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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CC2D1B Gene

protein-coding   GIFtS: 44
GCID: GC01M052811

Coiled-Coil And C2 Domain Containing 1B

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coiled-Coil And C2 Domain Containing 1B1 2     freud-22
Five Prime Repressor Element Under Dual Repression-Binding Protein 22 3     Freud-23
FRE Under Dual Repression-Binding Protein 22 3     KIAA18363
Coiled-Coil And C2 Domain-Containing Protein 1B2     

External Ids:    HGNC: 293861   Entrez Gene: 2000142   Ensembl: ENSG000001542227   UniProtKB: Q5T0F93   

Export aliases for CC2D1B gene to outside databases

Previous GC identifers: GC01M052529 GC01M050932


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CC2D1B Gene: 
CC2D1B (coiled-coil and C2 domain containing 1B) is a protein-coding gene. Diseases associated with CC2D1B include neuronitis. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is CC2D1A.

UniProtKB/Swiss-Prot: C2D1B_HUMAN, Q5T0F9
Function: Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A
gene transcription in neuronal cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CC2D1B gene promoter:
         NF-1   Pax-5   p53   AP-1   STAT5A   MIF-1   AP-2gamma   AREB6   MZF-1   Ik-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCC2D1B promoter sequence
   Search SABiosciences Chromatin IP Primers for CC2D1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CC2D1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

CC2D1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CC2D1B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M052811:  view genomic region     (about GC identifiers)

Start:
52,811,395 bp from pter      End:
52,831,877 bp from pter
Size:
20,483 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: C2D1B_HUMAN, Q5T0F9 (See protein sequence)
Recommended Name: Coiled-coil and C2 domain-containing protein 1B  
Size: 858 amino acids; 94224 Da
Subcellular location: Nucleus
Sequence caution: Sequence=BAC85450.1; Type=Miscellaneous discrepancy; Sequence=CAI12282.1; Type=Erroneous gene
model prediction;
Secondary accessions: Q49AE8 Q5T0F8 Q5T0G0 Q6ZNQ1 Q96AP3 Q96I04 Q96JJ1
Alternative splicing: 5 isoforms:  Q5T0F9-1   Q5T0F9-2   Q5T0F9-3   Q5T0F9-4   Q5T0F9-5   

Explore the universe of human proteins at neXtProt for CC2D1B: NX_Q5T0F9

Explore proteomics data for CC2D1B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5T0F9

  • CC2D1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CC2D1B Protein Expression
    REFSEQ proteins: NP_115825.1  
    ENSEMBL proteins: 
     ENSP00000360642   ENSP00000284376   ENSP00000395921   ENSP00000402440   ENSP00000406300  

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    Cloud-Clone Corp. Proteins for CC2D1B 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    CC2D1B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR000008 C2_Ca-dep
     IPR006608 DM14

    Graphical View of Domain Structure for InterPro Entry Q5T0F9

    ProtoNet protein and cluster: Q5T0F9

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: C2D1B_HUMAN, Q5T0F9
    Similarity: Belongs to the CC2D1 family
    Similarity: Contains 1 C2 domain


    CC2D1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: C2D1B_HUMAN, Q5T0F9
    Function: Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A
    gene transcription in neuronal cells

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA--
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA--
    GO:0005515protein binding ----
         
    CC2D1B for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidCC2D1B 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CC2D1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for CC2D1B (ENSP000003606424) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL4ENSP000003495944STRING: ENSP00000349594
    GCSAMLENSP000003554444STRING: ENSP00000355444
    GPX7ENSP000003546774STRING: ENSP00000354677
    KTI12ENSP000003606764STRING: ENSP00000360676
    PPIHENSP000003066144STRING: ENSP00000306614
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ----

    CC2D1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CC2D1B (C2D1B)

    Search CenterWatch for drugs/clinical trials and news about CC2D1B / C2D1B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CC2D1B gene: 
    NM_032449.2  

    Unigene Cluster for CC2D1B:

    Coiled-coil and C2 domain containing 1B
    Hs.591451  [show with all ESTs]
    Unigene Representative Sequence: NM_032449
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470844 ENST00000371586(uc001ctq.2) ENST00000491136 ENST00000284376(uc001ctr.3 uc001cts.3)
    ENST00000438021 ENST00000460261 ENST00000450942 ENST00000460370 ENST00000492426
    ENST00000485966 ENST00000494789 ENST00000438831
    miRNA
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    hsa-miR-2052 hsa-miR-199a-3p hsa-miR-15a hsa-miR-1260b hsa-miR-503 hsa-miR-624* hsa-miR-3653 hsa-miR-301a
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB058739.1 AK093605.1 AK095487.1 AK130874.1 BC007912.2 BC014080.2 BC016880.1 BC039308.1 

    11 DOTS entries:

    DT.95353625  DT.92429656  DT.100774037  DT.95084803  DT.211362  DT.215433  DT.91924706  DT.121435052 
    DT.121435088  DT.91837587  DT.92429658 

    24/189 AceView cDNA sequences (see all 189):

