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Aliases for CBX6 Gene

Aliases for CBX6 Gene

  • Chromobox 6 2 3 5
  • Chromobox Homolog 6 2

External Ids for CBX6 Gene

Previous GeneCards Identifiers for CBX6 Gene

  • GC22M035871
  • GC22M037500
  • GC22M037503
  • GC22M037584
  • GC22M039257
  • GC22M022225

Summaries for CBX6 Gene

GeneCards Summary for CBX6 Gene

CBX6 (Chromobox 6) is a Protein Coding gene. Among its related pathways are Cellular Senescence. GO annotations related to this gene include single-stranded RNA binding. An important paralog of this gene is CBX4.

UniProtKB/Swiss-Prot for CBX6 Gene

  • Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBX6 Gene

Genomics for CBX6 Gene

Regulatory Elements for CBX6 Gene

Enhancers for CBX6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CBX6 on UCSC Golden Path with GeneCards custom track

Promoters for CBX6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CBX6 on UCSC Golden Path with GeneCards custom track

Genomic Location for CBX6 Gene

Chromosome:
22
Start:
38,861,216 bp from pter
End:
38,872,334 bp from pter
Size:
11,119 bases
Orientation:
Minus strand

Genomic View for CBX6 Gene

Genes around CBX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBX6 Gene

Proteins for CBX6 Gene

  • Protein details for CBX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95503-CBX6_HUMAN
    Recommended name:
    Chromobox protein homolog 6
    Protein Accession:
    O95503
    Secondary Accessions:
    • A8KAH0
    • Q96EM5

    Protein attributes for CBX6 Gene

    Size:
    412 amino acids
    Molecular mass:
    43898 Da
    Quaternary structure:
    • Component of a PRC1-like complex. Interacts with PCGF1, PCGF2, PCGF3, BMI1, PCGF5, PCGF6, RING1 and RNF2.
    Miscellaneous:
    • The human orthologuous proteins of Drosphila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nulear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes.

    Three dimensional structures from OCA and Proteopedia for CBX6 Gene

neXtProt entry for CBX6 Gene

Proteomics data for CBX6 Gene at MOPED

Post-translational modifications for CBX6 Gene

  • Ubiquitination at Lys 100
  • Modification sites at PhosphoSitePlus

Other Protein References for CBX6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CBX6 Gene

Domains & Families for CBX6 Gene

Gene Families for CBX6 Gene

Protein Domains for CBX6 Gene

Suggested Antigen Peptide Sequences for CBX6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95503

UniProtKB/Swiss-Prot:

CBX6_HUMAN :
  • Contains 1 chromo domain.
Domain:
  • Contains 1 chromo domain.
genes like me logo Genes that share domains with CBX6: view

Function for CBX6 Gene

Molecular function for CBX6 Gene

GENATLAS Biochemistry:
Drosophila polycomb-like (PcG) chromobox homolog 6,mouse ortholog,involved in the compaction of chromatin
UniProtKB/Swiss-Prot Function:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

Gene Ontology (GO) - Molecular Function for CBX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20601937
genes like me logo Genes that share ontologies with CBX6: view
genes like me logo Genes that share phenotypes with CBX6: view

Animal Models for CBX6 Gene

MGI Knock Outs for CBX6:
  • Cbx6 tm1a(EUCOMM)Wtsi

Animal Model Products

miRNA for CBX6 Gene

miRTarBase miRNAs that target CBX6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBX6 Gene

Localization for CBX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBX6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CBX6 Gene COMPARTMENTS Subcellular localization image for CBX6 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for CBX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21282530
genes like me logo Genes that share ontologies with CBX6: view

Pathways & Interactions for CBX6 Gene

genes like me logo Genes that share pathways with CBX6: view

Pathways by source for CBX6 Gene

Gene Ontology (GO) - Biological Process for CBX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 21282530
genes like me logo Genes that share ontologies with CBX6: view

