Aliases for CBX5 Gene
Aliases for CBX5 Gene
External Ids for CBX5 Gene
- HGNC: 1555
- Entrez Gene: 23468
- Ensembl: ENSG00000094916
- OMIM: 604478
- UniProtKB: P45973
Previous GeneCards Identifiers for CBX5 Gene
- GC12M054761
- GC12M054351
- GC12M052921
- GC12M054624
Summaries for CBX5 Gene
-
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for CBX5 Gene
CBX5 (Chromobox 5) is a Protein Coding gene. Diseases associated with CBX5 include Reynolds Syndrome and Axenfeld-Rieger Syndrome, Type 3. Among its related pathways are Aurora B signaling and E2F transcription factor network. GO annotations related to this gene include protein homodimerization activity and histone deacetylase binding. An important paralog of this gene is CBX1.
UniProtKB/Swiss-Prot for CBX5 Gene
-
Component of heterochromatin that recognizes and binds histone H3 tails methylated at Lys-9 (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when Tyr-41 of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBX5 Gene
Genomics for CBX5 Gene
Regulatory Elements for CBX5 Gene
Enhancers for CBX5 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CBX5 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CBX5 gene promoter:
Regulatory Element Products
Genomic Location for CBX5 Gene
- Chromosome:
- 12
- Start:
- 54,230,940 bp from pter
- End:
- 54,280,133 bp from pter
- Size:
- 49,194 bases
- Orientation:
- Minus strand
Genomic View for CBX5 Gene
Genes around CBX5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by Ensembl
- 12q13.13 by Entrez Gene
- 12q13.13 by HGNC
CBX5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBX5 Gene
Proteins for CBX5 Gene
-
Protein details for CBX5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P45973-CBX5_HUMAN
- Recommended name:
- Chromobox protein homolog 5
- Protein Accession:
- P45973
- B2R8T9
Protein attributes for CBX5 Gene
- Size:
- 191 amino acids
- Molecular mass:
- 22225 Da
- Quaternary structure:
-
- Interacts with KMT5B and KMT5C (By similarity). Interacts with HP1BP3. Interacts directly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 and TRIM28 via the chromoshadow domain. Can interact directly with CBX3 via the chromoshadow domain. Interacts with histone H3 methylated at Lys-9. Interacts with BAHD1, MIS12 and DSN1. Interacts with POGZ; POGZ and PXVXL motif-containing proteins such as INCENP and TRIM28 compete for interaction with CBX5. Interacts with INCENP and TRIM24. Interacts with JC virus agnoprotein; this interaction induces the dissociation of CBX5 from LBR, resulting in destabilization of the nuclear envelope. Interacts with CHAMP1. Interacts with ASXL1.
Protein Expression for CBX5 Gene
Post-translational modifications for CBX5 Gene
- Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
- Ubiquitinated.
- Ubiquitination at Lys32, Lys42, posLast=9191, Lys102, posLast=125125, posLast=143143, Lys154, and Lys159
- Modification sites at PhosphoSitePlus
Other Protein References for CBX5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore top CBX5 Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CBX5
- Cell Signaling Technology (CST) Antibodies for CBX5 (HP1 alpha)
-
Custom Antibody ServicesOriGene Antibodies for CBX5
- Novus Biologicals Antibodies for CBX5
-
Abcam antibodies for CBX5
- Invitrogen Antibodies for CBX5
- antibodies-online Antibodies for CBX5: See all 194
- GeneTex CBX5 antibody for CBX5
-
Santa Cruz Biotechnology (SCBT) Antibodies for CBX5
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CBX5
- Origene Custom Protein Services for CBX5
- ProSpec Recombinant Proteins for CBX5
- antibodies-online Proteins for CBX5: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CBX5
-
Abcam proteins for CBX5
Assay Products
- antibodies-online Kits for CBX5: See all 5
No data available for DME Specific Peptides for CBX5 Gene
Domains & Families for CBX5 Gene
Gene Families for CBX5 Gene
- HGNC:
Protein Domains for CBX5 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CBX5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CBX5 Gene
Function for CBX5 Gene
Molecular function for CBX5 Gene
- UniProtKB/Swiss-Prot Function:
- Component of heterochromatin that recognizes and binds histone H3 tails methylated at Lys-9 (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when Tyr-41 of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 8663349 |
