CBX5 Gene
protein-coding GIFtS: 62
GCID: GC12M054624
|
|
chromobox homolog 5(Previous names: chromobox homolog 5 (Drosophila HP1 alpha), chromobox homolog...)
| |
Aliases
for CBX5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromobox Homolog 51 2 | | HP1Hs-Alpha1 | | HP11 2 | | Chromobox Homolog 5 (Drosophila HP1 Alpha)1 | | HP1-ALPHA1 2 | | Chromobox Protein Homolog 52 | | Chromobox Homolog 5 (HP1 Alpha Homolog, Drosophila)1 2 | | Heterochromatin Protein 1-Alpha2 | | Antigen P252 3 | | HP1 Alpha Homolog2 | | Heterochromatin Protein 1 Homolog Alpha2 3 | | HP1Hs Alpha2 | | HP1A2 3 | | HP1 Alpha3 |
Export aliases for CBX5 gene to outside databasesPrevious GC identifers: GC12M054761 GC12M054351 GC12M052921 |
Summaries
for CBX5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CBX5:
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. Theprotein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminalchromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain(CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistoneproteins. The encoded product is involved in the formation of functional kinetochore through interaction withessential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively splicedvariants, encoding the same protein, have been identified. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CBX5_HUMAN, P45973Function: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me),leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 isphosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the associationof the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore throughinteraction with MIS12 complex proteins
Gene Wiki entry for CBX5
|
Genomic Views
for CBX5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CBX5 gene promoter:
TBP AML1a C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for CBX5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBX5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.13CBX5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M054624: view genomic region
(about GC identifiers)
Start:
|
54,624,724 bp from pter |
End:
|
54,673,955 bp from pter |
Size:
|
49,232 bases |
Orientation:
|
minus strand |
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Proteins
for CBX5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CBX5_HUMAN, P45973 (See
protein sequence)Recommended Name: Chromobox protein homolog 5 Size: 191 amino acids; 22225 Da
Subunit: Interacts with SUV420H1 and SUV420H2 (By similarity). Interacts with HP1BP3 (By similarity). Interactsdirectly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 and TRIM28 via the chromoshadow domain. Can interact directlywith CBX3 via the chromoshadow domain. Interacts with histone H3 methylated at 'Lys-9'. Interacts with BAHD1, MIS12and DSN1. Interacts with POGZ; POGZ and PXVXL motif-containing proteins such as INCENP and TRIM28 compete forinteraction with CBX5. Interacts with INCENP and TRIM24. Interacts with JC virus agnoprotein; this interaction inducesthe dissociation of CBX5 from LBR, resulting in destabilization of the nuclear envelope. Interacts with CHAMP1.Interacts with ASXL1
Subcellular location: Nucleus. Chromosome. Chromosome, centromere. Note=Component of centromeric and pericentromericheterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphaseand anaphase
2 PDB 3D structures from  and Proteopedia  for CBX5:3FDT (3D)
3I3C (3D)
Secondary accessions: B2R8T9Explore the universe of human proteins at neXtProt for CBX5: NX_P45973
Post-translational modifications:
Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclearstructure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase andpossibly hyper-phosphorylated during mitosis1
Ubiquitinated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P45973
CBX5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001120793.1 NP_001120794.1 NP_036249.1
ENSEMBL proteins: ENSP00000209875 ENSP00000401009 ENSP00000448452 ENSP00000449207 ENSP00000450190 Reactome Protein details: P45973
Human Recombinant Protein Products:
Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14): About this table
CBX5 for ontologies About GeneDecksing
CBX5 Antibody Products:
Assay Products for CBX5: |
Protein
Domains /
Families
for CBX5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CBX5 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P45973ProtoNet protein and cluster: P45973 2 Blocks protein families: IPB000953 Chromo domain IPB008251 Chromo shadow
UniProtKB/Swiss-Prot: CBX5_HUMAN, P45973Similarity: Contains 2 chromo domains |
Function
for CBX5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CBX5_HUMAN, P45973Function: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me),leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 isphosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the associationof the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore throughinteraction with MIS12 complex proteins
