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CBX6 Gene

protein-coding   GIFtS: 54
GCID: GC22M039257

Chromobox Homolog 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromobox Homolog 61 2
Chromobox Protein Homolog 62

External Ids:    HGNC: 15561   Entrez Gene: 234662   Ensembl: ENSG000001837417   UniProtKB: O955033   

Export aliases for CBX6 gene to outside databases

Previous GC identifers: GC22M035871 GC22M037500 GC22M037503 GC22M037584 GC22M022225


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CBX6 Gene:
CBX6 (chromobox homolog 6) is a protein-coding gene. Diseases associated with CBX6 include neuronitis, and thyroiditis. GO annotations related to this gene include single-stranded RNA binding. An important paralog of this gene is CBX8.

UniProtKB/Swiss-Prot: CBX6_HUMAN, O95503
Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain
the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1
complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A
'Lys-119', rendering chromatin heritably changed in its expressibility




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CBX6 gene promoter:
         AhR   Spz1   STAT1   ATF-2   RREB-1   STAT1beta   E47   STAT1alpha   CRE-BP1   Zic1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCBX6 promoter sequence
   Search Chromatin IP Primers for CBX6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CBX6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

CBX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBX6 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M039257:  view genomic region     (about GC identifiers)

Start:
39,257,455 bp from pter      End:
39,268,319 bp from pter
Size:
10,865 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CBX6_HUMAN, O95503 (See protein sequence)
Recommended Name: Chromobox protein homolog 6  
Size: 412 amino acids; 43898 Da
Subunit: Component of a PRC1-like complex. Interacts with PCGF1, PCGF2, PCGF3, BMI1, PCGF5, PCGF6, RING1 and RNF2
Miscellaneous: The human orthologuous proteins of Drosphila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and
CBX8, show distinct nulear localizations, contribute differently to transcriptional repression, and appear to be
part of distinct PRC1-like protein complexes
2 PDB 3D structures from and Proteopedia for CBX6:
3GV6 (3D)        3I90 (3D)    
Secondary accessions: A8KAH0 Q96EM5

Explore the universe of human proteins at neXtProt for CBX6: NX_O95503

Explore proteomics data for CBX6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys100
  • Modification sites at PhosphoSitePlus

  • See CBX6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055107.3  
    ENSEMBL proteins: 
     ENSP00000384490   ENSP00000216083  
    Reactome Protein details: O95503

    CBX6 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CBX6
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    OriGene Custom Protein Services for CBX6
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    Novus Biologicals CBX6 Protein
    Novus Biologicals CBX6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CBX6

    CBX6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Antibodies for CBX6
    OriGene Custom Antibody Services for CBX6
    Novus Biologicals CBX6 Antibodies
    Abcam antibodies for CBX6 (O95503, Q9HC52)
    Cloud-Clone Corp. Antibodies for CBX6
    Search ThermoFisher Antibodies for CBX6
    LSBio Antibodies in human, mouse, rat for CBX6

    CBX6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CBX6
    Cloud-Clone Corp. CLIAs for CBX6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR000953 Chromo_domain/shadow
     IPR023780 Chromo_domain
     IPR016197 Chromodomain-like
     IPR023779 Chromodomain_CS
     IPR017984 Chromo_dom_subgr

    Graphical View of Domain Structure for InterPro Entry O95503

    ProtoNet protein and cluster: O95503

    1 Blocks protein domain: IPB000953 Chromo domain

    UniProtKB/Swiss-Prot: CBX6_HUMAN, O95503
    Similarity: Contains 1 chromo domain


    CBX6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBX6_HUMAN, O95503
    Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain
    the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1
    complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A
    'Lys-119', rendering chromatin heritably changed in its expressibility

         Genatlas biochemistry entry for CBX6:
    Drosophila polycomb-like (PcG) chromobox homolog 6,mouse ortholog,involved in the compaction of chromatin

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003727single-stranded RNA binding IEA--
    GO:0005515protein binding IPI--
         
    CBX6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CBX6:
     Increased cell number in G2M,  

