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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CBX5 Gene

protein-coding   GIFtS: 62
GCID: GC12M054624

Chromobox Homolog 5

(Previous names: chromobox homolog 5 (Drosophila HP1 alpha), chromobox homolog...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromobox Homolog 51 2     HP12
Chromobox Homolog 5 (HP1 Alpha Homolog, Drosophila)1 2     HP1-ALPHA2
Antigen P252 3     Chromobox Protein Homolog 52
Heterochromatin Protein 1 Homolog Alpha2 3     Heterochromatin Protein 1-Alpha2
HP1A2 3     HP1 Alpha Homolog2
Chromobox Homolog 5 (Drosophila HP1 Alpha)1     HP1Hs Alpha2
HP1 Alpha Homolog (Drosophila)1     HP1 Alpha3

External Ids:    HGNC: 15551   Entrez Gene: 234682   Ensembl: ENSG000000949167   OMIM: 6044785   UniProtKB: P459733   

Export aliases for CBX5 gene to outside databases

Previous GC identifers: GC12M054761 GC12M054351 GC12M052921


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CBX5 Gene:
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family.
The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single
N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal
chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of
chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional
kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on
chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. (provided
by RefSeq, Jul 2008)

GeneCards Summary for CBX5 Gene: 
CBX5 (chromobox homolog 5) is a protein-coding gene. Diseases associated with CBX5 include papillary thyroid carcinoma, and myeloid leukemia, and among its related super-pathways are Activation of the pre-replicative complex and Platelet activation, signaling and aggregation. GO annotations related to this gene include histone deacetylase binding and chromatin binding. An important paralog of this gene is CBX3.

UniProtKB/Swiss-Prot: CBX5_HUMAN, P45973
Function: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me),
leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is
phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the
association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional
kinetochore through interaction with MIS12 complex proteins

Gene Wiki entry for CBX5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CBX5 gene promoter:
         TBP   AML1a   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCBX5 promoter sequence
   Search SABiosciences Chromatin IP Primers for CBX5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBX5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

CBX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBX5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M054624:  view genomic region     (about GC identifiers)

Start:
54,624,724 bp from pter      End:
54,673,915 bp from pter
Size:
49,192 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CBX5_HUMAN, P45973 (See protein sequence)
Recommended Name: Chromobox protein homolog 5  
Size: 191 amino acids; 22225 Da
Subunit: Interacts with SUV420H1 and SUV420H2 (By similarity). Interacts with HP1BP3 (By similarity). Interacts
directly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 and TRIM28 via the chromoshadow domain. Can interact
directly with CBX3 via the chromoshadow domain. Interacts with histone H3 methylated at 'Lys-9'. Interacts with
BAHD1, MIS12 and DSN1. Interacts with POGZ; POGZ and PXVXL motif-containing proteins such as INCENP and TRIM28
compete for interaction with CBX5. Interacts with INCENP and TRIM24. Interacts with JC virus agnoprotein; this
interaction induces the dissociation of CBX5 from LBR, resulting in destabilization of the nuclear envelope.
Interacts with CHAMP1. Interacts with ASXL1
Subcellular location: Nucleus. Chromosome. Chromosome, centromere. Note=Component of centromeric and
pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with
chromatin during metaphase and anaphase
2 PDB 3D structures from and Proteopedia for CBX5:
3FDT (3D)        3I3C (3D)    
Secondary accessions: B2R8T9

Explore the universe of human proteins at neXtProt for CBX5: NX_P45973

Explore proteomics data for CBX5 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and
    nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during
    interphase and possibly hyper-phosphorylated during mitosis
  • UniProtKB: Ubiquitinated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P45973

  • CBX5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CBX5 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001120793.1  NP_001120794.1  NP_036249.1  

    ENSEMBL proteins: 
     ENSP00000209875   ENSP00000401009   ENSP00000449207   ENSP00000450190  
    Reactome Protein details: P45973
    Human Recombinant Protein Products for CBX5: 
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    Novus Biologicals CBX5 Proteins
    Novus Biologicals CBX5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CBX5
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118histone deacetylase complex ISS--
    GO:0000776kinetochore IEA--
    GO:0000792heterochromatin ----
    GO:0005634nucleus IDA--
    GO:0005635nuclear envelope TAS8663349

    CBX5 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR000953 Chromo_domain/shadow
     IPR023780 Chromo_domain
     IPR016197 Chromodomain-like
     IPR023779 Chromodomain_CS
     IPR017984 Chromo_dom_subgr

