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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CBY1 Gene

protein-coding   GIFtS: 54
GCID: GC22P039052

Chibby Homolog 1 (Drosophila)

(Previous names: chromosome 22 open reading frame 2, PKD2 interactor, golgi...)
(Previous symbols: C22orf2, PGEA1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chibby Homolog 1 (Drosophila)1 2     HS508I15A2 5
C22orf21 2 3 5     Chromosome 22 Open Reading Frame 21
PGEA11 2 3     PIGEA142
CBY2 3 5     arb12
PKD2 Interactor, Golgi And Endoplasmic Reticulum Associated 11 2     Coiled-Coil Protein PIGEA-142
Cytosolic Leucine-Rich Protein2 3     Polycystin-2 Interactor, Golgi- And Endoplasmic Reticulum-Associated
Protein, 14 KDa2
PIGEA-142 3     Protein Chibby Homolog 12
ARPP-Binding Protein2 3     ARB13
PKD2 Interactor, Golgi And Endoplasmic Reticulum-Associated 12 3     

External Ids:    HGNC: 13071   Entrez Gene: 257762   Ensembl: ENSG000001002117   OMIM: 6077575   UniProtKB: Q9Y3M23   

Export aliases for CBY1 gene to outside databases

Previous GC identifers: GC22P037382 GC22P022018


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CBY1 Gene:
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The
protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic
beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to
beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CBY1 Gene: 
CBY1 (chibby homolog 1 (Drosophila)) is a protein-coding gene. Diseases associated with CBY1 include pediatric ependymoma, and ependymoma. GO annotations related to this gene include beta-catenin binding and identical protein binding. An important paralog of this gene is CBY3.

UniProtKB/Swiss-Prot: CBY1_HUMAN, Q9Y3M2
Function: Inhibits the Wnt/Wingless pathway by binding to beta-catenin and inhibiting beta-catenin-mediated
transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a
role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular
proteins. Promotes adipocyte and cardiomyocyte differentiation

Gene Wiki entry for CBY1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CBY1 gene promoter:
         Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCBY1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CBY1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q12

CBY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBY1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P039052:  view genomic region     (about GC identifiers)

Start:
39,052,641 bp from pter      End:
39,069,859 bp from pter
Size:
17,219 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CBY1_HUMAN, Q9Y3M2 (See protein sequence)
Recommended Name: Protein chibby homolog 1  
Size: 126 amino acids; 14470 Da
Subunit: Homodimer. Interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of
beta-catenin
Subcellular location: Nucleus speckle. Golgi apparatus, trans-Golgi network. Note=Nuclear, in a punctate manner.
Also found in the trans-Golgi
Miscellaneous: 'Chibby' is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies
Secondary accessions: B2R4S2 Q66GT6 Q9UIK9

Explore the universe of human proteins at neXtProt for CBY1: NX_Q9Y3M2

Explore proteomics data for CBY1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y3M2

  • CBY1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CBY1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001002880.2  NP_056188.1  

    ENSEMBL proteins: 
     ENSP00000413934   ENSP00000380026   ENSP00000216029   ENSP00000412260  

    Human Recombinant Protein Products for CBY1: 
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    Novus Biologicals CBY1 Proteins
    Novus Biologicals CBY1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CBY1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12712206
    GO:0005794Golgi apparatus IEA--
    GO:0005802trans-Golgi network IDA15194699
    GO:0005932microtubule basal body IEA--
    GO:0016607nuclear speck IEA--

    CBY1 for ontologies           About GeneDecksing



    CBY1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CBY1 

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    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CBY1 
    Cloud-Clone Corp. CLIAs for CBY1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9Y3M2

    UniProtKB/Swiss-Prot: CBY1_HUMAN, Q9Y3M2
    Similarity: Belongs to the chibby family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBY1_HUMAN, Q9Y3M2
    Function: Inhibits the Wnt/Wingless pathway by binding to beta-catenin and inhibiting beta-catenin-mediated
    transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a
    role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular
    proteins. Promotes adipocyte and cardiomyocyte differentiation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15194699
    GO:0008013beta-catenin binding IDA12712206
    GO:0042802identical protein binding IPI15194699
         
    CBY1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CBY1:
     Decreased TP53 protein express 

         10 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cby1):
     adipose tissue  embryogenesis  growth/size  hearing/vestibular/ear  hematopoietic system 
     immune system  integument  mortality/aging  reproductive system  respiratory system 

    CBY1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cby1tm1Ktkm for CBY1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CBY1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CBY1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CBY1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CBY1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CBY1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CBY1:
    hsa-miR-562 hsa-miR-3190
    SwitchGear 3'UTR luciferase reporter plasmidCBY1 3' UTR sequence
    Inhib. RNA
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    Sirion Biotech Customized adenovirus for overexpression of CBY1

    Clone
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    Sino Biological Human cDNA Clone for CBY1
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBY1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CBY1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    1 BioSystems Pathway for CBY1
        Regulation of Wnt-mediated beta catenin signaling and target gene transcription



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CBY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/13 Interacting proteins for CBY1 (Q9Y3M22, 3 ENSP000002160294) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGTPBP1Q9UPW52, 3, ENSP000003385124MINT-2871559 MINT-2871578 I2D: score=3 STRING: ENSP00000338512
    YWHAEP622582, 3, ENSP000002643354MINT-8008465 I2D: score=1 STRING: ENSP00000264335
    YWHAZP631042, 3, ENSP000003095034MINT-8008472 MINT-8009477 I2D: score=1 STRING: ENSP00000309503
    CTNNB1P352223, ENSP000003444564I2D: score=4 STRING: ENSP00000344456
    PROP1O753603I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008104protein localization IMP15194699
    GO:0030178negative regulation of Wnt receptor signaling pathway IDA12712206
    GO:0042384cilium assembly IEA--
    GO:0045444fat cell differentiation ISS--
    GO:0045892negative regulation of transcription, DNA-dependent IDA12712206

    CBY1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CBY1

    Search CenterWatch for drugs/clinical trials and news about CBY1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CBY1 gene (2 alternative transcripts): 
    NM_001002880.1  NM_015373.3  

    Unigene Clusters for CBY1:

    Chibby homolog 1 (Drosophila)
    Hs.334911  [show with all ESTs], Hs.744261  [show with all ESTs]
    Unigene Representative Sequences: NM_001002880, AK128685
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475924 ENST00000485501(uc011any.1) ENST00000411557 ENST00000396811(uc003awb.3)
    ENST00000216029(uc003awc.3) ENST00000492537 ENST00000492576 ENST00000416285
    ENST00000489847 ENST00000467118
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CBY1:
    hsa-miR-562 hsa-miR-3190
    SwitchGear 3'UTR luciferase reporter plasmidCBY1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CBY1 (NM_015373)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBY1
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    Sirion Biotech Customized lentivirus for stable overexpression of CBY1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBY1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBY1

    Additional mRNA sequence: 

    AK128685.1 BC008839.2 BC036921.1 

    13 DOTS entries:

    DT.100796215  DT.220669  DT.100637387  DT.100796212  DT.95321837  DT.220675  DT.91877124  DT.92424817 
    DT.95072638  DT.92424814  DT.102830131  DT.120652210  DT.95320422 

    24/515 AceView cDNA sequences (see all 515):

    BM554645 BM021487 AI198108 BQ674748 BU167613 AA133768 BU552645 AA678500 
    AB041906 BM998243 AI122822 AW015368 AI609300 AW874604 AA854805 CR456410 
    AA846394 AW372438 AF331041 CR610817 AB040119 BM839734 BU633560 BQ961547 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for CBY1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d
    SP1:                                      -           -     -                                                         
    SP2:                          -           -           -     -                       -     -                           
    SP3:                                -                 -     -                                                         
    SP4:                          -     -     -           -     -                       -     -                           
    SP5:                          -     -     -           -     -                       -     -                           


    ECgene alternative splicing isoforms for CBY1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CBY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGAGCGGC
    CBY1 Expression
    About this image


    See CBY1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CBY1

    SOURCE GeneReport for Unigene clusters: Hs.334911 Hs.744261

    UniProtKB/Swiss-Prot: CBY1_HUMAN, Q9Y3M2
    Tissue specificity: Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta.
    Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine
    tumors

        SABiosciences Custom PCR Arrays for CBY1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBY1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CBY1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cby11 , 5 chibby homolog 1 (Drosophila)1, 5 80.42(n)1
    82.54(a)1
      15 (37.84 cM)5
    737391  NM_028634.31  NP_082910.11 
     796592275 
    chicken
    (Gallus gallus)
    Aves CBY11 chibby homolog 1 (Drosophila) 72.8(n)
    83.2(a)
      771364  XM_001234192.2  XP_001234193.1 
    lizard
    (Anolis carolinensis)
    Reptilia CBY16
    Uncharacterized protein
    82(a)
    1 ↔ 1
    5(24135280-24142203)
    zebrafish
    (Danio rerio)
    Actinopterygii cby11 chibby homolog 1 (Drosophila) 69.62(n)
    75(a)
      326875  NM_001003838.1  NP_001003838.1 


    ENSEMBL Gene Tree for CBY1 (if available)
    TreeFam Gene Tree for CBY1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CBY1 gene
    CBY32  
    1 SIMAP similar gene for CBY1 using alignment to 3 protein entries:     CBY1_HUMAN (see all proteins):
    CBY3

    CBY1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CBY1
    PGOHUM00000240429 PGOHUM00000251347 PGOHUM00000249470


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/353 SNPs in CBY1 are shown (see all 353)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1883272141,2
    --39054671(+) AGAGAC/TGGGGT 2 -- int10--------
    rs1478397481,2
    --39054694(+) GCCAGA/CGTGGT 2 -- int10--------
    rs48203421,2
    C,F,A--39054771(+) ccaccG/Acgccc 2 -- int12Minor allele frequency- A:0.50NA 4
    rs60011861,2
    C,A--39055049(+) aattcG/Tcatgc 2 -- int11Minor allele frequency- T:0.50WA 2
    rs1493811251,2
    C--39055131(+) AAATGC/TGGTTT 2 -- int10--------
    rs57572161,2
    C,F,A--39055204(+) ccaaaA/Gtgctg 2 -- int13Minor allele frequency- G:0.33NA 6
    rs2010589191,2
    --39055249(+) ATTGG-/TTTTTT 2 -- int10--------
    rs1382166961,2
    --39055258(+) TTTTTG/TTTTGT 2 -- int10--------
    rs1997754991,2
    --39055258(+) TTTTT-/GTTTGT 2 -- int10--------
    rs1808602011,2
    --39055299(+) TTGCTC/GCGTCG 2 -- int10--------

    HapMap Linkage Disequilibrium report for CBY1 (39052641 - 39069859 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CBY1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724232CNV Deletion23290073
    nsv508733CNV Insertion20534489
    nsv915067CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607757    OMIM disorders: --

    5 diseases for CBY1:    About MalaCards
    pediatric ependymoma    ependymoma    neuroblastoma    colorectal cancer
    thyroiditis


    CBY1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CBY1
    Human Genome Epidemiology (HuGE) Navigator: CBY1 (4 documents)

    Export disorders for CBY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CBY1 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with CBY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2. (PubMed id 15194699)1, 2, 3, 9 Hidaka S....Witzgall R. (2004)
    2. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I....O'Brien K.P. (1999)
    3. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (2010)
    4. Racial disparity in pathophysiologic pathways of pret erm birth based on genetic variants. (PubMed id 19527514)1, 4 Menon R....Thorsen P. (2009)
    5. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PubMed id 19019335)1, 4 Velez D.R....Menon R. (2008)
    6. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PubMed id 18818748)1, 4 Velez D.R....Menon R. (2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    9. Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway. (PubMed id 12712206)1, 2 Takemaru K....Moon R.T. (2003)
    10. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)1, 2 Collins J.E.... Dunham I. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25776 HGNC: 1307 AceView: TOMM22andPGEA1 Ensembl:ENSG00000100211 euGenes: HUgn25776
    ECgene: CBY1 H-InvDB: CBY1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CBY1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CBY1 gene:
    Search GeneIP for patents involving CBY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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