No data available for SIGNOR curated interactions for CBX6 Gene

Drugs & Compounds for CBX6 Gene

No Compound Related Data Available

Transcripts for CBX6 Gene

Unigene Clusters for CBX6 Gene

Chromobox homolog 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CBX6 Gene

No ASD Table

Relevant External Links for CBX6 Gene

GeneLoc Exon Structure for
CBX6
ECgene alternative splicing isoforms for
CBX6

Expression for CBX6 Gene

mRNA expression in normal human tissues for CBX6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CBX6 Gene

This gene is overexpressed in Lung (21.1), Heart (10.8), Pancreas (8.4), Peripheral blood mononuclear cells (6.9), CD8 Tcells (6.3), and Fetal testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CBX6 Gene



SOURCE GeneReport for Unigene cluster for CBX6 Gene Hs.592201

genes like me logo Genes that share expression patterns with CBX6: view

Protein tissue co-expression partners for CBX6 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CBX6 Gene

Orthologs for CBX6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CBX6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CBX6 35
  • 89.14 (n)
  • 91.09 (a)
CBX6 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CBX6 35
  • 89.14 (n)
  • 92.11 (a)
mouse
(Mus musculus)
Mammalia Cbx6 35
  • 86.09 (n)
  • 88.55 (a)
Cbx6 16
Cbx6 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CBX6 35
  • 99.82 (n)
  • 100 (a)
CBX6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cbx6 35
  • 85.42 (n)
  • 87.47 (a)
oppossum
(Monodelphis domestica)
Mammalia CBX6 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CBX6 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cbx6 35
  • 67.61 (n)
  • 76.2 (a)
Str.20464 35
zebrafish
(Danio rerio)
Actinopterygii LOC556231 35
  • 62.18 (n)
  • 67.69 (a)
cbx6a 36
  • 38 (a)
OneToMany
cbx6b 36
  • 37 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pc 36
  • 20 (a)
OneToMany
Species with no ortholog for CBX6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBX6 Gene

ENSEMBL:
Gene Tree for CBX6 (if available)
TreeFam:
Gene Tree for CBX6 (if available)

Paralogs for CBX6 Gene

Paralogs for CBX6 Gene

(3) SIMAP similar genes for CBX6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CBX6: view

Variants for CBX6 Gene

Sequence variations from dbSNP and Humsavar for CBX6 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2235140 -- 38,865,130(+) ACACC(C/G)GGAGG intron-variant, utr-variant-3-prime
rs7292074 -- 38,870,446(+) GCCCA(A/C)CAGCC intron-variant
rs7292471 -- 38,863,622(+) CATGC(A/G)CCAAG intron-variant, utr-variant-3-prime
rs34110620 -- 38,865,407(+) GGCAG(-/C)CTGGG intron-variant, utr-variant-3-prime
rs34191704 -- 38,874,022(+) TCCAC(-/T)TTGTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CBX6 Gene

Variant ID Type Subtype PubMed ID
dgv769n67 CNV Gain 20364138
nsv471199 CNV Loss 18288195
nsv915069 CNV Loss 21882294
nsv915070 CNV Loss 21882294
nsv915071 CNV Loss 21882294
nsv915072 CNV Loss 21882294
dgv4971n71 CNV Loss 21882294
nsv520961 CNV Loss 19592680
nsv525343 CNV Loss 19592680
nsv829210 CNV Loss 20364138

Variation tolerance for CBX6 Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CBX6 Gene

Disorders for CBX6 Gene

Relevant External Links for CBX6

Genetic Association Database (GAD)
CBX6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CBX6

No disorders were found for CBX6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBX6 Gene

Publications for CBX6 Gene

  1. Recognition and specificity determinants of the human cbx chromodomains. (PMID: 21047797) Kaustov L. … Arrowsmith C.H. (J. Biol. Chem. 2011) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genome-wide association study identifies multiple loci associated with bladder cancer risk. (PMID: 24163127) Figueroa J.D. … Rothman N. (Hum. Mol. Genet. 2014) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PMID: 23503679) Zhu J. … Elledge S.J. (Nat. Biotechnol. 2013) 3

Products for CBX6 Gene

Sources for CBX6 Gene

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