    Graphical View of Domain Structure for InterPro Entry P45973

    ProtoNet protein and cluster: P45973

    2 Blocks protein domains:
    IPB000953 Chromo domain
    IPB008251 Chromo shadow


    UniProtKB/Swiss-Prot: CBX5_HUMAN, P45973
    Similarity: Contains 2 chromo domains


    CBX5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBX5_HUMAN, P45973
    Function: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me),
    leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is
    phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the
    association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional
    kinetochore through interaction with MIS12 complex proteins

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI10330177
    GO:0019899enzyme binding IPI19486527
    GO:0030674protein binding, bridging ISS--
    GO:0035064methylated histone residue binding IDA19783980
         
    CBX5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CBX5:
     Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cbx5):
     immune system  mortality/aging  normal  skeleton 

    CBX5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cbx5tm1.1Ics for CBX5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CBX5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CBX5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CBX5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CBX5 

    miRNA
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    miRTarBase miRNAs that target CBX5:
    hsa-mir-98 (MIRT004950)

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    8/261 QIAGEN miScript miRNA Assays for microRNAs that regulate CBX5 (see all 261):
    hsa-miR-411* hsa-miR-605 hsa-miR-376a* hsa-miR-3116 hsa-miR-200b hsa-miR-509-3-5p hsa-miR-761 hsa-miR-200c*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CBX5 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Activation of the pre-replicative complex
    Cell cycle Start of DNA replication in early S phase0.54
    2Platelet activation, signaling and aggregation
    Hemostasis0.43
    3Signal transduction Activin A signaling regulation
    Histone modification0.31
    4Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production
    5E2F transcription factor network
    E2F transcription factor network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for CBX5
        Histone modification
    Cell cycle Start of DNA replication in early S phase


    1 Cell Signaling Technology (CST) Pathway for CBX5
        Chromatin Regulation / Acetylation

    1 GeneGo (Thomson Reuters) Pathway for CBX5
        Cell cycle Start of DNA replication in early S phase

    2 BioSystems Pathways for CBX5
        Aurora B signaling
    E2F transcription factor network


    2        Reactome Pathways for CBX5
        Hemostasis
    Factors involved in megakaryocyte development and platelet production



    CBX5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CBX5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/245 Interacting proteins for CBX5 (P459731, 2, 3 ENSP000002098754) via UniProtKB, MINT, STRING, and/or I2D (see all 245)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3CP684312, 3MINT-2830662 MINT-2830965 MINT-8087423 MINT-2830941 MINT-8087264 MINT-8087281 MINT-7221095 MINT-8087449 MINT-7221313 MINT-8087437 I2D: score=3 
    HIST1H3DP684312, 3MINT-2830662 MINT-2830965 MINT-8087423 MINT-2830941 MINT-8087264 MINT-8087281 MINT-7221095 MINT-8087449 MINT-7221313 MINT-8087437 I2D: score=3 
    HIST1H3EP684312, 3MINT-2830662 MINT-2830965 MINT-8087423 MINT-2830941 MINT-8087264 MINT-8087281 MINT-7221095 MINT-8087449 MINT-7221313 MINT-8087437 I2D: score=3 
    HIST1H3FP684312, 3MINT-2830662 MINT-2830965 MINT-8087423 MINT-2830941 MINT-8087264 MINT-8087281 MINT-7221095 MINT-8087449 MINT-7221313 MINT-8087437 I2D: score=3 
    HIST1H3GP684312, 3MINT-2830662 MINT-2830965 MINT-8087423 MINT-2830941 MINT-8087264 MINT-8087281 MINT-7221095 MINT-8087449 MINT-7221313 MINT-8087437 I2D: score=3 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007596blood coagulation TAS--
    GO:0019048modulation by virus of host morphology or physiology IEA--
    GO:0045892negative regulation of transcription, DNA-dependent IMP9636146

    CBX5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CBX5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CBX5

    10/13 Novoseek inferred chemical compound relationships for CBX5 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hsm 1 85 1 8200530 (1)
    lysine 54.9 5 12151603 (1), 19788305 (1), 11859155 (1), 12642487 (1) (see all 5)
    methylammonium 54.8 1 16372014 (1)
    4',6-diamidino-2-phenylindole 29.4 1 17178833 (1)
    cytosine 27.6 1 16705157 (1)
    amino acid 27.5 4 12840071 (1), 14570930 (1)
    protamine 24.1 2 10194639 (1), 11315969 (1)
    zinc 20.7 2 15342492 (1), 14570930 (1)
    retinoic acid 13 3 19880879 (1), 15507473 (1), 16569592 (1)
    tyrosine 0 1 12538453 (1)

