Aliases for CBX4 Gene
Aliases for CBX4 Gene
External Ids for CBX4 Gene
- HGNC: 1554
- Entrez Gene: 8535
- Ensembl: ENSG00000141582
- OMIM: 603079
- UniProtKB: O00257
Previous GeneCards Identifiers for CBX4 Gene
- GC17M077736
- GC17M081095
- GC17M078371
- GC17M078507
- GC17M075422
- GC17M077806
- GC17M073247
Summaries for CBX4 Gene
GeneCards Summary for CBX4 Gene
CBX4 (Chromobox 4) is a Protein Coding gene. Among its related pathways are Cellular Senescence and C-MYB transcription factor network. GO annotations related to this gene include chromatin binding and ligase activity. An important paralog of this gene is CBX6.
UniProtKB/Swiss-Prot for CBX4 Gene
-
E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.
-
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBX4 Gene
Genomics for CBX4 Gene
Regulatory Elements for CBX4 Gene
Enhancers for CBX4 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH17G079808 | 2 | FANTOM5 Ensembl ENCODE dbSUPER | 12 | +26.9 | 26860 | 8.0 | HDGF PKNOX1 AGO1 ZFP64 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF766 | CBX8 CBX2 CBX4 CCDC40 PIR54271 |
| GH17G079942 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 11.7 | -103.4 | -103377 | 1.4 | PKNOX1 ATF1 NFIB ZNF366 PCBP1 RELB CREM IKZF2 ZNF263 YY2 | CBX4 SGSH GC17P079941 PIR49167 |
| GH17G079745 | 1.5 | Ensembl ENCODE dbSUPER | 11.2 | +92.1 | 92061 | 3.0 | HDGF FOXA2 WRNIP1 ZNF2 ZNF48 ZNF143 ZNF263 NCOA1 REST KAT8 | CBX2 CBX4 ENPP7 |
| GH17G079792 | 1.4 | Ensembl ENCODE dbSUPER | 11.8 | +45.7 | 45678 | 3.2 | TBP AGO1 KLF17 SIN3A RAD21 RFX5 ZNF121 GATA2 ZNF366 ZSCAN5C | CBX8 CBX4 GC17P079785 ENSG00000262768 |
| GH17G079948 | 1.4 | Ensembl ENCODE dbSUPER | 11.3 | -111.6 | -111624 | 5.2 | HDAC1 PKNOX1 RAD21 TCF12 ZNF121 ZNF366 CREM CEBPB ZNF398 REST | LOC100294362 CBX4 CBX2 ENSG00000275516 PIR49167 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CBX4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CBX4 gene promoter:
Regulatory Element Products
Genomic Location for CBX4 Gene
- Chromosome:
- 17
- Start:
- 79,833,156 bp from pter
- End:
- 79,839,429 bp from pter
- Size:
- 6,274 bases
- Orientation:
- Minus strand
Genomic View for CBX4 Gene
Genes around CBX4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by Ensembl
- 17q25.3 by Entrez Gene
- 17q25.3 by HGNC
CBX4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBX4 Gene
Proteins for CBX4 Gene
-
Protein details for CBX4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00257-CBX4_HUMAN
- Recommended name:
- E3 SUMO-protein ligase CBX4
- Protein Accession:
- O00257
- B1PJR7
- Q6TPI8
- Q96C04
Protein attributes for CBX4 Gene
- Size:
- 560 amino acids
- Molecular mass:
- 61368 Da
- Quaternary structure:
-
- Interacts with histone H3-K9Me3. Interacts with CHTOP (By similarity). Component of a PRC1-like complex. Self-associates. Interacts with SUV39H1 and HIPK2. Interacts with CSNK2B.
- Miscellaneous:
-
- The human orthologs of the Drosophila Polycomb group protein Pc are CBX2, CBX4, CBX6, CBX7 and CBX8. These show distinct nuclear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes. The hPRC-H complex purified in PubMed:12167701 probably presents a mixture of different complexes containing different Polycomb group proteins.