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBX5 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CBX5 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): CBX5 (NM_012117) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CBX5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBX5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX5 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
CBX5 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CBX5:
Animal Models:
Mouse knock-out Cbx5tm1.1Ics for CBX5
4 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Cbx5):
CBX5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CBX5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell cycle_Start of DNA replication in early S phase | | | 2 | Chromatin Regulation / Acetylation | | | 3 | Factors involved in megakaryocyte development and platelet production | | | 4 | Aurora B signaling | | | 5 | E2F transcription factor network | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for CBX5
1 
Cell Signaling Technology (CST) Pathway for CBX5
1  GeneGo (Thomson Reuters) Pathway for CBX5
2  BioSystems Pathways for CBX5
2 
Reactome Pathways for CBX5
CBX5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CBX5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/235 Interacting proteins for CBX5 (P459731, 2, 3 ENSP000002098754) via UniProtKB, MINT, STRING, and/or I2D (see all 235)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007596 | blood coagulation |
TAS | -- | | GO:0019048 | virus-host interaction |
IEA | -- | | GO:0044419 | interspecies interaction between organisms |
-- | -- | | GO:0045892 | negative regulation of transcription, DNA-dependent |
IMP | 9636146 |
CBX5 for ontologies About GeneDecksing
|
Drugs & Compounds
for CBX5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CBX5 for compounds About GeneDecksing
 Browse Tocris compounds for CBX5
10/13 Novoseek chemical compound relationships for CBX5 gene (see all 13) About this table
Search CenterWatch for drugs/clinical trials and news about CBX5
|
Transcripts
for CBX5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CBX5 gene (3 alternative transcripts): NM_001127321.1 NM_001127322.1 NM_012117.2 Unigene Cluster for CBX5: Chromobox homolog 5 Hs.349283 [show with all ESTs]Unigene Representative Sequence: NM_0011273226 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000209875(uc001sfh.4 uc001sfj.4 uc001sfk.4) ENST00000439541
ENST00000550489 ENST00000547872 ENST00000550411 ENST00000552562
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBX5 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CBX5 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): CBX5 (NM_012117) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CBX5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBX5 |
Additional cDNA sequence: AF147443.1 AK023520.1 AK055641.1 AK056315.1 AK095108.1 AK313506.1 BC006821.1 BC030149.2 BC047432.1 CR457418.1 L07515.1 S62077.1 U26311.1 24/41 DOTS entries (see all 41): DT.214683 DT.100804605 DT.100809536 DT.318677 DT.121142656 DT.121142966 DT.121142699 DT.100804583 DT.97860793 DT.121142668 DT.456048 DT.100829089 DT.95080323 DT.121142801 DT.95080322 DT.121142640 DT.121142776 DT.209038 DT.121643376 DT.100755172 DT.121142961 DT.75148726 DT.91938437 DT.95184911 24/643 AceView cDNA sequences (see all 643): AA461514 BM799194 AI015524 AA425658 AW131550 BX956984 BU154099 AI912870 AA948055 CR605190 BM466049 CA432297 BU165961 BU949683 BQ938090 AA491219 AI051850 AA204654 AA731340 BM798966 AA345472 BU508305 W69506 AA909524
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for CBX5 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CBX5
|
Expression
for CBX5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CBX5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGCTTTTG
About this image
See CBX5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CBX5
SOURCE GeneReport for Unigene cluster: Hs.349283
SABiosciences Expression via Pathway-Focused PCR Arrays including CBX5: | HIV Host Response in human mouse rat | | Polycomb & Trithorax Complexes in human mouse rat | | Epigenetic Chromatin Remodeling Factors in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CBX5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CBX5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBX5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBX5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX5 |
Orthologs
for CBX5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CBX5 gene from 8/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cbx51 , 5 |
chromobox homolog 5 (Drosophila HP1a)5
chromobox 51 |
92.32(n)1
97.91(a)1 |
|
15 (58.34 cM)5
124191 NM_007626.31 NP_031652.11
1031915445 |
lizard
(Anolis carolinensis) |
Reptilia |
CBX56 |
-- |
92(a) |
1 ↔ 1 |
2(71299435-71323631) |
African clawed frog
(Xenopus laevis) |
Amphibia |
cbx5-prov2 |
chromobox homolog 5 (HP1 alpha homolog, Drosophila) |
80.63(n) |
|
BC054962.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
cbx51 |
chromobox homolog 5 (HP1 alpha homolog, Drosophila) |
67.4(n)
73.77(a) |
|
563396 NM_001080184.1 NP_001073653.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
HP1b3
Su(var)2051 |
chromatin binding3
Suppressor of variegation 2051 |
