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Aliases for CBX7 Gene

Aliases for CBX7 Gene

  • Chromobox 7 2 3 5
  • Chromobox Homolog 7 2

External Ids for CBX7 Gene

Previous GeneCards Identifiers for CBX7 Gene

  • GC22U990068
  • GC22M036145
  • GC22M037769
  • GC22M037851
  • GC22M039518
  • GC22M039519
  • GC22M022493
  • GC22M039605
  • GC22M040104
  • GC22M039153
  • GC22M039830
  • GC22M039833
  • GC22M039940

Summaries for CBX7 Gene

Entrez Gene Summary for CBX7 Gene

  • This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided by RefSeq, Oct 2016]

GeneCards Summary for CBX7 Gene

CBX7 (Chromobox 7) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and single-stranded RNA binding. An important paralog of this gene is CBX6.

UniProtKB/Swiss-Prot for CBX7 Gene

  • Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at Lys-9 (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBX7 Gene

Genomics for CBX7 Gene

Regulatory Elements for CBX7 Gene

Enhancers for CBX7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F039232 1.5 FANTOM5 ENCODE 19.9 -86.5 -86458 12.4 PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 PDGFB CBX7 FUNDC2P4 ENSG00000228274 SYNGR1 ENSG00000244627 MGAT3 NPTXR SUN2 GC22M040915
GH22F039252 1.6 FANTOM5 Ensembl ENCODE 12.5 -101.7 -101668 4.3 PKNOX1 GLIS2 FOS ZNF263 JUNB ZNF610 RFX3 GLIS1 ETV4 KDM1A FUNDC2P4 CBX7 SYNGR1 APOBEC3A ATF4 SUN2 PDGFB GC22M041398
GH22F039204 1.4 FANTOM5 Ensembl ENCODE 12.6 -54.2 -54244 4.0 PKNOX1 KLF17 ZNF48 RARA ZNF366 FOS EGR2 SMARCC1 ZNF280D JUNB CBX7 FUNDC2P4 PDGFB APOBEC3B-AS1 RPL3 MGAT3 GC22M041371 GC22M040915
GH22F039362 1.2 FANTOM5 Ensembl ENCODE 11.9 -211.3 -211285 3.7 CTCF TAL1 NRF1 MAFG ZBTB8A RAD21 ZIC2 ARID1B GATA2 SMARCA4 CBX7 SYNGR1 RPL3 TAB1 FUNDC2P4 MGAT3 GC22M041392
GH22F039212 1.1 Ensembl ENCODE 12.6 -61.7 -61678 4.4 CTCF PKNOX1 HINFP JUN TEAD4 RAD21 RARA TEAD3 ZNF121 POLR2A FUNDC2P4 CBX7 PDGFB APOBEC3B-AS1 RPL3 GC22M040915 GC22M041371
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CBX7 on UCSC Golden Path with GeneCards custom track

Promoters for CBX7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000170419 74 2400 HDGF PKNOX1 ATF1 GLIS2 ELK1 FOS SP3 SP5 GLIS1 MXD3

Genomic Location for CBX7 Gene

Chromosome:
22
Start:
39,120,167 bp from pter
End:
39,152,674 bp from pter
Size:
32,508 bases
Orientation:
Minus strand

Genomic View for CBX7 Gene

Genes around CBX7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBX7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBX7 Gene

Proteins for CBX7 Gene

  • Protein details for CBX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95931-CBX7_HUMAN
    Recommended name:
    Chromobox protein homolog 7
    Protein Accession:
    O95931
    Secondary Accessions:
    • Q86T17

    Protein attributes for CBX7 Gene

    Size:
    251 amino acids
    Molecular mass:
    28341 Da
    Quaternary structure:
    • Component of a PRC1-like complex. Interacts with RING1 and RNF2/RING1B, but not with BMI1, EED or EZH2. Interacts with PCGF1, PCGF2, PCGF3, PCGF5 and PCGF6.
    Miscellaneous:
    • The human orthologuous proteins of Drosphila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nulear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes.

    Three dimensional structures from OCA and Proteopedia for CBX7 Gene

neXtProt entry for CBX7 Gene

Post-translational modifications for CBX7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CBX7 Gene

Domains & Families for CBX7 Gene

Gene Families for CBX7 Gene

Suggested Antigen Peptide Sequences for CBX7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95931

UniProtKB/Swiss-Prot:

CBX7_HUMAN :
  • Contains 1 chromo domain.
Domain:
  • Contains 1 chromo domain.
genes like me logo Genes that share domains with CBX7: view

Function for CBX7 Gene

Molecular function for CBX7 Gene

GENATLAS Biochemistry:
Drosophila polycomb-like (PcG) chromobox homolog 7,mouse ortholog,involved in the compaction of chromatin
UniProtKB/Swiss-Prot Function:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at Lys-9 (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.

