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Aliases for CCAR1 Gene

Aliases for CCAR1 Gene

  • Cell Division Cycle And Apoptosis Regulator 1 2 3 5
  • Cell Cycle And Apoptosis Regulatory Protein 1 4
  • Death Inducer With SAP Domain 4
  • CARP-1 4
  • CARP1 4
  • DIS 4

External Ids for CCAR1 Gene

Previous GeneCards Identifiers for CCAR1 Gene

  • GC10P069826
  • GC10P070150
  • GC10P070480
  • GC10P064482

Summaries for CCAR1 Gene

GeneCards Summary for CCAR1 Gene

CCAR1 (Cell Division Cycle And Apoptosis Regulator 1) is a Protein Coding gene. Diseases associated with CCAR1 include Multiple Personality Disorder and Dissociative Amnesia. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is CCAR2.

UniProtKB/Swiss-Prot for CCAR1 Gene

  • Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938).

Gene Wiki entry for CCAR1 Gene

Additional gene information for CCAR1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCAR1 Gene

Genomics for CCAR1 Gene

Regulatory Elements for CCAR1 Gene

Enhancers for CCAR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H069179 1.2 ENCODE 77.7 +459.6 459648 3 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CCAR1 DDX50 TYSND1 DDX21 HNRNPH3 SAR1A VPS26A HKDC1 RPL26P27 SUPV3L1
GH10H068119 0.8 dbSUPER 105 -601.2 -601164 1 ZBTB21 ZFP64 ZNF140 ZNF266 ZNF697 ZNF664 ZNF138 ZNF354C RBAK ZNF19 CCAR1 HNRNPH3 DDX50 SIRT1 HERC4 KIF1BP RPL26P27 RPL12P8 TET1 MYPN
GH10H068954 1.4 ENCODE dbSUPER 38.6 +235.5 235498 3 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 CCAR1 DDX50 HERC4 KIF1BP DDX21 HNRNPH3 VPS26A STOX1 GC10P068966
GH10H068559 1.1 ENCODE 48.7 -159.2 -159162 4 HDGF PKNOX1 ARNT ARID4B FEZF1 DMAP1 ZNF2 SLC30A9 SP3 REST CCAR1 HERC4 DDX50 SIRT1 HNRNPH3 DNA2 ATOH7 TET1 GC10P068600
GH10H068091 1.7 FANTOM5 Ensembl ENCODE dbSUPER 30.6 -626.9 -626894 4 TBP NFIB JUN MAX RFX5 ZKSCAN1 GTF3C2 E2F1 CTBP1 ZNF316 CCAR1 DDX50 SIRT1 HNRNPH3 HERC4 ATOH7 ENSG00000233590 PBLD RPL12P8 DDX21
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCAR1 on UCSC Golden Path with GeneCards custom track

Promoters for CCAR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000029170 588 2001 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766

Genomic Location for CCAR1 Gene

Chromosome:
10
Start:
68,721,012 bp from pter
End:
68,792,377 bp from pter
Size:
71,366 bases
Orientation:
Plus strand

Genomic View for CCAR1 Gene

Genes around CCAR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCAR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCAR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCAR1 Gene

Proteins for CCAR1 Gene

  • Protein details for CCAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX12-CCAR1_HUMAN
    Recommended name:
    Cell division cycle and apoptosis regulator protein 1
    Protein Accession:
    Q8IX12
    Secondary Accessions:
    • A0JLT7
    • A1L4P7
    • A8K9D4
    • B4DNP8
    • B4DRK8
    • Q32NE3
    • Q5EBM3
    • Q5VUP6
    • Q6PIZ0
    • Q6X935
    • Q9H8N4
    • Q9NVA7
    • Q9NVQ0
    • Q9NWM6

    Protein attributes for CCAR1 Gene

    Size:
    1150 amino acids
    Molecular mass:
    132821 Da
    Quaternary structure:
    • Directly interacts with ESR1, NR3C1 and p53/TP53 (By similarity). Interacts (via N-terminus) with CALCOCO1. Interacts with MED1 (By similarity). Interacts with GATA1. Interacts with AR and GATA2.
    SequenceCaution:
    • Sequence=AAH26036.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI08683.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91354.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCAR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCAR1 Gene

Post-translational modifications for CCAR1 Gene

  • Ubiquitination at Lys368, Lys486, Lys637, Lys1054, and posLast=10881088
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCAR1 Gene

Domains & Families for CCAR1 Gene

Gene Families for CCAR1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CCAR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCAR1: view

No data available for UniProtKB/Swiss-Prot for CCAR1 Gene

Function for CCAR1 Gene

Molecular function for CCAR1 Gene

UniProtKB/Swiss-Prot Function:
Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938).