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cbx6):
     adipose tissue  cardiovascular system  growth/size/body  homeostasis/metabolism  integument 
     pigmentation 

    CBX6 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CBX6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CBX6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CBX6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CBX6

    miRNA
    Products:
        
    miRTarBase miRNAs that target CBX6:
    hsa-mir-182-5p (MIRT047178), hsa-mir-328-3p (MIRT043813), hsa-let-7c-5p (MIRT051814), hsa-mir-92a-3p (MIRT049019), hsa-let-7b-5p (MIRT052310), hsa-mir-484 (MIRT041709), hsa-mir-26b-5p (MIRT029448), hsa-mir-874-3p (MIRT037768), hsa-mir-615-3p (MIRT039667)

    Block miRNA regulation of human, mouse, rat CBX6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CBX6 (see all 42):
    hsa-miR-1321 hsa-miR-330-5p hsa-miR-938 hsa-miR-29a hsa-miR-507 hsa-miR-570 hsa-miR-890 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidCBX6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CBX6
    Predesigned siRNA for gene silencing in human, mouse, rat CBX6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CBX6

    Clone
    Products:
         
    OriGene clones in human, mouse for CBX6 (see all 6)
    OriGene ORF clones in mouse, rat for CBX6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CBX6 (NM_014292)
    Sino Biological Human cDNA Clone for CBX6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBX6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBX6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CBX6
    Browse ESI BIO Cell Lines and PureStem Progenitors for CBX6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CBX6_HUMAN, O95503: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000792heterochromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0031519PcG protein complex IDA--

    CBX6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CBX6 About    
    See pathways by source

    SuperPathContained pathways About
    1Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CBX6
        Oxidative Stress Induced Senescence



    CBX6 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CBX6: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CBX6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CBX6 (O955031, 2, 3 ENSP000003844904) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3MINT-8010325 I2D: score=1 
    HIST1H4BP628052, 3MINT-8010325 I2D: score=1 
    HIST1H4CP628052, 3MINT-8010325 I2D: score=1 
    HIST1H4DP628052, 3MINT-8010325 I2D: score=1 
    HIST1H4EP628052, 3MINT-8010325 I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0006351transcription, DNA-templated IEA--
    GO:0016568chromatin modification IEA--

    CBX6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CBX6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CBX6 gene: 
    NM_014292.3  

    Unigene Cluster for CBX6:

    Chromobox homolog 6
    Hs.592201  [show with all ESTs]
    Unigene Representative Sequence: NM_014292
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407418(uc003awl.3) ENST00000216083 ENST00000469420(uc003awm.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CBX6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CBX6 (see all 42):
    hsa-miR-1321 hsa-miR-330-5p hsa-miR-938 hsa-miR-29a hsa-miR-507 hsa-miR-570 hsa-miR-890 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidCBX6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CBX6
    Predesigned siRNA for gene silencing in human, mouse, rat CBX6
    Clone
    Products:
         
    OriGene clones in human, mouse for CBX6 (see all 6)
    OriGene ORF clones in mouse, rat for CBX6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CBX6 (NM_014292)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBX6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBX6
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CBX6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBX6
      QuantiTect SYBR Green Assays in human, mouse, rat CBX6
      QuantiFast Probe-based Assays in human, mouse, rat CBX6

    Additional mRNA sequence: 

    AK094829.1 AK293035.1 BC012111.1 BC064900.1 BC127848.1 

    11 DOTS entries:

    DT.411847  DT.100764798  DT.100030372  DT.100774140  DT.99933939  DT.75114816  DT.86842136  DT.100653721 
    DT.100775305  DT.100775304  DT.95203366 

    Selected AceView cDNA sequences (see all 401):

    AW467549 BQ668642 AA262944 CD625513 BE349092 AI052282 BM711559 BE670708 
    AW291772 CK906293 AI367290 AI421424 BM459056 BU855123 R87949 H23426 
    BE464704 AW088164 BC064900 AI360365 BU783771 AW572283 H55534 BQ688125 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CBX6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCCTCCC
    CBX6 Expression
    About this image


