CBX7 Gene

Aliases
for CBX7 gene

Previous GC identifers: GC22U990068 GC22M036145 GC22M037769 GC22M037851 GC22M039518 GC22M022493

Summaries
for CBX7 gene

Genomic Views
for CBX7 gene

RefSeq DNA sequence:

NC_000022.10  NC_018933.1  NT_011520.12  

SwitchGear Promoter luciferase reporter plasmid: CBX7 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBX7

CBX7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M039519:  view genomic region     (about GC identifiers)

Proteins
for CBX7 gene

4 PDB 3D structures from and Proteopedia for CBX7:

2K1B (3D)        2L12 (3D)        2L1B (3D)        3GS2 (3D)    

Explore the universe of human proteins at neXtProt for CBX7: NX_O95931

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CBX7 OriGene Custom Protein Services for CBX7
	GenScript Custom Purified and Recombinant Proteins Services for CBX7
	Novus Biologicals CBX7 Protein Novus Biologicals CBX7 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CBX7

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for CBX7
	GenScript Custom Superior Antibodies Services for CBX7
	Novus Biologicals CBX7 Antibodies
	Search for Antibodies for CBX7 at Abcam
	Uscn Antibodies for CBX7
	Search ThermoFisher Antibodies for CBX7

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CBX7
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CBX7

Protein Domains /
Families
for CBX7 gene

ProtoNet protein and cluster: O95931

Function
for CBX7 gene

miRNA Products:		miRTarBase miRNAs that target CBX7: hsa-mir-421 (MIRT001104)
		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CBX7
		8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate CBX7 (see all 60):
		hsa-miR-579 hsa-miR-549 hsa-miR-193a-3p hsa-miR-631 hsa-miR-99b* hsa-miR-3653 hsa-miR-218 hsa-miR-3667-5p
		SwitchGear 3'UTR luciferase reporter plasmid: CBX7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CBX7 (see all 7) OriGene shRNA RFP: CBX7 OriGene siRNA: CBX7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CBX7

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CBX7

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBX7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CBX7 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CBX7 (NM_175709)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBX7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBX7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CBX7
		Search LifeMap BioReagents cell lines for CBX7

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX7

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Cbx7)

Pathways & Interactions
for CBX7 gene

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for CBX7 gene

Transcripts
for CBX7 gene

Expression
for CBX7 gene

CBX7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTTGCTGA

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BrainBlood Brain BarrierAdult Endothelial Cells			Blood Brain Barrier, Endothelium
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CBX7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CBX7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBX7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBX7

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX7

Orthologs
for CBX7 gene

Paralogs
for CBX7 gene

Paralogs for CBX7 gene

CBX8²  CBX2²  CBX4²  

6 SIMAP similar genes for CBX7 using alignment to 3 protein entries:     CBX7_HUMAN (see all proteins):

CBX4    CBX8    CBX1    CBX5    CBX6    CBX2

CBX7 for paralogs           About GeneDecksing

Genomic Variants
for CBX7 gene

10/416 NCBI SNPs in CBX7 are shown (see all 416)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1496783851,2		--	39526291(+)	TGTCCA/GAGATT	1	--	ds5001		0	--	--	--	--
rs1393811,2	C,F,A,H,	--	39526296(+)	GAGATC/TATGGC	1	--	ds5001		17		NS EA NA WA CSA	795
rs731615961,2	C,F,	--	39526303(+)	TGGCCG/AGTGAC	1	--	ds5001		1		NA	120
rs1911808801,2		--	39526535(+)	GATCTC/TCCCAA	1	--	ds5001		0	--	--	--	--
rs1825910491,2		--	39526668(+)	GGACTC/TAGCCC	1	--	ds5001		0	--	--	--	--
rs1454622971,2		--	39526727(+)	TTGGTA/GGACGG	1	--	ds5001		0	--	--	--	--
rs1881659021,2		--	39526730(+)	GTGGAC/TGGATG	1	--	ds5001		0	--	--	--	--
rs614922791,2	C,	--	39526735(+)	CGGATG/ACACTT	1	--	ds5001		1		WA	2
rs1453083621,2		--	39526759(+)	AGGAAC/TAATCA	1	--	ds5001		0	--	--	--	--
rs1393821,2	C,F,H,	--	39526760(+)	GGAATG/AATCAA	1	--	ds5001		19		NS EA NA WA CSA	1177

HapMap Linkage Disequilibrium report for CBX7 (39516172 - 39548679 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CBX7: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CBX7

DNA2.0 Custom Variant and Variant Library Synthesis for CBX7

Disorders / Diseases
for CBX7 gene

Publications
for CBX7 gene

PubMed articles for CBX7 gene, integrated from 9 sources (see all 25): (articles sorted by number of sources associating them with CBX7)

Utopia: connect your pdf to the dynamic world of online information

1. Several distinct polycomb complexes regulate and co-l ocalize on the INK4a tumor suppressor locus. (PubMed id 19636380)^{1, 2, 9} Maertens G.N....Peters G. (2009)
2. Recognition and specificity determinants of the human cbx chromodomains. (PubMed id 21047797)^{1, 2} Kaustov L.... Arrowsmith C.H. (2011)
3. Polycomb CBX7 directly controls trimethylation of histone H3 at lysine 9 at the p16 locus. (PubMed id 21060834)^{1, 2} Li Q.... Deng D. (2010)
4. Polycomb CBX7 has a unifying role in cellular lifespan. (PubMed id 14647293)^{1, 2} Gil J.... Beach D. (2004)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
7. Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein. (PubMed id 19706751)^{1, 9} Federico A....Fusco A. (2009)
8. Expression parameters of the polycomb group proteins BMI1, SUZ12, RING1 and CBX7 in urothelial carcinoma of the bladder and their prognostic relevance. (PubMed id 18984978)^{1, 9} Hinz S....Weikert S. (2008)
9. MicroRNA regulation of Cbx7 mediates a switch of Polyc omb orthologs during ESC differentiation. (PubMed id 22226354)¹ O'Loghlen A....Gil J. (2012)
10. CBX7 is a tumor suppressor in mice and humans. (PubMed id 22214847)¹ Forzati F....Fusco A. (2012)

External Searches for CBX7 gene

Genome Databases showing CBX7 gene

Other Databases showing CBX7 gene

Specialized Databases showing CBX7 gene

Products
for CBX7 gene