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CCAR2 Gene

protein-coding   GIFtS: 47
GCID: GC08P022463

Cell Cycle And Apoptosis Regulator 2

(Previous name: KIAA1967)
(Previous symbol: KIAA1967)
  See CCAR2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Cycle And Apoptosis Regulator 21 2     Cell Cycle And Apoptosis Regulator Protein 22
KIAA19671 2 3 5     Deleted In Breast Cancer 12
DBC12 3 5     P30 DBC Protein2
Cell Division Cycle And Apoptosis Regulator Protein 22 3     p30DBC2
DBC-12 3     DBC.13
P30 DBC2 3     DBIRD Complex Subunit KIAA19673
Deleted In Breast Cancer1     Deleted In Breast Cancer Gene 1 Protein3
NET352     

External Ids:    HGNC: 233601   Entrez Gene: 578052   Ensembl: ENSG000001589417   OMIM: 6073595   UniProtKB: Q8N1633   

Export aliases for CCAR2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCAR2 Gene:
CCAR2 (cell cycle and apoptosis regulator 2) is a protein-coding gene. Diseases associated with CCAR2 include breast cancer. GO annotations related to this gene include RNA polymerase II core binding and enzyme binding. An important paralog of this gene is CCAR1.

UniProtKB/Swiss-Prot: CCAR2_HUMAN, Q8N163
Function: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP
particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative
splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of
exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of
p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a
histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear
hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following
UV-induced genotoxic stress

Gene Wiki entry for CCAR2 (KIAA1967) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CCAR2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCAR2 promoter sequence
   Search Chromatin IP Primers for CCAR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCAR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p22

CCAR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCAR2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P022463:  view genomic region     (about GC identifiers)

Start:
22,462,145 bp from pter      End:
22,479,027 bp from pter
Size:
16,883 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCAR2_HUMAN, Q8N163 (See protein sequence)
Recommended Name: Cell cycle and apoptosis regulator protein 2  
Size: 923 amino acids; 102902 Da
Subunit: Component of the DBIRD complex. Interacts with ZNF326/ZIRD; the interaction is direct. Interacts (via
N-terminus) with SIRT1. Interacts (via N-terminus) with SUV39H1; this interaction abolishes the interaction with
SIRT1. Part of a complex composed at least of ASCL2, C11orf30/EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5,
TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity
Sequence caution: Sequence=AAG02472.1; Type=Frameshift; Positions=610, 622, 794, 810; Sequence=BAB85553.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A6NL03 B2RB79 D3DSR6 Q6P0Q9 Q8N3G7 Q8N8M1 Q8TF34 Q9H9Q9 Q9HD12 Q9NT55
Alternative splicing: 2 isoforms:  Q8N163-1   Q8N163-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCAR2: NX_Q8N163

Explore proteomics data for CCAR2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys93, Lys97, Lys112, Lys123, Lys309, Lys347, Lys742, Lys832, Lys839
  • Modification sites at PhosphoSitePlus

  • See CCAR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066997.3  
    ENSEMBL proteins: 
     ENSP00000310670   ENSP00000430974   ENSP00000429769   ENSP00000373930   ENSP00000430978  
     ENSP00000428843   ENSP00000431046   ENSP00000429773   ENSP00000429739   ENSP00000428549  
    Reactome Protein details: Q8N163

    CCAR2 Human Recombinant Protein Products:

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    Novus Biologicals CCAR2 Proteins
    Novus Biologicals CCAR2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CCAR2 

     
    antibodies-online proteins for CCAR2 (2 products) 

     
    antibodies-online peptides for CCAR2

    CCAR2 Antibody Products:

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    antibodies-online antibodies for CCAR2 (21 products) 

    CCAR2 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CCAR2 
    antibodies-online kits for CCAR2 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR025223 S1-like_RNA-bd_dom
     IPR025954 DBC1/CARP1_inactive_NUDIX_dom
     IPR028811 CCAR2
     IPR025224 DBC1/CARP1

    Graphical View of Domain Structure for InterPro Entry Q8N163

    ProtoNet protein and cluster: Q8N163


    Find genes that share domains with CCAR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCAR2_HUMAN, Q8N163
    Function: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP
    particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative
    splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of
    exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of
    p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a
    histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear
    hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following
    UV-induced genotoxic stress

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000993RNA polymerase II core binding IDA--
    GO:0004857enzyme inhibitor activity IMP19218236
    GO:0005515protein binding IPI17314511
    GO:0019899enzyme binding IPI18235501
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with CCAR2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CCAR2:
     Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for 2610301G19Rik):
     immune system  liver/biliary system 