Phenotypes From GWAS Catalog for CCAR1 Gene

Gene Ontology (GO) - Molecular Function for CCAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001047 core promoter binding IDA 24245781
GO:0003713 transcription coactivator activity IMP 23887938
GO:0003714 transcription corepressor activity IMP 23887938
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 14743216
genes like me logo Genes that share ontologies with CCAR1: view
genes like me logo Genes that share phenotypes with CCAR1: view

Animal Model Products

CRISPR Products

miRNA for CCAR1 Gene

miRTarBase miRNAs that target CCAR1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCAR1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCAR1 Gene

Localization for CCAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCAR1 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCAR1 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2
golgi apparatus 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with CCAR1: view

Pathways & Interactions for CCAR1 Gene

genes like me logo Genes that share pathways with CCAR1: view

Pathways by source for CCAR1 Gene

Gene Ontology (GO) - Biological Process for CCAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with CCAR1: view

No data available for SIGNOR curated interactions for CCAR1 Gene

Drugs & Compounds for CCAR1 Gene

No Compound Related Data Available

Transcripts for CCAR1 Gene

Unigene Clusters for CCAR1 Gene

Cell division cycle and apoptosis regulator 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCAR1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CCAR1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23a ·
SP1: -
SP2: - - -
SP3: - -
SP4: - -
SP5: - -
SP6: -
SP7:
SP8: - -
SP9:
SP10:
SP11:

ExUns: 23b ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b
SP1:
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:

Relevant External Links for CCAR1 Gene

GeneLoc Exon Structure for
CCAR1
ECgene alternative splicing isoforms for
CCAR1

Expression for CCAR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCAR1 Gene

Protein differential expression in normal tissues from HIPED for CCAR1 Gene

This gene is overexpressed in Lymph node (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCAR1 Gene



Protein tissue co-expression partners for CCAR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCAR1 Gene:

CCAR1

SOURCE GeneReport for Unigene cluster for CCAR1 Gene:

Hs.49853

mRNA Expression by UniProt/SwissProt for CCAR1 Gene:

Q8IX12-CCAR1_HUMAN
Tissue specificity: Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.

Evidence on tissue expression from TISSUES for CCAR1 Gene

  • Nervous system(4.9)
  • Lung(4.5)
  • Muscle(4.5)
  • Liver(4.4)
  • Skin(4.4)
  • Heart(2.6)
  • Blood(2.5)
  • Intestine(2.5)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with CCAR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCAR1 Gene

Orthologs for CCAR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCAR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCAR1 33 34
  • 99.62 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 99 (a)
OneToMany
CCAR1 33 34
  • 94.14 (n)
dog
(Canis familiaris)
Mammalia CCAR1 33 34
  • 94.75 (n)
oppossum
(Monodelphis domestica)
Mammalia CCAR1 34
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 94 (a)
OneToMany
-- 34
  • 88 (a)
OneToMany
-- 34
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ccar1 33 16 34
  • 90.58 (n)
rat
(Rattus norvegicus)
Mammalia Ccar1 33
  • 90.24 (n)
chicken
(Gallus gallus)
Aves CCAR1 33 34
  • 82.69 (n)
lizard
(Anolis carolinensis)
Reptilia CCAR1 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccar1 33
  • 77.06 (n)
Str.7672 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.30247 33
zebrafish
(Danio rerio)
Actinopterygii ccar1 34
  • 66 (a)
OneToOne
LOC568087 33
  • 65.82 (n)
worm
(Caenorhabditis elegans)
Secernentea lst-3 34
  • 26 (a)
OneToMany
Species where no ortholog for CCAR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCAR1 Gene

ENSEMBL:
Gene Tree for CCAR1 (if available)
TreeFam:
Gene Tree for CCAR1 (if available)

Paralogs for CCAR1 Gene

Paralogs for CCAR1 Gene

(1) SIMAP similar genes for CCAR1 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with CCAR1: view

Variants for CCAR1 Gene

Sequence variations from dbSNP and Humsavar for CCAR1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_035497 A colorectal cancer sample
rs1000119523 -- 68,719,425(+) CAGAA(A/G)TGTTA upstream-variant-2KB
rs1000159818 -- 68,734,094(+) GAAAT(C/T)AGACT intron-variant
rs1000168421 -- 68,747,893(+) CTGTC(A/G)CCCAG intron-variant
rs1000236303 -- 68,740,012(+) TGTGG(C/T)CCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCAR1 Gene

Variant ID Type Subtype PubMed ID
dgv919n100 CNV gain 25217958
esv2759764 CNV loss 17122850
esv3406931 CNV insertion 20981092
esv3546462 CNV deletion 23714750
nsv1047983 CNV gain 25217958
nsv1052569 CNV gain 25217958
nsv1134023 CNV deletion 24896259
nsv1144498 CNV deletion 24896259
nsv551435 CNV loss 21841781
nsv6999 CNV insertion 18451855
nsv8684 CNV gain 18304495

Variation tolerance for CCAR1 Gene

Residual Variation Intolerance Score: 7.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCAR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCAR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCAR1 Gene

Disorders for CCAR1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCAR1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
multiple personality disorder
  • dissociative identity disorder
dissociative amnesia
  • psychogenic amnesia
- elite association - COSMIC cancer census association via MalaCards
Search CCAR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCAR1

Genetic Association Database (GAD)
CCAR1
Human Genome Epidemiology (HuGE) Navigator
CCAR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCAR1
genes like me logo Genes that share disorders with CCAR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCAR1 Gene

Publications for CCAR1 Gene

  1. Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437. (PMID: 12816952) Rishi AK … Reichert U (The Journal of biological chemistry 2003) 2 3 4 60
  2. CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function. (PMID: 24245781) Mizuta S … Ito M (Genes to cells : devoted to molecular & cellular mechanisms 2014) 3 4 60
  3. CCAR1 promotes chromatin loading of androgen receptor (AR) transcription complex by stabilizing the association between AR and GATA2. (PMID: 23887938) Seo WY … Kim JH (Nucleic acids research 2013) 3 4 60
  4. CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. (PMID: 18722177) Kim JH … Stallcup MR (Molecular cell 2008) 3 4 60
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 45 60

Products for CCAR1 Gene

Sources for CCAR1 Gene

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