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CBX8 Gene

protein-coding   GIFtS: 55
GCID: GC17M077765

Chromobox Homolog 8

(Previous name: chromobox homolog 8 (Drosophila Pc class))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromobox Homolog 81 2     Chromobox Homolog 8 (Pc Class Homolog, Drosophila)2
Polycomb 31 2     Chromobox Protein Homolog 82
Rectachrome 12 3     Pc Class 3 Homolog2
PC32 3     Pc33
RC12 3     hPc33
Chromobox Homolog 8 (Drosophila Pc Class)1     Polycomb 3 Homolog3
Pc Class 3 Homolog (Drosophila)1     

External Ids:    HGNC: 159621   Entrez Gene: 573322   Ensembl: ENSG000001415707   UniProtKB: Q9HC523   
ORGUL members:         

Export aliases for CBX8 gene to outside databases

Previous GC identifers: GC17M077418 GC17M081056 GC17M078332 GC17M078468 GC17M078452 GC17M075382 GC17M073209


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CBX8 Gene:
CBX8 (chromobox homolog 8) is a protein-coding gene. Diseases associated with CBX8 include childhood leukemia, and mouth disease. GO annotations related to this gene include ubiquitin-protein ligase activity and single-stranded RNA binding. An important paralog of this gene is CBX6.

UniProtKB/Swiss-Prot: CBX8_HUMAN, Q9HC52
Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain
the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1
complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A
'Lys-119', rendering chromatin heritably changed in its expressibility

Gene Wiki entry for CBX8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CBX8 gene promoter:
         Pax-6   NF-kappaB   c-Ets-1   Gfi-1   SRY   POU2F1   NF-kappaB2   POU2F1a   Pax-4a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCBX8 promoter sequence
   Search Chromatin IP Primers for CBX8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CBX8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

CBX8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBX8 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M077765:  view genomic region     (about GC identifiers)

Start:
77,765,931 bp from pter      End:
77,775,482 bp from pter
Size:
9,552 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CBX8_HUMAN, Q9HC52 (See protein sequence)
Recommended Name: Chromobox protein homolog 8  
Size: 389 amino acids; 43396 Da
Subunit: Component of a PRC1-like complex. Interacts with RING1 RNF2, PCGF1, PCGF2, PCGF3, BMI1, PCGF5 AND PCGF6.
Interacts with MLLT3 and histone H3. Interacts with PHC2 (By similarity)
Miscellaneous: The human orthologuous proteins of Drosphila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and
CBX8, show distinct nulear localizations, contribute differently to transcriptional repression, and appear to be
part of distinct PRC1-like protein complexes. The hPRC-H complex purification reported by PubMed:12167701
probably presents a mixture of different complexes
1 PDB 3D structure from and Proteopedia for CBX8:
3I91 (3D)    
Secondary accessions: Q96H39 Q9NR07

Explore the universe of human proteins at neXtProt for CBX8: NX_Q9HC52

Explore proteomics data for CBX8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CBX8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065700.1  
    ENSEMBL proteins: 
     ENSP00000269385   ENSP00000405058   ENSP00000408753  
    Reactome Protein details: Q9HC52

    CBX8 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CBX8
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CBX8
    GenScript Custom Purified and Recombinant Proteins Services for CBX8
    Novus Biologicals CBX8 Protein
    Novus Biologicals CBX8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CBX8

    CBX8 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CBX8
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CBX8
    OriGene Custom Antibody Services for CBX8
    Novus Biologicals CBX8 Antibodies
    Abcam antibodies for CBX8
    Cloud-Clone Corp. Antibodies for CBX8
    ThermoFisher Antibody for CBX8
    LSBio Antibodies in human, mouse, rat for CBX8

    CBX8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CBX8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CBX8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CBX8
    Cloud-Clone Corp. CLIAs for CBX8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000953 Chromo_domain/shadow
     IPR023780 Chromo_domain
     IPR016197 Chromodomain-like
     IPR023779 Chromodomain_CS

    Graphical View of Domain Structure for InterPro Entry Q9HC52

    ProtoNet protein and cluster: Q9HC52

    1 Blocks protein domain: IPB000953 Chromo domain

    UniProtKB/Swiss-Prot: CBX8_HUMAN, Q9HC52
    Similarity: Contains 1 chromo domain


    CBX8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBX8_HUMAN, Q9HC52
    Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain
    the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1
    complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A
    'Lys-119', rendering chromatin heritably changed in its expressibility

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003727single-stranded RNA binding IEA--
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI16169070
    GO:0035064methylated histone residue binding IDA--
         
    CBX8 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cbx8):
     cellular  hematopoietic system  mortality/aging 