    Search CenterWatch for drugs/clinical trials and news about CBX5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CBX5 gene (3 alternative transcripts): 
    NM_001127321.1  NM_001127322.1  NM_012117.2  

    Unigene Cluster for CBX5:

    Chromobox homolog 5
    Hs.349283  [show with all ESTs]
    Unigene Representative Sequence: NM_001127322
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000209875(uc001sfh.4 uc001sfj.4 uc001sfk.4) ENST00000439541
    ENST00000547872 ENST00000550411 ENST00000552562
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/261 QIAGEN miScript miRNA Assays for microRNAs that regulate CBX5 (see all 261):
    hsa-miR-411* hsa-miR-605 hsa-miR-376a* hsa-miR-3116 hsa-miR-200b hsa-miR-509-3-5p hsa-miR-761 hsa-miR-200c*
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    Additional mRNA sequence: 

    AF147443.1 AK023520.1 AK055641.1 AK056315.1 AK095108.1 AK313506.1 BC006821.1 BC030149.2 
    BC047432.1 CR457418.1 L07515.1 S62077.1 U26311.1 

    24/41 DOTS entries (see all 41):

    DT.214683  DT.100804605  DT.100809536  DT.318677  DT.121142656  DT.121142966  DT.100804583  DT.121142699 
    DT.97860793  DT.121142668  DT.456048  DT.100829089  DT.95080323  DT.121142801  DT.95080322  DT.121142640 
    DT.121142776  DT.209038  DT.121643376  DT.100755172  DT.121142961  DT.75148726  DT.91938437  DT.95184911 

    24/643 AceView cDNA sequences (see all 643):

    CR605673 CA432297 AA399326 AA343953 BQ222857 AA769094 AU133338 BU508305 
    CA866837 BE349450 CR605190 BX956984 AI015524 AI332765 T33647 AA491219 
    BM798038 AW131550 AA453000 BC006821 BU630206 AA284337 AK055641 CA413901 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CBX5    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
    SP1:                                                                              
    SP2:              -     -     -     -                                             
    SP3:                                                                              
    SP4:                                                                              
    SP5:              -                                                               


    ECgene alternative splicing isoforms for CBX5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CBX5 expression in normal human tissues (normalized intensities)      CBX5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGCTTTTG
    CBX5 Expression
    About this image


    CBX5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             superior temporal gyrus   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             sensory organ/ear/inner ear   

    See CBX5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CBX5

    SOURCE GeneReport for Unigene cluster: Hs.349283
        SABiosciences Expression via Pathway-Focused PCR Arrays including CBX5: 
              HIV Host Response in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CBX5 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cbx51 , 5 chromobox homolog 5 (Drosophila HP1a)5
    chromobox 51
    92.32(n)1
    97.91(a)1
      15 (58.34 cM)5
    124191  NM_007626.31  NP_031652.11 
     1031915445 
    lizard
    (Anolis carolinensis)
    Reptilia CBX56
    Uncharacterized protein
    92(a)
    1 ↔ 1
    2(71299394-71328158)
    African clawed frog
    (Xenopus laevis)
    Amphibia cbx5-prov2 chromobox homolog 5 (HP1 alpha homolog, Drosophila) 80.63(n)    BC054962.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cbx51 chromobox homolog 5 (HP1 alpha homolog, Drosophila) 67.4(n)
    73.77(a)
      563396  NM_001080184.1  NP_001073653.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta HP1b3
    Su(var)2051
    chromatin binding3
    Suppressor of variegation 2051
    52(a)3
    56.48(n)1
    48.89(a)1
      8C73
    341191  NM_057407.31  NP_476755.11 
    worm
    (Caenorhabditis elegans)
    Secernentea hpl-16
    Protein HPL-1
    29(a)
    1 → many
    X(13245390-13247044)


    ENSEMBL Gene Tree for CBX5 (if available)
    TreeFam Gene Tree for CBX5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CBX5 gene
    CBX32  CBX12  
    16 SIMAP similar genes for CBX5 using alignment to 3 protein entries:     CBX5_HUMAN (see all proteins):
    CBX4    CBX1    CBX8    CBX3    CBX2    CDYL2
    CDYL    SUV39H2    CBX6    CBX7    CDY1    CDY1B
    CDY2A    CDY2B    MPHOSPH8    SUV39H1

