Aliases for CBX3 Gene
Aliases for CBX3 Gene
External Ids for CBX3 Gene
- HGNC: 1553
- Entrez Gene: 11335
- Ensembl: ENSG00000122565
- OMIM: 604477
- UniProtKB: Q13185
Previous GeneCards Identifiers for CBX3 Gene
- GC07P025883
- GC07P025983
- GC07P026014
- GC07P026207
- GC07P026240
Summaries for CBX3 Gene
-
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]
GeneCards Summary for CBX3 Gene
CBX3 (Chromobox 3) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Gene Expression. GO annotations related to this gene include identical protein binding and protein domain specific binding. An important paralog of this gene is CBX1.
UniProtKB/Swiss-Prot for CBX3 Gene
-
Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 Lys-9 trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBX3 Gene
Genomics for CBX3 Gene
Regulatory Elements for CBX3 Gene
Enhancers for CBX3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CBX3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CBX3 gene promoter:
Regulatory Element Products
Genomic Location for CBX3 Gene
- Chromosome:
- 7
- Start:
- 26,201,162 bp from pter
- End:
- 26,213,607 bp from pter
- Size:
- 12,446 bases
- Orientation:
- Plus strand
Genomic View for CBX3 Gene
Genes around CBX3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p15.2 by Ensembl
- 7p15.2 by Entrez Gene
- 7p15.2 by HGNC
CBX3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBX3 Gene
Proteins for CBX3 Gene
-
Protein details for CBX3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13185-CBX3_HUMAN
- Recommended name:
- Chromobox protein homolog 3
- Protein Accession:
- Q13185
- Q96CD7
- Q99409
- Q9BVS3
- Q9P0Z6
Protein attributes for CBX3 Gene
- Size:
- 183 amino acids
- Molecular mass:
- 20811 Da
- Quaternary structure:
-
- Binds directly to CHAF1A. Interacts with histone H3 methylated at Lys-9. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with LBR, INCENP, TRIM28/TIF1B, KMT5B, KMT5C and SP100. Interacts with TIF1A. Interacts with MIS12 and DSN1. Can interact directly with CBX5 via the chromoshadow domain. Interacts with POGZ. Interacts with CHAMP1. Interacts with ASXL1. The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex. Interacts with INCENP.
Protein Expression for CBX3 Gene
Post-translational modifications for CBX3 Gene
- Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
- Ubiquitination at Lys34, Lys44, posLast=5050, Lys52, posLast=143143, Lys154, and Lys159
- Modification sites at PhosphoSitePlus
Other Protein References for CBX3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore top CBX3 Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CBX3
- Cell Signaling Technology (CST) Antibodies for CBX3 (CBX3)
-
Custom Antibody ServicesOriGene Antibodies for CBX3
- Novus Biologicals Antibodies for CBX3
-
Cloud-Clone Corp. Antibodies for CBX3
- Invitrogen Antibodies for CBX3
- antibodies-online Antibodies for CBX3: See all 120
- GeneTex CBX3 antibody for CBX3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CBX3
- Origene Custom Protein Services for CBX3
- ProSpec Recombinant Proteins for CBX3
-
Cloud-Clone Corp. Proteins for CBX3
- antibodies-online Proteins for CBX3: See all 14
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CBX3
No data available for DME Specific Peptides for CBX3 Gene
Domains & Families for CBX3 Gene
Gene Families for CBX3 Gene
- HGNC:
Protein Domains for CBX3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CBX3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CBX3 Gene
Function for CBX3 Gene
Molecular function for CBX3 Gene
- UniProtKB/Swiss-Prot Function:
- Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 Lys-9 trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 8663349 |
| GO:0019899 | enzyme binding | IPI | 19486527 |
| GO:0019904 | protein domain specific binding | IPI | 8663349 |
| GO:0042802 | identical protein binding | IPI | 19486527 |
| GO:1990226 | histone methyltransferase binding | IPI | 19486527 |
Phenotypes for CBX3 Gene
- MGI mutant phenotypes for CBX3:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CBX3:
Animal Models for CBX3 Gene
- MGI Knock Outs for CBX3:
-
- Cbx3 tm1Ics
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBX3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CBX3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CBX3 gene
- Search ViGene Biosciences for CBX3
CRISPR Products
-
OriGene CRISPR knockouts for CBX3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBX3
- GenScript: Design CRISPR guide RNA sequences for CBX3
miRNA for CBX3 Gene
- miRTarBase miRNAs that target CBX3
-
- hsa-mir-148a-3p (MIRT025978)
- hsa-mir-935 (MIRT036684)
- hsa-mir-186-5p (MIRT045000)
- hsa-mir-100-5p (MIRT048414)
- hsa-mir-93-5p (MIRT048788)
- hsa-mir-559 (MIRT103345)
- hsa-mir-548b-5p (MIRT103346)
- hsa-mir-548a-5p (MIRT103347)
- hsa-mir-548c-5p (MIRT103348)
- hsa-mir-548d-5p (MIRT103349)
- hsa-mir-548d-3p (MIRT103350)
- hsa-mir-548j-5p (MIRT103351)
- hsa-mir-548h-5p (MIRT103352)
- hsa-mir-548h-3p (MIRT103353)
- hsa-mir-548i (MIRT103354)
- hsa-mir-1825 (MIRT103355)
- hsa-mir-548w (MIRT103356)
- hsa-mir-3613-3p (MIRT103357)
- hsa-mir-548y (MIRT103358)
- hsa-mir-548z (MIRT103359)
- hsa-mir-548o-5p (MIRT103360)
- hsa-mir-548ab (MIRT103361)
- hsa-mir-548ac (MIRT103362)
- hsa-mir-548ad-5p (MIRT103363)
- hsa-mir-548ae-5p (MIRT103364)
- hsa-mir-548ak (MIRT103365)
- hsa-mir-548am-5p (MIRT103366)
- hsa-mir-3973 (MIRT103367)
- hsa-mir-548ap-5p (MIRT103368)
- hsa-mir-548aq-5p (MIRT103369)
- hsa-mir-548ar-5p (MIRT103370)
- hsa-mir-548as-5p (MIRT103371)
- hsa-mir-548as-3p (MIRT103372)
- hsa-mir-548au-5p (MIRT103373)
- hsa-mir-548aw (MIRT103374)
- hsa-mir-548ay-5p (MIRT103375)
- hsa-mir-6771-3p (MIRT103376)
- hsa-mir-548bb-5p (MIRT103378)
- hsa-mir-548bb-3p (MIRT103379)
- hsa-mir-524-5p (MIRT103395)
- hsa-mir-520d-5p (MIRT103396)
- hsa-mir-520g-3p (MIRT103397)
- hsa-mir-520h (MIRT103398)
- hsa-mir-4679 (MIRT221555)
- hsa-mir-34a-5p (MIRT221560)
- hsa-mir-34c-5p (MIRT221561)
- hsa-mir-449a (MIRT221562)
- hsa-mir-449b-5p (MIRT221565)
- hsa-mir-3163 (MIRT221567)
- hsa-mir-4282 (MIRT221568)
- hsa-mir-6826-5p (MIRT221576)
- hsa-mir-30a-5p (MIRT258175)
- hsa-mir-30c-5p (MIRT258176)
- hsa-mir-30d-5p (MIRT258177)
- hsa-mir-30b-5p (MIRT258178)
- hsa-mir-30e-5p (MIRT258179)
- hsa-mir-208a-5p (MIRT320267)
- hsa-mir-208b-5p (MIRT320271)
- hsa-mir-548au-3p (MIRT549028)
- hsa-mir-6893-3p (MIRT549029)
- hsa-mir-370-3p (MIRT549030)
- hsa-mir-6739-3p (MIRT562576)
- hsa-mir-375 (MIRT562577)
- hsa-mir-31-3p (MIRT562578)
- hsa-mir-1468-3p (MIRT562579)
- hsa-mir-548x-5p (MIRT562580)
- hsa-mir-548g-5p (MIRT562581)
- hsa-mir-548f-5p (MIRT562582)
- hsa-mir-548aj-5p (MIRT562583)
- hsa-mir-1246 (MIRT562584)
- hsa-mir-657 (MIRT574834)
- hsa-mir-3665 (MIRT574835)
- hsa-mir-154-5p (MIRT574836)
- hsa-mir-8485 (MIRT631709)
- hsa-mir-3941 (MIRT647054)
- hsa-mir-603 (MIRT647055)
- hsa-mir-362-3p (MIRT647056)
- hsa-mir-329-3p (MIRT647057)
miRNA Products
- Search ViGene Biosciences for CBX3
Inhibitory RNA Products
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for CBX3
- Browse OriGene Inhibitory RNA Products For CBX3
-
ViGene Biosciences ready-to-package AAV shRNAs for CBX3 gene
Clone Products
- Sino Biological Human cDNA Clone for CBX3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CBX3
- VectorBuilder custom plasmid, inducible vectors for CBX3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBX3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CBX3
-
ViGene Biosciences adenoviral particle packaged cDNA for CBX3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CBX3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CBX3 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBX3 Gene
Localization for CBX3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CBX3 Gene
- Nucleus. Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential). {ECO:0000305}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000775 | chromosome, centromeric region | IDA | 10504293 |
| GO:0000779 | condensed chromosome, centromeric region | ISS | -- |
| GO:0000784 | nuclear chromosome, telomeric region | IDA | 19135898 |
| GO:0000785 | chromatin | IDA | 11101528 |
| GO:0005634 | nucleus | IDA,IEA | 17540172 |
Pathways & Interactions for CBX3 Gene
Pathways by source for CBX3 Gene
1 Cell Signaling Technology pathway for CBX3 Gene
1 BioSystems pathway for CBX3 Gene
Interacting Proteins for CBX3 Gene
Selected Interacting proteins:
Q13185-CBX3_HUMAN
ENSP00000336687
for CBX3 Gene via
IID
STRING
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006338 | chromatin remodeling | NAS | 8663349 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0016569 | covalent chromatin modification | IEA | -- |
| GO:0045892 | negative regulation of transcription, DNA-templated | IMP | 9636147 |
Transcripts for CBX3 Gene
mRNA/cDNA for CBX3 Gene
- (3) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (864) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CBX3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBX3
- GenScript: Design CRISPR guide RNA sequences for CBX3
miRNA Products
- Search ViGene Biosciences for CBX3
Inhibitory RNA Products
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for CBX3
- Browse OriGene Inhibitory RNA Products For CBX3
-
ViGene Biosciences ready-to-package AAV shRNAs for CBX3 gene
Clone Products
- Sino Biological Human cDNA Clone for CBX3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CBX3
- VectorBuilder custom plasmid, inducible vectors for CBX3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBX3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - |
Expression for CBX3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
This gene is overexpressed in Peripheral blood mononuclear cells (11.4), Fetal ovary (7.5), and Tlymphocyte (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CBX3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CBX3 Gene:
CBX3SOURCE GeneReport for Unigene cluster for CBX3 Gene:
Hs.381189Evidence on tissue expression from TISSUES for CBX3 Gene
- Nervous system(4.9)
- Bone marrow(4.4)
- Liver(4.4)
- Lung(2.7)
- Skin(2.7)
- Intestine(2.6)
- Eye(2.5)
- Kidney(2.4)
Primer Products
-
OriGene qPCR primer pairs for CBX3
-
OriGene qPCR primer pairs and template standards for CBX3
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBX3 Gene
Orthologs for CBX3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CBX3 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Gm10068 35 |
|
OneToMany | |
| Cbx3 34 16 35 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | CBX3 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CBX3 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CBX3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CBX3 34 |
|
||
| -- 35 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Cbx3 34 |
|
||
| chicken (Gallus gallus) |
Aves | CBX3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CBX3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cbx3 34 |
|
||
| Str.7994 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | cbx3a 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | HP1b 36 35 |
|
||
| Su(var)205 35 |
|
ManyToMany | |||
| HP6 35 |
|
ManyToMany | |||
| HP1e 35 |
|
ManyToMany | |||
| HP1c 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | hpl-1 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3133 35 |
|
OneToMany |
- Species where no ortholog for CBX3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CBX3 Gene
(7) SIMAP similar genes for CBX3 Gene using alignment to 5 proteins:
Pseudogenes.org Pseudogenes for CBX3 Gene
Variants for CBX3 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000172555 | -- | 26,207,056(+) | ATGCA(A/G)CAATT | intron-variant | |
| rs1000259971 | -- | 26,200,774(+) | CTTTT(C/G)TAGAA | nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1000317211 | -- | 26,210,055(+) | GAAAC(C/T)AAAGC | intron-variant | |
| rs1000607386 | -- | 26,210,708(+) | AAACA(A/G)ATTTC | intron-variant | |
| rs1000770172 | -- | 26,206,271(+) | AAATT(C/G/T)ATGTC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1093n67 | CNV | gain | 20364138 |
| dgv3757e59 | CNV | duplication | 20981092 |
| esv23140 | CNV | gain | 19812545 |
| esv2390496 | CNV | deletion | 18987734 |
| esv2734157 | CNV | deletion | 23290073 |
| esv2734158 | CNV | deletion | 23290073 |
| esv2734159 | CNV | deletion | 23290073 |
| esv3612632 | CNV | loss | 21293372 |
| nsv1076880 | CNV | deletion | 25765185 |
| nsv1130864 | CNV | deletion | 24896259 |
| nsv1140754 | CNV | deletion | 24896259 |
| nsv606459 | CNV | gain | 21841781 |
| nsv606460 | CNV | loss | 21841781 |
| nsv7393 | OTHER | inversion | 18451855 |
| nsv970454 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.23;
5.18% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CBX3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CBX3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBX3 Gene
Disorders for CBX3 Gene
Relevant External Links for CBX3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CBX3
No disorders were found for CBX3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBX3 Gene
Publications for CBX3 Gene
- A complex with chromatin modifiers that occupies E2F- and Myc- responsive genes in G0 cells. (PMID: 12004135) Ogawa H. … Nakatani Y. (Science 2002) 3 4 22 64
- Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1. (PMID: 10664448) Koike N. … Iguchi-Ariga S.M.M. (FEBS Lett. 2000) 3 4 22 64
- KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Kruppel-associated box-zinc finger proteins in heterochromatin- mediated gene silencing. (PMID: 10330177) Ryan R.F. … Rauscher F.J. III (Mol. Cell. Biol. 1999) 3 4 22 64
- Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells. (PMID: 10460410) Minc E. … Buendia B. (Chromosoma 1999) 3 4 22 64
- Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. (PMID: 8663349) Ye Q. … Worman H.J. (J. Biol. Chem. 1996) 2 3 4 64
Products for CBX3 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
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- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CBX3
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CBX3
- Origene Custom Protein Services for CBX3
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBX3
- Browse OriGene Inhibitory RNA Products For CBX3
- OriGene qPCR primer pairs and template standards for CBX3
- OriGene qPCR primer pairs for CBX3
- OriGene CRISPR knockouts for CBX3
- OriGene ORF clones in human for CBX3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CBX3
- GenScript: Next-day shipping cDNA ORF clone for CBX3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CBX3
- GenScript Custom Assay Services for CBX3
- GenScript Custom overexpressing Cell Line Services for CBX3
- GenScript: Design CRISPR guide RNA sequences for CBX3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CBX3
- Cell Signaling Technology (CST) Antibodies for CBX3 (CBX3)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for CBX3
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CBX3
- Novus Biologicals proteins and lysates for CBX3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for CBX3
- Cloud-Clone Corp. Antibodies for CBX3
- Cloud-Clone Corp. Proteins for CBX3
- Cloud-Clone Corp Assay Kits for CBX3
- Addgene plasmids for CBX3
- antibodies-online Antibodies for CBX3: See all 120
- antibodies-online Kits for CBX3: See all 36
- antibodies-online Proteins for CBX3: See all 14
- Search antibodies-online for peptides
- GeneTex CBX3 antibody for CBX3
- Search GeneTex for Proteins for CBX3
- ViGene Biosciences adenoviral particle packaged cDNA for CBX3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CBX3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CBX3 gene
- Search ViGene Biosciences for CBX3
- Search Santa Cruz Biotechnology (SCBT) for CBX3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CBX3
- Horizon Cell Lines for CBX3
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBX3
- VectorBuilder custom plasmid, inducible vectors for CBX3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBX3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CBX3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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- (21) IntAct
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- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
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- (136) ViGene Biosciences
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- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer