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CBX8 Gene(Protein Coding)

Chromobox 8

GCID:
GC17M079794
GIFtS:
54
Genes Participants
UDN Logo

Aliases for CBX8 Gene

Aliases for CBX8 Gene

  • Chromobox 8 2 3 5
  • Rectachrome 1 3 4
  • Polycomb 3 2 3
  • PC3 3 4
  • RC1 3 4
  • Chromobox Homolog 8 (Pc Class Homolog, Drosophila) 3
  • Chromobox Homolog 8 (Drosophila Pc Class) 2
  • Pc Class 3 Homolog (Drosophila) 2
  • Chromobox Protein Homolog 8 3
  • Chromobox Homolog 8 2
  • Pc Class 3 Homolog 3
  • Polycomb 3 Homolog 4
  • HPc3 4

External Ids for CBX8 Gene

Previous GeneCards Identifiers for CBX8 Gene

  • GC17M077418
  • GC17M081056
  • GC17M078332
  • GC17M078468
  • GC17M078452
  • GC17M075382
  • GC17M077765
  • GC17M073209

Summaries for CBX8 Gene

GeneCards Summary for CBX8 Gene

CBX8 (Chromobox 8) is a Protein Coding gene. Diseases associated with CBX8 include Conversion Disorder. Among its related pathways are Cellular Senescence and Metabolism of proteins. GO annotations related to this gene include ubiquitin-protein transferase activity and single-stranded RNA binding. An important paralog of this gene is CBX6.

UniProtKB/Swiss-Prot for CBX8 Gene

  • Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

Gene Wiki entry for CBX8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBX8 Gene

Genomics for CBX8 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CBX8 Gene

Enhancers for CBX8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G079804 1.6 FANTOM5 Ensembl ENCODE 27.2 -2.8 -2816 0.8 ZFP64 ARID4B SIN3A ZNF48 GLIS2 ZNF143 ZNF263 SP3 JUNB KAT8 CBX8 CBX2 CBX4 PIR54271
GH17G079808 2 FANTOM5 Ensembl ENCODE dbSUPER 16 -10.9 -10887 8.0 HDGF PKNOX1 AGO1 ZFP64 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF766 CBX8 CBX2 CBX4 CCDC40 PIR54271
GH17G079792 1.4 Ensembl ENCODE dbSUPER 21.3 +7.9 7932 3.2 TBP AGO1 KLF17 SIN3A RAD21 RFX5 ZNF121 GATA2 ZNF366 ZSCAN5C CBX8 CBX4 ENSG00000262768 GC17P079785
GH17G079826 1.4 Ensembl ENCODE dbSUPER 13.3 -24.8 -24812 0.6 ATF1 CREB3L1 GATA2 ELK1 ZMIZ1 GTF2B NCOA1 REST ZNF592 MBD2 EIF4A3 CBX8 SGSH LINC01977 CBX4
GH17G079796 1.4 ENCODE dbSUPER 7.2 +4.6 4622 2.1 HDGF FOXA2 PKNOX1 ARNT AGO1 ARID4B SIN3A DMAP1 YY1 ZNF143 CBX4 CBX8 ENSG00000262768 GC17P079785
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CBX8 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CBX8 gene promoter:

Genomic Location for CBX8 Gene

Chromosome:
17
Start:
79,792,132 bp from pter
End:
79,801,683 bp from pter
Size:
9,552 bases
Orientation:
Minus strand

Genomic View for CBX8 Gene

Genes around CBX8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBX8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBX8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CBX8 Gene

Proteins for CBX8 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CBX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC52-CBX8_HUMAN
    Recommended name:
    Chromobox protein homolog 8
    Protein Accession:
    Q9HC52
    Secondary Accessions:
    • Q96H39
    • Q9NR07

    Protein attributes for CBX8 Gene

    Size:
    389 amino acids
    Molecular mass:
    43396 Da
    Quaternary structure:
    • Component of a PRC1-like complex. Interacts with RING1 RNF2, PCGF1, PCGF2, PCGF3, BMI1, PCGF5 AND PCGF6. Interacts with MLLT3 and histone H3. Interacts with PHC2 (By similarity).
    Miscellaneous:
    • The human orthologuous proteins of Drosphila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nulear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes. The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different complexes.

    Three dimensional structures from OCA and Proteopedia for CBX8 Gene

neXtProt entry for CBX8 Gene

Protein Expression for CBX8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CBX8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CBX8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CBX8 (CBX8)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CBX8

No data available for DME Specific Peptides for CBX8 Gene

Domains & Families for CBX8 Gene

Gene Families for CBX8 Gene

HGNC:

Protein Domains for CBX8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CBX8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CBX8: view

No data available for UniProtKB/Swiss-Prot for CBX8 Gene

Function for CBX8 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CBX8 Gene

UniProtKB/Swiss-Prot Function:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

Gene Ontology (GO) - Molecular Function for CBX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003727 single-stranded RNA binding IEA --
GO:0005515 protein binding IPI 16169070
GO:0035064 methylated histone binding IDA 21029866
GO:0097027 ubiquitin-protein transferase activator activity IEA --
genes like me logo Genes that share ontologies with CBX8: view
genes like me logo Genes that share phenotypes with CBX8: view

Animal Models for CBX8 Gene

MGI Knock Outs for CBX8:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CBX8

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBX8 Gene

Localization for CBX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBX8 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CBX8 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for CBX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IEA --
GO:0000790 nuclear chromatin IDA 19636380
GO:0000792 heterochromatin IEA --
GO:0005634 nucleus IEA,IDA 21282530
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CBX8: view

Pathways & Interactions for CBX8 Gene

genes like me logo Genes that share pathways with CBX8: view

Pathways by source for CBX8 Gene

1 Cell Signaling Technology pathway for CBX8 Gene

Gene Ontology (GO) - Biological Process for CBX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 19636380
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0016569 covalent chromatin modification IEA --
genes like me logo Genes that share ontologies with CBX8: view

No data available for SIGNOR curated interactions for CBX8 Gene

Drugs & Compounds for CBX8 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CBX8 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CBX8 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(48) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CBX8 Gene

Chromobox homolog 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CBX8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CBX8 Gene

No ASD Table

Relevant External Links for CBX8 Gene

GeneLoc Exon Structure for
CBX8
ECgene alternative splicing isoforms for
CBX8

Expression for CBX8 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CBX8 Gene

mRNA expression in normal human tissues for CBX8 Gene
mRNA expression by BioGPS for CBX8 GenemRNA expression by GTEx for CBX8 Gene

Protein differential expression in normal tissues from HIPED for CBX8 Gene

This gene is overexpressed in Retina (28.7), Fetal Brain (8.2), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CBX8 Gene



Protein tissue co-expression partners for CBX8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CBX8 Gene:

CBX8

SOURCE GeneReport for Unigene cluster for CBX8 Gene:

Hs.387258

Evidence on tissue expression from TISSUES for CBX8 Gene

  • Liver(4.2)
  • Lung(4.1)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with CBX8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBX8 Gene

Orthologs for CBX8 Gene

This gene was present in the common ancestor of animals.

Orthologs for CBX8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CBX8 34 35
  • 97.24 (n)
cow
(Bos Taurus)
 Mammalia CBX8 34 35
  • 89.39 (n)
dog
(Canis familiaris)
 Mammalia CBX8 34 35
  • 89.36 (n)
mouse
(Mus musculus)
 Mammalia Cbx8 34 16 35
  • 87.11 (n)
rat
(Rattus norvegicus)
 Mammalia Cbx8 34
  • 86.61 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia CBX8 35
  • 80 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CBX8 34 35
  • 71.41 (n)
lizard
(Anolis carolinensis)
 Reptilia CBX8 35
  • 69 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cbx8 34
  • 65.15 (n)
zebrafish
(Danio rerio)
 Actinopterygii LOC100535436 34
  • 66.92 (n)
cbx8a 35 35
  • 45 (a)
 OneToMany
cbx8b 35
  • 45 (a)
 OneToMany
Dr.20034 34
fruit fly
(Drosophila melanogaster)
 Insecta Pc 35
  • 20 (a)
 OneToMany
Species where no ortholog for CBX8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBX8 Gene

ENSEMBL:
Gene Tree for CBX8 (if available)
TreeFam:
Gene Tree for CBX8 (if available)

Paralogs for CBX8 Gene

Paralogs for CBX8 Gene

(4) SIMAP similar genes for CBX8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CBX8: view

Variants for CBX8 Gene

Sequence variations from dbSNP and Humsavar for CBX8 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000095911 -- 79,795,790(+) GAAGT(A/T)GTCAT intron-variant
rs1000645033 -- 79,797,600(+) CCCCC(A/C)CCGCC upstream-variant-2KB
rs1001049861 -- 79,796,702(+) AAGTG(C/T)ATGCA intron-variant
rs1001500874 -- 79,796,932(+) TACTT(C/T)CCGTA reference, missense
rs1002218411 -- 79,797,211(+) ACGTT(C/G)CTAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CBX8 Gene

Variant ID Type Subtype PubMed ID
dgv538n67 CNV gain 20364138
nsv469865 CNV loss 16826518
nsv828116 CNV loss 20364138

Variation tolerance for CBX8 Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CBX8 Gene

Human Gene Mutation Database (HGMD)
CBX8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CBX8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBX8 Gene

Disorders for CBX8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CBX8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
conversion disorder
  • dissociative disorder
- elite association - COSMIC cancer census association via MalaCards
Search CBX8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CBX8

Genetic Association Database (GAD)
CBX8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CBX8
genes like me logo Genes that share disorders with CBX8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CBX8 Gene

Publications for CBX8 Gene

  1. HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties. (PMID: 10825164) Bardos J.I. … Freemont P.S. (J. Biol. Chem. 2000) 2 3 4 22 64
  2. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PMID: 19636380) Maertens G.N. … Peters G. (PLoS ONE 2009) 3 4 22 64
  3. Recognition and specificity determinants of the human cbx chromodomains. (PMID: 21047797) Kaustov L. … Arrowsmith C.H. (J. Biol. Chem. 2011) 3 4 64
  4. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PMID: 21282530) Vandamme J. … Angrand P.O. (Mol. Cell. Proteomics 2011) 3 4 64
  5. Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. (PMID: 17332741) Dietrich N. … Hansen K.H. (EMBO J. 2007) 3 22 64

Products for CBX8 Gene

  • Addgene plasmids for CBX8

Sources for CBX8 Gene

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