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Aliases for CBX8 Gene

Aliases for CBX8 Gene

  • Chromobox Homolog 8 2 3
  • Rectachrome 1 3 4
  • Polycomb 3 2 3
  • PC3 3 4
  • RC1 3 4
  • Chromobox Homolog 8 (Pc Class Homolog, Drosophila) 3
  • Chromobox Homolog 8 (Drosophila Pc Class) 2
  • Pc Class 3 Homolog (Drosophila) 2
  • Chromobox Protein Homolog 8 3
  • Pc Class 3 Homolog 3
  • Polycomb 3 Homolog 4
  • HPc3 4

External Ids for CBX8 Gene

Summaries for CBX8 Gene

GeneCards Summary for CBX8 Gene

CBX8 (Chromobox Homolog 8) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Cellular Senescence. GO annotations related to this gene include ubiquitin-protein transferase activity and single-stranded RNA binding. An important paralog of this gene is CBX4.

UniProtKB/Swiss-Prot for CBX8 Gene

  • Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

Gene Wiki entry for CBX8 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBX8 Gene

Genomics for CBX8 Gene

Genomic Location for CBX8 Gene

Start:
79,792,132 bp from pter
End:
79,801,683 bp from pter
Size:
9,552 bases
Orientation:
Minus strand

Genomic View for CBX8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CBX8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBX8 Gene

Regulatory Elements for CBX8 Gene

Proteins for CBX8 Gene

  • Protein details for CBX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC52-CBX8_HUMAN
    Recommended name:
    Chromobox protein homolog 8
    Protein Accession:
    Q9HC52
    Secondary Accessions:
    • Q96H39
    • Q9NR07

    Protein attributes for CBX8 Gene

    Size:
    389 amino acids
    Molecular mass:
    43396 Da
    Quaternary structure:
    • Component of a PRC1-like complex. Interacts with RING1 RNF2, PCGF1, PCGF2, PCGF3, BMI1, PCGF5 AND PCGF6. Interacts with MLLT3 and histone H3. Interacts with PHC2 (By similarity).
    Miscellaneous:
    • The human orthologuous proteins of Drosphila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nulear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes. The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different complexes

    Three dimensional structures from OCA and Proteopedia for CBX8 Gene

neXtProt entry for CBX8 Gene

Proteomics data for CBX8 Gene at MOPED

Post-translational modifications for CBX8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CBX8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CBX8 Gene

Domains for CBX8 Gene

Protein Domains for CBX8 Gene

Suggested Antigen Peptide Sequences for CBX8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HC52

UniProtKB/Swiss-Prot:

CBX8_HUMAN
Domain:
  • Contains 1 chromo domain.:
    • Q9HC52
genes like me logo Genes that share domains with CBX8: view

No data available for Gene Families for CBX8 Gene

Function for CBX8 Gene

Molecular function for CBX8 Gene

UniProtKB/Swiss-Prot Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

Gene Ontology (GO) - Molecular Function for CBX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003727 single-stranded RNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IPI 16169070
GO:0035064 methylated histone binding IDA 21029866
genes like me logo Genes that share ontologies with CBX8: view

Phenotypes for CBX8 Gene

genes like me logo Genes that share phenotypes with CBX8: view

Animal Models for CBX8 Gene

MGI Knock Outs for CBX8:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CBX8 Gene

Localization for CBX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBX8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CBX8 Gene COMPARTMENTS Subcellular localization image for CBX8 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for CBX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex --
GO:0000790 nuclear chromatin IDA 19636380
GO:0000792 heterochromatin IEA --
GO:0005634 nucleus IDA 21282530
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CBX8: view

Pathways for CBX8 Gene

genes like me logo Genes that share pathways with CBX8: view

Pathways by source for CBX8 Gene

Gene Ontology (GO) - Biological Process for CBX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 19636380
GO:0006351 transcription, DNA-templated IEA --
GO:0016574 histone ubiquitination IEA --
GO:0016925 protein sumoylation TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with CBX8: view

Transcripts for CBX8 Gene

mRNA/cDNA for CBX8 Gene

Unigene Clusters for CBX8 Gene

Chromobox homolog 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CBX8 Gene

No ASD Table

Relevant External Links for CBX8 Gene

GeneLoc Exon Structure for
CBX8
ECgene alternative splicing isoforms for
CBX8

Expression for CBX8 Gene

mRNA expression in normal human tissues for CBX8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CBX8 Gene

SOURCE GeneReport for Unigene cluster for CBX8 Gene Hs.387258

genes like me logo Genes that share expressions with CBX8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CBX8 Gene

Orthologs for CBX8 Gene

This gene was present in the common ancestor of animals.

Orthologs for CBX8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CBX8 35
  • 97.24 (n)
  • 98.97 (a)
CBX8 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CBX8 35
  • 89.39 (n)
  • 93.9 (a)
CBX8 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CBX8 35
  • 89.36 (n)
  • 92.61 (a)
CBX8 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cbx8 35
  • 87.11 (n)
  • 93.92 (a)
Cbx8 16
Cbx8 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CBX8 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cbx8 35
  • 86.61 (n)
  • 93.44 (a)
chicken
(Gallus gallus)
Aves CBX8 35
  • 71.41 (n)
  • 71.83 (a)
CBX8 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CBX8 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cbx8 35
  • 65.15 (n)
  • 69.93 (a)
zebrafish
(Danio rerio)
Actinopterygii cbx8a 36
  • 45 (a)
OneToMany
cbx8a 36
  • 45 (a)
OneToMany
cbx8b 36
  • 45 (a)
OneToMany
Dr.20034 35
LOC100535436 35
  • 66.92 (n)
  • 74.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pc 36
  • 20 (a)
OneToMany
Species with no ortholog for CBX8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBX8 Gene

ENSEMBL:
Gene Tree for CBX8 (if available)
TreeFam:
Gene Tree for CBX8 (if available)

Paralogs for CBX8 Gene

Paralogs for CBX8 Gene

Selected SIMAP similar genes for CBX8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CBX8: view

Variants for CBX8 Gene

Sequence variations from dbSNP and Humsavar for CBX8 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4327084 -- 79,796,539(+) TGCGA(C/T)CCTGC missense, reference
rs4523954 -- 79,796,538(+) ATGCG(A/T)TCCTG reference, synonymous-codon
rs4889891 - 79,794,855(+) CCCCC(A/C)CAGAG reference, missense
rs8070713 -- 79,797,754(+) TCCCC(C/G)GGAGC upstream-variant-2KB
rs8082452 -- 79,797,749(+) ccccc(G/T)ccccc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CBX8 Gene

Variant ID Type Subtype PubMed ID
nsv908947 CNV Loss 21882294
nsv483050 CNV Loss 15286789
nsv908948 CNV Loss 21882294
dgv3292n71 CNV Loss 21882294
nsv828116 CNV Loss 20364138
dgv3293n71 CNV Loss 21882294
dgv538n67 CNV Gain 20364138
nsv469865 CNV Loss 16826518
nsv908957 CNV Loss 21882294
dgv3294n71 CNV Loss 21882294

Relevant External Links for CBX8 Gene

HapMap Linkage Disequilibrium report
CBX8
Human Gene Mutation Database (HGMD)
CBX8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBX8 Gene

Disorders for CBX8 Gene

Relevant External Links for CBX8

Genetic Association Database (GAD)
CBX8
genes like me logo Genes that share disorders with CBX8: view

No data available for UniProtKB/Swiss-Prot for CBX8 Gene

Publications for CBX8 Gene

  1. HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties. (PMID: 10825164) Bardos J.I. … Freemont P.S. (J. Biol. Chem. 2000) 2 3 4 23
  2. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PMID: 19636380) Maertens G.N. … Peters G. (PLoS ONE 2009) 3 4 23
  3. The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3. (PMID: 11313972) Garcia-Cuellar M.P. … Slany R.K. (Oncogene 2001) 3 4
  4. The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. (PMID: 12167701) Levine S.S. … Kingston R.E. (Mol. Cell. Biol. 2002) 3 4
  5. Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. (PMID: 15009096) Obuse C. … Yoda K. (Genes Cells 2004) 3 23

Products for CBX8 Gene

Sources for CBX8 Gene

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