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Aliases for CBX7 Gene

Aliases for CBX7 Gene

  • Chromobox Homolog 7 2 3

External Ids for CBX7 Gene

Summaries for CBX7 Gene

GeneCards Summary for CBX7 Gene

CBX7 (Chromobox Homolog 7) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and single-stranded RNA binding. An important paralog of this gene is CBX4.

UniProtKB/Swiss-Prot for CBX7 Gene

  • Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at Lys-9 (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBX7 Gene

Genomics for CBX7 Gene

Genomic Location for CBX7 Gene

Start:
39,120,167 bp from pter
End:
39,152,674 bp from pter
Size:
32,508 bases
Orientation:
Minus strand

Genomic View for CBX7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CBX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBX7 Gene

Regulatory Elements for CBX7 Gene

Proteins for CBX7 Gene

  • Protein details for CBX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95931-CBX7_HUMAN
    Recommended name:
    Chromobox protein homolog 7
    Protein Accession:
    O95931
    Secondary Accessions:
    • Q86T17

    Protein attributes for CBX7 Gene

    Size:
    251 amino acids
    Molecular mass:
    28341 Da
    Quaternary structure:
    • Component of a PRC1-like complex. Interacts with RING1 and RNF2/RING1B, but not with BMI1, EED or EZH2. Interacts with PCGF1, PCGF2, PCGF3, PCGF5 and PCGF6.
    Miscellaneous:
    • The human orthologuous proteins of Drosphila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nulear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes

    Three dimensional structures from OCA and Proteopedia for CBX7 Gene

neXtProt entry for CBX7 Gene

Proteomics data for CBX7 Gene at MOPED

Post-translational modifications for CBX7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CBX7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CBX7 Gene

Domains for CBX7 Gene

Protein Domains for CBX7 Gene

UniProtKB/Swiss-Prot:

CBX7_HUMAN
Domain:
  • Contains 1 chromo domain.:
    • O95931
genes like me logo Genes that share domains with CBX7: view

No data available for Gene Families for CBX7 Gene

Function for CBX7 Gene

Molecular function for CBX7 Gene

GENATLAS Biochemistry: Drosophila polycomb-like (PcG) chromobox homolog 7,mouse ortholog,involved in the compaction of chromatin
UniProtKB/Swiss-Prot Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at Lys-9 (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.

Gene Ontology (GO) - Molecular Function for CBX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003727 single-stranded RNA binding IEA --
GO:0005515 protein binding IPI 10369680
GO:0035064 methylated histone binding IEA --
genes like me logo Genes that share ontologies with CBX7: view
genes like me logo Genes that share phenotypes with CBX7: view

Animal Models for CBX7 Gene

MGI Knock Outs for CBX7:

miRNA for CBX7 Gene

miRTarBase miRNAs that target CBX7

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CBX7 Gene

Localization for CBX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBX7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CBX7 Gene COMPARTMENTS Subcellular localization image for CBX7 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for CBX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 19636380
GO:0000792 heterochromatin IEA --
GO:0005634 nucleus IDA 21282530
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CBX7: view

Pathways for CBX7 Gene

SuperPathways for CBX7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CBX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 19636380
GO:0006351 transcription, DNA-templated IEA --
GO:0016568 chromatin modification IEA --
GO:0048733 sebaceous gland development IEA --
genes like me logo Genes that share ontologies with CBX7: view

No data available for Pathways by source for CBX7 Gene

Transcripts for CBX7 Gene

Unigene Clusters for CBX7 Gene

Chromobox homolog 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CBX7 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2:
SP3:

Relevant External Links for CBX7 Gene

GeneLoc Exon Structure for
CBX7
ECgene alternative splicing isoforms for
CBX7

Expression for CBX7 Gene

mRNA expression in normal human tissues for CBX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CBX7 Gene

SOURCE GeneReport for Unigene cluster for CBX7 Gene Hs.356416

genes like me logo Genes that share expressions with CBX7: view

Orthologs for CBX7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CBX7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CBX7 36
  • 99.73 (n)
  • 100 (a)
CBX7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CBX7 36
  • 94.42 (n)
  • 95.62 (a)
CBX7 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CBX7 36
  • 91.7 (n)
  • 92.37 (a)
CBX7 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cbx7 36
  • 84.99 (n)
  • 84.8 (a)
Cbx7 16
Cbx7 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CBX7 37
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CBX7 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cbx7 36
  • 85.19 (n)
  • 87.13 (a)
chicken
(Gallus gallus)
Aves CBX7 36
  • 73.33 (n)
  • 73.75 (a)
CBX7 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CBX7 37
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cbx7 36
  • 62.96 (n)
  • 64.96 (a)
zebrafish
(Danio rerio)
Actinopterygii cbx7a 37
  • 26 (a)
OneToMany
cbx7b 37
  • 46 (a)
OneToMany
LOC101882865 36
  • 57.69 (n)
  • 54.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pc 37
  • 19 (a)
OneToMany
Species with no ortholog for CBX7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBX7 Gene

ENSEMBL:
Gene Tree for CBX7 (if available)
TreeFam:
Gene Tree for CBX7 (if available)

Paralogs for CBX7 Gene

Paralogs for CBX7 Gene

Selected SIMAP similar genes for CBX7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CBX7: view

Variants for CBX7 Gene

Sequence variations from dbSNP and Humsavar for CBX7 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs79502 -- 39,131,578(+) CCACC(A/C/T)GTCCC utr-variant-3-prime
rs79503 -- 39,132,435(+) CCCCA(A/G)TCTGG utr-variant-3-prime
rs139381 -- 39,130,291(+) GAGAT(C/T)ATGGC downstream-variant-500B
rs139382 -- 39,130,755(+) GGAAT(A/G)ATCAA downstream-variant-500B
rs139383 -- 39,131,904(+) CCTCC(A/G)CTGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CBX7 Gene

Variant ID Type Subtype PubMed ID
nsv834196 CNV Loss 17160897
nsv510807 CNV Loss 20534489
nsv834197 CNV Gain 17160897
nsv915090 CNV Loss 21882294
dgv4973n71 CNV Loss 21882294

Relevant External Links for CBX7 Gene

HapMap Linkage Disequilibrium report
CBX7

Disorders for CBX7 Gene

No disorders were found for CBX7 Gene.

No data available for UniProtKB/Swiss-Prot for CBX7 Gene

Publications for CBX7 Gene

  1. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PMID: 19636380) Maertens G.N. … Peters G. (PLoS ONE 2009) 3 4 23
  2. Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein. (PMID: 19706751) Federico A. … Fusco A. (Cancer Res. 2009) 3 23
  3. Expression parameters of the polycomb group proteins BMI1, SUZ12, RING1 and CBX7 in urothelial carcinoma of the bladder and their prognostic relevance. (PMID: 18984978) Hinz S. … Weikert S. (Tumour Biol. 2008) 3 23
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  5. Polycomb CBX7 has a unifying role in cellular lifespan. (PMID: 14647293) Gil J. … Beach D. (Nat. Cell Biol. 2004) 3 4

Products for CBX7 Gene

  • Addgene plasmids for CBX7

Sources for CBX7 Gene

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