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CCAR1 Gene

protein-coding   GIFtS: 58
GCID: GC10P070480

Cell Division Cycle And Apoptosis Regulator 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Division Cycle And Apoptosis Regulator 11 2     Cell Division Cycle And Apoptosis Regulator Protein 12
Cell Cycle And Apoptosis Regulatory Protein 12 3     CARP-13
Death Inducer With SAP Domain2 3     DIS3
CARP13 5     

External Ids:    HGNC: 242361   Entrez Gene: 557492   Ensembl: ENSG000000603397   OMIM: 6125695   UniProtKB: Q8IX123   

Export aliases for CCAR1 gene to outside databases

Previous GC identifers: GC10P069826 GC10P070150 GC10P064482


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCAR1 Gene:
CCAR1 (cell division cycle and apoptosis regulator 1) is a protein-coding gene. GO annotations related to this gene include ligand-dependent nuclear receptor transcription coactivator activity and nucleic acid binding. An important paralog of this gene is CCAR2.

UniProtKB/Swiss-Prot: CCAR1_HUMAN, Q8IX12
Function: Associates with components of the Mediator and p160 coactivator complexes that play a role as
intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal
transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response
to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in
transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid
CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of
multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression
and/or cell proliferation

Gene Wiki entry for CCAR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCAR1 gene promoter:
         GR   GR-beta   SREBP-1c   SREBP-1b   N-Myc   SRY   POU2F1   SREBP-1a   GR-alpha   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CCAR1 promoter sequence
   Search Chromatin IP Primers for CCAR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCAR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.3   Ensembl cytogenetic band:  10q21.3   HGNC cytogenetic band: 10q22.1

CCAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCAR1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P070480:  view genomic region     (about GC identifiers)

Start:
70,480,769 bp from pter      End:
70,552,134 bp from pter
Size:
71,366 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCAR1_HUMAN, Q8IX12 (See protein sequence)
Recommended Name: Cell division cycle and apoptosis regulator protein 1  
Size: 1150 amino acids; 132821 Da
Subunit: Directly interacts with CALCOCO1, ESR1, NR3C1 and TP53 (By similarity)
Sequence caution: Sequence=AAH26036.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAI08683.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAA91354.1; Type=Erroneous initiation;
Secondary accessions: A0JLT7 A1L4P7 A8K9D4 B4DNP8 B4DRK8 Q32NE3 Q5EBM3 Q5VUP6 Q6PIZ0 Q6X935
Q9H8N4 Q9NVA7 Q9NVQ0 Q9NWM6
Alternative splicing: 2 isoforms:  Q8IX12-1   Q8IX12-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCAR1: NX_Q8IX12

Explore proteomics data for CCAR1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys368, Lys486, Lys637, Lys1054, Lys1088
  • Modification sites at PhosphoSitePlus

  • See CCAR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269888.1  NP_001269889.1  NP_060707.2  

    ENSEMBL proteins: 
     ENSP00000438881   ENSP00000265872   ENSP00000442410   ENSP00000445254   ENSP00000439153  
     ENSP00000439571   ENSP00000439252   ENSP00000438610   ENSP00000439642   ENSP00000443808  
     ENSP00000437760   ENSP00000440224   ENSP00000438939   ENSP00000441820  
    Reactome Protein details: Q8IX12

    CCAR1 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCAR1

     
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    Search antibodies-online for peptides for CCAR1

    CCAR1 Antibody Products:

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    Abcam antibodies for CCAR1
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    ThermoFisher Antibodies for CCAR1
    antibodies-online antibodies for CCAR1 (25 products) 

    CCAR1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CCAR1
    Cloud-Clone Corp. CLIAs for CCAR1
    Search eBioscience for ELISAs for CCAR1 
    antibodies-online kits for CCAR1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR025223 S1-like_RNA-bd_dom
     IPR025954 DBC1/CARP1_inactive_NUDIX_dom
     IPR012340 NA-bd_OB-fold
     IPR003034 SAP_dom
     IPR025224 DBC1/CARP1

    Graphical View of Domain Structure for InterPro Entry Q8IX12

    ProtoNet protein and cluster: Q8IX12

    1 Blocks protein domain: IPB003034 DNA-binding SAP

    UniProtKB/Swiss-Prot: CCAR1_HUMAN, Q8IX12
    Similarity: Contains 1 SAP domain


    Find genes that share domains with CCAR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCAR1_HUMAN, Q8IX12
    Function: Associates with components of the Mediator and p160 coactivator complexes that play a role as
    intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal
    transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response
    to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in
    transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid
    CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of
    multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression
    and/or cell proliferation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding IPI18157088
    GO:0030374ligand-dependent nuclear receptor transcription coactivator activity IGI18722177
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with CCAR1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CCAR1

    miRNA
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    miRTarBase miRNAs that target CCAR1:
    hsa-mir-92a-3p (MIRT049109), hsa-mir-186-5p (MIRT045240), hsa-mir-24-3p (MIRT030489)

