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CBY1 Gene

protein-coding   GIFtS: 56
GCID: GC22P039052

Chibby Homolog 1 (Drosophila)

(Previous names: chromosome 22 open reading frame 2, PKD2 interactor, golgi...)
(Previous symbols: C22orf2, PGEA1)
  See CBY1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chibby Homolog 1 (Drosophila)1 2     PKD2 Interactor, Golgi And Endoplasmic Reticulum-Associated 12 3
C22orf21 2 3 5     HS508I15A2 5
PGEA11 2 3     Chromosome 22 Open Reading Frame 21
CBY2 3 5     PIGEA142
PKD2 Interactor, Golgi And Endoplasmic Reticulum Associated 11 2     arb12
Chibby CTNNB1-Mediated Transcription Inhibitor1 2     Coiled-Coil Protein PIGEA-142
Cytosolic Leucine-Rich Protein2 3     Polycystin-2 Interactor, Golgi- And Endoplasmic Reticulum-Associated
Protein, 14 KDa2
PIGEA-142 3     Protein Chibby Homolog 12
ARPP-Binding Protein2 3     ARB13

External Ids:    HGNC: 13071   Entrez Gene: 257762   Ensembl: ENSG000001002117   OMIM: 6077575   UniProtKB: Q9Y3M23   
ORGUL members:         

Export aliases for CBY1 gene to outside databases

Previous GC identifers: GC22P037382 GC22P022018


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CBY1 Gene:
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The
protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic
beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to
beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CBY1 Gene:
CBY1 (chibby homolog 1 (Drosophila)) is a protein-coding gene. Diseases associated with CBY1 include pediatric ependymoma. GO annotations related to this gene include beta-catenin binding and identical protein binding. An important paralog of this gene is CBY3.

UniProtKB/Swiss-Prot: CBY1_HUMAN, Q9Y3M2
Function: Inhibits the Wnt/Wingless pathway by binding to beta-catenin and inhibiting beta-catenin-mediated
transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a
role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular
proteins. Promotes adipocyte and cardiomyocyte differentiation

Gene Wiki entry for CBY1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CBY1 gene promoter:
         Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCBY1 promoter sequence
   Search Chromatin IP Primers for CBY1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CBY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q12

CBY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBY1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P039052:  view genomic region     (about GC identifiers)

Start:
39,052,641 bp from pter      End:
39,069,859 bp from pter
Size:
17,219 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CBY1_HUMAN, Q9Y3M2 (See protein sequence)
Recommended Name: Protein chibby homolog 1  
Size: 126 amino acids; 14470 Da
Subunit: Homodimer. Interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of
beta-catenin
Miscellaneous: 'Chibby' is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies
Secondary accessions: B2R4S2 Q66GT6 Q9UIK9

Explore the universe of human proteins at neXtProt for CBY1: NX_Q9Y3M2

Explore proteomics data for CBY1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CBY1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001002880.2  NP_056188.1  

    ENSEMBL proteins: 
     ENSP00000413934   ENSP00000380026   ENSP00000216029   ENSP00000412260  
    Reactome Protein details: Q9Y3M2

    CBY1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028118 Chibby_fam

    Graphical View of Domain Structure for InterPro Entry Q9Y3M2

    ProtoNet protein and cluster: Q9Y3M2

    UniProtKB/Swiss-Prot: CBY1_HUMAN, Q9Y3M2
    Similarity: Belongs to the chibby family


    Find genes that share domains with CBY1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBY1_HUMAN, Q9Y3M2
    Function: Inhibits the Wnt/Wingless pathway by binding to beta-catenin and inhibiting beta-catenin-mediated
    transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a
    role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular
    proteins. Promotes adipocyte and cardiomyocyte differentiation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15194699
    GO:0008013beta-catenin binding IDA12712206
    GO:0042802identical protein binding IPI15194699
         
    Find genes that share ontologies with CBY1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CBY1:
     Decreased TP53 protein express 

         10 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cby1):
     adipose tissue  embryogenesis  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     immune system  integument  mortality/aging  reproductive system  respiratory system 

    Find genes that share phenotypes with CBY1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cby1tm1Ktkm for CBY1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CBY1
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    miRNA
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    miRTarBase miRNAs that target CBY1:
    hsa-mir-30c-5p (MIRT047988), hsa-mir-26b-5p (MIRT029177)

