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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCAR1 Gene

protein-coding   GIFtS: 53
GCID: GC10P070480

cell division cycle and apoptosis regulator 1
 Explore 11 diseases affiliated with
CCAR1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CCAR1    

Aliases
for CCAR1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cell Division Cycle And Apoptosis Regulator 11 2     FLJ105901
CARP11 3 5     RP11-437A18.12
CARP-11 3     Cell Division Cycle And Apoptosis Regulator Protein 12
Cell Cycle And Apoptosis Regulatory Protein 12 3     DIS3
Death Inducer With SAP Domain2 3     

External Ids:    HGNC: 242361   Entrez Gene: 557492   Ensembl: ENSG000000603397   OMIM: 6125695   UniProtKB: Q8IX123   

Export aliases for CCAR1 gene to outside databases

Previous GC identifers: GC10P069826 GC10P070150 GC10P064482


Summaries
for CCAR1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CCAR1_HUMAN, Q8IX12
Function: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries
transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at
the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also
functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be
involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of
14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and
CDKN1A. Plays a role in cell cycle progression and/or cell proliferation

Gene Wiki entry for CCAR1


Genomic Views
for CCAR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCAR1 gene promoter:
         GR   GR-beta   SREBP-1c   SREBP-1b   N-Myc   SRY   POU2F1   SREBP-1a   GR-alpha   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CCAR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCAR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCAR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.3   Ensembl cytogenetic band:  10q21.3   HGNC cytogenetic band: 10q22.1

CCAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCAR1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P070480:  view genomic region     (about GC identifiers)

Start:
 70,480,769 bp from pter      End:
 70,552,134 bp from pter
Size:
 71,366 bases      Orientation:
 plus strand

Proteins
for CCAR1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CCAR1_HUMAN, Q8IX12 (See protein sequence)
Recommended Name: Cell division cycle and apoptosis regulator protein 1  
Size: 1150 amino acids; 132821 Da
Subunit: Directly interacts with CALCOCO1, ESR1, NR3C1 and TP53 (By similarity)
Subcellular location: Cytoplasm, perinuclear region
Sequence caution: Sequence=AAH26036.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence; Sequence=AAI08683.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=BAA91354.1; Type=Erroneous initiation;
Secondary accessions: A0JLT7 A1L4P7 A8K9D4 B4DNP8 B4DRK8 Q32NE3 Q5EBM3 Q5VUP6 Q6PIZ0 Q6X935 Q9H8N4
Q9NVA7 Q9NVQ0 Q9NWM6
Alternative splicing: 2 isoforms:  Q8IX12-1   Q8IX12-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCAR1: NX_Q8IX12

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IX12

    • CCAR1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060707.2  
    ENSEMBL proteins: 
     ENSP00000438881   ENSP00000265872   ENSP00000442410   ENSP00000445254   ENSP00000439153  
     ENSP00000439571   ENSP00000439252   ENSP00000438610   ENSP00000439642   ENSP00000443808  
     ENSP00000437760   ENSP00000445607   ENSP00000440224   ENSP00000438939   ENSP00000437969  
     ENSP00000441820  
    Reactome Protein details: Q8IX12
    Human Recombinant Protein Products: 
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    Uscn Proteins for CCAR1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0048471perinuclear region of cytoplasm IEA--


    CCAR1 for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for CCAR1

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    Uscn ELISAs and CLIAs for CCAR1

    Protein Domains /
    Families
    for CCAR1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CCAR1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR025223 S1-like_RNA-bd_dom
     IPR025954 DBC1/CARP1_inactive_NUDIX_dom
     IPR012340 NA-bd_OB-fold
     IPR003034 SAP_dom
     IPR025224 DBC1/CARP1

    Graphical View of Domain Structure for InterPro Entry Q8IX12

    ProtoNet protein and cluster: Q8IX12

    1 Blocks protein family: IPB003034 DNA-binding SAP

    UniProtKB/Swiss-Prot: CCAR1_HUMAN, Q8IX12
    Similarity: Contains 1 SAP domain


    Function
    for CCAR1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CCAR1_HUMAN, Q8IX12
    Function: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries
    transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at
    the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also
    functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be
    involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of
    14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and
    CDKN1A. Plays a role in cell cycle progression and/or cell proliferation

    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate CCAR1 (see all 11):
    hsa-miR-21* hsa-miR-433 hsa-miR-495 hsa-miR-7-2* hsa-miR-548e hsa-miR-106a* hsa-miR-551b* hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CCAR1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCAR1 (see all 7)
    OriGene shRNA RFP: CCAR1
    OriGene siRNA: CCAR1
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0005509calcium ion binding ----
    GO:0005515protein binding IPI--
    GO:0030374ligand-dependent nuclear receptor transcription coactivator activity IGI18722177