    Find genes that share phenotypes with CCAR2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCAR2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCAR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCAR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCAR2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCAR2:
    hsa-mir-760 (MIRT036741), hsa-mir-124-3p (MIRT023212), hsa-mir-19b-3p (MIRT031225), hsa-mir-149-5p (MIRT045623), hsa-mir-877-3p (MIRT037197), hsa-mir-24-3p (MIRT030599), hsa-mir-615-3p (MIRT039823)

    Block miRNA regulation of human, mouse, rat CCAR2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CCAR2
    SwitchGear 3'UTR luciferase reporter plasmidCCAR2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCAR2

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCAR2
    Addgene plasmids for CCAR2 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCAR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCAR2_HUMAN, Q8N163: Nucleus. Note=Recruited to chromatin, post-UV irradiation

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA--
    GO:0005634nucleus IDA--
    GO:0005681colocalizes with spliceosomal complex IDA--
    GO:0005737cytoplasm IDA15824730
    GO:0005759mitochondrial matrix IDA15824730

    Find genes that share ontologies with CCAR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCAR2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    DNA Damage0.32
    2TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    3Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation
    4Apoptosis and Autophagy
    Apoptosis and Autophagy


    Find genes that share SuperPaths with CCAR2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for CCAR2
        Chromatin Regulation / Acetylation
    Apoptosis and Autophagy
    DNA Damage

    1 BioSystems Pathway for CCAR2
        TNF-alpha/NF-kB Signaling Pathway

    1 Reactome Pathway for CCAR2
        Regulation of HSF1-mediated heat shock response


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCAR2
    Interactions:

        Search GeneGlobe Interaction Network for CCAR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCAR2 (Q8N1631, 2, 3 ENSP000003106704) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011061, 3, ENSP000003672074EBI-355410,EBI-447544 I2D: score=3 STRING: ENSP00000367207
    RELBQ012012, 3, ENSP000002214524MINT-49016 I2D: score=2 STRING: ENSP00000221452
    NFKB1P198382, 3, ENSP000002265744MINT-48675 I2D: score=1 STRING: ENSP00000226574
    SF3A2Q154282, 3, ENSP000002214944MINT-5206277 I2D: score=1 STRING: ENSP00000221494
    MAP3K3Q997592, 3MINT-48469 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0006915apoptotic process ----
    GO:0006974cellular response to DNA damage stimulus IEA--
    GO:0007049cell cycle IEA--
    GO:0008380RNA splicing IMP--

    Find genes that share ontologies with CCAR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCAR2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCAR2 gene (2 alternative transcripts): 
    NM_199205.1  NM_021174.5  

    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308511(uc003xch.3) ENST00000523801 ENST00000521301 ENST00000389279(uc003xci.3)
    ENST00000521837 ENST00000523349 ENST00000518989 ENST00000520861(uc003xcj.1)
    ENST00000522599 ENST00000521020 ENST00000520738 ENST00000521436 ENST00000520536

    miRNA
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    Block miRNA regulation of human, mouse, rat CCAR2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CCAR2
    SwitchGear 3'UTR luciferase reporter plasmidCCAR2 3' UTR sequence
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    Addgene plasmids for CCAR2 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCAR2
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat CCAR2
      QuantiTect SYBR Green Assays in human, mouse, rat CCAR2
      QuantiFast Probe-based Assays in human, mouse, rat CCAR2

    Selected AceView cDNA sequences (see all 408):

    C00227 BQ007072 BM561272 AY217349 AK022661 BE672042 AI266275 AK055782 
    AV648739 CR608632 CR594495 BQ003845 CF121260 AA804789 CA312164 BI760829 
    BU682837 CR623059 BM715147 NM_176871 NM_021630 AL834351 BU194818 BU508154 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCAR2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                                -                 -                                                                                                   
    SP2:                                                                                                                                                      
    SP3:                                                  -                                                                                                   
    SP4:                                                                                                                                                      
    SP5:                                                  -                                                                                                   


    ECgene alternative splicing isoforms for CCAR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCAR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CCAR2 Expression
    About this image


    CCAR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    CCAR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCAR2 Protein Expression

    UniProtKB/Swiss-Prot: CCAR2_HUMAN, Q8N163
    Tissue specificity: Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung,
    and colon tissues

