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Aliases for CBX3 Gene

Aliases for CBX3 Gene

  • Chromobox Homolog 3 2 3
  • Heterochromatin Protein 1 Homolog Gamma 3 4
  • Modifier 2 Protein 3 4
  • HECH 3 4
  • Chromobox Homolog 3 (HP1 Gamma Homolog, Drosophila) 3
  • Chromobox Homolog 3 (Drosophila HP1 Gamma) 2
  • Heterochromatin Protein HP1 Gamma 3
  • HP1 Gamma Homolog (Drosophila) 2
  • Heterochromatin-Like Protein 1 3
  • Chromobox Protein Homolog 3 3
  • HP1 Gamma Homolog 3
  • HP1Hs-Gamma 3
  • HP1-GAMMA 3
  • HP1 Gamma 4

External Ids for CBX3 Gene

Previous GeneCards Identifiers for CBX3 Gene

  • GC07P025883
  • GC07P025983
  • GC07P026014
  • GC07P026207
  • GC07P026240

Summaries for CBX3 Gene

Entrez Gene Summary for CBX3 Gene

  • At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]

GeneCards Summary for CBX3 Gene

CBX3 (Chromobox Homolog 3) is a Protein Coding gene. Among its related pathways are Gene Expression and Chromatin Regulation / Acetylation. GO annotations related to this gene include identical protein binding and protein domain specific binding. An important paralog of this gene is CBX1.

UniProtKB/Swiss-Prot for CBX3 Gene

  • Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 Lys-9 trimethylation, mediates the recruitment of the mehtyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1

Gene Wiki entry for CBX3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBX3 Gene

Genomics for CBX3 Gene

Regulatory Elements for CBX3 Gene

Transcription factor binding sites by QIAGEN in the CBX3 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CBX3 Gene

Start:
26,201,162 bp from pter
End:
26,213,607 bp from pter
Size:
12,446 bases
Orientation:
Plus strand

Genomic View for CBX3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CBX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBX3 Gene

Proteins for CBX3 Gene

  • Protein details for CBX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13185-CBX3_HUMAN
    Recommended name:
    Chromobox protein homolog 3
    Protein Accession:
    Q13185
    Secondary Accessions:
    • Q96CD7
    • Q99409
    • Q9BVS3
    • Q9P0Z6

    Protein attributes for CBX3 Gene

    Size:
    183 amino acids
    Molecular mass:
    20811 Da
    Quaternary structure:
    • Binds directly to CHAF1A. Interacts with histone H3 methylated at Lys-9. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with LBR, INCENP, TRIM28/TIF1B, SUV420H1, SUV420H2 and SP100. Interacts with TIF1A. Interacts with MIS12 and DSN1. Can interact directly with CBX5 via the chromoshadow domain. Interacts with POGZ. Interacts with CHAMP1. Interacts with ASXL1. The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex.

    Three dimensional structures from OCA and Proteopedia for CBX3 Gene

neXtProt entry for CBX3 Gene

Proteomics data for CBX3 Gene at MOPED

Post-translational modifications for CBX3 Gene

  • Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
  • Ubiquitination at Lys5, Lys34, Lys44, Lys50, Lys52, Lys92, Lys143, Lys154, and Lys159
  • Modification sites at PhosphoSitePlus

Other Protein References for CBX3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CBX3 (CBX3)

No data available for DME Specific Peptides for CBX3 Gene

Domains for CBX3 Gene

Suggested Antigen Peptide Sequences for CBX3 Gene

Graphical View of Domain Structure for InterPro Entry

Q13185

UniProtKB/Swiss-Prot:

CBX3_HUMAN :
  • Q13185
Domain:
  • Contains 2 chromo domains.
genes like me logo Genes that share domains with CBX3: view

No data available for Gene Families for CBX3 Gene

Function for CBX3 Gene

Molecular function for CBX3 Gene

UniProtKB/Swiss-Prot Function: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 Lys-9 trimethylation, mediates the recruitment of the mehtyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1

Gene Ontology (GO) - Molecular Function for CBX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10330177
GO:0019899 enzyme binding IPI 19486527
GO:0019904 protein domain specific binding IPI 8663349
GO:0042802 identical protein binding IPI 19486527
GO:1990226 histone methyltransferase binding IPI 19486527
genes like me logo Genes that share ontologies with CBX3: view
genes like me logo Genes that share phenotypes with CBX3: view

Animal Models for CBX3 Gene

MGI Knock Outs for CBX3:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CBX3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CBX3 Gene

Localization for CBX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBX3 Gene

Nucleus. Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential). {ECO:0000305}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CBX3 Gene COMPARTMENTS Subcellular localization image for CBX3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5

Gene Ontology (GO) - Cellular Components for CBX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IDA 10504293
GO:0000779 condensed chromosome, centromeric region ISS --
GO:0000785 chromatin IDA 11101528
GO:0005634 nucleus IDA --
GO:0005635 nuclear envelope ISS --
genes like me logo Genes that share ontologies with CBX3: view

Pathways for CBX3 Gene

genes like me logo Genes that share pathways with CBX3: view

Pathways by source for CBX3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Remodeling Factors in human,mouse,rat
    • Polycomb & Trithorax Complexes in human,mouse,rat

Gene Ontology (GO) - Biological Process for CBX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling NAS 8663349
GO:0006351 transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IMP 9636147
GO:0048511 rhythmic process IEA --
genes like me logo Genes that share ontologies with CBX3: view

Transcripts for CBX3 Gene

Unigene Clusters for CBX3 Gene

Chromobox homolog 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CBX3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CBX3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d
SP1: - - - - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7:
SP8: -

Relevant External Links for CBX3 Gene

GeneLoc Exon Structure for
CBX3
ECgene alternative splicing isoforms for
CBX3

Expression for CBX3 Gene

mRNA expression in normal human tissues for CBX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CBX3 Gene

SOURCE GeneReport for Unigene cluster for CBX3 Gene Hs.381189

genes like me logo Genes that share expressions with CBX3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CBX3 Gene

Orthologs for CBX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CBX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CBX3 35
  • 100 (n)
  • 100 (a)
CBX3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CBX3 35
  • 93.62 (n)
  • 100 (a)
CBX3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 91 (a)
OneToMany
CBX3 35
  • 91.06 (n)
  • 94.41 (a)
mouse
(Mus musculus)
Mammalia Cbx3 35
  • 90.16 (n)
  • 100 (a)
Cbx3 16
Cbx3 36
  • 100 (a)
OneToMany
Gm10068 36
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CBX3 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CBX3 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cbx3 35
  • 90.53 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves CBX3 35
  • 85.55 (n)
  • 96.53 (a)
CBX3 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CBX3 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cbx3 35
  • 83.82 (n)
  • 92.49 (a)
Str.7994 35
zebrafish
(Danio rerio)
Actinopterygii cbx3a 35
  • 72.09 (n)
  • 79.65 (a)
cbx3a 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta HP1b 36
  • 38 (a)
ManyToMany
HP1c 36
  • 29 (a)
ManyToMany
HP1e 36
  • 30 (a)
ManyToMany
HP6 36
  • 38 (a)
ManyToMany
Su(var)205 36
  • 40 (a)
ManyToMany
HP1b 37
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea hpl-1 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3133 36
  • 43 (a)
OneToMany
Species with no ortholog for CBX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CBX3 Gene

ENSEMBL:
Gene Tree for CBX3 (if available)
TreeFam:
Gene Tree for CBX3 (if available)

Paralogs for CBX3 Gene

Paralogs for CBX3 Gene

Selected SIMAP similar genes for CBX3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CBX3: view

Variants for CBX3 Gene

Sequence variations from dbSNP and Humsavar for CBX3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs7186 -- 26,213,182(-) GTAAA(A/G)AAAAA utr-variant-3-prime
rs2391265 -- 26,204,745(+) AATGA(C/T)TGAGC intron-variant
rs3735554 -- 26,212,837(-) CACTG(C/T)AATTA utr-variant-3-prime
rs3757667 -- 26,206,164(-) CTTAC(A/G)ACCCA intron-variant
rs3757668 -- 26,204,894(-) GAGAA(C/T)TGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CBX3 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
dgv7229n71 CNV Loss 21882294
dgv7230n71 CNV Loss 21882294
esv2734157 CNV Deletion 23290073
esv2390496 CNV Deletion 18987734
esv2734158 CNV Deletion 23290073
esv2734159 CNV Deletion 23290073
dgv1093n67 CNV Gain 20364138
esv23140 CNV Gain 19812545

Relevant External Links for CBX3 Gene

HapMap Linkage Disequilibrium report
CBX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBX3 Gene

Disorders for CBX3 Gene

No disorders were found for CBX3 Gene.

No data available for UniProtKB/Swiss-Prot for CBX3 Gene

Publications for CBX3 Gene

  1. KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Kruppel-associated box-zinc finger proteins in heterochromatin- mediated gene silencing. (PMID: 10330177) Ryan R.F. … Rauscher F.J. III (Mol. Cell. Biol. 1999) 3 4 23
  2. Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells. (PMID: 10460410) Minc E. … Buendia B. (Chromosoma 1999) 3 4 23
  3. Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1. (PMID: 10664448) Koike N. … Iguchi-Ariga S.M.M. (FEBS Lett. 2000) 3 4 23
  4. A complex with chromatin modifiers that occupies E2F- and Myc- responsive genes in G0 cells. (PMID: 12004135) Ogawa H. … Nakatani Y. (Science 2002) 3 4 23
  5. Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. (PMID: 8663349) Ye Q. … Worman H.J. (J. Biol. Chem. 1996) 2 3 4

Products for CBX3 Gene

  • Addgene plasmids for CBX3

Sources for CBX3 Gene

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