    CCAR1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for CCAR1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		mRNA Splicing1.00
    		Processing of Capped Intron-Containing Pre-mRNA0.96
    		mRNA Splicing - Major Pathway1.00
    		mRNA Processing0.82
    2Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for CCAR1
        mRNA Splicing - Major Pathway
    mRNA Splicing
    Gene Expression
    mRNA Processing
    Processing of Capped Intron-Containing Pre-mRNA



    CCAR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCAR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/118 Interacting proteins for CCAR1 (Q8IX121, 2, 3 ENSP000002658724) via UniProtKB, MINT, STRING, and/or I2D (see all 118)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM63Q969Q12, 3, ENSP000003633904MINT-6492181 MINT-6503450 I2D: score=1 STRING: ENSP00000363390
    IKBKGQ9Y6K92, 3MINT-48222 MINT-47966 I2D: score=2 
    SF3A2Q154282, 3, ENSP000002214944MINT-5206025 I2D: score=1 STRING: ENSP00000221494
    WWTR1Q9GZV51, 3, ENSP000003538474EBI-356265,EBI-747743 I2D: score=1 STRING: ENSP00000353847
    SMURF2Q9HAU42, 3, ENSP000002624354MINT-6503780 I2D: score=1 STRING: ENSP00000262435
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006915apoptotic process IEA--
    GO:0007049cell cycle IEA--


    CCAR1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CCAR1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCAR1
    Search CenterWatch for drugs/clinical trials and news about CCAR1 

    Transcripts
    for CCAR1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CCAR1 gene: 
    NM_018237.2  

    Unigene Cluster for CCAR1:

    Cell division cycle and apoptosis regulator 1
    Hs.49853  [show with all ESTs]
    Unigene Representative Sequence: AK128100
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000536391 ENST00000265872(uc001jol.1 uc001joo.3 uc010qjb.2)
    ENST00000538031 ENST00000543719(uc010qja.1) ENST00000541012 ENST00000543229
    ENST00000539539 ENST00000543225 ENST00000536012 ENST00000494903 ENST00000540210
    ENST00000540807 ENST00000483264 ENST00000479143 ENST00000543706 ENST00000539250
    ENST00000483471 ENST00000398676

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCAR1
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate CCAR1 (see all 11):
    hsa-miR-21* hsa-miR-433 hsa-miR-495 hsa-miR-7-2* hsa-miR-548e hsa-miR-106a* hsa-miR-551b* hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CCAR1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCAR1 (see all 7)
    OriGene shRNA RFP: CCAR1
    OriGene siRNA: CCAR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCAR1
    Clone
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    GenScript: all cDNA clones in your preferred vector: CCAR1 (NM_018237)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCAR1

    Additional cDNA sequence: 

    AF086334.1 AF465616.1 AK000741.1 AK001701.1 AK023438.1 AK122871.1 AK128100.1 AK292649.1 
    AK298004.1 AK299307.1 AK307550.1 AK307671.1 AK307704.1 AY249140.1 BC015475.1 BC026036.2 
    BC058846.1 BC089420.1 BC108682.1 BC130626.1 BC132725.1 BC144118.1 BX647943.1 

    20 DOTS entries:

    DT.97783681  DT.92442415  DT.407617  DT.97787447  DT.100893836  DT.100893837  DT.121273036  DT.442463 
    DT.121273028  DT.92009400  DT.100035985  DT.100695586  DT.40250930  DT.65286045  DT.95276548  DT.99936229 
    DT.121273041  DT.92442419  DT.121273092  DT.121273093 

    24/224 AceView cDNA sequences (see all 224):

    AL705594 AW499979 BQ129975 BC026036 BM782353 BQ773062 AW304931 AW262626 
    NM_018237 AA373153 BM905703 CK430477 AL602897 AK023438 AA730055 AK000741 
    BM996129 AA309118 CB134427 BM782394 BM747799 BC015475 AA662650 CB134825 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for CCAR1 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23a ·
    SP1:                                                                          -                                                                                 
    SP2:        -           -                                                     -                                                                                 
    SP3:                                                                          -           -                                                                     
    SP4:                                                                                                                                                  -     -   
    SP5:                                                                                                                                                  -     -   

    ExUns: 23b ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:        -                                 
    SP5:        -                                 


    ECgene alternative splicing isoforms for CCAR1

    Expression
    for CCAR1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCAR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTGATTTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CCAR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCAR1

    SOURCE GeneReport for Unigene cluster: Hs.49853

    UniProtKB/Swiss-Prot: CCAR1_HUMAN, Q8IX12
    Tissue specificity: Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic
    and leukemia. Expression is regulated by growth factors

