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Aliases for CC2D1B Gene

Aliases for CC2D1B Gene

  • Coiled-Coil And C2 Domain Containing 1B 2 3
  • Five Prime Repressor Element Under Dual Repression-Binding Protein 2 3 4
  • FRE Under Dual Repression-Binding Protein 2 3 4
  • Freud-2 3 4
  • Coiled-Coil And C2 Domain-Containing Protein 1B 3
  • KIAA1836 4

External Ids for CC2D1B Gene

Previous GeneCards Identifiers for CC2D1B Gene

  • GC01M052529
  • GC01M052811
  • GC01M050932

Summaries for CC2D1B Gene

GeneCards Summary for CC2D1B Gene

CC2D1B (Coiled-Coil And C2 Domain Containing 1B) is a Protein Coding gene. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription. An important paralog of this gene is CC2D1A.

UniProtKB/Swiss-Prot for CC2D1B Gene

  • Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CC2D1B Gene

Genomics for CC2D1B Gene

Regulatory Elements for CC2D1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CC2D1B Gene

Start:
52,345,723 bp from pter
End:
52,366,205 bp from pter
Size:
20,483 bases
Orientation:
Minus strand

Genomic View for CC2D1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CC2D1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CC2D1B Gene

Proteins for CC2D1B Gene

  • Protein details for CC2D1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T0F9-C2D1B_HUMAN
    Recommended name:
    Coiled-coil and C2 domain-containing protein 1B
    Protein Accession:
    Q5T0F9
    Secondary Accessions:
    • Q49AE8
    • Q5T0F8
    • Q5T0G0
    • Q6ZNQ1
    • Q96AP3
    • Q96I04
    • Q96JJ1

    Protein attributes for CC2D1B Gene

    Size:
    858 amino acids
    Molecular mass:
    94224 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85450.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305}; Sequence=CAI12282.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CC2D1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CC2D1B Gene

Proteomics data for CC2D1B Gene at MOPED

Post-translational modifications for CC2D1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CC2D1B Gene

No data available for DME Specific Peptides for CC2D1B Gene

Domains for CC2D1B Gene

Protein Domains for CC2D1B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CC2D1B Gene

Graphical View of Domain Structure for InterPro Entry

Q5T0F9

UniProtKB/Swiss-Prot:

C2D1B_HUMAN :
  • Q5T0F9
Domain:
  • Contains 1 C2 domain.
Family:
  • Belongs to the CC2D1 family.
genes like me logo Genes that share domains with CC2D1B: view

No data available for Gene Families for CC2D1B Gene

Function for CC2D1B Gene

Molecular function for CC2D1B Gene

UniProtKB/Swiss-Prot Function: Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells.

Gene Ontology (GO) - Molecular Function for CC2D1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CC2D1B: view

Animal Model Products

CRISPR Products

miRNA for CC2D1B Gene

miRTarBase miRNAs that target CC2D1B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CC2D1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CC2D1B Gene

Localization for CC2D1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CC2D1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CC2D1B Gene COMPARTMENTS Subcellular localization image for CC2D1B gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CC2D1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with CC2D1B: view

Pathways for CC2D1B Gene

SuperPathways for CC2D1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for CC2D1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with CC2D1B: view

No data available for Pathways by source for CC2D1B Gene

Transcripts for CC2D1B Gene

Unigene Clusters for CC2D1B Gene

Coiled-coil and C2 domain containing 1B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CC2D1B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CC2D1B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CC2D1B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a ·
SP1: - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - -
SP7:
SP8: -
SP9:
SP10:

ExUns: 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b · 22c · 22d ^ 23
SP1: - -
SP2: - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6:
SP7:
SP8:
SP9: - -
SP10:

Relevant External Links for CC2D1B Gene

GeneLoc Exon Structure for
CC2D1B
ECgene alternative splicing isoforms for
CC2D1B

Expression for CC2D1B Gene

mRNA expression in normal human tissues for CC2D1B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CC2D1B Gene

SOURCE GeneReport for Unigene cluster for CC2D1B Gene Hs.591451

mRNA Expression by UniProt/SwissProt for CC2D1B Gene

Q5T0F9-C2D1B_HUMAN
Tissue specificity: Widely distributed in brain and peripheral tissues.
genes like me logo Genes that share expressions with CC2D1B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CC2D1B Gene

Orthologs for CC2D1B Gene

This gene was present in the common ancestor of animals.

Orthologs for CC2D1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CC2D1B 35
  • 99.69 (n)
  • 99.77 (a)
CC2D1B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CC2D1B 35
  • 87.41 (n)
  • 86.55 (a)
CC2D1B 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CC2D1B 35
  • 86.56 (n)
  • 84.96 (a)
CC2D1B 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cc2d1b 35
  • 84.08 (n)
  • 81.68 (a)
Cc2d1b 16
Cc2d1b 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CC2D1B 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 48 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cc2d1b 35
  • 84.36 (n)
  • 81.56 (a)
chicken
(Gallus gallus)
Aves CC2D1B 35
  • 61.2 (n)
  • 59.71 (a)
CC2D1B 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CC2D1B 36
  • 55 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68887 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cc2d1b 35
  • 59.42 (n)
  • 57.61 (a)
zebrafish
(Danio rerio)
Actinopterygii cc2d1b 35
  • 59.96 (n)
  • 55 (a)
cc2d1b 36
  • 49 (a)
OneToOne
wufb71c02 35
fruit fly
(Drosophila melanogaster)
Insecta l(2)gd1 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y37H9A.3 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
Species with no ortholog for CC2D1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CC2D1B Gene

ENSEMBL:
Gene Tree for CC2D1B (if available)
TreeFam:
Gene Tree for CC2D1B (if available)

Paralogs for CC2D1B Gene

Paralogs for CC2D1B Gene

Selected SIMAP similar genes for CC2D1B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CC2D1B: view

Variants for CC2D1B Gene

Sequence variations from dbSNP and Humsavar for CC2D1B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13916 -- 52,352,673(+) GTCCT(C/T)AGGGA utr-variant-3-prime
rs1062039 -- 52,352,189(+) GGGGT(A/C)TTTCT utr-variant-3-prime, downstream-variant-500B
rs2477101 -- 52,354,216(-) CACTG(C/T)AGCAC intron-variant
rs2820334 -- 52,354,554(+) AGTGC(A/G)TATTG intron-variant
rs3748620 -- 52,351,678(-) TCGAA(C/T)TCCTG utr-variant-3-prime

Relevant External Links for CC2D1B Gene

HapMap Linkage Disequilibrium report
CC2D1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CC2D1B Gene

Disorders for CC2D1B Gene

No disorders were found for CC2D1B Gene.

No data available for UniProtKB/Swiss-Prot for CC2D1B Gene

Publications for CC2D1B Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Human Freud-2/CC2D1B: a novel repressor of postsynaptic serotonin-1A receptor expression. (PMID: 19423080) Hadjighassem M.R. … Albert P.R. (Biol. Psychiatry 2009) 3 4
  4. A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PMID: 22779921) Long P. … Rose S. (Eur. J. Neurosci. 2012) 3
  5. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3

Products for CC2D1B Gene

  • antibodies-online peptides for CC2D1B
  • antibodies-online antibodies for CC2D1B
  • antibodies-online kits for CC2D1B

Sources for CC2D1B Gene

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