Aliases for CBX2 Gene
Aliases for CBX2 Gene
External Ids for CBX2 Gene
- HGNC: 1552
- Entrez Gene: 84733
- Ensembl: ENSG00000173894
- OMIM: 602770
- UniProtKB: Q14781
Previous HGNC Symbols for CBX2 Gene
- CDCA6
Previous GeneCards Identifiers for CBX2 Gene
- GC17U990011
- GC17M081046
- GC17P078322
- GC17P078458
- GC17P075373
- GC17P077751
- GC17P073192
Summaries for CBX2 Gene
-
This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2010]
GeneCards Summary for CBX2 Gene
CBX2 (Chromobox 2) is a Protein Coding gene. Diseases associated with CBX2 include 46Xy Sex Reversal 5 and 46 Xy Gonadal Dysgenesis. Among its related pathways are Cellular Senescence and Metabolism of proteins. GO annotations related to this gene include chromatin binding and methylated histone binding. An important paralog of this gene is CBX8.
UniProtKB/Swiss-Prot for CBX2 Gene
-
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBX2 Gene
Genomics for CBX2 Gene
Regulatory Elements for CBX2 Gene
- Transcription factor binding sites by QIAGEN in the CBX2 gene promoter:
Regulatory Element Products
Genomic Location for CBX2 Gene
- Chromosome:
- 17
- Start:
- 79,777,188 bp from pter
- End:
- 79,787,983 bp from pter
- Size:
- 10,796 bases
- Orientation:
- Plus strand
Genomic View for CBX2 Gene
- Cytogenetic band:
-
- 17q25.3 by Ensembl
- 17q25.3 by Entrez Gene
- 17q25.3 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBX2 Gene
Proteins for CBX2 Gene
-
Protein details for CBX2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14781-CBX2_HUMAN
- Recommended name:
- Chromobox protein homolog 2
- Protein Accession:
- Q14781
- Q0VDA5
- Q9BTB1
Protein attributes for CBX2 Gene
- Size:
- 532 amino acids
- Molecular mass:
- 56081 Da
- Quaternary structure:
-
- Component of a PRC1-like complex.
- Miscellaneous:
-
- The human orthologuous proteins of Drosphila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nulear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes. The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different complexes.
Protein Expression for CBX2 Gene
Post-translational modifications for CBX2 Gene
Other Protein References for CBX2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CBX2 (Cbx2)
-
Custom Antibody ServicesOriGene Antibodies for CBX2
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Abcam antibodies for CBX2
- Invitrogen Antibodies for CBX2
- antibodies-online Antibodies for CBX2: See all 66
- GeneTex CBX2 antibody for CBX2
-
Santa Cruz Biotechnology (SCBT) Antibodies for CBX2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CBX2
- Origene Custom Protein Services for CBX2
- antibodies-online Proteins for CBX2: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CBX2
-
Abcam proteins for CBX2
Assay Products
- antibodies-online Kits for CBX2: See all 4
No data available for DME Specific Peptides for CBX2 Gene
Domains & Families for CBX2 Gene
Gene Families for CBX2 Gene
- HGNC:
Protein Domains for CBX2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CBX2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CBX2 Gene
Function for CBX2 Gene
Molecular function for CBX2 Gene
- GENATLAS Biochemistry:
- Drosophila polycomb-like (PcG) chromobox homolog 2,involved in the compaction of chromatin
- UniProtKB/Swiss-Prot Function:
- Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0035064 | methylated histone binding | IEA | -- |
Phenotypes for CBX2 Gene
- MGI mutant phenotypes for CBX2:
-
inferred from 3 alleles
- mortality/aging
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- immune system phenotype
- digestive/alimentary phenotype
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- skeleton phenotype
- hematopoietic system phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for CBX2:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for CBX2 gene
-
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- Search ViGene Biosciences for CBX2
CRISPR Products
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OriGene CRISPR knockouts for CBX2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBX2
- GenScript: Design CRISPR guide RNA sequences for CBX2
miRNA for CBX2 Gene
- miRTarBase miRNAs that target CBX2
-
- hsa-mir-124-3p (MIRT023121)
- hsa-mir-1-3p (MIRT024030)
- hsa-mir-186-5p (MIRT045012)
- hsa-mir-222-3p (MIRT046777)
- hsa-mir-92a-3p (MIRT049303)
- hsa-mir-15a-5p (MIRT289625)
- hsa-mir-16-5p (MIRT289626)
- hsa-mir-30a-5p (MIRT289627)
- hsa-mir-30c-5p (MIRT289628)
- hsa-mir-30d-5p (MIRT289629)
- hsa-mir-15b-5p (MIRT289630)
- hsa-mir-30b-5p (MIRT289631)
- hsa-mir-138-1-3p (MIRT289632)
- hsa-mir-195-5p (MIRT289633)
- hsa-mir-30e-5p (MIRT289634)
- hsa-mir-424-5p (MIRT289635)
- hsa-mir-497-5p (MIRT289636)
- hsa-mir-545-3p (MIRT289637)
- hsa-mir-934 (MIRT289638)
- hsa-mir-3121-3p (MIRT289640)
- hsa-mir-4524a-5p (MIRT289642)
- hsa-mir-4803 (MIRT289643)
- hsa-mir-4524b-5p (MIRT289644)
- hsa-mir-6838-5p (MIRT289646)
- hsa-mir-8064 (MIRT406431)
- hsa-mir-4719 (MIRT562585)
- hsa-mir-646 (MIRT562586)
- hsa-mir-8485 (MIRT562587)
- hsa-mir-548c-3p (MIRT562588)
- hsa-mir-503-5p (MIRT562589)
- hsa-mir-5003-3p (MIRT568206)
- hsa-mir-4715-3p (MIRT611421)
- hsa-mir-3064-3p (MIRT611422)
- hsa-mir-377-3p (MIRT611423)
- hsa-mir-4317 (MIRT611424)
- hsa-mir-362-3p (MIRT611425)
- hsa-mir-329-3p (MIRT611426)
- hsa-mir-584-3p (MIRT669211)
- hsa-mir-874-3p (MIRT704953)
- hsa-mir-3157-3p (MIRT704954)
- hsa-mir-127-5p (MIRT704955)
- hsa-mir-7843-3p (MIRT704956)
- hsa-mir-3148 (MIRT704957)
- hsa-mir-146b-3p (MIRT704958)
- hsa-mir-6799-3p (MIRT704959)
- hsa-mir-3173-5p (MIRT704960)
- hsa-mir-7976 (MIRT704961)
- hsa-mir-4635 (MIRT704962)
- hsa-mir-6812-3p (MIRT704963)
- hsa-mir-4733-3p (MIRT704964)
- hsa-mir-5003-5p (MIRT704965)
- hsa-mir-29c-3p (MIRT704966)
- hsa-mir-29b-3p (MIRT704967)
- hsa-mir-29a-3p (MIRT704968)
miRNA Products
- Search ViGene Biosciences for CBX2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBX2
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Clone Products
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBX2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CBX2
-
ViGene Biosciences adenoviral particle packaged cDNA for CBX2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CBX2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CBX2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CBX2 Gene
Localization for CBX2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CBX2 Gene
- Nucleus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000791 | euchromatin | IEA | -- |
| GO:0000792 | heterochromatin | IEA | -- |
| GO:0005634 | nucleus | IDA,IEA | 21282530 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0031519 | PcG protein complex | IDA | 21282530 |
Pathways & Interactions for CBX2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular Senescence | ||
| 2 | SUMOylation |
.95
|
|
| 3 | Metabolism of proteins | ||
| 4 | Transport of the SLBP independent Mature mRNA | ||
Pathways by source for CBX2 Gene
9 Reactome pathways for CBX2 Gene
Interacting Proteins for CBX2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IMP | 21282530 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007548 | sex differentiation | IEA | -- |
| GO:0016569 | covalent chromatin modification | IEA | -- |
No data available for SIGNOR curated interactions for CBX2 Gene
Transcripts for CBX2 Gene
mRNA/cDNA for CBX2 Gene
- (4) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (90) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CBX2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBX2
- GenScript: Design CRISPR guide RNA sequences for CBX2
miRNA Products
- Search ViGene Biosciences for CBX2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBX2
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-
ViGene Biosciences ready-to-package AAV shRNAs for CBX2 gene
Clone Products
- Sino Biological Human cDNA Clone for CBX2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CBX2
- VectorBuilder custom plasmid, inducible vectors for CBX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBX2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CBX2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Gonad (Reproductive System)
- Gonad Somatic Cells Primitive Gonad
-
Ovary (Reproductive System)
- Gonad Somatic Cells Primitive Gonad
-
Testis (Reproductive System)
- Gonad Somatic Cells Primitive Gonad
- Intestine (Gastrointestinal Tract)
- Blood (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for CBX2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CBX2 Gene
NURSA nuclear receptor signaling pathways regulating expression of CBX2 Gene:
CBX2SOURCE GeneReport for Unigene cluster for CBX2 Gene:
Hs.368410Evidence on tissue expression from TISSUES for CBX2 Gene
- Blood(4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CBX2 Gene
- ectoderm
- endoderm
- mesoderm
- endocrine
- integumentary
- nervous
- reproductive
- skeleton
- brain
- head
- pituitary gland
- breast
- clavicle
- fallopian tube
- ovary
- penis
- prostate
- testicle
- uterus
- vagina
- vas deferens
- vulva
- arm
- digit
- femur
- fibula
- finger
- foot
- forearm
- hand
- humerus
- lower limb
- radius
- shin
- thigh
- tibia
- toe
- ulna
- upper limb
- hair
- skin
Primer Products
-
OriGene qPCR primer pairs and template standards for CBX2
-
OriGene qPCR primer pairs for CBX2
No data available for mRNA Expression by UniProt/SwissProt for CBX2 Gene
Orthologs for CBX2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CBX2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CBX2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CBX2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cbx2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Cbx2 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CBX2 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CBX2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CBX2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CBX2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100491304 34 |
|
||
| Str.5870 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Pc1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cbx2 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Pc 35 |
|
OneToMany |
- Species where no ortholog for CBX2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CBX2 Gene
Variants for CBX2 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs121908255 | Pathogenic, 46,XY sex reversal 5 (SRXY5) [MIM:613080] | 79,783,736(+) | GGAAC(C/T)CGATG | reference, missense | |
| rs121908256 | Pathogenic, 46,XY sex reversal 5 (SRXY5) [MIM:613080] | 79,784,771(+) | GAGCC(A/C/G)CACAG | reference, missense | |
| rs1057519060 | Uncertain significance | 79,781,777(+) | TCCTC(-/C)TGCAG | reference, frameshift-variant | |
| rs1000019274 | -- | 79,785,428(+) | CTTTG(A/G)TCCCT | reference, utr-variant-3-prime, stop-gained | |
| rs1000165054 | -- | 79,785,864(+) | TATGG(C/G)TGCCA | utr-variant-3-prime |
Relevant External Links for CBX2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBX2 Gene
Disorders for CBX2 Gene
(3) MalaCards diseases for CBX2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| 46xy sex reversal 5 |
|
|
| 46 xy gonadal dysgenesis |
|
|
| cbx2-related 46,xy dsd and 46,xy cgd |
|
|
UniProtKB/Swiss-Prot
CBX2_HUMAN- 46,XY sex reversal 5 (SRXY5) [MIM:613080]: A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. {ECO:0000269 PubMed:19361780}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for CBX2
No data available for Genatlas for CBX2 Gene
Publications for CBX2 Gene
- Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25. (PMID: 7782071) Gecz J. … Fontes M. (Genomics 1995) 2 3 4 22 64
- Ovaries and female phenotype in a girl with 46,XY karyotype and mutations in the CBX2 gene. (PMID: 19361780) Biason-Lauber A. … Schoenle E.J. (Am. J. Hum. Genet. 2009) 3 4 22 64
- Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PMID: 21282530) Vandamme J. … Angrand P.O. (Mol. Cell. Proteomics 2011) 3 4 64
- Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PMID: 19636380) Maertens G.N. … Peters G. (PLoS ONE 2009) 3 4 64
- The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. (PMID: 12167701) Levine S.S. … Kingston R.E. (Mol. Cell. Biol. 2002) 3 4 64
Products for CBX2 Gene
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- Custom Antibody ServicesOriGene Antibodies for CBX2
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- OriGene qPCR primer pairs and template standards for CBX2
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- Novus Biologicals Antibodies for CBX2
- Novus Biologicals proteins and lysates for CBX2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CBX2
- Abcam proteins for CBX2
- Search for Assays for CBX2 at Abcam
- Find your target
- Search knockout validated antibodies
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- Addgene plasmids for CBX2
- antibodies-online Antibodies for CBX2: See all 66
- antibodies-online Kits for CBX2: See all 4
- antibodies-online Proteins for CBX2: See all 8
- Search antibodies-online for peptides
- GeneTex CBX2 antibody for CBX2
- Search GeneTex for Proteins for CBX2
- ViGene Biosciences adenoviral particle packaged cDNA for CBX2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CBX2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CBX2 gene
- Search ViGene Biosciences for CBX2
- Santa Cruz Biotechnology (SCBT) Antibodies for CBX2
- Search Santa Cruz Biotechnology (SCBT) for CBX2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CBX2
- Horizon Cell Lines for CBX2
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBX2
- VectorBuilder custom plasmid, inducible vectors for CBX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBX2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CBX2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
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