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Aliases for CBX7 Gene

Aliases for CBX7 Gene

  • Chromobox 7 2 3 5
  • Chromobox Homolog 7 2

External Ids for CBX7 Gene

Previous GeneCards Identifiers for CBX7 Gene

  • GC22U990068
  • GC22M036145
  • GC22M037769
  • GC22M037851
  • GC22M039518
  • GC22M039519
  • GC22M022493
  • GC22M039605
  • GC22M040104
  • GC22M039153
  • GC22M039830

Summaries for CBX7 Gene

GeneCards Summary for CBX7 Gene

CBX7 (Chromobox 7) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and single-stranded RNA binding. An important paralog of this gene is CBX4.

UniProtKB/Swiss-Prot for CBX7 Gene

  • Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at Lys-9 (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBX7 Gene

Genomics for CBX7 Gene

Regulatory Elements for CBX7 Gene

Promoters for CBX7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CBX7 on UCSC Golden Path with GeneCards custom track

Genomic Location for CBX7 Gene

Chromosome:
22
Start:
39,120,167 bp from pter
End:
39,152,674 bp from pter
Size:
32,508 bases
Orientation:
Minus strand

Genomic View for CBX7 Gene

Genes around CBX7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBX7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBX7 Gene

Proteins for CBX7 Gene

  • Protein details for CBX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95931-CBX7_HUMAN
    Recommended name:
    Chromobox protein homolog 7
    Protein Accession:
    O95931
    Secondary Accessions:
    • Q86T17

    Protein attributes for CBX7 Gene

    Size:
    251 amino acids
    Molecular mass:
    28341 Da
    Quaternary structure:
    • Component of a PRC1-like complex. Interacts with RING1 and RNF2/RING1B, but not with BMI1, EED or EZH2. Interacts with PCGF1, PCGF2, PCGF3, PCGF5 and PCGF6.
    Miscellaneous:
    • The human orthologuous proteins of Drosphila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nulear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes.

    Three dimensional structures from OCA and Proteopedia for CBX7 Gene

neXtProt entry for CBX7 Gene

Proteomics data for CBX7 Gene at MOPED

Post-translational modifications for CBX7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CBX7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CBX7 Gene

Domains & Families for CBX7 Gene

Gene Families for CBX7 Gene

Protein Domains for CBX7 Gene

Suggested Antigen Peptide Sequences for CBX7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95931

UniProtKB/Swiss-Prot:

CBX7_HUMAN :
  • Contains 1 chromo domain.
Domain:
  • Contains 1 chromo domain.
genes like me logo Genes that share domains with CBX7: view

Function for CBX7 Gene

Molecular function for CBX7 Gene

GENATLAS Biochemistry:
Drosophila polycomb-like (PcG) chromobox homolog 7,mouse ortholog,involved in the compaction of chromatin
UniProtKB/Swiss-Prot Function:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at Lys-9 (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.

Gene Ontology (GO) - Molecular Function for CBX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10369680
GO:0035064 methylated histone binding IEA --
genes like me logo Genes that share ontologies with CBX7: view
genes like me logo Genes that share phenotypes with CBX7: view

Animal Models for CBX7 Gene

MGI Knock Outs for CBX7:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBX7 Gene

Localization for CBX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBX7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CBX7 Gene COMPARTMENTS Subcellular localization image for CBX7 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CBX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000792 heterochromatin IEA --
GO:0005634 nucleus IEA,IDA 21282530
GO:0005737 cytoplasm IDA --
GO:0035102 PRC1 complex IEA,ISS --
genes like me logo Genes that share ontologies with CBX7: view

Pathways & Interactions for CBX7 Gene

SuperPathways for CBX7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CBX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 19636380
GO:0048733 sebaceous gland development IEA --
genes like me logo Genes that share ontologies with CBX7: view

No data available for Pathways by source and SIGNOR curated interactions for CBX7 Gene