- SequenceCaution:
-
- Sequence=AAH14967.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
Protein Expression for CBX4 Gene
Post-translational modifications for CBX4 Gene
- Phosphorylated on Thr-497 by HIPK2 upon DNA damage. This phosphorylation stimulates E3 SUMO-protein ligase activity and promotes sumoylation on Lys-494, as well as sumoylation of other target proteins, such as HNRNPK.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CBX4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CBX4
-
Custom Antibody ServicesOriGene Antibodies for CBX4
- Novus Biologicals Antibodies for CBX4
- Invitrogen Antibodies for CBX4
- antibodies-online Antibodies for CBX4: See all 51
- GeneTex CBX4 antibody for CBX4
-
Custom Antibody ServicesProSci Antibodies for CBX4
-
Santa Cruz Biotechnology (SCBT) Antibodies for CBX4
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CBX4
- Origene Custom Protein Services for CBX4
- antibodies-online Proteins for CBX4: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CBX4
Assay Products
- antibodies-online Kits for CBX4: See all 4
No data available for DME Specific Peptides for CBX4 Gene
Domains & Families for CBX4 Gene
Gene Families for CBX4 Gene
- HGNC:
Protein Domains for CBX4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CBX4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O00257UniProtKB/Swiss-Prot:
CBX4_HUMAN :- The polyhistidine repeat may act as a targeting signal to nuclear speckles.
- Domain:
-
- The polyhistidine repeat may act as a targeting signal to nuclear speckles.
Function for CBX4 Gene
Molecular function for CBX4 Gene
- UniProtKB/Swiss-Prot Function:
- E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.
- UniProtKB/Swiss-Prot Function:
- Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.
Enzyme Numbers (IUBMB) for CBX4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0003714 | transcription corepressor activity | TAS | 9315667 |
| GO:0003727 | single-stranded RNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16169070 |
| GO:0016874 | ligase activity | IEA | -- |
Phenotypes for CBX4 Gene
- MGI mutant phenotypes for CBX4:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CBX4:
-
- Increased vaccinia virus (VACV) infection
- Increased shRNA abundance (Z-score > 2)
- Decreased NF-kappaB reporter expression
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased Aire reporter expression
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBX4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CBX4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CBX4 gene
- Search ViGene Biosciences for CBX4
CRISPR Products
-
OriGene CRISPR knockouts for CBX4
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBX4
- GenScript: Design CRISPR guide RNA sequences for CBX4
miRNA for CBX4 Gene
- miRTarBase miRNAs that target CBX4
-
- hsa-mir-335-5p (MIRT018685)
- hsa-mir-101-3p (MIRT027349)
- hsa-mir-328-3p (MIRT043804)
- hsa-mir-325 (MIRT147676)
- hsa-mir-552-5p (MIRT147688)
- hsa-mir-628-3p (MIRT147692)
- hsa-mir-374a-5p (MIRT440997)
- hsa-mir-498 (MIRT479945)
- hsa-mir-7702 (MIRT479946)
- hsa-mir-6079 (MIRT479947)
- hsa-mir-633 (MIRT479948)
- hsa-mir-671-5p (MIRT479949)
- hsa-mir-4699-3p (MIRT479950)
- hsa-mir-6828-5p (MIRT479951)
- hsa-mir-4259 (MIRT479952)
- hsa-mir-4715-5p (MIRT479953)
- hsa-mir-181b-5p (MIRT479954)
- hsa-mir-181a-5p (MIRT479955)
- hsa-mir-4262 (MIRT479956)
- hsa-mir-181d-5p (MIRT479957)
- hsa-mir-181c-5p (MIRT479958)
- hsa-mir-590-5p (MIRT479959)
- hsa-mir-21-5p (MIRT479960)
- hsa-mir-508-3p (MIRT541405)
- hsa-mir-302c-5p (MIRT541406)
- hsa-mir-4777-5p (MIRT541407)
- hsa-mir-526a (MIRT541408)
- hsa-mir-523-5p (MIRT541409)
- hsa-mir-522-5p (MIRT541410)
- hsa-mir-520c-5p (MIRT541411)
- hsa-mir-519c-5p (MIRT541412)
- hsa-mir-519b-5p (MIRT541413)
- hsa-mir-519a-5p (MIRT541414)
- hsa-mir-518f-5p (MIRT541415)
- hsa-mir-518e-5p (MIRT541416)
- hsa-mir-518d-5p (MIRT541417)
- hsa-mir-4524b-5p (MIRT541418)
- hsa-mir-4524a-5p (MIRT541419)
- hsa-mir-520g-5p (MIRT541420)
- hsa-mir-3614-3p (MIRT541421)
- hsa-mir-646 (MIRT541422)
- hsa-mir-6856-5p (MIRT541423)
- hsa-mir-6758-5p (MIRT541424)
- hsa-mir-7-2-3p (MIRT541425)
- hsa-mir-7-1-3p (MIRT541426)
- hsa-mir-503-5p (MIRT541427)
- hsa-mir-6838-5p (MIRT541428)
- hsa-mir-15b-5p (MIRT541429)
- hsa-mir-16-5p (MIRT541430)
- hsa-mir-195-5p (MIRT541431)
- hsa-mir-15a-5p (MIRT541432)
- hsa-mir-497-5p (MIRT541433)
- hsa-mir-424-5p (MIRT541434)
