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Aliases for CCAR2 Gene

Aliases for CCAR2 Gene

  • Cell Cycle And Apoptosis Regulator 2 2 3
  • KIAA1967 2 3 4 6
  • DBC1 3 4 6
  • Cell Division Cycle And Apoptosis Regulator Protein 2 3 4
  • P30 DBC 3 4
  • DBC-1 3 4
  • Cell Cycle And Apoptosis Regulator Protein 2 3
  • Deleted In Breast Cancer Gene 1 Protein 4
  • DBIRD Complex Subunit KIAA1967 4
  • Deleted In Breast Cancer 1 3
  • Deleted In Breast Cancer 2
  • P30 DBC Protein 3
  • P30DBC 3
  • NET35 3
  • DBC.1 4

External Ids for CCAR2 Gene

Previous Symbols for CCAR2 Gene

  • KIAA1967

Summaries for CCAR2 Gene

GeneCards Summary for CCAR2 Gene

CCAR2 (Cell Cycle And Apoptosis Regulator 2) is a Protein Coding gene. Diseases associated with CCAR2 include breast cancer. Among its related pathways are Chromatin Regulation / Acetylation and Cell Cycle / Checkpoint Control. GO annotations related to this gene include enzyme binding and RNA polymerase II core binding. An important paralog of this gene is CCAR1.

UniProtKB/Swiss-Prot for CCAR2 Gene

  • Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation.

Gene Wiki entry for CCAR2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCAR2 Gene

Genomics for CCAR2 Gene

Genomic Location for CCAR2 Gene

Start:
22,604,632 bp from pter
End:
22,621,514 bp from pter
Size:
16,883 bases
Orientation:
Plus strand

Genomic View for CCAR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCAR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCAR2 Gene

No data available for Regulatory Elements for CCAR2 Gene

Proteins for CCAR2 Gene

  • Protein details for CCAR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N163-CCAR2_HUMAN
    Recommended name:
    Cell cycle and apoptosis regulator protein 2
    Protein Accession:
    Q8N163
    Secondary Accessions:
    • A6NL03
    • B2RB79
    • D3DSR6
    • Q6P0Q9
    • Q8N3G7
    • Q8N8M1
    • Q8TF34
    • Q9H9Q9
    • Q9HD12
    • Q9NT55

    Protein attributes for CCAR2 Gene

    Size:
    923 amino acids
    Molecular mass:
    102902 Da
    Quaternary structure:
    • Component of the DBIRD complex. Interacts with ZNF326/ZIRD; the interaction is direct. Interacts (via N-terminus) with SIRT1, which inhibits the deacetylation of substrates. Interacts (via N-terminus) with SUV39H1; this interaction abolishes the interaction with SIRT1. Part of a complex composed at least of ASCL2, C11orf30/EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity. Interacts with NR1D1.
    SequenceCaution:
    • Sequence=AAG02472.1; Type=Frameshift; Positions=610, 622, 794, 810; Evidence={ECO:0000305}; Sequence=BAB85553.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCAR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCAR2 Gene

Proteomics data for CCAR2 Gene at MOPED

Post-translational modifications for CCAR2 Gene

  • Acetylation at Lys-112 and Lys-215 by KAT8 prevents inhibitory binding to SIRT1 and increases its deacetylase activity.
  • ATM/ATR-mediated phosphorylation at Thr-454 upon DNA damage promotes binding to SIRT1.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys93, Lys97, Lys112, Lys123, Lys309, Lys347, Lys742, Lys832, and Lys839

No data available for DME Specific Peptides for CCAR2 Gene

Domains for CCAR2 Gene

Protein Domains for CCAR2 Gene

genes like me logo Genes that share domains with CCAR2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCAR2 Gene

Function for CCAR2 Gene

Molecular function for CCAR2 Gene

UniProtKB/Swiss-Prot Function: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation.

Gene Ontology (GO) - Molecular Function for CCAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II core binding IDA 22446626
GO:0004857 enzyme inhibitor activity IMP 19218236
GO:0005515 protein binding IPI 17314511
GO:0019899 enzyme binding IPI 18235501
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CCAR2: view

Phenotypes for CCAR2 Gene

MGI mutant phenotypes for CCAR2:
inferred from 1 alleles
GenomeRNAi human phenotypes for CCAR2:
genes like me logo Genes that share phenotypes with CCAR2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCAR2 Gene

Localization for CCAR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCAR2 Gene

Nucleus. Note=Recruited to chromatin, post-UV irradiation.

