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CBX4 Gene

protein-coding   GIFtS: 61
GCID: GC17M077806

Chromobox Homolog 4

(Previous name: chromobox homolog 4 (Drosophila Pc class))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromobox Homolog 41 2     PC22
NS5ATP1-Binding Protein 161 2     Chromobox Homolog 4 (Pc Class Homolog, Drosophila)2
Chromobox Protein Homolog 42 3     E3 SUMO-Protein Ligase CBX42
Polycomb 2 Homolog2 3     Pc Class 2 Homolog2
Chromobox Homolog 4 (Drosophila Pc Class)1     EC 6.3.2.-3
Pc Class 2 Homolog (Drosophila)1     Pc23
NBP162     hPc23

External Ids:    HGNC: 15541   Entrez Gene: 85352   Ensembl: ENSG000001415827   OMIM: 6030795   UniProtKB: O002573   

Export aliases for CBX4 gene to outside databases

Previous GC identifers: GC17M077736 GC17M081095 GC17M078371 GC17M078507 GC17M075422 GC17M073247


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CBX4 Gene:
CBX4 (chromobox homolog 4) is a protein-coding gene. Diseases associated with CBX4 include brain cancer, and retinoblastoma. GO annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is CBX8.

UniProtKB/Swiss-Prot: CBX4_HUMAN, O00257
Function: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of
HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation
resulting in p21/CDKN1A expression. Monosumoylates ZNF131
Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain
the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1
complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A
'Lys-119', rendering chromatin heritably changed in its expressibility




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CBX4 gene promoter:
         E2F-3a   E2F-4   E2F-5   Pax-5   E2F-2   HEN1   E2F   E2F-1   IRF-7A   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CBX4 promoter sequence
   Search Chromatin IP Primers for CBX4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CBX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

CBX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBX4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M077806:  view genomic region     (about GC identifiers)

Start:
77,806,955 bp from pter      End:
77,813,228 bp from pter
Size:
6,274 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CBX4_HUMAN, O00257 (See protein sequence)
Recommended Name: E3 SUMO-protein ligase CBX4  
Size: 560 amino acids; 61368 Da
Subunit: Interacts with histone H3-K9Me3. Interacts with CHTOP (By similarity). Component of a PRC1-like complex.
Self-associates. Interacts with SUV39H1 and HIPK2. Interacts with CSNK2B
Miscellaneous: The human orthologs of the Drosophila Polycomb group protein Pc are CBX2, CBX4, CBX6, CBX7 and
CBX8. These show distinct nuclear localizations, contribute differently to transcriptional repression, and appear
to be part of distinct PRC1-like protein complexes. The hPRC-H complex purified in PubMed:12167701 probably
presents a mixture of different complexes containing different Polycomb group proteins
Sequence caution: Sequence=AAH14967.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
2 PDB 3D structures from and Proteopedia for CBX4:
2K28 (3D)        3I8Z (3D)    
Secondary accessions: B1PJR7 Q6TPI8 Q96C04
Alternative splicing: 2 isoforms:  O00257-1   O00257-3   

Explore the universe of human proteins at neXtProt for CBX4: NX_O00257

Explore proteomics data for CBX4 at MOPED

Post-translational modifications: 

  • Phosphorylated on Thr-497 by HIPK2 upon DNA damage. This phosphorylation stimulates E3 SUMO-protein ligase
    activity and promotes sumoylation on Lys-494, as well as sumoylation of other target proteins, such as HNRNPK1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CBX4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003646.2  
    ENSEMBL proteins: 
     ENSP00000269397   ENSP00000415348   ENSP00000461198  
    Reactome Protein details: O00257

    CBX4 Human Recombinant Protein Products:

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    Novus Biologicals CBX4 Protein
    Novus Biologicals CBX4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CBX4

    CBX4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CBX4
    Browse R&D Systems for Antibodies
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    Novus Biologicals CBX4 Antibodies
    Abcam antibodies for CBX4
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    ThermoFisher Antibodies for CBX4
    LSBio Antibodies in human, mouse, rat for CBX4

    CBX4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CBX4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CBX4
    Cloud-Clone Corp. CLIAs for CBX4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR000953 Chromo_domain/shadow
     IPR023780 Chromo_domain
     IPR016197 Chromodomain-like
     IPR023779 Chromodomain_CS
     IPR017984 Chromo_dom_subgr

    Graphical View of Domain Structure for InterPro Entry O00257

    ProtoNet protein and cluster: O00257

    1 Blocks protein domain: IPB000953 Chromo domain

    UniProtKB/Swiss-Prot: CBX4_HUMAN, O00257
    Domain: The polyhistidine repeat may act as a targeting signal to nuclear speckles (PubMed:19266028)
    Similarity: Contains 1 chromo domain


    CBX4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBX4_HUMAN, O00257
    Function: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of
    HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation
    resulting in p21/CDKN1A expression. Monosumoylates ZNF131
    Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain
    the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1
    complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A
    'Lys-119', rendering chromatin heritably changed in its expressibility

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0003714transcription corepressor activity TAS9315667
    GO:0003727single-stranded RNA binding IEA--
    GO:0005515protein binding IPI17332741
    GO:0016874ligase activity IEA--
         
    CBX4 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cbx4):
     hematopoietic system  immune system  mortality/aging 

    CBX4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cbx4tm1.2Gxu for CBX4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CBX4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CBX4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CBX4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CBX4

    miRNA
    Products:
        
    miRTarBase miRNAs that target CBX4:
    hsa-mir-328-3p (MIRT043804), hsa-mir-101-3p (MIRT027349), hsa-mir-335-5p (MIRT018685)

    Block miRNA regulation of human, mouse, rat CBX4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CBX4 (see all 49):
    hsa-miR-21* hsa-miR-136 hsa-miR-429 hsa-miR-15a hsa-miR-503 hsa-let-7a-2* hsa-miR-628-3p hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidCBX4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CBX4
    Predesigned siRNA for gene silencing in human, mouse, rat CBX4

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for CBX4 (see all 8)
    OriGene ORF clones in mouse, rat for CBX4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CBX4 (NM_003655)
    Sino Biological Human cDNA Clone for CBX4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBX4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CBX4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CBX4_HUMAN, O00257: Nucleus. Nucleus speckle. Note=Localization to nuclear polycomb bodies is required for
    ZNF131 sumoylation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus4
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus ----
    GO:0016604nuclear body ----

    CBX4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CBX4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    2Proteolysis Putative SUMO 1 pathway
    Proteolysis Putative SUMO 1 pathway0.33
    3Regulation of retinoblastoma protein
    Regulation of retinoblastoma protein
    4C-MYB transcription factor network
    C-MYB transcription factor network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CBX4
        Proteolysis Putative SUMO-1 pathway

    2 BioSystems Pathways for CBX4
        C-MYB transcription factor network
    Regulation of retinoblastoma protein


    1 Reactome Pathway for CBX4
        Oxidative Stress Induced Senescence


    UniProtKB/Swiss-Prot: CBX4_HUMAN, O00257
    Pathway: Protein modification; protein sumoylation


    CBX4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CBX4: 

              Polycomb & Trithorax Complexes in human mouse rat
              Apoptosis 384HT in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CBX4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CBX4 (O002571, 2, 3 ENSP000002693974) via UniProtKB, MINT, STRING, and/or I2D (see all 154)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMI1P352261, 2, 3, ENSP000003658514EBI-722425,EBI-2341576 MINT-8010325 MINT-4543631 I2D: score=2 STRING: ENSP00000365851
    ENSG00000235107Q065872, 3, ENSP000003964394MINT-8010325 MINT-8010390 I2D: score=3 STRING: ENSP00000396439
    RING1Q065872, 3, ENSP000003637874MINT-8010325 MINT-8010390 I2D: score=3 STRING: ENSP00000363787
    ENSG00000206287Q065872, 3MINT-8010325 MINT-8010390 I2D: score=3 
    ENSG00000226788Q065872, 3MINT-8010325 MINT-8010390 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0006351transcription, DNA-templated IEA--
    GO:0016568chromatin modification IEA--
    GO:0016925protein sumoylation IEA--
    GO:0043066negative regulation of apoptotic process TAS9315667

    CBX4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CBX4

    1 Novoseek inferred chemical compound relationship for CBX4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamine 23.8 2 11414760 (1), 12497610 (1)



    CBX4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CBX4 gene: 
    NM_003655.2  

    Unigene Cluster for CBX4:

    Chromobox homolog 4
    Hs.405046  [show with all ESTs]
    Unigene Representative Sequence: NM_003655
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269397(uc002jxe.3) ENST00000448310 ENST00000495122 ENST00000494546

    miRNA
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    Block miRNA regulation of human, mouse, rat CBX4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CBX4 (see all 49):
    hsa-miR-21* hsa-miR-136 hsa-miR-429 hsa-miR-15a hsa-miR-503 hsa-let-7a-2* hsa-miR-628-3p hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidCBX4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CBX4
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    GenScript: all cDNA clones in your preferred vector: CBX4 (NM_003655)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBX4
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBX4
      QuantiTect SYBR Green Assays in human, mouse, rat CBX4
      Search QuantiFast Probe-based Assays in human, mouse, rat CBX4

    Additional mRNA sequence: 

    AF013956.1 AY390430.1 BC014967.1 EU439707.1 U94344.1 

    3 DOTS entries:

    DT.95369650  DT.207354  DT.91733994 

    Selected AceView cDNA sequences (see all 56):

    AY390430 D20381 AI351619 AI076023 BX280228 BM452847 AI148768 BC014967 
    BQ219412 CR616461 BX436959 BG222508 BI836958 BG029608 AI796748 BQ049740 
    BM452215 BF221869 BM989303 CD743207 BQ639572 BU188400 BU171393 BQ225831 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CBX4    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d
    SP1:                          -                 -                     
    SP2:                          -     -           -                     
    SP3:                                                                  
    SP4:                          -                                       


    ECgene alternative splicing isoforms for CBX4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CBX4 expression in normal human tissues (normalized intensities)      CBX4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGTCTTGT
    CBX4 Expression
    About this image


    CBX4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CBX4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CBX4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.405046

    UniProtKB/Swiss-Prot: CBX4_HUMAN, O00257
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CBX4: 
              Polycomb & Trithorax Complexes in human mouse rat
              Apoptosis 384HT in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CBX4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBX4
    QuantiTect SYBR Green Assays in human, mouse, rat CBX4
    Search QuantiFast Probe-based Assays in human, mouse, rat CBX4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CBX4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cbx41 , 5 chromobox homolog 4 (Drosophila Pc class)5
    chromobox 41
    85.85(n)1
    90.53(a)1
      11 (83.34 cM)5
    124181  NM_007625.21  NP_031651.21 
     1190775735 
    chicken
    (Gallus gallus)
    Aves CBX41 chromobox homolog 4 76.96(n)
    73.82(a)
      395354  NM_204642.1  NP_989973.1 
    lizard
    (Anolis carolinensis)
    Reptilia CBX46
    chromobox homolog 4
    57(a)
    1 ↔ 1
    2(100834406-100843377)
    African clawed frog
    (Xenopus laevis)
    Amphibia cbx4-A-prov2 chromobox homolog 4 (Polycomb) 76.52(n)    U39929.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.209702 Danio rerio polycomb 2 mRNA, complete cds 79.81(n)    AY186581.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pc6
    Polycomb
    21(a)
    1 → many
    3L(21299238-21311120)


    ENSEMBL Gene Tree for CBX4 (if available)
    TreeFam Gene Tree for CBX4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CBX4 gene
    CBX82  CBX62  CBX22  CBX72  
    6 SIMAP similar genes for CBX4 using alignment to 3 protein entries:     CBX4_HUMAN (see all proteins):
    CBX7    CBX8    CBX5    CBX3    CBX1    SUV39H2

    CBX4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CBX4 (see all 184)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1872616451,2
    --77806650(+) CCCCAA/CCCGCG 1 -- ds50010--------
    rs129489071,2
    C--77806674(+) CACCCC/TTGCAC 1 -- ds50011Minor allele frequency- T:0.00NA 2
    rs1921344101,2
    --77806865(+) CAAAAA/CCAGCC 1 -- ds50010--------
    rs581745571,2
    F--77806954(+) CGAAAA/CTGCAC 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1838131101,2
    --77806965(+) CTTCAA/GCATCT 1 -- ut310--------
    rs113502251,2
    C,F--77807074(+) CAAACT/-TTTTT 1 -- ut312Minor allele frequency- -:0.50NA 4
    rs1887391761,2
    --77807124(+) GTACAA/GTATCA 1 -- ut310--------
    rs1808346501,2
    --77807555(+) GCACCG/TCGTGG 1 -- ut310--------
    rs2002383471,2
    --77807716(+) CCCCGC/TCCCCC 1 -- ut310--------
    rs1447573741,2
    C--77807720(+) GCCCCC/GCCGCG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CBX4 (77806955 - 77813228 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CBX4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv828116CNV Loss20364138
    nsv469865CNV Loss16826518
    nsv483050CNV Loss15286789
    nsv908960CNV Loss21882294
    dgv3292n71CNV Loss21882294
    nsv908961CNV Loss21882294
    dgv3294n71CNV Loss21882294
    nsv828120CNV Gain20364138
    dgv538n67CNV Gain20364138

    Human Gene Mutation Database (HGMD): CBX4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CBX4
    DNA2.0 Custom Variant and Variant Library Synthesis for CBX4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603079    OMIM disorders: --

    7 diseases for CBX4:    About MalaCards
    brain cancer    retinoblastoma    schizophrenia    hodgkin's lymphoma
    hiv-1    prostate cancer    prostatitis


    CBX4 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CBX4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 12527301 (1)

    Genetic Association Database (GAD): CBX4

    Export disorders for CBX4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CBX4 gene, integrated from 10 sources (see all 80):
    (articles sorted by number of sources associating them with CBX4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis. (PubMed id 9315667)1, 2, 3 Satijn D.P.E.... Otte A.P. (Mol. Cell. Biol. 1997)
    2. Multiple activities contribute to Pc2 E3 function. (PubMed id 15592428)1, 2, 9 Kagey M.H.... Wotton D. (EMBO J. 2005)
    3. The polycomb protein Pc2 is a SUMO E3. (PubMed id 12679040)1, 2, 9 Kagey M.H.... Wotton D. (Cell 2003)
    4. Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin. (PubMed id 16061479)1, 2, 9 Long J.... Park M. (J. Biol. Chem. 2005)
    5. Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling. (PubMed id 22467880)1, 2 Oh Y. and Chung K.C. (J. Biol. Chem. 2012)
    6. DNA damage-induced heterogeneous nuclear ribonucleoprotein K SUMOylation regulates p53 transcriptional activation. (PubMed id 22825850)1, 2 Pelisch F.... Srebrow A. (J. Biol. Chem. 2012)
    7. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PubMed id 21282530)1, 2 Vandamme J.... Angrand P.O. (Mol. Cell. Proteomics 2011)
    8. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PubMed id 19636380)1, 2 Maertens G.N.... Peters G. (PLoS ONE 2009)
    9. Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2. (PubMed id 17018294)1, 2 Roscic A.... Schmitz M.L. (Mol. Cell 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8535 HGNC: 1554 AceView: CBX4 Ensembl:ENSG00000141582 euGenes: HUgn8535
    ECgene: CBX4 H-InvDB: CBX4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CBX4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CBX4 gene:
    Search GeneIP for patents involving CBX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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