| GO:0030674 | protein binding, bridging | ISS | -- |
| GO:0035064 | methylated histone binding | IDA | 19783980 |
| GO:0042803 | protein homodimerization activity | IEA | -- |
Phenotypes for CBX5 Gene
- MGI mutant phenotypes for CBX5:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for CBX5:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability in esophageal squamous lineage
- Decreased ionizing radiation sensitivity
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Decreased viability after Maraba virus infection
Animal Model Products
-
Taconic Biosciences Mouse Models for CBX5
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBX5
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CBX5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CBX5 gene
- Search ViGene Biosciences for CBX5
CRISPR Products
-
OriGene CRISPR knockouts for CBX5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBX5
- GenScript: Design CRISPR guide RNA sequences for CBX5
miRNA for CBX5 Gene
- miRTarBase miRNAs that target CBX5
-
- hsa-mir-98-5p (MIRT004950)
- hsa-mir-1-3p (MIRT023531)
- hsa-mir-484 (MIRT041993)
- hsa-mir-339-5p (MIRT042774)
- hsa-mir-320a (MIRT044429)
- hsa-mir-197-3p (MIRT048055)
- hsa-mir-92a-3p (MIRT049796)
- hsa-let-7e-5p (MIRT051655)
- hsa-let-7b-5p (MIRT052318)
- hsa-mir-345-5p (MIRT065823)
- hsa-mir-4795-3p (MIRT187596)
- hsa-mir-1343-3p (MIRT248351)
- hsa-mir-6716-5p (MIRT248353)
- hsa-mir-6783-3p (MIRT248354)
- hsa-mir-6852-5p (MIRT248356)
- hsa-mir-6736-3p (MIRT248364)
- hsa-mir-548p (MIRT338259)
- ebv-mir-bart10-3p (MIRT440998)
- hsa-mir-4438 (MIRT448968)
- hsa-mir-4635 (MIRT448969)
- hsa-mir-488-3p (MIRT448970)
- hsa-mir-583 (MIRT448971)
- hsa-mir-4650-5p (MIRT479924)
- hsa-mir-1304-5p (MIRT479925)
- hsa-mir-6878-3p (MIRT479926)
- hsa-mir-6734-5p (MIRT479927)
- hsa-mir-1226-5p (MIRT479928)
- hsa-mir-6834-5p (MIRT479929)
- hsa-mir-6721-5p (MIRT479930)
- hsa-mir-6744-3p (MIRT479931)
- hsa-mir-4757-5p (MIRT479932)
- hsa-mir-4763-3p (MIRT479933)
- hsa-mir-6781-3p (MIRT479934)
- hsa-mir-1207-5p (MIRT479935)
- hsa-mir-2682-3p (MIRT479936)
- hsa-mir-4721 (MIRT479937)
- hsa-mir-3616-3p (MIRT479938)
- hsa-mir-7843-5p (MIRT479939)
- hsa-mir-6879-5p (MIRT479940)
- hsa-mir-6735-5p (MIRT479941)
- hsa-mir-4632-5p (MIRT479942)
- hsa-mir-4436b-3p (MIRT479943)
- hsa-mir-548at-5p (MIRT479944)
- hsa-mir-376a-2-5p (MIRT549015)
- hsa-mir-202-3p (MIRT549016)
- hsa-mir-6831-5p (MIRT549017)
- hsa-mir-4668-3p (MIRT549018)
- hsa-mir-3927-3p (MIRT549019)
- hsa-let-7a-5p (MIRT549020)
- hsa-let-7c-5p (MIRT549021)
- hsa-let-7d-5p (MIRT549022)
- hsa-let-7g-5p (MIRT549023)
- hsa-mir-4458 (MIRT549024)
- hsa-let-7i-5p (MIRT549025)
- hsa-mir-4500 (MIRT549026)
- hsa-let-7f-5p (MIRT549027)
- hsa-mir-514b-3p (MIRT558905)
- hsa-mir-514a-3p (MIRT558906)
- hsa-mir-4477a (MIRT558907)
- hsa-mir-4316 (MIRT558908)
- hsa-mir-1294 (MIRT558909)
- hsa-mir-4677-3p (MIRT558910)
- hsa-mir-16-1-3p (MIRT558911)
- hsa-mir-126-5p (MIRT558912)
- hsa-mir-5683 (MIRT558913)
- hsa-mir-370-5p (MIRT558914)
- hsa-mir-383-3p (MIRT558915)
- hsa-mir-3065-3p (MIRT558916)
- hsa-mir-5089-5p (MIRT633094)
- hsa-mir-7151-3p (MIRT633095)
- hsa-mir-5095 (MIRT633096)
- hsa-mir-5589-5p (MIRT633097)
- hsa-mir-4731-5p (MIRT633098)
- hsa-mir-6778-3p (MIRT633099)
- hsa-mir-4252 (MIRT633100)
- hsa-mir-6506-5p (MIRT633101)
- hsa-mir-619-5p (MIRT633102)
- hsa-mir-150-5p (MIRT633103)
- hsa-mir-3937 (MIRT633104)
- hsa-mir-520h (MIRT633105)
- hsa-mir-520g-3p (MIRT633106)
- hsa-mir-6504-3p (MIRT633107)
- hsa-mir-512-3p (MIRT633108)
- hsa-mir-449b-3p (MIRT633109)
- hsa-mir-520e (MIRT633110)
- hsa-mir-520d-3p (MIRT633111)
- hsa-mir-520c-3p (MIRT633112)
- hsa-mir-520b (MIRT633113)
- hsa-mir-520a-3p (MIRT633114)
- hsa-mir-373-3p (MIRT633115)
- hsa-mir-372-3p (MIRT633116)
- hsa-mir-302e (MIRT633117)
- hsa-mir-302d-3p (MIRT633118)
- hsa-mir-302c-3p (MIRT633119)
- hsa-mir-302b-3p (MIRT633120)
- hsa-mir-302a-3p (MIRT633121)
- hsa-mir-93-5p (MIRT633122)
- hsa-mir-526b-3p (MIRT633123)
- hsa-mir-519d-3p (MIRT633124)
- hsa-mir-20b-5p (MIRT633125)
- hsa-mir-20a-5p (MIRT633126)
- hsa-mir-17-5p (MIRT633127)
- hsa-mir-106b-5p (MIRT633128)
- hsa-mir-106a-5p (MIRT633129)
- hsa-mir-6771-5p (MIRT659777)
- hsa-mir-7977 (MIRT659778)
- hsa-mir-566 (MIRT659779)