Drugs & Compounds for CBX7 Gene

No Compound Related Data Available

Transcripts for CBX7 Gene

Unigene Clusters for CBX7 Gene

Chromobox homolog 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CBX7 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2:
SP3:

Relevant External Links for CBX7 Gene

GeneLoc Exon Structure for
CBX7
ECgene alternative splicing isoforms for
CBX7

Expression for CBX7 Gene

mRNA expression in normal human tissues for CBX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CBX7 Gene

This gene is overexpressed in Retina (25.5) and Blymphocyte (21.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CBX7 Gene



SOURCE GeneReport for Unigene cluster for CBX7 Gene Hs.356416

genes like me logo Genes that share expression patterns with CBX7: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CBX7 Gene

Orthologs for CBX7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CBX7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CBX7 35
  • 99.73 (n)
  • 100 (a)
CBX7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CBX7 36
  • 96 (a)
OneToOne
CBX7 35
  • 94.42 (n)
  • 95.62 (a)
dog
(Canis familiaris)
Mammalia CBX7 35
  • 91.7 (n)
  • 92.37 (a)
CBX7 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cbx7 16
Cbx7 35
  • 84.99 (n)
  • 84.8 (a)
Cbx7 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CBX7 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CBX7 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cbx7 35
  • 85.19 (n)
  • 87.13 (a)
chicken
(Gallus gallus)
Aves CBX7 35
  • 73.33 (n)
  • 73.75 (a)
CBX7 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CBX7 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cbx7 35
  • 62.96 (n)
  • 64.96 (a)
zebrafish
(Danio rerio)
Actinopterygii cbx7a 36
  • 26 (a)
OneToMany
cbx7b 36
  • 46 (a)
OneToMany
LOC101882865 35
  • 57.69 (n)
  • 54.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pc 36
  • 19 (a)
OneToMany
Species with no ortholog for CBX7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBX7 Gene

ENSEMBL:
Gene Tree for CBX7 (if available)
TreeFam:
Gene Tree for CBX7 (if available)

Paralogs for CBX7 Gene

Paralogs for CBX7 Gene

(6) SIMAP similar genes for CBX7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CBX7: view

Variants for CBX7 Gene

Sequence variations from dbSNP and Humsavar for CBX7 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs139385 -- 39,134,127(+) CAACT(A/C)CAGCT intron-variant
rs139386 -- 39,134,854(+) TGCCA(C/T)GTCTA intron-variant
rs139387 -- 39,135,080(+) ATTAA(A/G)GAGTT intron-variant
rs139388 -- 39,135,727(+) CAGTG(C/G)CTGGG intron-variant
rs139389 -- 39,135,950(+) ccggg(C/T)gtggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CBX7 Gene

Variant ID Type Subtype PubMed ID
nsv834196 CNV Loss 17160897
nsv510807 CNV Loss 20534489
nsv834197 CNV Gain 17160897
nsv915090 CNV Loss 21882294
dgv4973n71 CNV Loss 21882294

Variation tolerance for CBX7 Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CBX7 Gene

HapMap Linkage Disequilibrium report
CBX7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBX7 Gene

Disorders for CBX7 Gene

Relevant External Links for CBX7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CBX7

No disorders were found for CBX7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBX7 Gene

Publications for CBX7 Gene

  1. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PMID: 19636380) Maertens G.N. … Peters G. (PLoS ONE 2009) 3 4 23 67
  2. Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein. (PMID: 19706751) Federico A. … Fusco A. (Cancer Res. 2009) 3 23
  3. Expression parameters of the polycomb group proteins BMI1, SUZ12, RING1 and CBX7 in urothelial carcinoma of the bladder and their prognostic relevance. (PMID: 18984978) Hinz S. … Weikert S. (Tumour Biol. 2008) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Up-regulation of miR-9 target CBX7 to regulate invasion ability of bladder transitional cell carcinoma. (PMID: 25596753) Xie D. … Tong X. (Med. Sci. Monit. 2015) 3

Products for CBX7 Gene

Sources for CBX7 Gene

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