Aliases for CBX4 Gene
External Ids for CBX4 Gene
Previous GeneCards Identifiers for CBX4 Gene
GeneCards Summary for CBX4 Gene
CBX4 (Chromobox 4) is a Protein Coding gene. Among its related pathways are Cellular Senescence and C-MYB transcription factor network. GO annotations related to this gene include chromatin binding and ligase activity. An important paralog of this gene is CBX6.
UniProtKB/Swiss-Prot for CBX4 Gene
E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.