    Block miRNA regulation of human, mouse, rat CCAR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCAR1 (see all 11):
    hsa-miR-21* hsa-miR-433 hsa-miR-495 hsa-miR-7-2* hsa-miR-548e hsa-miR-106a* hsa-miR-551b* hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmidCCAR1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CCAR1
    Predesigned siRNA for gene silencing in human, mouse, rat CCAR1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for CCAR1 (see all 8)
    OriGene ORF clones in mouse, rat for CCAR1
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    GenScript: all cDNA clones in your preferred vector: CCAR1 (NM_018237)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCAR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCAR1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCAR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCAR1_HUMAN, Q8IX12: Cytoplasm, perinuclear region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    mitochondrion2
    cytosol1
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with CCAR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCAR1 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    2Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with CCAR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for CCAR1
        mRNA Splicing - Major Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCAR1
    Interactions:

        GeneGlobe Interaction Network for CCAR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCAR1 (Q8IX121, 2, 3 ENSP000002658724) via UniProtKB, MINT, STRING, and/or I2D (see all 125)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM63Q969Q11, 2, 3, ENSP000003633904EBI-356265,EBI-5661333 MINT-6492181 MINT-6503450 I2D: score=1 STRING: ENSP00000363390
    IKBKGQ9Y6K92, 3MINT-48222 MINT-47966 I2D: score=2 
    SF3A2Q154282, 3, ENSP000002214944MINT-5206025 I2D: score=1 STRING: ENSP00000221494
    WWTR1Q9GZV51, 3, ENSP000003538474EBI-356265,EBI-747743 I2D: score=1 STRING: ENSP00000353847
    SMURF2Q9HAU42, 3, ENSP000002624354MINT-6503780 I2D: score=1 STRING: ENSP00000262435
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006915apoptotic process IEA--
    GO:0007049cell cycle IEA--

    Find genes that share ontologies with CCAR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCAR1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCAR1 gene (3 alternative transcripts): 
    NM_001282959.1  NM_001282960.1  NM_018237.3  

    Unigene Cluster for CCAR1:

    Cell division cycle and apoptosis regulator 1
    Hs.49853  [show with all ESTs]
    Unigene Representative Sequence: AK128100
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536391 ENST00000265872(uc001jol.1 uc001joo.3 uc010qjb.2)
    ENST00000538031 ENST00000543719(uc010qja.1) ENST00000541012 ENST00000543229
    ENST00000539539 ENST00000543225 ENST00000536012 ENST00000494903 ENST00000540210
    ENST00000483264 ENST00000479143 ENST00000543706 ENST00000539250 ENST00000398676
    ENST00000480627 ENST00000535016(uc001jom.1 uc009xpx.1 uc001jon.1 uc010qiz.1)

    miRNA
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    Block miRNA regulation of human, mouse, rat CCAR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCAR1 (see all 11):
    hsa-miR-21* hsa-miR-433 hsa-miR-495 hsa-miR-7-2* hsa-miR-548e hsa-miR-106a* hsa-miR-551b* hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmidCCAR1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CCAR1
    Predesigned siRNA for gene silencing in human, mouse, rat CCAR1
    Clone
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    OriGene ORF clones in mouse, rat for CCAR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCAR1 (NM_018237)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCAR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCAR1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCAR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCAR1
      QuantiTect SYBR Green Assays in human, mouse, rat CCAR1
      QuantiFast Probe-based Assays in human, mouse, rat CCAR1

    Additional mRNA sequence: 

    AF086334.1 AF465616.1 AK000741.1 AK001701.1 AK023438.1 AK122871.1 AK128100.1 AK292649.1 
    AK298004.1 AK299307.1 AK307550.1 AK307671.1 AK307704.1 AY249140.1 BC015475.1 BC026036.2 
    BC058846.1 BC089420.1 BC108682.1 BC130626.1 BC132725.1 BC144118.1 BX647943.1 

    20 DOTS entries:

    DT.97783681  DT.92442415  DT.407617  DT.97787447  DT.100893836  DT.100893837  DT.121273036  DT.442463 
    DT.121273028  DT.92009400  DT.100035985  DT.100695586  DT.40250930  DT.65286045  DT.95276548  DT.99936229 
    DT.121273041  DT.92442419  DT.121273092  DT.121273093 

    Selected AceView cDNA sequences (see all 224):

    AA662650 AA782687 BQ129975 AK000741 AW262626 BG433383 BU681608 BQ773062 
    CA946681 AA085664 AW304931 BM978518 NM_018237 BM905703 AL602897 AA373153 
    AA442527 CK430477 BM996129 AW499979 BM782712 AW675068 AA730055 AI890840 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCAR1 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23a ·
    SP1:                                                                          -                                                                                 
    SP2:        -           -                                                     -                                                                                 
    SP3:                                                                          -           -                                                                     
    SP4:                                                                                                                                                  -     -   
    SP5:                                                                                                                                                  -     -   

    ExUns: 23b ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:        -                                 
    SP5:        -                                 


    ECgene alternative splicing isoforms for CCAR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCAR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGATTTTA
    CCAR1 Expression
    About this image


    CCAR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    CCAR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCAR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.49853

    UniProtKB/Swiss-Prot: CCAR1_HUMAN, Q8IX12
    Tissue specificity: Expressed in various epithelial cancer cell lines, including breast, colon, prostate,
    pancreatic and leukemia. Expression is regulated by growth factors

        Custom PCR Arrays for CCAR1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCAR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CCAR1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccar11 , 5 cell division cycle and apoptosis regulator 11, 5 90.58(n)1
    94.42(a)1
      10 (32.47 cM)5
    675001  NM_026201.31  NP_080477.11 
     627439285 
    chicken
    (Gallus gallus)
    Aves CCAR11 cell division cycle and apoptosis regulator 1 82.69(n)
    92.42(a)
      423692  XM_004942009.1  XP_004942066.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCAR16
    cell division cycle and apoptosis regulator 1
    89(a)
    1 ↔ 1
    GL343215.1(1787362-1815243)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.302472 Xenopus laevis transcribed sequence with weak similarity more 77.58(n)    CF283529.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5680871 novel protein similar to vertebrate cell division cycle more 65.82(n)
    68.86(a)
      568087  NM_001145599.1  NP_001139071.1 
    worm
    (Caenorhabditis elegans)
    Secernentea lst-36
    Protein LST-3, isoform a
    26(a)
    1 → many
    IV(14071373-14076744) WBGene00003085


    ENSEMBL Gene Tree for CCAR1 (if available)
    TreeFam Gene Tree for CCAR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCAR1 gene
    CCAR22  
    1 SIMAP similar gene for CCAR1 using alignment to 10 protein entries:     CCAR1_HUMAN (see all proteins):
    CCAR2

    Find genes that share paralogs with CCAR1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CCAR1
    PGOHUM00000258530


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCAR1 (see all 1505)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354974
    A colorectal cancer sample4--see VAR_0354972 E K mis40--------
    rs1121484701,2
    C--64514039(+) ATAGAATAG/-  
            
    ATAGA
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1473915691,2
    C--70479136(+) AAGGCC/GACATA 1 -- us2k10--------
    rs1395653401,2
    --70479197(+) TTGACC/TGAGAC 1 -- us2k10--------
    rs1923279671,2
    --70479209(+) GGGAAA/GAGCAG 1 -- us2k10--------
    rs1127956351,2
    C--70479220(+) GGATT-/AGGGGG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs794858531,2
    C,F--70479226(+) GGGGGC/TTGTTG 1 -- us2k11Minor allele frequency- T:0.12EA 120
    rs109984001,2
    C,H--70479316(+) CTATAC/TTAAAA 1 -- us2k16Minor allele frequency- T:0.00NS EA NA 602
    rs1845449261,2
    --70479322(+) TAAAAC/GCCACT 1 -- us2k10--------
    rs122527351,2
    C,F--70479414(+) acctcT/Cgcctc 1 -- us2k16Minor allele frequency- C:0.33NA WA 12

    HapMap Linkage Disequilibrium report for CCAR1 (70480769 - 70552134 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CCAR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6999CNV Insertion18451855
    nsv8684CNV Gain18304495
    dgv296e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCAR1
    DNA2.0 Custom Variant and Variant Library Synthesis for CCAR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612569    OMIM disorders: --


    Find genes that share disorders with CCAR1           About GenesLikeMe

    Genetic Association Database (GAD): CCAR1
    Human Genome Epidemiology (HuGE) Navigator: CCAR1 (1 document)

    Export disorders for CCAR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCAR1 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with CCAR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437. (PubMed id 12816952)1, 2, 3 Rishi A.K....Reichert U. (J. Biol. Chem. 2003)
    2. CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. (PubMed id 18722177)1, 2 Kim J.H.... Stallcup M.R. (Mol. Cell 2008)
    3. Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. (PubMed id 18655026)1, 2 Tan F.... Peng X. (Proteomics 2008)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    8. Par-4/THAP1 complex and Notch3 competitively regulated pre-mRNA splicing of CCAR1 and affected inversely the survival of T-cell acute lymphoblastic leukemia cells. (PubMed id 23975424)1 Lu C....Zhou G.P. (Oncogene 2013)
    9. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)
    10. Necdin enhances myoblasts survival by facilitating the degradation of the mediator of apoptosis CCAR1/CARP1. (PubMed id 22905258)1 FranAsois S....Brunelli S. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55749 HGNC: 24236 AceView: CCAR1 Ensembl:ENSG00000060339 euGenes: HUgn55749
    ECgene: CCAR1 H-InvDB: CCAR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCAR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCAR1 gene:
    Search GeneIP for patents involving CCAR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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