CBX4 Gene
protein-coding GIFtS: 56
GCID: GC17M077806
|
|
chromobox homolog 4(Previous name: chromobox homolog 4 (Drosophila Pc class) )
| |
Aliases
for CBX4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromobox Homolog 41 2 | | Chromobox Homolog 4 (Pc Class Homolog, Drosophila)2 | | NBP161 2 | | E3 SUMO-Protein Ligase CBX42 | | PC21 2 | | NS5ATP1-Binding Protein 162 | | Chromobox Protein Homolog 42 3 | | Pc Class 2 Homolog2 | | Polycomb 2 Homolog2 3 | | EC 6.3.2.-3 | | Chromobox Homolog 4 (Drosophila Pc Class)1 | | Pc23 | | HPC21 | | HPc21 |
Export aliases for CBX4 gene to outside databasesPrevious GC identifers: GC17M077736 GC17M081095 GC17M078371 GC17M078507 GC17M075422 GC17M073247 |
Summaries
for CBX4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CBX4_HUMAN, O00257Function: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, ap53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting inp21/CDKN1A expressionFunction: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain thetranscriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex actsvia chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119',rendering chromatin heritably changed in its expressibility
|
Genomic Views
for CBX4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CBX4 gene promoter:
E2F-3a E2F-4 E2F-5 Pax-5 E2F-2 HEN1 E2F E2F-1 IRF-7A NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CBX4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBX4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3CBX4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M077806: view genomic region
(about GC identifiers)
Start:
|
77,806,955 bp from pter |
End:
|
77,813,228 bp from pter |
Size:
|
6,274 bases |
Orientation:
|
minus strand |
|
Proteins
for CBX4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CBX4_HUMAN, O00257 (See
protein sequence)Recommended Name: E3 SUMO-protein ligase CBX4 Size: 560 amino acids; 61368 Da
Subunit: Interacts with histone H3-K9Me3. Interacts with CHTOP (By similarity). Component of a PRC1-like complex.Self-associates. Interacts with SUV39H1 and HIPK2. Interacts with CSNK2B
Subcellular location: Nucleus. Nucleus speckle
Miscellaneous: The human orthologs of the Drosophila Polycomb group protein Pc are CBX2, CBX4, CBX6, CBX7 and CBX8.These show distinct nuclear localizations, contribute differently to transcriptional repression, and appear to be partof distinct PRC1-like protein complexes. The hPRC-H complex purified in PubMed:12167701 probably presents a mixture ofdifferent complexes containing different Polycomb group proteins
Sequence caution: Sequence=AAH14967.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
2 PDB 3D structures from  and Proteopedia  for CBX4:2K28 (3D)
3I8Z (3D)
Secondary accessions: B1PJR7 Q6TPI8 Q96C04Alternative splicing: 2 isoforms: O00257-1 O00257-3 Explore the universe of human proteins at neXtProt for CBX4: NX_O00257
Post-translational modifications:
Phosphorylated on Thr-497 by HIPK2 upon DNA damage. This phosphorylation stimulates E3 SUMO-protein ligase activity andpromotes sumoylation on Lys-494, as well as sumoylation of other target proteins, such as HNRNPK1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00257
CBX4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003646.2
ENSEMBL proteins: ENSP00000269397 ENSP00000415348 ENSP00000461198
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
CBX4 for ontologies About GeneDecksing
CBX4 Antibody Products:
Assay Products for CBX4: |
Protein
Domains /
Families
for CBX4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CBX4 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00257ProtoNet protein and cluster: O00257 1 Blocks protein family: IPB000953 Chromo domain
UniProtKB/Swiss-Prot: CBX4_HUMAN, O00257Domain: The polyhistidine repeat may act as a targeting signal to nuclear speckles (PubMed:19266028)Similarity: Contains 1 chromo domain |
Function
for CBX4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CBX4_HUMAN, O00257Function: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, ap53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting inp21/CDKN1A expressionFunction: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain thetranscriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex actsvia chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119',rendering chromatin heritably changed in its expressibilityEnzyme Number (IUBMB): EC 6.3.2.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBX4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CBX4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CBX4 (NM_003655) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CBX4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBX4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX4 |
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table
CBX4 for ontologies About GeneDecksing
|
Pathways & Interactions
for CBX4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Proteolysis Putative SUMO-1 pathway | | | 2 | C-MYB transcription factor network | | | 3 | Regulation of retinoblastoma protein | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CBX4
1  GeneGo (Thomson Reuters) Pathway for CBX4
2  BioSystems Pathways for CBX4
UniProtKB/Swiss-Prot: CBX4_HUMAN, O00257Pathway: Protein modification; protein sumoylation
CBX4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CBX4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/127 Interacting proteins for CBX4 (O002571, 2, 3 ENSP000002693974) via UniProtKB, MINT, STRING, and/or I2D (see all 127)
| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| RNF2 | Q994961, 2, 3, ENSP000003564804 | EBI-4392727,EBI-722416 MINT-8010325 MINT-8010390 I2D:
score=9 STRING: ENSP00000356480 | | BMI1 | P352261, 2, 3, ENSP000003658514 | EBI-4392727,EBI-2341576 MINT-8010325 MINT-4543631 I2D:
score=2 STRING: ENSP00000365851 | | CBX8 | Q9HC522, 3, ENSP000002693854 | MINT-4543739 MINT-8010325 MINT-8010390 I2D:
score=1 STRING: ENSP00000269385 | | USP11 | P517842, 3, ENSP000002183484 | MINT-8013010 MINT-8010325 MINT-8010390 I2D:
score=1 STRING: ENSP00000218348 | | PHC1 | P783642, 3, ENSP000002517574 | MINT-8010325 MINT-8010390 I2D:
score=1 STRING: ENSP00000251757 |
About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IMP | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0016568 | chromatin modification |
IEA | -- | | GO:0016925 | protein sumoylation |
IEA | -- | | GO:0043066 | negative regulation of apoptotic process |
TAS | 9315667 |
CBX4 for ontologies About GeneDecksing
|
Drugs & Compounds
for CBX4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CBX4 for compounds About GeneDecksing
 Browse Tocris compounds for CBX4
1 Novoseek chemical compound relationship for CBX4 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| glutamine |
23.8 |
2 |
11414760 (1), 12497610 (1) |
Search CenterWatch for drugs/clinical trials and news about CBX4
|
Transcripts
for CBX4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CBX4 gene: NM_003655.2 Unigene Cluster for CBX4: Chromobox homolog 4 Hs.743401 [show with all ESTs]Unigene Representative Sequence: NM_0036554 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000269397(uc002jxe.3) ENST00000448310 ENST00000495122 ENST00000494546
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBX4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CBX4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CBX4 (NM_003655) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CBX4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBX4 |
Additional cDNA sequence: AF013956.1 AY390430.1 BC014967.1 EU439707.1 U94344.1 3 DOTS entries: DT.95369650 DT.207354 DT.91733994 24/56 AceView cDNA sequences (see all 56): CR616461 BM452847 AI351619 AI148768 BX280228 BX436959 AY390430 D20381 BC014967 AI076023 BQ219412 AI401035 BG222508 BM451430 BM452215 BF221869 CD743207 BM989303 BU188400 BQ225831 AI796748 BQ049740 BQ639572 BM475166
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for CBX4 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d |
|---|
|
| SP1: | | | | | | | | | - | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CBX4
|
Expression
for CBX4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CBX4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGTCTTGT
About this image
See CBX4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CBX4
SOURCE GeneReport for Unigene cluster: Hs.743401
UniProtKB/Swiss-Prot: CBX4_HUMAN, O00257Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Arrays including CBX4: | Polycomb & Trithorax Complexes in human mouse rat | | Apoptosis 384HT in human mouse rat | | Epigenetic Chromatin Remodeling Factors in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CBX4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CBX4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBX4 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBX4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX4 |
Orthologs
for CBX4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CBX4 gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CBX41 |
chromobox homolog 4 |
76.33(n)
72.4(a) |
|