        Custom PCR Arrays for CCAR2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCAR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CCAR2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2610301G19Rik5
    Ccar21
    RIKEN cDNA 2610301G19 gene5
    cell cycle activator and apoptosis regulator 21
    87.92(n)1
    91.54(a)1
      14 (36.24 cM)5
    2191581  NM_146055.31  NP_666167.31 
     701381685 
    lizard
    (Anolis carolinensis)
    Reptilia CCAR26
    cell cycle and apoptosis regulator 2
    58(a)
    1 ↔ 1
    GL343443.1(564698-588394)
    zebrafish
    (Danio rerio)
    Actinopterygii CCAR26
    cell cycle and apoptosis regulator 2
    29(a)
    1 ↔ 1
    10(2903212-2925594) ENSDARG00000038302
    worm
    (Caenorhabditis elegans)
    Secernentea lst-36
    Protein LST-3, isoform a
    17(a)
    1 → many
    IV(14071373-14076744) WBGene00003085


    ENSEMBL Gene Tree for CCAR2 (if available)
    TreeFam Gene Tree for CCAR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCAR2 gene
    CCAR12  
    1 SIMAP similar gene for CCAR2 using alignment to 9 protein entries:     CCAR2_HUMAN (see all proteins):
    CCAR1

    Find genes that share paralogs with CCAR2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCAR2 (see all 885)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115555431,2
    C--22462346(+) TGCCCG/TGGCCC 2 -- us2k1 nc-transcript-variant0--------
    rs37359011,2
    C,A--22462374(-) GCGGCA/GGGGGG 2 -- us2k1 int15Minor allele frequency- G:0.31NA WA EA 362
    rs1422863161,2
    C--22462542(+) GGAGAA/GACCGC 2 -- ut51 int10--------
    rs1180072351,2
    C,F--22462579(+) CGCCGC/G/TGGCTC 3 -- ut51 int11EA 120
    rs1167656171,2
    C,F--22462672(+) GGTTTC/TGCGTT 2 -- ut51 int12Minor allele frequency- T:0.06WA EA 238
    rs117778081,2
    C,F,A,H--22462755(+) CACACA/C/GGTCTC 3 -- ut51 int122NS EA NA WA CSA 2124
    rs795501391,2
    C,F--22462758(+) ACAGTC/GTCCTC 2 -- ut51 int11Minor allele frequency- G:0.14WA 118
    rs750912321,2
    C--22462835(+) AAGGAA/GTGTCA 2 -- ut51 int10--------
    rs117786931,2
    C,F,A,H--22462852(+) CTCTCT/CCGAGC 2 -- ut51 int125Minor allele frequency- C:0.30NS EA NA WA CSA 2357
    rs1456196741,2
    C--22462963(+) GTTATA/GTGGCC 2 -- int10--------

    HapMap Linkage Disequilibrium report for CCAR2 (22462145 - 22479027 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCAR2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCAR2
    DNA2.0 Custom Variant and Variant Library Synthesis for CCAR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607359    OMIM disorders: --

    1 disease for CCAR2:    
    About MalaCards
    breast cancer


    Find genes that share disorders with CCAR2           About GenesLikeMe


    Export disorders for CCAR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCAR2 gene, integrated from 10 sources (see all 83):
    (articles sorted by number of sources associating them with CCAR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DBC2, a candidate for a tumor suppressor gene involved in breast cancer. (PubMed id 12370419)1, 2, 3 Hamaguchi M.... Wigler M.H. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Deleted in breast cancer 1 (DBC1) deficiency results in apoptosis of breast cancer cells through impaired responses to UV-induced DNA damage. (PubMed id 23352644)1, 2 Kim W. and Kim J.E. (Cancer Lett. 2013)
    3. DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. (PubMed id 22446626)1, 2 Close P.... Svejstrup J.Q. (Nature 2012)
    4. Inhibition of SUV39H1 methyltransferase activity by DBC1. (PubMed id 19218236)1, 2 Li Z.... Chen J. (J. Biol. Chem. 2009)
    5. Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. (PubMed id 19131338)1, 2 Garapaty S....Samuels H.H. (J. Biol. Chem. 2009)
    6. DBC1 is a negative regulator of SIRT1. (PubMed id 18235501)1, 2 Kim J.-E.... Lou Z. (Nature 2008)
    7. Negative regulation of the deacetylase SIRT1 by DBC1. (PubMed id 18235502)1, 2 Zhao W.... Gu W. (Nature 2008)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57805 HGNC: 23360 AceView: DBC-1andPDLIM2 Ensembl:ENSG00000158941 euGenes: HUgn57805
    ECgene: CCAR2 H-InvDB: CCAR2

    (According to HUGE)
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    HUGE: KIAA1967

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCAR2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCAR2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCAR2 gene:
    Search GeneIP for patents involving CCAR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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