    AW170708 BX108093 AI678189 BM673856 CR613939 CK823434 CD367616 BU616172 
    AK130874 AI582316 BQ073406 AI473377 BQ023304 CD671255 AI201159 BC007912 
    BM713072 CF785948 BQ448428 AW168171 AW675636 AA515398 BQ423631 CA432711 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CC2D1B (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a ·
    SP1:                                                                                                                                            -           -   
    SP2:                                                              -     -                                                     -                             -   
    SP3:                                                                                                                                            -           -   
    SP4:                                                                                                                          -                 -           -   
    SP5:                                                                                                                          -                 -           -   

    ExUns: 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b · 22c · 22d ^ 23
    SP1:                                                  -                       -         
    SP2:                                            -     -                                 
    SP3:                                            -     -                                 
    SP4:                                            -     -           -     -     -         
    SP5:                                            -     -                       -         


    ECgene alternative splicing isoforms for CC2D1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CC2D1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CC2D1B Expression
    About this image


    See CC2D1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CC2D1B

    SOURCE GeneReport for Unigene cluster: Hs.591451

    UniProtKB/Swiss-Prot: C2D1B_HUMAN, Q5T0F9
    Tissue specificity: Widely distributed in brain and peripheral tissues

        SABiosciences Custom PCR Arrays for CC2D1B
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CC2D1B gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cc2d1b1 , 5 coiled-coil and C2 domain containing 1B1, 5 83.85(n)1
    81.56(a)1
      4 (50.64 cM)5
    3199651  NM_177045.31  NP_796019.11 
     1086199405 
    chicken
    (Gallus gallus)
    Aves CC2D1B1 coiled-coil and C2 domain containing 1B 61.48(n)
    59.95(a)
      772226  XM_001235392.2  XP_001235393.2 
    lizard
    (Anolis carolinensis)
    Reptilia CC2D1B6
    coiled-coil and C2 domain containing 1B
    52(a)
    1 ↔ 1
    4(114508600-114546606)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC688872 hypothetical protein MGC68887 75.66(n)    BC057723.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb71c022 wufb71c02 71.69(n)   322706  BQ449850.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)gd11 lethal (2) giant discs 1 48.7(n)
    38.67(a)
      34543  NM_135644.3  NP_609488.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y37H9A.31 Protein Y37H9A.3 44.43(n)
    34.4(a)
      173244  NM_061011.2  NP_493412.2 


    ENSEMBL Gene Tree for CC2D1B (if available)
    TreeFam Gene Tree for CC2D1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CC2D1B gene
    CC2D1A2  
    1 SIMAP similar gene for CC2D1B using alignment to 4 protein entries:     C2D1B_HUMAN (see all proteins):
    CC2D1A

    CC2D1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/525 SNPs in CC2D1B are shown (see all 525)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1849342371,2
    --52815780(+) AGATGG/TGGTTT 1 -- int10--------
    rs1392863291,2
    --52815876(+) GCCACC/TGTGCC 1 -- int10--------
    rs1488496711,2
    --52816020(+) AGAAAC/TGAATC 1 -- int10--------
    rs1897435761,2
    --52816337(+) ATCAAA/CGAATT 1 -- ut310--------
    rs728959841,2
    C,F--52816415(+) TTGGAT/AACTGT 1 -- ut313Minor allele frequency- A:0.30WA CSA 121
    rs1830631941,2
    --52816472(+) GAGTGC/TAGTGG 1 -- ut310--------
    rs1116526161,2
    C,F--52816505(+) CTCTGC/GTTCCT 1 -- ut314Minor allele frequency- G:0.30WA CSA 123
    rs1873977561,2
    --52816564(+) AGGCGC/TCGGCC 1 -- ut310--------
    rs1170788691,2
    C,F--52816577(+) CATGCC/TCAGCT 1 -- ut311Minor allele frequency- T:0.03EA 120
    rs1917986311,2
    --52816587(+) TAATTA/GTTTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CC2D1B (52811395 - 52831877 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CC2D1B: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CC2D1B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for CC2D1B:    About MalaCards
    neuronitis    


    CC2D1B for disorders           About GeneDecksing


    Export disorders for CC2D1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CC2D1B gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with CC2D1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2, 3 Nagase T.... Ohara O. (2001)
    2. Human Freud-2/CC2D1B: a novel repressor of postsynapt ic serotonin-1A receptor expression. (PubMed id 19423080)1, 2 Hadjighassem M.R....Albert P.R. (2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A yeast two-hybrid screen reveals that osteopontin ass ociates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (2012)
    5. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. The Drosophila Notch inhibitor and tumor suppressor gene lethal (2) giant discs encodes a conserved regulator of endosomal trafficking. (PubMed id 17084358)1 Jaekel R. and Klein T. (2006)
    8. The conserved c2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila. (PubMed id 17084357)1 Gallagher C.M. and Knoblich J.A. (2006)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 200014 HGNC: 29386 AceView: KIAA1836 Ensembl:ENSG00000154222 euGenes: HUgn200014
    ECgene: CC2D1B H-InvDB: CC2D1B

    (According to HUGE)
    About This Section
    HUGE: KIAA1836

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CC2D1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CC2D1B gene:
    Search GeneIP for patents involving CC2D1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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