    CBX5 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CBX5
    PGOHUM00000237585 PGOHUM00000237674 PGOHUM00000235190


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/750 SNPs in CBX5 are shown (see all 750)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1129475551,2
    C--51694506(+) TTACAG/AGCATG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs111708531,2
    C,F,H--54624328(+) ACAAAT/ATCACA 3 -- ds50016Minor allele frequency- A:0.02NS EA NA 530
    rs171094751,2
    C,F,H--54624374(+) TGTGGT/CATTCC 3 -- ds500119Minor allele frequency- C:0.23NA EA NS 2150
    rs1909339871,2
    --54624461(+) ATTAGA/GAGCAG 3 -- ds50010--------
    rs1466876701,2
    --54624503(+) CTGAAC/TCAGTT 3 -- ds50010--------
    rs733210271,2
    C--54624597(+) GAGACC/AAATAA 3 -- ds50012Minor allele frequency- A:0.04WA 120
    rs1839628211,2
    --54624664(+) TGACAC/TTCCAG 3 -- ds50010--------
    rs740899541,2
    C,F--54627373(+) GTCCCC/TACATA 3 -- ut312Minor allele frequency- T:0.07WA 120
    rs1392226421,2
    --54627488(+) GGCACA/GTGGAT 3 -- ut310--------
    rs1856203541,2
    --54627594(+) GTGTGC/TGCCTG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for CBX5 (54624724 - 54673915 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CBX5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509467CNV Insertion20534489
    nsv832419CNV Loss17160897
    esv25123CNV Loss19812545
    nsv832420CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604478    OMIM disorders: --

    10 diseases for CBX5:    About MalaCards
    papillary thyroid carcinoma    myeloid leukemia    breast cancer    retinoblastoma
    thyroiditis    parkinson's disease    leukemia    hepatocellular carcinoma
    prostatitis    neuronitis


    CBX5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/13 Novoseek inferred disease relationships for CBX5 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    icf syndrome 69 2 15470359 (2)
    promyelocytic leukemia 34.8 2 15470359 (1), 12840071 (1)
    carcinoma embryonal 25.5 1 15342492 (1)
    breast cancer metastatic 10.2 1 16648629 (1)
    myeloid leukemia 6.76 1 16569592 (1)
    tumors 3.79 2 11507703 (1), 16892059 (1)
    leukemia 3.33 2 15507473 (1), 16569592 (1)
    retinoblastoma 3.05 1 11484059 (1)
    autoimmune diseases 0 1 9169582 (1)
    breast cancer 0 11 19566924 (3), 16648629 (3), 12151603 (2), 16051232 (1)


    Export disorders for CBX5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CBX5 gene, integrated from 9 sources (see all 276):
    (articles sorted by number of sources associating them with CBX5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. (PubMed id 8663349)1, 2, 3, 9 Ye Q. and Worman H.J. (1996)
    2. ASXL1 represses retinoic acid receptor-mediated trans cription through associating with HP1 and LSD1. (PubMed id 19880879)1, 2, 9 Lee S.W....Um S.J. (2010)
    3. Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells. (PubMed id 10460410)1, 2, 9 Minc E.... Buendia B. (1999)
    4. In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation. (PubMed id 15899859)1, 2, 9 Verschure P.J.... van Driel R. (2005)
    5. Human BAHD1 promotes heterochromatic gene silencing. (PubMed id 19666599)1, 2, 9 Bierne H.... Cossart P. (2009)
    6. Common properties of nuclear protein SP100 and TIF1alpha chromatin factor: role of SUMO modification. (PubMed id 11313457)1, 2, 9 Seeler J.-S.... Dejean A. (2001)
    7. Recognition and specificity determinants of the human cbx chromodomains. (PubMed id 21047797)1, 2 Kaustov L.... Arrowsmith C.H. (2011)
    8. Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1, 2 Nozawa R.S....Obuse C. (2010)
    9. Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10. (PubMed id 20498703)1, 2 Chaturvedi P. and Parnaik V.K. (2010)
    10. JAK2 phosphorylates histone H3Y41 and excludes HP1alp ha from chromatin. (PubMed id 19783980)1, 2 Dawson M.A....Kouzarides T. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23468 HGNC: 1555 AceView: CBX5 Ensembl:ENSG00000094916 euGenes: HUgn23468
    ECgene: CBX5 H-InvDB: CBX5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CBX5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CBX5 gene:
    Search GeneIP for patents involving CBX5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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