Gene Ontology (GO) - Molecular Function for CBX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003727 single-stranded RNA binding IEA --
GO:0005515 protein binding IPI 10369680
GO:0035064 methylated histone binding IEA --
genes like me logo Genes that share ontologies with CBX7: view
genes like me logo Genes that share phenotypes with CBX7: view

Animal Models for CBX7 Gene

MGI Knock Outs for CBX7:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBX7 Gene

Localization for CBX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBX7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CBX7 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for CBX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 19636380
GO:0000792 heterochromatin IEA --
GO:0005634 nucleus IEA,IDA 21282530
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CBX7: view

Pathways & Interactions for CBX7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CBX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 19636380
GO:0003006 developmental process involved in reproduction IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016569 covalent chromatin modification IEA --
genes like me logo Genes that share ontologies with CBX7: view

No data available for Pathways by source and SIGNOR curated interactions for CBX7 Gene

Drugs & Compounds for CBX7 Gene

(1) Drugs for CBX7 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
UNC3866 Pharma a potent antagonist of CBX4 and CBX7 chromodomains 0

(1) ApexBio Compounds for CBX7 Gene

Compound Action Cas Number
UNC3866 a potent antagonist of CBX4 and CBX7 chromodomains
genes like me logo Genes that share compounds with CBX7: view

Transcripts for CBX7 Gene

Unigene Clusters for CBX7 Gene

Chromobox homolog 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CBX7 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2:
SP3:

Relevant External Links for CBX7 Gene

GeneLoc Exon Structure for
CBX7
ECgene alternative splicing isoforms for
CBX7

Expression for CBX7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CBX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CBX7 Gene

This gene is overexpressed in Retina (25.5) and Blymphocyte (21.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CBX7 Gene



NURSA nuclear receptor signaling pathways regulating expression of CBX7 Gene:

CBX7

SOURCE GeneReport for Unigene cluster for CBX7 Gene:

Hs.356416
genes like me logo Genes that share expression patterns with CBX7: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CBX7 Gene

Orthologs for CBX7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CBX7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CBX7 34 35
  • 99.73 (n)
cow
(Bos Taurus)
Mammalia CBX7 34 35
  • 94.42 (n)
dog
(Canis familiaris)
Mammalia CBX7 34 35
  • 91.7 (n)
rat
(Rattus norvegicus)
Mammalia Cbx7 34
  • 85.19 (n)
mouse
(Mus musculus)
Mammalia Cbx7 34 16 35
  • 84.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CBX7 35
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CBX7 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves CBX7 34 35
  • 73.33 (n)
lizard
(Anolis carolinensis)
Reptilia CBX7 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cbx7 34
  • 62.96 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101882865 34
  • 57.69 (n)
cbx7b 35
  • 46 (a)
OneToMany
cbx7a 35
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pc 35
  • 19 (a)
OneToMany
Species where no ortholog for CBX7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBX7 Gene

ENSEMBL:
Gene Tree for CBX7 (if available)
TreeFam:
Gene Tree for CBX7 (if available)

Paralogs for CBX7 Gene

Paralogs for CBX7 Gene

(6) SIMAP similar genes for CBX7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CBX7: view

Variants for CBX7 Gene

Sequence variations from dbSNP and Humsavar for CBX7 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs193920857 Uncertain significance 39,138,655(-) GAAAC(C/G)CAAGC reference, missense
rs1005300 -- 39,151,886(+) GGTGG(C/G)GTAGA intron-variant
rs1043804 -- 39,130,776(-) aaaaa(A/G)aaaat utr-variant-3-prime
rs10439918 -- 39,151,422(+) CTACC(C/T)CCCTA intron-variant
rs11089928 -- 39,133,424(-) TTTGA(C/T)CAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CBX7 Gene

Variant ID Type Subtype PubMed ID
nsv834197 CNV gain 17160897
nsv834196 CNV loss 17160897
nsv510807 CNV deletion 20534489

Variation tolerance for CBX7 Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CBX7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CBX7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBX7 Gene

Disorders for CBX7 Gene

Relevant External Links for CBX7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CBX7

No disorders were found for CBX7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBX7 Gene

Publications for CBX7 Gene

  1. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PMID: 19636380) Maertens G.N. … Peters G. (PLoS ONE 2009) 3 4 22 64
  2. Recognition and specificity determinants of the human cbx chromodomains. (PMID: 21047797) Kaustov L. … Arrowsmith C.H. (J. Biol. Chem. 2011) 3 4 64
  3. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PMID: 21282530) Vandamme J. … Angrand P.O. (Mol. Cell. Proteomics 2011) 3 4 64
  4. Polycomb CBX7 directly controls trimethylation of histone H3 at lysine 9 at the p16 locus. (PMID: 21060834) Li Q. … Deng D. (PLoS ONE 2010) 3 4 64
  5. Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein. (PMID: 19706751) Federico A. … Fusco A. (Cancer Res. 2009) 3 22 64

Products for CBX7 Gene

Sources for CBX7 Gene

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