395354 NM_204642.1 NP_989973.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CBX46 |
-- |
44(a) |
1 ↔ 1 |
2(100834406-100843377) |
African clawed frog
(Xenopus laevis) |
Amphibia |
cbx4-A-prov2 |
chromobox homolog 4 (Polycomb) |
76.52(n) |
|
U39929.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.209702 |
Danio rerio polycomb 2 mRNA, complete cds |
79.81(n) |
|
AY186581.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Pc6 |
Polycomb |
14(a) |
1 → many |
3L(21299238-21311120) |
ENSEMBL Gene Tree for CBX4 (if available)
TreeFam Gene Tree for CBX4 (if available) |
Paralogs
for CBX4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CBX4 gene
- CBX82 CBX22 CBX72
6 SIMAP similar genes for CBX4 using alignment to 3 protein entries: CBX4_HUMAN (see all proteins):CBX7 CBX8 CBX3 CBX5 CBX1 SUV39H2
CBX4 for paralogs About GeneDecksing
|
Genomic Variants
for CBX4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CBX4 (77806955 - 77813228 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CBX4
2 CNVs: 0213 2234
Human Gene Mutation Database (HGMD): CBX4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CBX4 |
|
Disorders
/ Diseases
for CBX4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CBX4 for disorders About GeneDecksing
OMIM gene information: 603079
OMIM disorders: --
6  diseases for CBX4: About MalaCardshodgkin's lymphoma breast carcinoma prostate cancer prostatitis
schizophrenia carcinoma
1 Novoseek disease relationship for CBX4 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
1 |
12527301 (1) |
Export disorders for CBX4 gene to outside databases
|
Publications
for CBX4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CBX4 gene, integrated from 9 sources (see all 76):
(articles sorted by number of sources associating them with CBX4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis. (PubMed id 9315667)1, 2, 3 Satijn D.P.E.... Otte A.P. (1997)
- Multiple activities contribute to Pc2 E3 function. (PubMed id 15592428)1, 2, 9 Kagey M.H.... Wotton D. (2005)
- The polycomb protein Pc2 is a SUMO E3. (PubMed id 12679040)1, 2, 9 Kagey M.H.... Wotton D. (2003)
- Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin. (PubMed id 16061479)1, 2, 9 Long J.... Park M. (2005)
- DNA damage-induced heterogeneous nuclear ribonucleoprotein K SUMOylation regulates p53 transcriptional activation. (PubMed id 22825850)1, 2 Pelisch F.... Srebrow A. (2012)
- Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PubMed id 21282530)1, 2 Vandamme J.... Angrand P.O. (2011)
- Several distinct polycomb complexes regulate and co-l ocalize on the INK4a tumor suppressor locus. (PubMed id 19636380)1, 2 Maertens G.N....Peters G. (2009)
- Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2. (PubMed id 17018294)1, 2 Roscic A.... Schmitz M.L. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. (PubMed id 12167701)1, 2 Levine S.S....Kingston R.E. (2002)
|
External Searches for CBX4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CBX4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CBX4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CBX4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CBX4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CBX4 gene:
Search GeneIP for patents involving CBX4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CBX4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for CBX4 | | OriGene shRNA RFP for CBX4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CBX4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CBX4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CBX4 | | OriGene 3'-UTR Clone for CBX4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CBX4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBX4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CBX4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CBX4 | | OriGene Custom Protein Services for CBX4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CBX4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CBX4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBX4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CBX4 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBX4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBX4 |
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| | | | Search Tocris compounds for CBX4 |
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 | | | CBX4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX4 |
|  |  |  | | | | ThermoFisher Antibodies for CBX4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBX4 |
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