    Block miRNA regulation of human, mouse, rat CBY1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CBY1:
    hsa-miR-562 hsa-miR-3190
    SwitchGear 3'UTR luciferase reporter plasmidCBY1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CBY1 (NM_015373)
    Sino Biological Human cDNA Clone for CBY1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBY1
    Addgene plasmids for CBY1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBY1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CBY1_HUMAN, Q9Y3M2: Nucleus speckle. Golgi apparatus, trans-Golgi network. Note=Nuclear, in a punctate manner.
    Also found in the trans-Golgi
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus3
    cytoskeleton2
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12712206
    GO:0005794Golgi apparatus IEA--
    GO:0005802trans-Golgi network IDA15194699
    GO:0016607nuclear speck IEA--

    Find genes that share ontologies with CBY1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CBY1 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    Find genes that share SuperPaths with CBY1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CBY1
        WNT Signaling

    1 BioSystems Pathway for CBY1
        Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    1 Reactome Pathway for CBY1
        deactivation of the beta-catenin transactivating complex


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CBY1
    Interactions:

        GeneGlobe Interaction Network for CBY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for CBY1 (Q9Y3M22, 3 ENSP000002160294) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGTPBP1Q9UPW52, 3, ENSP000003385124MINT-2871559 MINT-2871578 I2D: score=3 STRING: ENSP00000338512
    YWHAEP622582, 3, ENSP000002643354MINT-8008465 I2D: score=1 STRING: ENSP00000264335
    YWHAZP631042, 3, ENSP000003095034MINT-8008472 MINT-8009477 I2D: score=1 STRING: ENSP00000309503
    PROP1O753603, ENSP000003112904I2D: score=1 STRING: ENSP00000311290
    CTNNB1P352223, ENSP000003444564I2D: score=4 STRING: ENSP00000344456
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008104protein localization IMP15194699
    GO:0030178negative regulation of Wnt signaling pathway IDA12712206
    GO:0042384cilium assembly IEA--
    GO:0045444fat cell differentiation ISS--
    GO:0045892negative regulation of transcription, DNA-templated IDA12712206

    Find genes that share ontologies with CBY1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CBY1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CBY1 gene (2 alternative transcripts): 
    NM_001002880.1  NM_015373.3  

    Unigene Cluster for CBY1:

    Chibby homolog 1 (Drosophila)
    Hs.334911  [show with all ESTs]
    Unigene Representative Sequence: NM_001002880
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475924 ENST00000485501(uc011any.1) ENST00000411557 ENST00000396811(uc003awb.3)
    ENST00000216029(uc003awc.3) ENST00000492537 ENST00000492576 ENST00000416285
    ENST00000489847 ENST00000467118
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate CBY1:
    hsa-miR-562 hsa-miR-3190
    SwitchGear 3'UTR luciferase reporter plasmidCBY1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CBY1
      QuantiFast Probe-based Assays in human, mouse, rat CBY1

    Additional mRNA sequence: 

    AB015347.1 AB111855.1 AF331041.1 AK307265.1 AK311928.1 AL050345.1 AL136686.1 BC016139.1 
    CR456410.1 

    11 DOTS entries:

    DT.100796215  DT.220669  DT.100637387  DT.100796212  DT.91877124  DT.92424817  DT.92424814  DT.102830131 
    DT.120652210  DT.95320422  DT.95321837 

    Selected AceView cDNA sequences (see all 515):

    BX391149 AI089387 BX089847 BU191238 AA877750 NM_001002880 AA604266 AW372438 
    BU167613 AA738360 BU163625 AI143358 AW173346 CA432856 AA854805 AI559186 
    AB111855 BG674837 AW517214 F10397 AA846394 CA438687 AW874604 BM699564 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CBY1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d
    SP1:                                      -           -     -                                                         
    SP2:                          -           -           -     -                       -     -                           
    SP3:                                -                 -     -                                                         
    SP4:                          -     -     -           -     -                       -     -                           
    SP5:                          -     -     -           -     -                       -     -                           


    ECgene alternative splicing isoforms for CBY1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CBY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGAGCGGC
    CBY1 Expression
    About this image

    CBY1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CBY1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.334911