52(a)3
56.48(n)1
48.89(a)1 |
|
8C73
341191 NM_057407.31 NP_476755.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
hpl-16 |
HP1 Like (heterochromatin protein) family member (... |
28(a) |
possible ortholog |
X(13245321-13246975) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
TFL26 |
chromo domain-containing protein LHP1 |
10(a) |
1 → many |
5(5827171-5829682) |
rice
(Oryza sativa) |
Liliopsida |
-- |
chromo domain-containing protein LHP1, putative, e... |
10(a) |
1 → many |
10(8921155-8925965) |
ENSEMBL Gene Tree for CBX5 (if available)
TreeFam Gene Tree for CBX5 (if available) |
Paralogs
for CBX5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CBX5 gene
- MPHOSPH82 CBX12 CBX32
18 SIMAP similar genes for CBX5 using alignment to 4 protein entries: CBX5_HUMAN (see all proteins):CBX4 CBX1 CBX8 CBX3 CBX2 CDYL2
CDYL SUV39H2 CBX6 CBX7 CDY1 CDY1B
CDY2A CDY2B MPHOSPH8 SUV39H1 CHD2 DKFZp781D1727
CBX5 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for CBX5
PGOHUM00000237585 PGOHUM00000237674 PGOHUM00000235190
|
Genomic Variants
for CBX5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CBX5 (54624724 - 54673955 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CBX5
1 CNV: 66229 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CBX5 |
|
Disorders
/ Diseases
for CBX5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CBX5 for disorders About GeneDecksing
OMIM gene information: 604478
OMIM disorders: --
12  diseases for CBX5: About MalaCardsmyeloid leukemia papillary thyroid carcinoma thyroid carcinoma breast cancer
leukemia parkinson's disease thyroiditis hepatocellular carcinoma
carcinoma immunodeficiency prostatitis neuronitis
10/13 Novoseek disease relationships for CBX5 gene (see all 13) About this table
Export disorders for CBX5 gene to outside databases
|
Publications
for CBX5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CBX5 gene, integrated from 9 sources (see all 265):
(articles sorted by number of sources associating them with CBX5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. (PubMed id 8663349)1, 2, 3, 9 Ye Q. and Worman H.J. (1996)
- ASXL1 represses retinoic acid receptor-mediated trans cription through associating with HP1 and LSD1. (PubMed id 19880879)1, 2, 9 Lee S.W....Um S.J. (2010)
- Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells. (PubMed id 10460410)1, 2, 9 Minc E.... Buendia B. (1999)
- In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation. (PubMed id 15899859)1, 2, 9 Verschure P.J.... van Driel R. (2005)
- Human BAHD1 promotes heterochromatic gene silencing. (PubMed id 19666599)1, 2, 9 Bierne H.... Cossart P. (2009)
- Common properties of nuclear protein SP100 and TIF1alpha chromatin factor: role of SUMO modification. (PubMed id 11313457)1, 2, 9 Seeler J.-S.... Dejean A. (2001)
- Recognition and specificity determinants of the human cbx chromodomains. (PubMed id 21047797)1, 2 Kaustov L.... Arrowsmith C.H. (2011)
- Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1, 2 Nozawa R.S....Obuse C. (2010)
- Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10. (PubMed id 20498703)1, 2 Chaturvedi P. and Parnaik V.K. (2010)
- JAK2 phosphorylates histone H3Y41 and excludes HP1alp ha from chromatin. (PubMed id 19783980)1, 2 Dawson M.A....Kouzarides T. (2009)
|
External Searches for CBX5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CBX5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CBX5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CBX5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for CBX5 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CBX5 gene:
Search GeneIP for patents involving CBX5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CBX5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for CBX5 | | OriGene shRNA RFP for CBX5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CBX5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CBX5 | | | OriGene Protein Over-expression Lysate for CBX5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CBX5 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CBX5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBX5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CBX5 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CBX5 | | OriGene Custom Protein Services for CBX5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CBX5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CBX5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBX5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CBX5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBX5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBX5 |
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| | Antibodies & Assays for CBX5
(HP1 alpha) |
| | | | Search Tocris compounds for CBX5 |
| |  |  |  |  | | | | | | Recombinant Protein for CBX5 |
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 | | | CBX5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX5 |
|  |  |  | | | | ThermoFisher Antibodies for CBX5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBX5 |
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