- hsa-mir-495-3p (MIRT541435)
- hsa-mir-5688 (MIRT541436)
- hsa-mir-3680-3p (MIRT613240)
- hsa-mir-557 (MIRT613241)
- hsa-mir-507 (MIRT613242)
- hsa-mir-450b-5p (MIRT613243)
- hsa-mir-5589-3p (MIRT613244)
- hsa-mir-129-5p (MIRT613245)
- hsa-mir-376c-3p (MIRT613246)
miRNA Products
- Search ViGene Biosciences for CBX4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBX4
- Browse OriGene Inhibitory RNA Products For CBX4
-
ViGene Biosciences ready-to-package AAV shRNAs for CBX4 gene
Clone Products
- Sino Biological Human cDNA Clone for CBX4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CBX4
- VectorBuilder custom plasmid, inducible vectors for CBX4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBX4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CBX4
-
ViGene Biosciences adenoviral particle packaged cDNA for CBX4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CBX4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CBX4 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBX4 Gene
Localization for CBX4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CBX4 Gene
- Nucleus. Nucleus speckle. Note=Localization to nuclear polycomb bodies is required for ZNF131 sumoylation (PubMed:22467880).
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| golgi apparatus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 9367786 |
| GO:0005654 | nucleoplasm | TAS,IDA | -- |
| GO:0016604 | nuclear body | IDA,IEA | -- |
| GO:0016607 | nuclear speck | IEA | -- |
| GO:0031519 | PcG protein complex | IDA | 21282530 |
Pathways & Interactions for CBX4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular Senescence | ||
| 2 | SUMOylation |
.95
|
|
| 3 | Metabolism of proteins | ||
| 4 | HIF Repressor Pathways | ||
| 5 | Transport of the SLBP independent Mature mRNA | ||
Pathways by source for CBX4 Gene
2 BioSystems pathways for CBX4 Gene
9 Reactome pathways for CBX4 Gene
1 GeneGo (Thomson Reuters) pathway for CBX4 Gene
1 R&D Systems pathway for CBX4 Gene
UniProtKB/Swiss-Prot O00257-CBX4_HUMAN
- Pathway: Protein modification; protein sumoylation.
Interacting Proteins for CBX4 Gene
Selected Interacting proteins:
O00257-CBX4_HUMAN
ENSP00000269397
for CBX4 Gene via
IID
STRING
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IMP | 21282530 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0016569 | covalent chromatin modification | IEA | -- |
| GO:0016925 | protein sumoylation | IEA | -- |
No data available for SIGNOR curated interactions for CBX4 Gene
Drugs & Compounds for CBX4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| UNC3866 | Pharma | a potent antagonist of CBX4 and CBX7 chromodomains | 0 |
(1) ApexBio Compounds for CBX4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| UNC3866 | a potent antagonist of CBX4 and CBX7 chromodomains |
Drug Products
- ApexBio compounds for CBX4
Transcripts for CBX4 Gene
mRNA/cDNA for CBX4 Gene
- (2) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (56) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CBX4
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBX4
- GenScript: Design CRISPR guide RNA sequences for CBX4
miRNA Products
- Search ViGene Biosciences for CBX4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBX4
- Browse OriGene Inhibitory RNA Products For CBX4
-
ViGene Biosciences ready-to-package AAV shRNAs for CBX4 gene
Clone Products
- Sino Biological Human cDNA Clone for CBX4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CBX4
- VectorBuilder custom plasmid, inducible vectors for CBX4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBX4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||
| SP3: | |||||||||||||||||||||
| SP4: | - |
Expression for CBX4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
This gene is overexpressed in Platelet (65.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CBX4 Gene
NURSA nuclear receptor signaling pathways regulating expression of CBX4 Gene:
CBX4SOURCE GeneReport for Unigene cluster for CBX4 Gene:
Hs.405046mRNA Expression by UniProt/SwissProt for CBX4 Gene:
O00257-CBX4_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for CBX4 Gene
- Intestine(4.2)
- Liver(4.2)
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for CBX4
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBX4 Gene
