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Aliases for CCAR1 Gene

Aliases for CCAR1 Gene

  • Cell Division Cycle And Apoptosis Regulator 1 2 3
  • CARP1 4 6
  • Cell Cycle And Apoptosis Regulatory Protein 1 4
  • Death Inducer With SAP Domain 4
  • CARP-1 4
  • DIS 4

External Ids for CCAR1 Gene

Summaries for CCAR1 Gene

GeneCards Summary for CCAR1 Gene

CCAR1 (Cell Division Cycle And Apoptosis Regulator 1) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is CCAR2.

UniProtKB/Swiss-Prot for CCAR1 Gene

  • Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation.

Gene Wiki entry for CCAR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCAR1 Gene

Genomics for CCAR1 Gene

Genomic Location for CCAR1 Gene

Start:
68,721,012 bp from pter
End:
68,792,377 bp from pter
Size:
71,366 bases
Orientation:
Plus strand

Genomic View for CCAR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCAR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCAR1 Gene

Regulatory Elements for CCAR1 Gene

Proteins for CCAR1 Gene

  • Protein details for CCAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX12-CCAR1_HUMAN
    Recommended name:
    Cell division cycle and apoptosis regulator protein 1
    Protein Accession:
    Q8IX12
    Secondary Accessions:
    • A0JLT7
    • A1L4P7
    • A8K9D4
    • B4DNP8
    • B4DRK8
    • Q32NE3
    • Q5EBM3
    • Q5VUP6
    • Q6PIZ0
    • Q6X935
    • Q9H8N4
    • Q9NVA7
    • Q9NVQ0
    • Q9NWM6

    Protein attributes for CCAR1 Gene

    Size:
    1150 amino acids
    Molecular mass:
    132821 Da
    Quaternary structure:
    • Directly interacts with CALCOCO1, ESR1, NR3C1 and TP53.
    SequenceCaution:
    • Sequence=AAH26036.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI08683.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91354.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCAR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCAR1 Gene

Proteomics data for CCAR1 Gene at MOPED

Post-translational modifications for CCAR1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys368, Lys486, Lys637, Lys1054, and Lys1088

No data available for DME Specific Peptides for CCAR1 Gene

Domains for CCAR1 Gene

Protein Domains for CCAR1 Gene

UniProtKB/Swiss-Prot:

CCAR1_HUMAN
Domain:
  • Contains 1 SAP domain.:
    • Q8IX12
genes like me logo Genes that share domains with CCAR1: view

No data available for Gene Families for CCAR1 Gene

Function for CCAR1 Gene

Molecular function for CCAR1 Gene

UniProtKB/Swiss-Prot Function: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation.

Gene Ontology (GO) - Molecular Function for CCAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 18157088
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IGI 18722177
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CCAR1: view

miRNA for CCAR1 Gene

miRTarBase miRNAs that target CCAR1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCAR1 Gene

Localization for CCAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCAR1 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCAR1 Gene COMPARTMENTS Subcellular localization image for CCAR1 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with CCAR1: view

Pathways for CCAR1 Gene

genes like me logo Genes that share pathways with CCAR1: view

Pathways by source for CCAR1 Gene

Gene Ontology (GO) - Biological Process for CCAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with CCAR1: view

Transcripts for CCAR1 Gene

Unigene Clusters for CCAR1 Gene

Cell division cycle and apoptosis regulator 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCAR1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23a ·
SP1: -
SP2: - - -
SP3: - -
SP4: - -
SP5: - -
SP6: -
SP7:
SP8: - -
SP9:
SP10:
SP11:

ExUns: 23b ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b
SP1:
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:

Relevant External Links for CCAR1 Gene

GeneLoc Exon Structure for
CCAR1
ECgene alternative splicing isoforms for
CCAR1

Expression for CCAR1 Gene

mRNA expression in normal human tissues for CCAR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCAR1 Gene

SOURCE GeneReport for Unigene cluster for CCAR1 Gene Hs.49853

mRNA Expression by UniProt/SwissProt for CCAR1 Gene

Q8IX12-CCAR1_HUMAN
Tissue specificity: Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.
genes like me logo Genes that share expressions with CCAR1: view

Orthologs for CCAR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCAR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCAR1 36
  • 99.62 (n)
  • 99.91 (a)
CCAR1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 99 (a)
OneToMany
CCAR1 36
  • 94.14 (n)
  • 99.03 (a)
CCAR1 37
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CCAR1 36
  • 94.75 (n)
  • 98.87 (a)
CCAR1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccar1 36
  • 90.58 (n)
  • 94.42 (a)
Ccar1 16
Ccar1 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCAR1 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 86 (a)
OneToMany
-- 37
  • 88 (a)
OneToMany
-- 37
  • 94 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ccar1 36
  • 90.24 (n)
  • 94.42 (a)
chicken
(Gallus gallus)
Aves CCAR1 36
  • 82.69 (n)
  • 92.42 (a)
CCAR1 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCAR1 37
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.30247 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ccar1 36
  • 77.06 (n)
  • 85.24 (a)
Str.7672 36
zebrafish
(Danio rerio)
Actinopterygii ccar1 37
  • 66 (a)
OneToOne
LOC568087 36
  • 65.82 (n)
  • 68.86 (a)
worm
(Caenorhabditis elegans)
Secernentea lst-3 37
  • 26 (a)
OneToMany
Species with no ortholog for CCAR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCAR1 Gene

ENSEMBL:
Gene Tree for CCAR1 (if available)
TreeFam:
Gene Tree for CCAR1 (if available)

Paralogs for CCAR1 Gene

Paralogs for CCAR1 Gene

Selected SIMAP similar genes for CCAR1 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for CCAR1 Gene

genes like me logo Genes that share paralogs with CCAR1: view

Variants for CCAR1 Gene

Sequence variations from dbSNP and Humsavar for CCAR1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs15341 -- 68,761,173(-) CAGAT(C/T)TCCTA reference, missense, nc-transcript-variant
rs1060145 - 68,761,128(+) GAAGG(A/G)GTTAG reference, missense, nc-transcript-variant
rs1137221 -- 68,771,308(+) aaaaa(A/G)aaaag missense, reference, nc-transcript-variant
rs1141945 -- 68,771,313(+) GAAAA(A/G)GATAA synonymous-codon, reference, nc-transcript-variant
rs1141946 -- 68,771,314(+) aaaag(A/G)ataaa missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CCAR1 Gene

Variant ID Type Subtype PubMed ID
dgv296e1 CNV Complex 17122850
nsv6999 CNV Insertion 18451855
nsv8684 CNV Gain 18304495

Relevant External Links for CCAR1 Gene

HapMap Linkage Disequilibrium report
CCAR1

Disorders for CCAR1 Gene

Relevant External Links for CCAR1

Genetic Association Database (GAD)
CCAR1
Human Genome Epidemiology (HuGE) Navigator
CCAR1
genes like me logo Genes that share disorders with CCAR1: view

No data available for UniProtKB/Swiss-Prot for CCAR1 Gene

Publications for CCAR1 Gene

  1. Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437. (PMID: 12816952) Rishi A.K. … Reichert U. (J. Biol. Chem. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49
  5. Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. (PMID: 18655026) Tan F. … Peng X. (Proteomics 2008) 3 4

Products for CCAR1 Gene

Sources for CCAR1 Gene

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