HGNC: 23360
- Entrez Gene: 57805
- Ensembl: ENSG00000158941
- OMIM: 607359
- UniProtKB: Q8N163
Previous HGNC Symbols for CCAR2 Gene
- KIAA1967
Previous GeneCards Identifiers for CCAR2 Gene
- GC08P022463
Summaries for CCAR2 Gene
GeneCards Summary for CCAR2 Gene
CCAR2 (Cell Cycle And Apoptosis Regulator 2) is a Protein Coding gene. Diseases associated with CCAR2 include Estrogen-Receptor Negative Breast Cancer and Breast Cancer. Among its related pathways are Circadian rythm related genes and Apoptosis and Autophagy. GO annotations related to this gene include poly(A) RNA binding and enzyme inhibitor activity. An important paralog of this gene is CCAR1.
UniProtKB/Swiss-Prot for CCAR2 Gene
-
Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:18235501, PubMed:18235502, PubMed:19131338, PubMed:19218236, PubMed:22446626, PubMed:23352644, PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCAR2 Gene
Genomics for CCAR2 Gene
Regulatory Elements for CCAR2 Gene
Enhancers for CCAR2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CCAR2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for CCAR2 Gene
- Chromosome:
- 8
- Start:
- 22,604,632 bp from pter
- End:
- 22,621,514 bp from pter
- Size:
- 16,883 bases
- Orientation:
- Plus strand
Genomic View for CCAR2 Gene
Genes around CCAR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p21.3 by Ensembl
- 8p21.3 by Entrez Gene
- 8p21.3 by HGNC
CCAR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCAR2 Gene
Proteins for CCAR2 Gene
-
Protein details for CCAR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N163-CCAR2_HUMAN
- Recommended name:
- Cell cycle and apoptosis regulator protein 2
- Protein Accession:
- Q8N163
- A6NL03
- B2RB79
- D3DSR6
- Q6P0Q9
- Q8N3G7
- Q8N8M1
- Q8TF34
- Q9H9Q9
- Q9HD12
- Q9NT55
Protein attributes for CCAR2 Gene
- Size:
- 923 amino acids
- Molecular mass:
- 102902 Da
- Quaternary structure:
-
- Component of the DBIRD complex. Interacts with ZNF326/ZIRD; the interaction is direct. Interacts (via N-terminus) with SIRT1, which inhibits the deacetylation of substrates. Interacts (via N-terminus) with SUV39H1; this interaction abolishes the interaction with SIRT1. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity. Interacts with NR1D1. Interacts (via N-terminus) with ESR1 and ESR2. Interacts (via N-terminus) with HDAC3 (via C-terminus). Interacts with HDAC1 and MED2F. Interacts with MCC. Interacts (via N-terminus) with NR1H2 and NR1H3 in a ligand-independent manner. Interacts with CSNK2A1. Interacts (via N-terminus) with p53/TP53. Interacts (via N-terminus) with BRCA1 (via the BRCT domains). Interacts (via N-terminus) with CHEK2 (via protein kinase domain). Interacts with PSEM3. Interacts (via N-terminus) with PSIA3 and SENP1. The sumoylated form shows a preferential interaction with SIRT1 as compared to its unmodified form.
- SequenceCaution:
-
- Sequence=AAG02472.1; Type=Frameshift; Positions=610, 622, 794, 810; Evidence={ECO:0000305}; Sequence=BAB85553.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for CCAR2 Gene
Post-translational modifications for CCAR2 Gene
- Acetylation at Lys-112 and Lys-215 by KAT8 prevents inhibitory binding to SIRT1 and increases its deacetylase activity.
- ATM/ATR-mediated phosphorylation at Thr-454 upon DNA damage promotes binding to SIRT1. Phosphorylation at Thr-454 promotes its sumoylation by switching the binding partner of CCAR2 from SENP1 to PIAS3.
- Genotoxic stress induces its sumoylation and sumoylation promotes the SIRT1-CCAR2 interaction which in turn inhibits SIRT1-mediated deacetylation of p53/TP53. Sumoylation leads to transcriptional activation of p53/TP53 by sequestering SIRT1 from p53/TP53. Desumoylated by SENP1.