- hsa-mir-4743-5p (MIRT659780)
- hsa-mir-4268 (MIRT659781)
- hsa-mir-6720-3p (MIRT659782)
- hsa-mir-20b-3p (MIRT659783)
- hsa-mir-6746-5p (MIRT659784)
- hsa-mir-4267 (MIRT659785)
- hsa-mir-2114-5p (MIRT659786)
- hsa-mir-5588-3p (MIRT659787)
- hsa-mir-4256 (MIRT720010)
- hsa-mir-6505-3p (MIRT720011)
- hsa-mir-617 (MIRT720012)
- hsa-mir-4646-5p (MIRT720013)
- hsa-mir-204-3p (MIRT720014)
- hsa-mir-4735-5p (MIRT720015)
- hsa-mir-6742-3p (MIRT720016)
- hsa-mir-939-3p (MIRT720017)
- hsa-mir-19b-3p (MIRT728041)
- hsa-mir-19a-3p (MIRT728043)
miRNA Products
- Search ViGene Biosciences for CBX5
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBX5
- Browse OriGene Inhibitory RNA Products For CBX5
-
ViGene Biosciences ready-to-package AAV shRNAs for CBX5 gene
Clone Products
- Sino Biological Human cDNA Clone for CBX5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CBX5
- VectorBuilder custom plasmid, inducible vectors for CBX5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBX5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CBX5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CBX5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CBX5 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBX5 Gene
Localization for CBX5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CBX5 Gene
- Nucleus. Chromosome. Chromosome, centromere. Note=Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000118 | histone deacetylase complex | ISS | -- |
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000776 | kinetochore | IEA | -- |
| GO:0000784 | nuclear chromosome, telomeric region | IDA | 19135898 |
| GO:0000792 | heterochromatin | IEA | -- |
Pathways & Interactions for CBX5 Gene
Pathways by source for CBX5 Gene
1 Cell Signaling Technology pathway for CBX5 Gene
2 BioSystems pathways for CBX5 Gene
2 Reactome pathways for CBX5 Gene
1 GeneGo (Thomson Reuters) pathway for CBX5 Gene
Interacting Proteins for CBX5 Gene
Selected Interacting proteins:
P45973-CBX5_HUMAN
ENSP00000209875
for CBX5 Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007596 | blood coagulation | TAS | -- |
| GO:0016032 | viral process | IEA | -- |
| GO:0045892 | negative regulation of transcription, DNA-templated | IMP,IDA | 9636146 |
Transcripts for CBX5 Gene
mRNA/cDNA for CBX5 Gene
- (3) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (643) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CBX5 Gene
- Chromobox homolog 5:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CBX5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBX5
- GenScript: Design CRISPR guide RNA sequences for CBX5
miRNA Products
- Search ViGene Biosciences for CBX5
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBX5
- Browse OriGene Inhibitory RNA Products For CBX5
-
ViGene Biosciences ready-to-package AAV shRNAs for CBX5 gene
Clone Products
- Sino Biological Human cDNA Clone for CBX5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CBX5
- VectorBuilder custom plasmid, inducible vectors for CBX5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBX5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||
| SP5: | - |
Expression for CBX5 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (9.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CBX5 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CBX5 Gene:
CBX5SOURCE GeneReport for Unigene cluster for CBX5 Gene:
Hs.349283Evidence on tissue expression from TISSUES for CBX5 Gene
- Liver(4.6)
- Nervous system(4.6)
- Kidney(4.4)
- Eye(3.2)
- Intestine(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CBX5
-
OriGene qPCR primer pairs for CBX5
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBX5 Gene
Orthologs for CBX5 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CBX5 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CBX5 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CBX5 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Cbx5 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cbx5 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | CBX5 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cbx5 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | cbx5-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cbx5 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | HP1b 36 35 |
|
||
