CC2D2B Gene
protein-coding GIFtS: 39
GCID: GC10P097709
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coiled-coil and C2 domain containing 2B(Previous name: chromosome 10 open reading frame 130 )
(Previous symbol: C10orf130)
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Aliases
for CC2D2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil And C2 Domain Containing 2B1 2 | | C10orf1301 2 3 | | BA248J23.41 | | Chromosome 10 Open Reading Frame 1301 | | Protein CC2D2B2 |
Export aliases for CC2D2B gene to outside databasesPrevious GC identifers: GC10P097725 GC10P097751 GC10P091387 |
Summaries
for CC2D2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CC2D2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CC2D2B gene promoter:
COUP-TF1 GR AML1a Pax-6 COUP IRF-1 Evi-1 COUP-TF ARP-1 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for CC2D2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CC2D2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q24.1 Ensembl cytogenetic band: 10q24.1 HGNC cytogenetic band: 10q23.33CC2D2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P097709: view genomic region
(about GC identifiers)
Start:
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97,709,744 bp from pter |
End:
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97,792,441 bp from pter |
Size:
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82,698 bases |
Orientation:
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plus strand |
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Proteins
for CC2D2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: C2D2B_HUMAN, Q6DHV5 (See
protein sequence)Recommended Name: Protein CC2D2B Size: 322 amino acids; 37073 Da
Secondary accessions: A2A3E9 B4DYD4 E9PCC3 Q5VUS0Alternative splicing: 2 isoforms: Q6DHV5-1 Q6DHV5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CC2D2B: NX_Q6DHV5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6DHV5
CC2D2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001001732.2 NP_001153219.1
ENSEMBL proteins: ENSP00000391834 ENSP00000386988 ENSP00000343747 ENSP00000360241 ENSP00000411217
Human Recombinant Protein Products:
CC2D2B Antibody Products:
Assay Products for CC2D2B: |
Protein
Domains /
Families
for CC2D2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6DHV5 |
Function
for CC2D2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CC2D2B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CC2D2B (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for CC2D2B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CC2D2B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CC2D2B |
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Pathways & Interactions
for CC2D2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CC2D2B
|
Drugs & Compounds
for CC2D2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CC2D2B
Search CenterWatch for drugs/clinical trials and news about CC2D2B / C2D2B
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Transcripts
for CC2D2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CC2D2B gene (2 alternative transcripts): NM_001001732.3 NM_001159747.1 Unigene Cluster for CC2D2B: Coiled-coil and C2 domain containing 2B Hs.652240 [show with all ESTs]Unigene Representative Sequence: NM_0011597479 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000469549 ENST00000484685 ENST00000472454 ENST00000475252 ENST00000424464
ENST00000410012 ENST00000344386 ENST00000371198(uc001klk.3) ENST00000451649(uc010qop.2 uc001kll.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CC2D2B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CC2D2B (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CC2D2B (NM_001001732) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CC2D2B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CC2D2B |
Additional cDNA sequence: AK302377.1 BC075861.1 5 DOTS entries: DT.95338646 DT.100836726 DT.100737081 DT.65288235 DT.121262557 11 AceView cDNA sequences: BI829244 BC075861 AA877128 AI888804 AA382570 AK123423 NM_001001732 AA621323 BX093579 AL045376 CD358293
GeneLoc Exon Structure
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Expression
for CC2D2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CC2D2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCTTTTGA
About this image
See CC2D2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CC2D2B
SOURCE GeneReport for Unigene cluster: Hs.652240
SABiosciences Custom PCR Arrays for CC2D2B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CC2D2B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CC2D2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CC2D2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CC2D2B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CC2D2B |
Orthologs
for CC2D2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CC2D2B gene from 4/18 species (see all 18) About this table
ENSEMBL Gene Tree for CC2D2B (if available)
TreeFam Gene Tree for CC2D2B (if available) |
Paralogs
for CC2D2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CC2D2B gene
- C10orf1312 CC2D2A2
1 SIMAP similar gene for CC2D2B using alignment to 4 protein entries: C2D2B_HUMAN (see all proteins):CC2D2A
CC2D2B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CC2D2B
PGOHUM00000232897
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Genomic Variants
for CC2D2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for CC2D2B (97709744 - 97792441 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CC2D2B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CC2D2B |
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Disorders
/ Diseases
for CC2D2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CC2D2B for disorders About GeneDecksing
1  disease for CC2D2B: About MalaCardsalzheimer's disease
1 disease from the University of Copenhagen DISEASES database for CC2D2B:Nephronophthisis Human Genome Epidemiology (HuGE) Navigator: CC2D2B (1 document)
Export disorders for CC2D2B gene to outside databases
|
Publications
for CC2D2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CC2D2B gene integrated from 9 sources:
(articles sorted by number of sources associating them with CC2D2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CC2D2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CC2D2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CC2D2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CC2D2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CC2D2B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CC2D2B gene:
Search GeneIP for patents involving CC2D2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CC2D2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CC2D2B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CC2D2B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CC2D2B | | | OriGene Protein Over-expression Lysate for CC2D2B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CC2D2B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CC2D2B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CC2D2B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | CC2D2B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CC2D2B |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CC2D2B |
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