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CBX3 Gene

protein-coding   GIFtS: 62
GCID: GC07P026240

Chromobox Homolog 3

(Previous name: chromobox homolog 3 (Drosophila HP1 gamma))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromobox Homolog 31 2     HP1Hs-gamma2
Heterochromatin Protein 1 Homolog Gamma2 3     Chromobox Homolog 3 (HP1 Gamma Homolog, Drosophila)2
Modifier 2 Protein2 3     Chromobox Protein Homolog 32
HECH2 3     Heterochromatin Protein HP1 Gamma2
Chromobox Homolog 3 (Drosophila HP1 Gamma)1     Heterochromatin-Like Protein 12
HP1 Gamma Homolog (Drosophila)1     HP1 Gamma Homolog2
HP1-GAMMA2     HP1 Gamma3

External Ids:    HGNC: 15531   Entrez Gene: 113352   Ensembl: ENSG000001225657   OMIM: 6044775   UniProtKB: Q131853   

Export aliases for CBX3 gene to outside databases

Previous GC identifers: GC07P025883 GC07P025983 GC07P026014 GC07P026207


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CBX3 Gene:
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The
protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B
receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the
encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein
binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced
DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5'
UTR, have been found for this gene.(provided by RefSeq, Mar 2011)

GeneCards Summary for CBX3 Gene:
CBX3 (chromobox homolog 3) is a protein-coding gene. GO annotations related to this gene include identical protein binding and protein domain specific binding. An important paralog of this gene is CBX1.

UniProtKB/Swiss-Prot: CBX3_HUMAN, Q13185
Function: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and
binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association
of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR).
Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins

Gene Wiki entry for CBX3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CBX3 gene promoter:
         STAT1   p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CBX3 promoter sequence
   Search Chromatin IP Primers for CBX3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CBX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.2   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15.2

CBX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBX3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P026240:  view genomic region     (about GC identifiers)

Start:
26,240,782 bp from pter      End:
26,253,227 bp from pter
Size:
12,446 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 26,291,980-26,304,374     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CBX3_HUMAN, Q13185 (See protein sequence)
Recommended Name: Chromobox protein homolog 3  
Size: 183 amino acids; 20811 Da
Subunit: Binds directly to CHAF1A. Interacts with histone H3 methylated at 'Lys-9'. Part of the E2F6.com-1 complex
in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2.
Interacts with LBR, INCENP, TRIM28/TIF1B, SUV420H1, SUV420H2 and SP100. Interacts with TIF1A (By similarity).
Interacts with MIS12 and DSN1. Can interact directly with CBX5 via the chromoshadow domain. Interacts with POGZ.
Interacts with CHAMP1. Interacts with ASXL1
4 PDB 3D structures from and Proteopedia for CBX3:
2L11 (3D)        3DM1 (3D)        3KUP (3D)        3TZD (3D)    
Secondary accessions: Q96CD7 Q99409 Q9BVS3 Q9P0Z6

Explore the universe of human proteins at neXtProt for CBX3: NX_Q13185

Explore proteomics data for CBX3 at MOPED

Post-translational modifications: 

  • Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis1
  • Ubiquitination2 at Lys5, Lys34, Lys44, Lys50, Lys52, Lys92, Lys143, Lys154, Lys159
  • Modification sites at PhosphoSitePlus

  • See CBX3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_009207.2  NP_057671.2  

    ENSEMBL proteins: 
     ENSP00000336687   ENSP00000379670   ENSP00000408672   ENSP00000387348   ENSP00000473748  
    Reactome Protein details: Q13185

    CBX3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CBX3
    OriGene MassSpec for CBX3
    OriGene Custom Protein Services for CBX3
    GenScript Custom Purified and Recombinant Proteins Services for CBX3
    Novus Biologicals CBX3 Proteins
    Novus Biologicals CBX3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CBX3
    Cloud-Clone Corp. Proteins for CBX3

     
    Search eBioscience for Proteins for CBX3 

    CBX3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CBX3
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CBX3 
    OriGene Antibodies for CBX3
    OriGene Custom Antibody Services for CBX3
    Novus Biologicals CBX3 Antibodies
    Abcam antibodies for CBX3
    Cloud-Clone Corp. Antibodies for CBX3
    ThermoFisher Antibody for CBX3
    LSBio Antibodies in human, mouse, rat for CBX3

    CBX3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CBX3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CBX3
    Cloud-Clone Corp. CLIAs for CBX3
    Search eBioscience for ELISAs for CBX3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR000953 Chromo_domain/shadow
     IPR023780 Chromo_domain
     IPR016197 Chromodomain-like
     IPR023779 Chromodomain_CS
     IPR017984 Chromo_dom_subgr

    Graphical View of Domain Structure for InterPro Entry Q13185

    ProtoNet protein and cluster: Q13185

    2 Blocks protein domains:
    IPB000953 Chromo domain
    IPB008251 Chromo shadow


    UniProtKB/Swiss-Prot: CBX3_HUMAN, Q13185
    Similarity: Contains 2 chromo domains


    Find genes that share domains with CBX3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBX3_HUMAN, Q13185
    Function: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and
    binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association
    of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR).
    Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10330177
    GO:0019899enzyme binding IPI19486527
    GO:0019904protein domain specific binding IPI8663349
    GO:0042802identical protein binding IPI19486527
    GO:1990226histone methyltransferase binding IPI19486527
         
    Find genes that share ontologies with CBX3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CBX3:
     G0/1 arrest  Increased G1 DNA content  Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cbx3):
     embryogenesis  endocrine/exocrine gland  immune system  mortality/aging  reproductive system 

    Find genes that share phenotypes with CBX3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cbx3tm1Ics for CBX3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CBX3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CBX3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CBX3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CBX3

    miRNA
    Products:
        
    miRTarBase miRNAs that target CBX3:
    hsa-mir-935 (MIRT036684), hsa-mir-93-5p (MIRT048788), hsa-mir-100-5p (MIRT048414), hsa-mir-186-5p (MIRT045000), hsa-mir-148a-3p (MIRT025978)

    Block miRNA regulation of human, mouse, rat CBX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CBX3 (see all 50):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-548k hsa-miR-16-1* hsa-miR-30d hsa-miR-548l hsa-miR-105 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidCBX3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CBX3
    Predesigned siRNA for gene silencing in human, mouse, rat CBX3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CBX3

    Clone
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    OriGene clones in human, mouse for CBX3 (see all 13)
    OriGene ORF clones in mouse, rat for CBX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CBX3 (NM_016587)
    Sino Biological Human cDNA Clone for CBX3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBX3
    Addgene plasmids for CBX3 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CBX3
    Browse ESI BIO Cell Lines and PureStem Progenitors for CBX3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CBX3_HUMAN, Q13185: Nucleus (Potential). Note=Associates with euchromatin and is largely excluded from
    constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000779condensed chromosome, centromeric region ISS--
    GO:0000785chromatin IDA11101528
    GO:0005634nucleus IDA--
    GO:0005635nuclear envelope ISS--
    GO:0005637nuclear inner membrane NAS8663349

    Find genes that share ontologies with CBX3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CBX3 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    RNA Polymerase I Chain Elongation0.78
    2Gene Expression
    Gene Expression0.40
    3Packaging Of Telomere Ends
    Histone modification0.31
    4Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs
    5Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with CBX3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CBX3
        Chromatin Regulation / Acetylation

    1 BioSystems Pathway for CBX3
        Diurnally regulated genes with circadian orthologs


    1 Reactome Pathway for CBX3
        RNA Polymerase I Chain Elongation


        Pathway & Disease-focused RT2 Profiler PCR Arrays including CBX3: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CBX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CBX3 (Q131851, 2, 3 ENSP000003366874) via UniProtKB, MINT, STRING, and/or I2D (see all 173)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3CP684311, 2, 3EBI-78176,EBI-79722 MINT-2831013 MINT-8087315 MINT-8087298 MINT-2830989 MINT-2830686 I2D: score=3 
    HIST1H3DP684311, 2, 3EBI-78176,EBI-79722 MINT-2831013 MINT-8087315 MINT-8087298 MINT-2830989 MINT-2830686 I2D: score=3 
    HIST1H3EP684311, 2, 3EBI-78176,EBI-79722 MINT-2831013 MINT-8087315 MINT-8087298 MINT-2830989 MINT-2830686 I2D: score=3 
    HIST1H3FP684311, 2, 3EBI-78176,EBI-79722 MINT-2831013 MINT-8087315 MINT-8087298 MINT-2830989 MINT-2830686 I2D: score=3 
    HIST1H3GP684311, 2, 3EBI-78176,EBI-79722 MINT-2831013 MINT-8087315 MINT-8087298 MINT-2830989 MINT-2830686 I2D: score=3 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006338chromatin remodeling NAS8663349
    GO:0006351transcription, DNA-templated IEA--
    GO:0045892negative regulation of transcription, DNA-templated IMP9636147

    Find genes that share ontologies with CBX3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CBX3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CBX3 gene (2 alternative transcripts): 
    NM_007276.4  NM_016587.3  

    Unigene Cluster for CBX3:

    Chromobox homolog 3
    Hs.381189  [show with all ESTs]
    Unigene Representative Sequence: NM_007276
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337620(uc003sxt.3) ENST00000396386(uc003sxu.3 uc003sxv.3)
    ENST00000456948 ENST00000409747 ENST00000497498 ENST00000481300 ENST00000462165
    ENST00000481057
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CBX3 (see all 50):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-548k hsa-miR-16-1* hsa-miR-30d hsa-miR-548l hsa-miR-105 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidCBX3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CBX3
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CBX3 (NM_016587)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBX3
    Addgene plasmids for CBX3 
    Primer
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    OriGene qPCR primer pairs and template standards for CBX3
    OriGene qSTAR qPCR primer pairs in human, mouse for CBX3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBX3
      QuantiTect SYBR Green Assays in human, mouse, rat CBX3
      QuantiFast Probe-based Assays in human, mouse, rat CBX3

    Additional mRNA sequence: 

    AB030905.1 AF086270.1 AF136630.1 BC000954.1 BC014380.1 BX647444.1 BX648807.1 U26312.1 

    Selected DOTS entries (see all 40):

    DT.97765315  DT.95135225  DT.452181  DT.100888406  DT.100717749  DT.97857245  DT.100888412  DT.100888382 
    DT.92339082  DT.100888397  DT.100888409  DT.75101118  DT.92463362  DT.95080266  DT.91939916  DT.95135244 
    DT.100756428  DT.121311080  DT.91719027  DT.121044034  DT.100888404  DT.121311083  DT.100888400  DT.120692156 

    Selected AceView cDNA sequences (see all 864):

    BX400385 BE350674 N33952 CR623845 NM_007276 AI291621 BM723299 AW474423 
    BE465569 BQ437536 AI826611 AW238854 CN481765 BQ773364 BM472699 BQ023944 
    AL514376 BM982716 AA142894 BF724106 AI652212 AI886794 W39742 AW673674 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CBX3 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d
    SP1:        -     -     -                                                     -     -     -                                       
    SP2:                                                                          -     -     -                                       
    SP3:                                                                          -     -     -                                       
    SP4:                                                  -                       -     -     -                                       
    SP5:                                                  -     -                 -     -     -                                       


    ECgene alternative splicing isoforms for CBX3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CBX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGCTCAAT
    CBX3 Expression
    About this image


    CBX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
    CBX3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CBX3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.381189
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CBX3: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CBX3
    OriGene qSTAR qPCR primer pairs in human, mouse for CBX3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBX3
    QuantiTect SYBR Green Assays in human, mouse, rat CBX3
    QuantiFast Probe-based Assays in human, mouse, rat CBX3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for CBX3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cbx31 , 5 chromobox homolog 3 (Drosophila HP1 gamma)5
    chromobox 31
    90.16(n)1
    100(a)1
      6 (24.89 cM)5
    124171  NM_007624.31  NP_031650.31 
     514703605 
    chicken
    (Gallus gallus)
    Aves CBX31 chromobox homolog 3 85.55(n)
    96.53(a)
      395355  NM_204643.1  NP_989974.1 
    lizard
    (Anolis carolinensis)
    Reptilia CBX36
    chromobox homolog 3
    93(a)
    1 ↔ 1
    6(31866784-31876263)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC046570.12   -- 83.16(n)    BC046570.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cbx3a1 chromobox homolog 3a (HP1 gamma homolog, Drosophila) 72.09(n)
    79.65(a)
      751689  NM_001045402.1  NP_001038867.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta HP1b3 chromatin binding 56(a)   8C7   --
    worm
    (Caenorhabditis elegans)
    Secernentea hpl-16
    Protein HPL-1 (hpl-1) mRNA, complete cds
    33(a)
    1 → many
    X(13245390-13247044) WBGene00001995


    ENSEMBL Gene Tree for CBX3 (if available)
    TreeFam Gene Tree for CBX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CBX3 gene
    CBX12  CBX52  
    7 SIMAP similar genes for CBX3 using alignment to 5 protein entries:     CBX3_HUMAN (see all proteins):
    CBX1    LOC645158    CBX4    CBX5    CDY2A    CBX8
    SUV39H2

    Find genes that share paralogs with CBX3           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for CBX3 (see all 9)
    PGOHUM00000242404 PGOHUM00000242624 PGOHUM00000242686 PGOHUM00000239295 PGOHUM00000239549


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CBX3 (see all 278)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1841515881,2
    --26242504(+) TCTACG/TTGGGG 2 -- int10--------
    rs1170919571,2
    C,F--26242543(+) GTTACC/TTTTTT 2 -- int12Minor allele frequency- T:0.00NA EU 713
    rs1888961721,2
    C,F--26242546(+) ACCTTT/CTTTGT 2 -- int11Minor allele frequency- C:0.01EU 593
    rs1924796871,2
    --26242555(+) GTGTCA/GTGCAA 2 -- int10--------
    rs1839523531,2
    C--26242577(+) CTGTCA/TTGCAT 2 -- int11Minor allele frequency- T:0.00EU 1219
    rs1425373151,2
    C--26242578(+) TGTCAC/TGCATT 2 -- int10--------
    rs2001660271,2
    --26242614(+) GCAATA/GAAAAA 2 -- ut510--------
    rs1882628441,2
    --26242921(+) ACACAC/TATTTT 2 -- int10--------
    rs1510952351,2
    --26242941(+) GAAAAA/CTGTTA 2 -- int10--------
    rs1917857211,2
    --26242953(+) ATAAAA/GTGGTA 2 -- int10--------

    HapMap Linkage Disequilibrium report for CBX3 (26240782 - 26253227 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CBX3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734158CNV Deletion23290073
    esv2734159CNV Deletion23290073
    esv2734157CNV Deletion23290073
    esv2390496CNV Deletion18987734
    dgv7229n71CNV Loss21882294
    dgv7230n71CNV Loss21882294
    esv23140CNV Gain19812545
    dgv1093n67CNV Gain20364138
    nsv7393OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CBX3
    DNA2.0 Custom Variant and Variant Library Synthesis for CBX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604477    OMIM disorders: --


    Find genes that share disorders with CBX3           About GenesLikeMe


    Export disorders for CBX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CBX3 gene, integrated from 10 sources (see all 145):
    (articles sorted by number of sources associating them with CBX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. (PubMed id 8663349)1, 2, 3 Ye Q. and Worman H.J. (J. Biol. Chem. 1996)
    2. Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1. (PubMed id 10664448)1, 2, 9 Koike N.... Iguchi-Ariga S.M.M. (FEBS Lett. 2000)
    3. Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells. (PubMed id 10460410)1, 2, 9 Minc E.... Buendia B. (Chromosoma 1999)
    4. A complex with chromatin modifiers that occupies E2F- and Myc- responsive genes in G0 cells. (PubMed id 12004135)1, 2, 9 Ogawa H.... Nakatani Y. (Science 2002)
    5. KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Kruppel-associated box-zinc finger proteins in heterochromatin- mediated gene silencing. (PubMed id 10330177)1, 2, 9 Ryan R.F.... Rauscher F.J. III (Mol. Cell. Biol. 1999)
    6. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PubMed id 20562864)1, 2 Nozawa R.S.... Obuse C. (Nat. Cell Biol. 2010)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. (PubMed id 15502821)1, 2 Obuse C....Yanagida M. (Nat. Cell Biol. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11335 HGNC: 1553 AceView: CBX3 Ensembl:ENSG00000122565 euGenes: HUgn11335
    ECgene: CBX3 H-InvDB: CBX3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CBX3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CBX3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CBX3 gene:
    Search GeneIP for patents involving CBX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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