Gene Ontology (GO) - Cellular Components for CCAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 23352644
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005681 colocalizes_with spliceosomal complex IDA 22446626
GO:0005737 cytoplasm IDA 15824730
genes like me logo Genes that share ontologies with CCAR2: view

Pathways for CCAR2 Gene

genes like me logo Genes that share pathways with CCAR2: view

Pathways by source for CCAR2 Gene

3 Cell Signaling Technology pathways for CCAR2 Gene
1 BioSystems pathway for CCAR2 Gene

Gene Ontology (GO) - Biological Process for CCAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006397 mRNA processing IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007049 cell cycle IEA --
GO:0008380 RNA splicing IMP 22446626
genes like me logo Genes that share ontologies with CCAR2: view

Transcripts for CCAR2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CCAR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - -
SP2:
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for CCAR2 Gene

GeneLoc Exon Structure for
CCAR2
ECgene alternative splicing isoforms for
CCAR2

Expression for CCAR2 Gene

mRNA expression in normal human tissues for CCAR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCAR2 Gene

mRNA Expression by UniProt/SwissProt for CCAR2 Gene

Q8N163-CCAR2_HUMAN
Tissue specificity: Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues.
genes like me logo Genes that share expressions with CCAR2: view

Orthologs for CCAR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCAR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCAR2 37
  • 100 (a)
OneToOne
KIAA1967 36
  • 99.49 (n)
  • 99.67 (a)
cow
(Bos Taurus)
Mammalia CCAR2 37
  • 90 (a)
OneToOne
KIAA1967 36
  • 87.95 (n)
  • 88.76 (a)
dog
(Canis familiaris)
Mammalia CCAR2 37
  • 94 (a)
OneToOne
KIAA1967 36
  • 90.05 (n)
  • 93.46 (a)
mouse
(Mus musculus)
Mammalia 2610301G19Rik 16
Ccar2 36
  • 87.92 (n)
  • 91.54 (a)
Ccar2 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCAR2 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCAR2 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccar2 36
  • 87.89 (n)
  • 91.43 (a)
lizard
(Anolis carolinensis)
Reptilia CCAR2 37
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CCAR2 37
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lst-3 37
  • 17 (a)
OneToMany
Species with no ortholog for CCAR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CCAR2 Gene

ENSEMBL:
Gene Tree for CCAR2 (if available)
TreeFam:
Gene Tree for CCAR2 (if available)

Paralogs for CCAR2 Gene

Paralogs for CCAR2 Gene

Selected SIMAP similar genes for CCAR2 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with CCAR2: view

Variants for CCAR2 Gene

Sequence variations from dbSNP and Humsavar for CCAR2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs7009524 -- 22,608,610(+) CCTTT(A/G)GGGTA intron-variant
rs7357458 -- 22,614,185(+) TCAGC(C/T)TTCCC reference, synonymous-codon, nc-transcript-variant
rs7818653 -- 22,611,406(+) tgtgt(A/G)tgtgt intron-variant
rs7825134 -- 22,619,501(+) GTGCC(C/G)CTGGT intron-variant
rs7832175 -- 22,615,994(+) GGACC(C/T)TCCCA intron-variant

Relevant External Links for CCAR2 Gene

HapMap Linkage Disequilibrium report
CCAR2
Human Gene Mutation Database (HGMD)
CCAR2

No data available for Structural Variations from Database of Genomic Variants (DGV) for CCAR2 Gene

Disorders for CCAR2 Gene

(1) MalaCards Diseases for CCAR2 Gene

Search for CCAR2 Gene in MalaCards »
genes like me logo Genes that share disorders with CCAR2: view

No data available for UniProtKB/Swiss-Prot for CCAR2 Gene

Publications for CCAR2 Gene

  1. DBC2, a candidate for a tumor suppressor gene involved in breast cancer. (PMID: 12370419) Hamaguchi M. … Wigler M.H. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  3. DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage. (PMID: 22735644) Zannini L. … Delia D. (J Mol Cell Biol 2012) 3 4
  4. Modulation of estrogen receptor alpha protein level and survival function by DBC-1. (PMID: 17473282) Trauernicht A.M. … Boyer T.G. (Mol. Endocrinol. 2007) 3 23
  5. Repression of estrogen receptor beta function by putative tumor suppressor DBC1. (PMID: 20074560) Koyama S. … Taketani Y. (Biochem. Biophys. Res. Commun. 2010) 3 23

Products for CCAR2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CCAR2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CCAR2
    • Block miRNA regulation of CCAR2 using miScript Target Protectors

    Sources for CCAR2 Gene

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