    CBX8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cbx8tm1.1Hko for CBX8

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CBX8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CBX8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CBX8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CBX8

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CBX8 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CBX8:
    hsa-miR-618 hsa-miR-518f* hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidCBX8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CBX8
    Predesigned siRNA for gene silencing in human, mouse, rat CBX8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CBX8

    Clone
    Products:
         
    OriGene clones in human, mouse for CBX8 (see all 5)
    OriGene ORF clones in mouse, rat for CBX8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CBX8 (NM_020649)
    Sino Biological Human cDNA Clone for CBX8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBX8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBX8

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CBX8
    Browse ESI BIO Cell Lines and PureStem Progenitors for CBX8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CBX8_HUMAN, Q9HC52: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex ----
    GO:0000790nuclear chromatin IDA19636380
    GO:0000792heterochromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--

    CBX8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CBX8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CBX8
        Oxidative Stress Induced Senescence



    CBX8 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CBX8: 
              Polycomb & Trithorax Complexes in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CBX8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CBX8 (Q9HC521, 2, 3 ENSP000002693854) via UniProtKB, MINT, STRING, and/or I2D (see all 238)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP11P517841, 2, 3, ENSP000002183484EBI-712912,EBI-306876 MINT-8001998 MINT-8001923 MINT-7999851 MINT-8012669 MINT-8003609 MINT-8010390 MINT-8001946 MINT-8001976 MINT-8010325 MINT-7999719 I2D: score=2 STRING: ENSP00000218348
    BMI1P352261, 2, 3, ENSP000003658514EBI-712912,EBI-2341576 MINT-8001998 MINT-8001923 MINT-4543665 MINT-8001946 MINT-4543725 MINT-8001976 MINT-8010325 MINT-4543674 I2D: score=3 STRING: ENSP00000365851
    ENSG00000235107Q065871, 2, 3, ENSP000003964394EBI-712912,EBI-752313 MINT-8010390 MINT-8001946 MINT-8010325 I2D: score=3 STRING: ENSP00000396439
    RING1Q065871, 2, 3, ENSP000003637874EBI-712912,EBI-752313 MINT-8010390 MINT-8001946 MINT-8010325 I2D: score=3 STRING: ENSP00000363787
    ENSG00000206287Q065871, 2, 3EBI-712912,EBI-752313 MINT-8010390 MINT-8001946 MINT-8010325 I2D: score=3 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP19636380
    GO:0006351transcription, DNA-templated IEA--
    GO:0016574histone ubiquitination IEA--

    CBX8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CBX8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CBX8 gene: 
    NM_020649.2  

    Unigene Cluster for CBX8:

    Chromobox homolog 8
    Hs.387258  [show with all ESTs]
    Unigene Representative Sequence: NM_020649
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269385(uc002jxd.2) ENST00000413392 ENST00000427800 ENST00000485449

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CBX8 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CBX8:
    hsa-miR-618 hsa-miR-518f* hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidCBX8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CBX8
    Predesigned siRNA for gene silencing in human, mouse, rat CBX8
    Clone
    Products:
         
    OriGene clones in human, mouse for CBX8 (see all 5)
    OriGene ORF clones in mouse, rat for CBX8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CBX8 (NM_020649)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBX8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBX8
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CBX8
    OriGene qSTAR qPCR primer pairs in human, mouse for CBX8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBX8
      QuantiTect SYBR Green Assays in human, mouse, rat CBX8
      Search QuantiFast Probe-based Assays in human, mouse, rat CBX8

    Additional mRNA sequence: 

    AF174482.1 AF266479.2 AK074560.1 BC008937.2 BC009376.2 BC019289.1 

    2 DOTS entries:

    DT.65287151  DT.100840784 

    Selected AceView cDNA sequences (see all 48):

    CD722217 BC019289 AW167196 AF174482 BQ425649 CR600853 BC009376 BC008937 
    NM_020649 BG248106 AK074560 CR591848 AF266479 BE892826 BE391068 CD365324 
    BI771784 BE616878 AL579037 BP364381 AI681636 AL577635 AW250888 BE222046 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CBX8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGCCCAGG
    CBX8 Expression
    About this image

