Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CBX5 Gene

Aliases for CBX5 Gene

  • Chromobox Homolog 5 2 3
  • Chromobox Homolog 5 (HP1 Alpha Homolog, Drosophila) 2 3
  • Heterochromatin Protein 1 Homolog Alpha 3 4
  • Antigen P25 3 4
  • HP1A 3 4
  • Chromobox Homolog 5 (Drosophila HP1 Alpha) 2
  • Heterochromatin Protein 1-Alpha 3
  • HP1 Alpha Homolog (Drosophila) 2
  • Epididymis Luminal Protein 25 3
  • Chromobox Protein Homolog 5 3
  • HP1 Alpha Homolog 3
  • HP1Hs Alpha 3
  • HP1-ALPHA 3
  • HP1 Alpha 4
  • HEL25 3
  • HP1 3

External Ids for CBX5 Gene

Previous GeneCards Identifiers for CBX5 Gene

  • GC12M054761
  • GC12M054351
  • GC12M052921
  • GC12M054624

Summaries for CBX5 Gene

Entrez Gene Summary for CBX5 Gene

  • This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for CBX5 Gene

CBX5 (Chromobox Homolog 5) is a Protein Coding gene. Among its related pathways are Hemostasis and Chromatin Regulation / Acetylation. GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is CBX1.

UniProtKB/Swiss-Prot for CBX5 Gene

  • Component of heterochromatin that recognizes and binds histone H3 tails methylated at Lys-9 (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when Tyr-41 of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Gene Wiki entry for CBX5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBX5 Gene

Genomics for CBX5 Gene

Regulatory Elements for CBX5 Gene

Genomic Location for CBX5 Gene

Start:
54,230,940 bp from pter
End:
54,280,133 bp from pter
Size:
49,194 bases
Orientation:
Minus strand

Genomic View for CBX5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CBX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBX5 Gene

Proteins for CBX5 Gene

  • Protein details for CBX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P45973-CBX5_HUMAN
    Recommended name:
    Chromobox protein homolog 5
    Protein Accession:
    P45973
    Secondary Accessions:
    • B2R8T9

    Protein attributes for CBX5 Gene

    Size:
    191 amino acids
    Molecular mass:
    22225 Da
    Quaternary structure:
    • Interacts with SUV420H1 and SUV420H2 (By similarity). Interacts with HP1BP3. Interacts directly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 and TRIM28 via the chromoshadow domain. Can interact directly with CBX3 via the chromoshadow domain. Interacts with histone H3 methylated at Lys-9. Interacts with BAHD1, MIS12 and DSN1. Interacts with POGZ; POGZ and PXVXL motif-containing proteins such as INCENP and TRIM28 compete for interaction with CBX5. Interacts with INCENP and TRIM24. Interacts with JC virus agnoprotein; this interaction induces the dissociation of CBX5 from LBR, resulting in destabilization of the nuclear envelope. Interacts with CHAMP1. Interacts with ASXL1.

    Three dimensional structures from OCA and Proteopedia for CBX5 Gene

neXtProt entry for CBX5 Gene

Proteomics data for CBX5 Gene at MOPED

Post-translational modifications for CBX5 Gene

  • Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
  • Ubiquitinated.
  • Ubiquitination at Lys32, Lys40, Lys42, Lys91, Lys102, Lys125, Lys143, Lys154, and Lys159
  • Modification sites at PhosphoSitePlus

Other Protein References for CBX5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CBX5 (HP1 alpha)

No data available for DME Specific Peptides for CBX5 Gene

Domains for CBX5 Gene

Suggested Antigen Peptide Sequences for CBX5 Gene

Graphical View of Domain Structure for InterPro Entry

P45973

UniProtKB/Swiss-Prot:

CBX5_HUMAN :
  • P45973
Domain:
  • Contains 2 chromo domains.
genes like me logo Genes that share domains with CBX5: view

No data available for Gene Families for CBX5 Gene

Function for CBX5 Gene

Molecular function for CBX5 Gene

UniProtKB/Swiss-Prot Function: Component of heterochromatin that recognizes and binds histone H3 tails methylated at Lys-9 (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when Tyr-41 of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Gene Ontology (GO) - Molecular Function for CBX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 10330177
GO:0030674 protein binding, bridging ISS --
GO:0035064 methylated histone binding IDA 19783980
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with CBX5: view
genes like me logo Genes that share phenotypes with CBX5: view

Animal Models for CBX5 Gene

MGI Knock Outs for CBX5:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CBX5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CBX5 Gene

Localization for CBX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBX5 Gene

Nucleus. Chromosome. Chromosome, centromere. Note=Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CBX5 Gene COMPARTMENTS Subcellular localization image for CBX5 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CBX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex ISS --
GO:0000776 kinetochore IEA --
GO:0000792 heterochromatin --
GO:0005634 nucleus IDA --
GO:0005635 nuclear envelope TAS 8663349
genes like me logo Genes that share ontologies with CBX5: view

Pathways for CBX5 Gene

genes like me logo Genes that share pathways with CBX5: view

Pathways by source for CBX5 Gene

1 Cell Signaling Technology pathway for CBX5 Gene
2 BioSystems pathways for CBX5 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Remodeling Factors in human,mouse,rat
    • HIV Host Response in human,mouse,rat
    • Polycomb & Trithorax Complexes in human,mouse,rat