    UniProtKB/Swiss-Prot: CBY1_HUMAN, Q9Y3M2
    Tissue specificity: Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta.
    Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine
    tumors

        Custom PCR Arrays for CBY1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBY1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CBY1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cby11 , 5 chibby homolog 1 (Drosophila)1, 5 80.42(n)1
    82.54(a)1
      15 (37.84 cM)5
    737391  NM_028634.31  NP_082910.11 
     796592275 
    chicken
    (Gallus gallus)
    Aves CBY11 chibby homolog 1 (Drosophila) 74.4(n)
    84.8(a)
      771364  NM_001278149.1  NP_001265078.1 
    lizard
    (Anolis carolinensis)
    Reptilia CBY16
    chibby homolog 1 (Drosophila)
    81(a)
    1 ↔ 1
    5(24135280-24142203)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cby11 chibby homolog 1 69.89(n)
    74.19(a)
      549007  NM_001016253.2  NP_001016253.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cby11 chibby homolog 1 (Drosophila) 69.62(n)
    75(a)
      326875  NM_001003838.1  NP_001003838.1 


    ENSEMBL Gene Tree for CBY1 (if available)
    TreeFam Gene Tree for CBY1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CBY1 gene
    CBY32  
    1 SIMAP similar gene for CBY1 using alignment to 3 protein entries:     CBY1_HUMAN (see all proteins):
    CBY3

    Find genes that share paralogs with CBY1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for CBY1
    PGOHUM00000240429 PGOHUM00000251347 PGOHUM00000249470


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CBY1 (see all 353)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1883272141,2
    --39054671(+) AGAGAC/TGGGGT 2 -- int10--------
    rs1478397481,2
    --39054694(+) GCCAGA/CGTGGT 2 -- int10--------
    rs48203421,2
    C,F,A--39054771(+) ccaccG/Acgccc 2 -- int12Minor allele frequency- A:0.50NA 4
    rs60011861,2
    C,A--39055049(+) aattcG/Tcatgc 2 -- int11Minor allele frequency- T:0.50WA 2
    rs1493811251,2
    C--39055131(+) AAATGC/TGGTTT 2 -- int10--------
    rs57572161,2
    C,F,A--39055204(+) ccaaaA/Gtgctg 2 -- int13Minor allele frequency- G:0.33NA 6
    rs2010589191,2
    --39055249(+) ATTGG-/TTTTTT 2 -- int10--------
    rs1382166961,2
    --39055258(+) TTTTTG/TTTTGT 2 -- int10--------
    rs1997754991,2
    --39055258(+) TTTTT-/GTTTGT 2 -- int10--------
    rs1808602011,2
    --39055299(+) TTGCTC/GCGTCG 2 -- int10--------

    HapMap Linkage Disequilibrium report for CBY1 (39052641 - 39069859 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CBY1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724232CNV Deletion23290073
    nsv508733CNV Insertion20534489
    nsv915067CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607757    OMIM disorders: --

    1 disease for CBY1:    
    About MalaCards
    pediatric ependymoma


    Find genes that share disorders with CBY1           About GenesLikeMe

    Genetic Association Database (GAD): CBY1
    Human Genome Epidemiology (HuGE) Navigator: CBY1 (4 documents)

    Export disorders for CBY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CBY1 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with CBY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2. (PubMed id 15194699)1, 2, 3, 9 Hidaka S.... Witzgall R. (J. Biol. Chem. 2004)
    2. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I.... Wright H. (Nature 1999)
    3. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (PLoS ONE 2010)
    4. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PubMed id 19019335)1, 4 Velez D.R....Menon R. (Am. J. Obstet. Gynecol. 2009)
    5. Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. (PubMed id 19527514)1, 4 Menon R....Thorsen P. (amp 2009)
    6. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PubMed id 18818748)1, 4 Velez D.R....Menon R. (PLoS ONE 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    9. Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway. (PubMed id 12712206)1, 2 Takemaru K....Moon R.T. (Nature 2003)
    10. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)1, 2 Collins J.E.... Dunham I. (Genome Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 25776 HGNC: 1307 AceView: TOMM22andPGEA1 Ensembl:ENSG00000100211 euGenes: HUgn25776
    ECgene: CBY1 H-InvDB: CBY1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CBY1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CBY1 gene:
    Search GeneIP for patents involving CBY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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