    CBX8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CBX8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.387258
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CBX8: 
              Polycomb & Trithorax Complexes in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CBX8
    OriGene qSTAR qPCR primer pairs in human, mouse for CBX8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBX8
    QuantiTect SYBR Green Assays in human, mouse, rat CBX8
    Search QuantiFast Probe-based Assays in human, mouse, rat CBX8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CBX8 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cbx81 , 5 chromobox homolog 8 (Drosophila Pc class)5
    chromobox 81
    87.11(n)1
    93.92(a)1
      11 (83.33 cM)5
    309511  NM_013926.11  NP_038954.11 
     1190363055 
    chicken
    (Gallus gallus)
    Aves CBX81 chromobox homolog 8 71.41(n)
    71.83(a)
      422084  XM_001231756.3  XP_001231757.2 
    lizard
    (Anolis carolinensis)
    Reptilia CBX86
    chromobox homolog 8
    69(a)
    1 ↔ 1
    2(100943913-100949831)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cbx81 chromobox homolog 8 65.15(n)
    69.93(a)
      779897  NM_001078975.1  NP_001072443.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.200342 Danio rerio polycomb 3 mRNA, complete cds 74.06(n)    AY179330.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pc6
    Polycomb
    20(a)
    1 → many
    3L(21299238-21311120)


    ENSEMBL Gene Tree for CBX8 (if available)
    TreeFam Gene Tree for CBX8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CBX8 gene
    CBX62  CBX22  CBX42  CBX72  
    4 SIMAP similar genes for CBX8 using alignment to 3 protein entries:     CBX8_HUMAN (see all proteins):
    CBX4    CBX7    CBX5    CBX3

    CBX8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CBX8 (see all 128)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1485662401,2
    --77767720(+) TGCATG/TTCCTG 1 -- int10--------
    rs1429586631,2
    --77767799(+) GAAAAA/GCTTAT 1 -- int10--------
    rs1501643941,2
    C--77767817(+) AATAC-/TTTTTT 1 -- int10--------
    rs357653901,2
    C--77767844(+) AAAAA-/A/AA  
            
    TAGAA
    1 -- int12NA CSA 4
    rs734203021,2
    C--77768068(+) CCAGGG/CCCCAA 1 -- int14Minor allele frequency- C:0.08NA WA EA 360
    rs1511198881,2
    --77768355(+) ATCCCA/CCCCAG 1 -- ut310--------
    rs2008640501,2
    C--77768405(+) CCCTGC/TTCTCC 1 -- ut310--------
    rs620003631,2
    F--77768534(+) CCAGGT/GTAGTC 2 /N /T mis11Minor allele frequency- G:0.05NS 74
    rs2001349601,2
    --77768538(+) GTTAGC/TCAGGG 2 T A mis10--------
    rs1498671701,2
    C,F--77768602(+) CTGGCG/AATGAG 2 /I syn11Minor allele frequency- A:0.00NA 3068

    HapMap Linkage Disequilibrium report for CBX8 (77765931 - 77775482 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CBX8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv828116CNV Loss20364138
    nsv469865CNV Loss16826518
    nsv908957CNV Loss21882294
    nsv483050CNV Loss15286789
    nsv908947CNV Loss21882294
    nsv908948CNV Loss21882294
    dgv3292n71CNV Loss21882294
    dgv3294n71CNV Loss21882294
    dgv3293n71CNV Loss21882294
    dgv538n67CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CBX8
    DNA2.0 Custom Variant and Variant Library Synthesis for CBX8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for CBX8:    About MalaCards
    childhood leukemia    mouth disease    acute leukemia    leukemia
    breast cancer


    CBX8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CBX8

    Export disorders for CBX8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CBX8 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with CBX8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties. (PubMed id 10825164)1, 2, 3, 9 Bardos J.I.... Freemont P.S. (J. Biol. Chem. 2000)
    2. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PubMed id 19636380)1, 2, 9 Maertens G.N.... Peters G. (PLoS ONE 2009)
    3. Recognition and specificity determinants of the human cbx chromodomains. (PubMed id 21047797)1, 2 Kaustov L.... Arrowsmith C.H. (J. Biol. Chem. 2011)
    4. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PubMed id 21282530)1, 2 Vandamme J.... Angrand P.O. (Mol. Cell. Proteomics 2011)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. (PubMed id 12167701)1, 2 Levine S.S....Kingston R.E. (Mol. Cell. Biol. 2002)
    8. The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3. (PubMed id 11313972)1, 2 Garcia-Cuellar M.P.... Slany R.K. (Oncogene 2001)
    9. Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. (PubMed id 17332741)1, 9 Dietrich N....Hansen K.H. (EMBO J. 2007)
    10. A phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin. (PubMed id 17936708)1, 9 Elderkin S....Hiom K. (Mol. Cell 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57332 HGNC: 15962 AceView: CBX8 Ensembl:ENSG00000141570 euGenes: HUgn57332
    ECgene: CBX8 H-InvDB: CBX8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CBX8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CBX8 gene:
    Search GeneIP for patents involving CBX8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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