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    In Situ
    Assay Products:     
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    Orthologs
    for CCAR1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCAR1 gene from 9/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ccar11 , 5 cell division cycle and apoptosis regulator 11, 5 91.16(n)1
    95.11(a)1    		   10 (32.47 cM)5
    675001  NM_026201.31  NP_080477.11 
     627439285 
    chicken
    (Gallus gallus)    		 Aves CCAR11 cell division cycle and apoptosis regulator 1 82.87(n)
    92.6(a)    		   423692  XM_421573.3  XP_421573.2 
    lizard
    (Anolis carolinensis)    		 Reptilia CCAR16
    		 --
    		 89(a)
    		 1 ↔ 1
    		 GL343215.1(1787408-1815243)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.302472 Xenopus laevis transcribed sequence with weak similarity more 77.58(n)    CF283529.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5680871 novel protein similar to vertebrate cell division cycle more 67.84(n)
    72.3(a)    		   568087  NM_001145599.1  NP_001139071.1 
    mosquito
    (Anopheles gambiae)    		 Insecta AgaP_AGAP0004631 AGAP000463-PA 48.71(n)
    50(a)    		   5666747  XM_001688251.1  XP_001688303.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea lst-31 Protein LST-3 43.08(n)
    31.22(a)    		   178362  NM_001028263.2  NP_001023434.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons emb15796
    		 ATP/GTP-binding protein-like protein
    		 13(a)
    		 1 → many
    		 2(951933-959188)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 transposon protein, putative, CACTA, En/Spm sub-cl...
    		 14(a)
    		 1 → many
    		 6(21613169-21616123)


    ENSEMBL Gene Tree for CCAR1 (if available)
    TreeFam Gene Tree for CCAR1 (if available) 

    Paralogs
    for CCAR1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCAR1 gene
    KIAA19672  
    1 SIMAP similar gene for CCAR1 using alignment to 12 protein entries:     CCAR1_HUMAN (see all proteins):
    KIAA1967

    CCAR1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCAR1
    PGOHUM00000258530


    Genomic Variants
    for CCAR1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1337 NCBI SNPs in CCAR1 are shown (see all 1337)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs347599941,2
    		C,--70478988(+) GAAAG-/AAAAAA 1 -- us2k10--------
    rs615917001,2
    		C--70478992(+) AAAAAA/-GAGAA 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1473915691,2
    		--70479136(+) AAGGCC/GACATA 1 -- us2k10--------
    rs1395653401,2
    		--70479197(+) TTGACC/TGAGAC 1 -- us2k10--------
    rs1923279671,2
    		--70479209(+) GGGAAA/GAGCAG 1 -- us2k10--------
    rs1127956351,2
    		C,--70479220(+) GGATT-/AGGGGG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs794858531,2
    		F,--70479226(+) GGGGGC/TTGTTG 1 -- us2k11Minor allele frequency- T:0.12EA 120
    rs109984001,2
    		C,H--70479316(+) CTATAC/TTAAAA 1 -- us2k16Minor allele frequency- T:0.00NS EA NA 602
    rs1845449261,2
    		--70479322(+) TAAAAC/GCCACT 1 -- us2k10--------
    rs122527351,2
    		C,F,--70479414(+) ACCTCT/CGCCTC 1 -- us2k16Minor allele frequency- C:0.33NA WA 12

    HapMap Linkage Disequilibrium report for CCAR1 (70480769 - 70552134 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CCAR1
         2 CNVs: 30510 3808

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CCAR1

    Disorders / Diseases
    for CCAR1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CCAR1 for disorders           About GeneDecksing

    OMIM gene information: 612569    OMIM disorders: --

    11 diseases for CCAR1:    About MalaCards
    malignant peritoneal mesothelioma    intrahepatic cholangiocarcinoma    peritonitis    cholangiocarcinoma
    colon carcinoma    alzheimer's disease    breast cancer    carcinoma
    pancreatitis    leukemia    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: CCAR1 (1 document)

    Export disorders for CCAR1 gene to outside databases

    Publications
    for CCAR1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCAR1 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with CCAR1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437. (PubMed id 12816952)1, 2, 3 Rishi A.K....Reichert U. (2003)
    2. CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. (PubMed id 18722177)1, 2 Kim J.H....Stallcup M.R. (2008)
    3. Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. (PubMed id 18655026)1, 2 Tan F....Peng X. (2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    7. Necdin enhances myoblasts survival by facilitating the degradation of the mediator of apoptosis CCAR1/CARP1. (PubMed id 22905258)1 Francois S....Brunelli S. (2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    9. CCAR1 is required for Ngn3-mediated endocrine differen tiation. (PubMed id 22266316)1 Lu C.K....Chiang M.K. (2012)
    10. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)

    External Searches for CCAR1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CCAR1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55749 HGNC: 24236 AceView: CCAR1 Ensembl:ENSG00000060339 euGenes: HUgn55749
    ECgene: CCAR1 H-InvDB: CCAR1

    Other Databases showing CCAR1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CCAR1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCAR1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CCAR1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCAR1 gene:
    Search GeneIP for patents involving CCAR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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