Gene Ontology (GO) - Biological Process for CBX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
GO:0016032 viral process IEA --
GO:0045892 negative regulation of transcription, DNA-templated IMP 9636146
genes like me logo Genes that share ontologies with CBX5: view

Compounds for CBX5 Gene

(13) Novoseek inferred chemical compound relationships for CBX5 Gene

Compound -log(P) Hits PubMed IDs
hsm 1 85 1
lysine 54.9 5
methylammonium 54.8 1
4,6-diamidino-2-phenylindole 29.4 1
cytosine 27.6 1
genes like me logo Genes that share compounds with CBX5: view

Transcripts for CBX5 Gene

Unigene Clusters for CBX5 Gene

Chromobox homolog 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CBX5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CBX5 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
SP1:
SP2: - - - -
SP3:
SP4:
SP5: -

Relevant External Links for CBX5 Gene

GeneLoc Exon Structure for
CBX5
ECgene alternative splicing isoforms for
CBX5

Expression for CBX5 Gene

mRNA expression in normal human tissues for CBX5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CBX5 Gene

SOURCE GeneReport for Unigene cluster for CBX5 Gene Hs.349283

genes like me logo Genes that share expressions with CBX5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CBX5 Gene

Orthologs for CBX5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CBX5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CBX5 35
  • 99.65 (n)
  • 100 (a)
CBX5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CBX5 35
  • 97.03 (n)
  • 100 (a)
CBX5 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CBX5 35
  • 96.68 (n)
  • 99.48 (a)
CBX5 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cbx5 35
  • 92.32 (n)
  • 97.91 (a)
Cbx5 16
Cbx5 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cbx5 35
  • 91.8 (n)
  • 97.91 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 89 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia CBX5 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cbx5-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cbx5 35
  • 77.05 (n)
  • 84.7 (a)
zebrafish
(Danio rerio)
Actinopterygii cbx5 35
  • 67.4 (n)
  • 73.77 (a)
cbx5 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta HP1b 36
  • 36 (a)
ManyToMany
HP1c 36
  • 27 (a)
ManyToMany
HP1e 36
  • 32 (a)
ManyToMany
HP6 36
  • 38 (a)
ManyToMany
Su(var)205 36
  • 40 (a)
ManyToMany
HP1b 37
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea hpl-1 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3133 36
  • 45 (a)
OneToMany
Species with no ortholog for CBX5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CBX5 Gene

ENSEMBL:
Gene Tree for CBX5 (if available)
TreeFam:
Gene Tree for CBX5 (if available)

Paralogs for CBX5 Gene

Paralogs for CBX5 Gene

Selected SIMAP similar genes for CBX5 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CBX5 Gene

genes like me logo Genes that share paralogs with CBX5: view

Variants for CBX5 Gene

Sequence variations from dbSNP and Humsavar for CBX5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs9382 -- 54,234,400(+) AAAAA(A/G)GCTGA utr-variant-3-prime
rs1133853 -- 54,278,089(-) cattg(C/T)caaat intron-variant
rs1133860 -- 54,236,637(-) AATAA(A/T)AAATA utr-variant-3-prime
rs1140681 -- 54,257,687(-) GGACC(C/T)GGTGG utr-variant-5-prime
rs1920045 -- 54,276,614(-) TGATT(A/G)CTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CBX5 Gene

Variant ID Type Subtype PubMed ID
nsv832419 CNV Loss 17160897
nsv832420 CNV Loss 17160897
nsv509467 CNV Insertion 20534489
esv25123 CNV Loss 19812545

Relevant External Links for CBX5 Gene

HapMap Linkage Disequilibrium report
CBX5
Human Gene Mutation Database (HGMD)
CBX5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBX5 Gene

Disorders for CBX5 Gene

(13) Novoseek inferred disease relationships for CBX5 Gene

Disease -log(P) Hits PubMed IDs
icf syndrome 69 2
promyelocytic leukemia 34.8 2
carcinoma embryonal 25.5 1
breast cancer metastatic 10.2 1
myeloid leukemia 6.76 1
genes like me logo Genes that share disorders with CBX5: view

No data available for UniProtKB/Swiss-Prot for CBX5 Gene

Publications for CBX5 Gene

  1. Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. (PMID: 8663349) Ye Q. … Worman H.J. (J. Biol. Chem. 1996) 2 3 4 23
  2. Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells. (PMID: 10460410) Minc E. … Buendia B. (Chromosoma 1999) 3 4 23
  3. In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation. (PMID: 15899859) Verschure P.J. … van Driel R. (Mol. Cell. Biol. 2005) 3 4 23
  4. Isoform-specific interaction of HP1 with human TAFII130. (PMID: 11959914) Vassallo M.F. … Tanese N. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 23
  5. Functional cooperation between HP1 and DNMT1 mediates gene silencing. (PMID: 17470536) Smallwood A. … Carey M. (Genes Dev. 2007) 3 23

Products for CBX5 Gene

  • Addgene plasmids for CBX5

Sources for CBX5 Gene

Back to Top

Content