Orthologs for CBX4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CBX4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CBX4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CBX4 35 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Cbx4 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Cbx4 16 35 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CBX4 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CBX4 35 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CBX4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cbx4 34 |
|
||
| Str.19494 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | cbx4-A-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cbx4 34 35 |
|
||
| Dr.20970 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Pc 35 |
|
OneToMany |
- Species where no ortholog for CBX4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CBX4 Gene
Variants for CBX4 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000012052 | -- | 79,840,693(+) | GACAG(A/C)GCGGC | upstream-variant-2KB | |
| rs1000043234 | -- | 79,840,553(+) | CCTCC(G/T)GCGGC | upstream-variant-2KB | |
| rs1000075979 | -- | 79,840,295(+) | GGGAG(A/G)CCAGG | upstream-variant-2KB | |
| rs1000429929 | -- | 79,835,518(+) | TGGGA(C/G)GTCTA | intron-variant | |
| rs1000922342 | -- | 79,835,781(+) | CGGAA(A/T)CTTCT | intron-variant |
Residual Variation Intolerance Score:
22.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.20;
76.03% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CBX4 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBX4 Gene
Disorders for CBX4 Gene
Relevant External Links for CBX4
No disorders were found for CBX4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBX4 Gene
Publications for CBX4 Gene
- Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin. (PMID: 16061479) Long J. … Park M. (J. Biol. Chem. 2005) 3 4 22 64
- Multiple activities contribute to Pc2 E3 function. (PMID: 15592428) Kagey M.H. … Wotton D. (EMBO J. 2005) 3 4 22 64
- The polycomb protein Pc2 is a SUMO E3. (PMID: 12679040) Kagey M.H. … Wotton D. (Cell 2003) 3 4 22 64
- Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis. (PMID: 9315667) Satijn D.P.E. … Otte A.P. (Mol. Cell. Biol. 1997) 2 3 4 64
- DNA damage-induced heterogeneous nuclear ribonucleoprotein K SUMOylation regulates p53 transcriptional activation. (PMID: 22825850) Pelisch F. … Srebrow A. (J. Biol. Chem. 2012) 3 4 64
Products for CBX4 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CBX4
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CBX4
- Origene Custom Protein Services for CBX4
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBX4
- Browse OriGene Inhibitory RNA Products For CBX4
- OriGene qPCR primer pairs for CBX4
- OriGene CRISPR knockouts for CBX4
- OriGene ORF clones in human for CBX4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CBX4
- GenScript: Next-day shipping cDNA ORF clone for CBX4 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CBX4
- GenScript Custom Assay Services for CBX4
- GenScript Custom overexpressing Cell Line Services for CBX4
- GenScript: Design CRISPR guide RNA sequences for CBX4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CBX4
- Sino Biological Human cDNA Clone for CBX4
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CBX4
- Novus Biologicals proteins and lysates for CBX4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for CBX4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CBX4
- Addgene plasmids for CBX4
- antibodies-online Antibodies for CBX4: See all 51
- antibodies-online Kits for CBX4: See all 4
- antibodies-online Proteins for CBX4: See all 8
- Search antibodies-online for peptides
- GeneTex CBX4 antibody for CBX4
- Search GeneTex for Proteins for CBX4
- ViGene Biosciences adenoviral particle packaged cDNA for CBX4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CBX4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CBX4 gene
- Search ViGene Biosciences for CBX4
- Santa Cruz Biotechnology (SCBT) Antibodies for CBX4
- Search Santa Cruz Biotechnology (SCBT) for CBX4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CBX4
- Custom Antibody ServicesProSci Antibodies for CBX4
- Search for CBX4 Proteins at ProSci
- Horizon Cell Lines for CBX4
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBX4
- VectorBuilder custom plasmid, inducible vectors for CBX4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBX4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CBX4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer