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Aliases for CBX6 Gene

Aliases for CBX6 Gene

  • Chromobox Homolog 6 2 3

External Ids for CBX6 Gene

Summaries for CBX6 Gene

GeneCards Summary for CBX6 Gene

CBX6 (Chromobox Homolog 6) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Cellular Senescence. GO annotations related to this gene include single-stranded RNA binding. An important paralog of this gene is CBX4.

UniProtKB/Swiss-Prot for CBX6 Gene

  • Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBX6 Gene

Genomics for CBX6 Gene

Genomic Location for CBX6 Gene

Start:
38,861,450 bp from pter
End:
38,872,314 bp from pter
Size:
10,865 bases
Orientation:
Minus strand

Genomic View for CBX6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CBX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBX6 Gene

Regulatory Elements for CBX6 Gene

Proteins for CBX6 Gene

  • Protein details for CBX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95503-CBX6_HUMAN
    Recommended name:
    Chromobox protein homolog 6
    Protein Accession:
    O95503
    Secondary Accessions:
    • A8KAH0
    • Q96EM5

    Protein attributes for CBX6 Gene

    Size:
    412 amino acids
    Molecular mass:
    43898 Da
    Quaternary structure:
    • Component of a PRC1-like complex. Interacts with PCGF1, PCGF2, PCGF3, BMI1, PCGF5, PCGF6, RING1 and RNF2.
    Miscellaneous:
    • The human orthologuous proteins of Drosphila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nulear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes

    Three dimensional structures from OCA and Proteopedia for CBX6 Gene

neXtProt entry for CBX6 Gene

Proteomics data for CBX6 Gene at MOPED

Post-translational modifications for CBX6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys100

Other Protein References for CBX6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CBX6 Gene

Domains for CBX6 Gene

Protein Domains for CBX6 Gene

UniProtKB/Swiss-Prot:

CBX6_HUMAN
Domain:
  • Contains 1 chromo domain.:
    • O95503
genes like me logo Genes that share domains with CBX6: view

No data available for Gene Families for CBX6 Gene

Function for CBX6 Gene

Molecular function for CBX6 Gene

GENATLAS Biochemistry: Drosophila polycomb-like (PcG) chromobox homolog 6,mouse ortholog,involved in the compaction of chromatin
UniProtKB/Swiss-Prot Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

Gene Ontology (GO) - Molecular Function for CBX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003727 single-stranded RNA binding IEA --
GO:0005515 protein binding IPI 20601937
genes like me logo Genes that share ontologies with CBX6: view
genes like me logo Genes that share phenotypes with CBX6: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CBX6 Gene

Localization for CBX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBX6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CBX6 Gene COMPARTMENTS Subcellular localization image for CBX6 gene
Compartment Confidence
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CBX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000792 heterochromatin IEA --
GO:0005634 nucleus IDA 21282530
GO:0005654 nucleoplasm TAS --
GO:0031519 PcG protein complex IDA 21282530
genes like me logo Genes that share ontologies with CBX6: view

Pathways for CBX6 Gene

genes like me logo Genes that share pathways with CBX6: view

Pathways by source for CBX6 Gene

Gene Ontology (GO) - Biological Process for CBX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 21282530
GO:0006351 transcription, DNA-templated IEA --
GO:0016568 chromatin modification IEA --
genes like me logo Genes that share ontologies with CBX6: view

Transcripts for CBX6 Gene

Unigene Clusters for CBX6 Gene

Chromobox homolog 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CBX6 Gene

No ASD Table

Relevant External Links for CBX6 Gene

GeneLoc Exon Structure for
CBX6
ECgene alternative splicing isoforms for
CBX6

Expression for CBX6 Gene

mRNA expression in normal human tissues for CBX6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CBX6 Gene

SOURCE GeneReport for Unigene cluster for CBX6 Gene Hs.592201

genes like me logo Genes that share expressions with CBX6: view

Orthologs for CBX6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CBX6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CBX6 36
  • 99.82 (n)
  • 100 (a)
CBX6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CBX6 36
  • 89.14 (n)
  • 91.09 (a)
CBX6 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CBX6 36
  • 89.14 (n)
  • 92.11 (a)
mouse
(Mus musculus)
Mammalia Cbx6 36
  • 86.09 (n)
  • 88.55 (a)
Cbx6 16
Cbx6 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CBX6 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CBX6 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cbx6 36
  • 85.42 (n)
  • 87.47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cbx6 36
  • 67.61 (n)
  • 76.2 (a)
Str.20464 36
zebrafish
(Danio rerio)
Actinopterygii cbx6a 37
  • 38 (a)
OneToMany
cbx6b 37
  • 37 (a)
OneToMany
LOC556231 36
  • 62.18 (n)
  • 67.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pc 37
  • 20 (a)
OneToMany
Species with no ortholog for CBX6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBX6 Gene

ENSEMBL:
Gene Tree for CBX6 (if available)
TreeFam:
Gene Tree for CBX6 (if available)

Paralogs for CBX6 Gene

Paralogs for CBX6 Gene

Selected SIMAP similar genes for CBX6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CBX6: view

Variants for CBX6 Gene

Sequence variations from dbSNP and Humsavar for CBX6 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs732016 -- 38,873,009(+) ACTCC(G/T)CCTTG upstream-variant-2KB
rs732017 -- 38,872,837(+) AGGGG(G/T)TGTGC upstream-variant-2KB
rs733106 -- 38,862,001(+) TAAAA(A/C)CAACA utr-variant-3-prime
rs733107 -- 38,862,073(+) CTACC(A/C/G/T)GGCCT utr-variant-3-prime
rs735305 -- 38,863,996(+) CGGGG(A/G)CCCGC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CBX6 Gene

Variant ID Type Subtype PubMed ID
dgv769n67 CNV Gain 20364138
nsv471199 CNV Loss 18288195
nsv915069 CNV Loss 21882294
nsv915070 CNV Loss 21882294
nsv915071 CNV Loss 21882294
nsv915072 CNV Loss 21882294
dgv4971n71 CNV Loss 21882294
nsv520961 CNV Loss 19592680
nsv525343 CNV Loss 19592680
nsv829210 CNV Loss 20364138

Relevant External Links for CBX6 Gene

HapMap Linkage Disequilibrium report
CBX6

Disorders for CBX6 Gene

Relevant External Links for CBX6

Genetic Association Database (GAD)
CBX6
genes like me logo Genes that share disorders with CBX6: view

No data available for UniProtKB/Swiss-Prot for CBX6 Gene

Publications for CBX6 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PMID: 21282530) Vandamme J. … Angrand P.O. (Mol. Cell. Proteomics 2011) 3 4
  5. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. (PMID: 20972438) Rothman N. … Chanock S.J. (Nat. Genet. 2010) 3 49

Products for CBX6 Gene

Sources for CBX6 Gene

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