- Ubiquitination at posLast=9393, Lys97, Lys112, Lys309, posLast=347347, posLast=742742, posLast=832832, and Lys839
- Modification sites at PhosphoSitePlus
Other Protein References for CCAR2 Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CCAR2
- Cell Signaling Technology (CST) Antibodies for CCAR2 (DBC-1)
-
Custom Antibody ServicesOriGene Antibodies for CCAR2
- Novus Biologicals Antibodies for CCAR2
- Invitrogen Antibodies for CCAR2
- antibodies-online Antibodies for CCAR2: See all 24
- GeneTex CCAR2 antibody for CCAR2
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCAR2
Protein Products
-
OriGene Purified Proteins for CCAR2
- Search Origene for MassSpec and Protein Over-expression Lysates for CCAR2
- Origene Custom Protein Services for CCAR2
- antibodies-online Proteins for CCAR2: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CCAR2
Assay Products
No data available for DME Specific Peptides for CCAR2 Gene
Domains & Families for CCAR2 Gene
Protein Domains for CCAR2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CCAR2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for CCAR2 Gene
Function for CCAR2 Gene
Molecular function for CCAR2 Gene
- UniProtKB/Swiss-Prot Function:
- Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:18235501, PubMed:18235502, PubMed:19131338, PubMed:19218236, PubMed:22446626, PubMed:23352644, PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000993 | RNA polymerase II core binding | IDA | 22446626 |
| GO:0003723 | RNA binding | IDA | 22658674 |
| GO:0004857 | enzyme inhibitor activity | IMP | 19218236 |
| GO:0005515 | protein binding | IPI | 17314511 |
| GO:0019899 | enzyme binding | IPI | 18235501 |
Phenotypes for CCAR2 Gene
- MGI mutant phenotypes for CCAR2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CCAR2:
Animal Models for CCAR2 Gene
- MGI Knock Outs for CCAR2:
-
- Ccar2 tm1Dac
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCAR2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CCAR2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCAR2 gene
- Search ViGene Biosciences for CCAR2
CRISPR Products
-
OriGene CRISPR knockouts for CCAR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCAR2
- GenScript: Design CRISPR guide RNA sequences for CCAR2
miRNA for CCAR2 Gene
- miRTarBase miRNAs that target CCAR2
miRNA Products
- Search ViGene Biosciences for CCAR2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCAR2
- Browse OriGene Inhibitory RNA Products For CCAR2
-
ViGene Biosciences ready-to-package AAV shRNAs for CCAR2 gene
Clone Products
-
OriGene ORF clones in human for CCAR2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CCAR2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CCAR2
- VectorBuilder custom plasmid, inducible vectors for CCAR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCAR2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CCAR2
-
ViGene Biosciences adenoviral particle packaged cDNA for CCAR2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CCAR2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCAR2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCAR2 Gene
Localization for CCAR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCAR2 Gene
- Nucleus. Cytoplasm. Note=Recruited to chromatin, post-UV irradiation. Sequestered to the cytoplasm in the presence of MCC. Translocated to the cytoplasm during UV-induced apoptosis. {ECO:0000269 PubMed:20160719, ECO:0000269 PubMed:24824780}.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| plasma membrane | 2 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IDA | 23352644 |
| GO:0005634 | nucleus | IDA,IEA | 15824730 |
| GO:0005654 | nucleoplasm | TAS,IDA | -- |
| GO:0005681 | colocalizes_with spliceosomal complex | IDA | 22446626 |
| GO:0005737 | cytoplasm | IEA,IDA | 15824730 |
Pathways & Interactions for CCAR2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular response to heat stress | ||
| 2 | Apoptosis and Autophagy | ||
| 3 | Chromatin Regulation / Acetylation | ||
| 4 | DNA Damage | ||
| 5 | Cellular Senescence | ||
Pathways by source for CCAR2 Gene
3 Cell Signaling Technology pathways for CCAR2 Gene
1 BioSystems pathway for CCAR2 Gene
3 Reactome pathways for CCAR2 Gene
Interacting Proteins for CCAR2 Gene
Selected Interacting proteins:
Q8N163-CCAR2_HUMAN
ENSP00000310670
for CCAR2 Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0006974 | cellular response to DNA damage stimulus | IEA | -- |
No data available for SIGNOR curated interactions for CCAR2 Gene
Transcripts for CCAR2 Gene
mRNA/cDNA for CCAR2 Gene
- (5) REFSEQ mRNAs :
- (408) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CCAR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCAR2
- GenScript: Design CRISPR guide RNA sequences for CCAR2
miRNA Products
- Search ViGene Biosciences for CCAR2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCAR2
- Browse OriGene Inhibitory RNA Products For CCAR2
-
ViGene Biosciences ready-to-package AAV shRNAs for CCAR2 gene
Clone Products
-
OriGene ORF clones in human for CCAR2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CCAR2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CCAR2
- VectorBuilder custom plasmid, inducible vectors for CCAR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCAR2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for CCAR2 Gene
This gene is overexpressed in Tlymphocyte (12.2) and Lymph node (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCAR2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CCAR2 Gene:
CCAR2mRNA Expression by UniProt/SwissProt for CCAR2 Gene:
Q8N163-CCAR2_HUMAN
Tissue specificity:
Expressed in gastric carcinoma tissue and the expression gradually increases with the progression of the carcinoma (at protein level). Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues.