| Su(var)205 35 |
|
ManyToMany | |||
| HP6 35 |
|
ManyToMany | |||
| HP1e 35 |
|
ManyToMany | |||
| HP1c 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | hpl-1 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3133 35 |
|
OneToMany |
- Species where no ortholog for CBX5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CBX5 Gene
(16) SIMAP similar genes for CBX5 Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for CBX5 Gene
Variants for CBX5 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs74625894 | Benign | 54,281,778(+) | CATAA(A/G)TTAAC | intron-variant, upstream-variant-2KB | |
| rs1000095385 | -- | 54,246,496(+) | ACTCC(A/G)GAGTC | intron-variant | |
| rs1000150733 | -- | 54,233,759(+) | GACTG(C/T)CTCTA | utr-variant-3-prime | |
| rs1000264281 | -- | 54,241,046(+) | AAGCA(G/T)AAGTG | utr-variant-3-prime | |
| rs1000353290 | -- | 54,253,531(+) | AGACC(A/G)GCCTA | intron-variant |
Residual Variation Intolerance Score:
49.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.06;
1.35% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CBX5 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBX5 Gene
Disorders for CBX5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| reynolds syndrome |
|
|
| axenfeld-rieger syndrome, type 3 |
|
|
| immunodeficiency, centromere instability and facial anomalies syndrome |
|
|
Search CBX5 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CBX5
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CBX5
No data available for UniProtKB/Swiss-Prot and Genatlas for CBX5 Gene
Publications for CBX5 Gene
- Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. (PMID: 8663349) Ye Q. … Worman H.J. (J. Biol. Chem. 1996) 2 3 4 22 64
- In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation. (PMID: 15899859) Verschure P.J. … van Driel R. (Mol. Cell. Biol. 2005) 3 4 22 64
- Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells. (PMID: 10460410) Minc E. … Buendia B. (Chromosoma 1999) 3 4 22 64
- Recognition and specificity determinants of the human cbx chromodomains. (PMID: 21047797) Kaustov L. … Arrowsmith C.H. (J. Biol. Chem. 2011) 3 4 64
- Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells. (PMID: 21346195) Kang J. … Yu H. (Mol. Biol. Cell 2011) 3 4 64
Products for CBX5 Gene
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- Custom Antibody ServicesOriGene Antibodies for CBX5
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CBX5
- Origene Custom Protein Services for CBX5
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBX5
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- OriGene qPCR primer pairs and template standards for CBX5
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- GenScript: Next-day shipping cDNA ORF clone for CBX5 in any vector
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- CloneReady with Over 120,000 Genes
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- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
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- Novus Biologicals Antibodies for CBX5
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- Find your target
- Search knockout validated antibodies
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- ProSpec Recombinant Proteins for CBX5
- Taconic Biosciences Mouse Models for CBX5
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Addgene plasmids for CBX5
- antibodies-online Antibodies for CBX5: See all 194
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- antibodies-online Proteins for CBX5: See all 8
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- GeneTex CBX5 antibody for CBX5
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- ViGene Biosciences adenoviral particle packaged cDNA for CBX5 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for CBX5 gene
- Search ViGene Biosciences for CBX5
- Santa Cruz Biotechnology (SCBT) Antibodies for CBX5
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- Santa Cruz Biotechnology (SCBT) CRISPR for CBX5
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBX5
- VectorBuilder custom plasmid, inducible vectors for CBX5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBX5
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CBX5 Gene
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