    CBX6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Thyroid (Endocrine System)
    CBX6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CBX6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592201
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CBX6: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CBX6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBX6
    QuantiTect SYBR Green Assays in human, mouse, rat CBX6
    QuantiFast Probe-based Assays in human, mouse, rat CBX6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CBX6 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cbx61 , 5 chromobox homolog 65
    chromobox 61
    86.09(n)1
    88.55(a)1
      15 (37.85 cM)5
    4944481  NM_028763.31  NP_083039.21 
     798238965 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.204642 Transcribed sequence with moderate similarity to protein more 77.09(n)    AL845721.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5562311 uncharacterized LOC556231 62.18(n)
    67.69(a)
      556231  XM_005171614.1  XP_005171671.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pc6
    Polycomb
    20(a)
    1 → many
    3L(21299238-21311120)


    ENSEMBL Gene Tree for CBX6 (if available)
    TreeFam Gene Tree for CBX6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CBX6 gene
    CBX82  CBX22  CBX42  CBX72  
    3 SIMAP similar genes for CBX6 using alignment to 2 protein entries:     CBX6_HUMAN (see all proteins):
    CBX5    CBX1    CBX7

    CBX6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CBX6 (see all 124)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1178715581,2
    F--22230303(+) AAGAAG/AGCCAT 1 -- int11Minor allele frequency- A:0.01NA 120
    rs734194311,2
    C,F--22230316(+) CCCCAC/TGGTTG 1 -- int16Minor allele frequency- T:0.34WA CSA NA 245
    rs794732031,2
    C,F--22230391(+) TTGGAT/AGCTTA 1 -- int13Minor allele frequency- A:0.30CSA WA 121
    rs1147421381,2
    F--22230456(+) GATCAC/TAACTC 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1159489521,2
    C,F--22230522(+) GAACGT/GGGCGT 1 -- int11Minor allele frequency- G:0.04WA 118
    rs731593271,2
    C,F--22230594(+) CCTGGG/AGCTGC 1 -- int11Minor allele frequency- A:0.04NA 120
    rs1161916901,2
    F--22230647(+) GCCGGG/ACCTGC 1 -- int11Minor allele frequency- A:0.04WA 118
    rs96110411,2
    C,F,A,H--22230658(+) CCATGG/CCAATG 1 -- int114Minor allele frequency- C:0.41NS EA NA WA 968
    rs1814560781,2
    --22230783(+) ACTTTA/CTGACT 1 -- int10--------
    rs1864840281,2
    --22230799(+) AAAGTG/TTTTAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for CBX6 (39257455 - 39268319 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CBX6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv915071CNV Loss21882294
    nsv915070CNV Loss21882294
    nsv525343CNV Loss19592680
    nsv915069CNV Loss21882294
    nsv520961CNV Loss19592680
    dgv4971n71CNV Loss21882294
    nsv471199CNV Loss18288195
    nsv829210CNV Loss20364138
    nsv915072CNV Loss21882294
    dgv769n67CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CBX6
    DNA2.0 Custom Variant and Variant Library Synthesis for CBX6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for CBX6:    
    About MalaCards
    neuronitis    thyroiditis


    CBX6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CBX6

    Export disorders for CBX6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CBX6 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with CBX6)
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    1. Recognition and specificity determinants of the human cbx chromodomains. (PubMed id 21047797)1, 2 Kaustov L.... Arrowsmith C.H. (J. Biol. Chem. 2011)
    2. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PubMed id 21282530)1, 2 Vandamme J.... Angrand P.O. (Mol. Cell. Proteomics 2011)
    3. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. (PubMed id 20972438)1, 4 Rothman N....Chanock S.J. (Nat. Genet. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    7. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. (PubMed id 22325352)1 Gao Z....Reinberg D. (Mol. Cell 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23466 HGNC: 1556 AceView: CBX6 Ensembl:ENSG00000183741 euGenes: HUgn23466
    ECgene: CBX6 H-InvDB: CBX6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CBX6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CBX6 gene:
    Search GeneIP for patents involving CBX6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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