Evidence on tissue expression from TISSUES for CCAR2 Gene
- Nervous system(4.8)
- Liver(4.3)
- Lymph node(2.2)
Primer Products
-
OriGene qPCR primer pairs for CCAR2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCAR2 Gene
Orthologs for CCAR2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCAR2 35 |
|
OneToOne | |
| KIAA1967 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | CCAR2 35 |
|
OneToOne | |
| KIAA1967 34 |
|
||||
| cow (Bos Taurus) |
Mammalia | CCAR2 35 |
|
OneToOne | |
| KIAA1967 34 |
|
||||
| mouse (Mus musculus) |
Mammalia | Ccar2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ccar2 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CCAR2 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CCAR2 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CCAR2 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | CCAR2 35 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | lst-3 35 |
|
OneToMany |
- Species where no ortholog for CCAR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for CCAR2 Gene
(1) SIMAP similar genes for CCAR2 Gene using alignment to 9 proteins:
Variants for CCAR2 Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000022196 | -- | 22,620,118(+) | CCCTC(C/T)TCCGG | nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime | |
| rs1000042341 | -- | 22,608,942(+) | CTTGA(C/T)TTTGT | intron-variant | |
| rs1000053184 | -- | 22,619,963(+) | TGGGG(C/T)CCTTT | nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime | |
| rs1000178075 | -- | 22,605,994(+) | CTGGA(A/G)CTGTA | intron-variant, upstream-variant-2KB | |
| rs1000503478 | -- | 22,616,378(+) | GAGGC(C/T)GCACA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759604 | CNV | loss | 17122850 |
Residual Variation Intolerance Score:
6.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.82;
47.76% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CCAR2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCAR2 Gene
Disorders for CCAR2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| estrogen-receptor negative breast cancer |
|
|
| breast cancer |
|
|
Search CCAR2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CCAR2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CCAR2
No data available for UniProtKB/Swiss-Prot and Genatlas for CCAR2 Gene
Publications for CCAR2 Gene
- Repression of estrogen receptor beta function by putative tumor suppressor DBC1. (PMID: 20074560) Koyama S. … Taketani Y. (Biochem. Biophys. Res. Commun. 2010) 3 4 22 64
- Identification of DBC1 as a transcriptional repressor for BRCA1. (PMID: 20160719) Hiraike H. … Taketani Y. (Br. J. Cancer 2010) 3 4 22 64
- DBC2, a candidate for a tumor suppressor gene involved in breast cancer. (PMID: 12370419) Hamaguchi M. … Wigler M.H. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 64
- CK2I+ phosphorylates DBC1 and is involved in the progression of gastric carcinoma and predicts poor survival of gastric carcinoma patients. (PMID: 24962073) Bae J.S. … Jang K.Y. (Int. J. Cancer 2015) 3 4 64
- CCAR2 negatively regulates nuclear receptor LXRalpha by competing with SIRT1 deacetylase. (PMID: 25661920) Sakurabashi A. … Fujii T. (J. Steroid Biochem. Mol. Biol. 2015) 3 4 64
Products for CCAR2 Gene
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- Addgene plasmids for CCAR2
- antibodies-online Antibodies for CCAR2: See all 24
- Search antibodies-online for kits
- antibodies-online Proteins for CCAR2: See all 3
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- GeneTex CCAR2 antibody for CCAR2
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- ViGene Biosciences adenoviral particle packaged cDNA for CCAR2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CCAR2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CCAR2 gene
- Search ViGene Biosciences for CCAR2
- Santa Cruz Biotechnology (SCBT) Antibodies for CCAR2
- Search Santa Cruz Biotechnology (SCBT) for CCAR2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CCAR2
- Horizon Cell Lines for CCAR2
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCAR2
- VectorBuilder custom plasmid, inducible vectors for CCAR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCAR2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CCAR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer