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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CBX2 Gene

protein-coding   GIFtS: 56
GCID: GC17P077751

Chromobox Homolog 2

(Previous names: chromobox homolog 2 (Drosophila Pc class), cell division...)
(Previous symbol: CDCA6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromobox Homolog 21 2     SRXY52
CDCA61 2     Chromobox Homolog 2 (Pc Class Homolog, Drosophila)2
Cell Division Cycle Associated 61 2     Chromobox Protein Homolog 22
M332 5     Modifier 32
Chromobox Homolog 2 (Drosophila Pc Class)1     Pc Class Homolog2
Pc Class Homolog (Drosophila)1     

External Ids:    HGNC: 15521   Entrez Gene: 847332   Ensembl: ENSG000001738947   OMIM: 6027705   UniProtKB: Q147813   

Export aliases for CBX2 gene to outside databases

Previous GC identifers: GC17U990011 GC17M081046 GC17P078322 GC17P078458 GC17P075373 GC17P073192


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CBX2 Gene:
This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the
transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification
of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this
gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding
different isoforms have been noted for this gene.(provided by RefSeq, Mar 2010)

GeneCards Summary for CBX2 Gene: 
CBX2 (chromobox homolog 2) is a protein-coding gene. Diseases associated with CBX2 include 46xy gonadal dysgenesis, complete, cbs2-related, and gonadal dysgenesis. GO annotations related to this gene include chromatin binding and methylated histone residue binding. An important paralog of this gene is CBX8.

UniProtKB/Swiss-Prot: CBX2_HUMAN, Q14781
Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain
the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1
complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A
'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as
activator of NR5A1 expression

Gene Wiki entry for CBX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CBX2 gene promoter:
         CREB   deltaCREB   NF-kappaB   NF-kappaB1   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCBX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CBX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

CBX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBX2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P077751:  view genomic region     (about GC identifiers)

Start:
77,751,931 bp from pter      End:
77,761,782 bp from pter
Size:
9,852 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CBX2_HUMAN, Q14781 (See protein sequence)
Recommended Name: Chromobox protein homolog 2  
Size: 532 amino acids; 56081 Da
Subunit: Component of a PRC1-like complex
Subcellular location: Nucleus
Miscellaneous: The human orthologuous proteins of Drosphila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and
CBX8, show distinct nulear localizations, contribute differently to transcriptional repression, and appear to be
part of distinct PRC1-like protein complexes. The hPRC-H complex purification reported by PubMed:12167701
probably presents a mixture of different complexes
2 PDB 3D structures from and Proteopedia for CBX2:
2D9U (3D)        3H91 (3D)    
Secondary accessions: Q0VDA5 Q9BTB1
Alternative splicing: 2 isoforms:  Q14781-1   Q14781-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CBX2: NX_Q14781

Explore proteomics data for CBX2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14781

  • CBX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CBX2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_005180.1  NP_116036.1  

    ENSEMBL proteins: 
     ENSP00000308750   ENSP00000269399  

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    Novus Biologicals CBX2 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CBX2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000792heterochromatin IEA--
    GO:0005634nucleus NAS--
    GO:0031519PcG protein complex IDA--
    GO:0035102PRC1 complex IDA12167701

    CBX2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR017956 AT_hook_DNA-bd_motif
     IPR000953 Chromo_domain/shadow
     IPR023780 Chromo_domain
     IPR016197 Chromodomain-like
     IPR023779 Chromodomain_CS

    Graphical View of Domain Structure for InterPro Entry Q14781

    ProtoNet protein and cluster: Q14781

    1 Blocks protein domain: IPB000953 Chromo domain

    UniProtKB/Swiss-Prot: CBX2_HUMAN, Q14781
    Similarity: Contains 1 A.T hook DNA-binding domain
    Similarity: Contains 1 chromo domain


    CBX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBX2_HUMAN, Q14781
    Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain
    the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1
    complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A
    'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as
    activator of NR5A1 expression

         Genatlas biochemistry entry for CBX2:
    Drosophila polycomb-like (PcG) chromobox homolog 2,involved in the compaction of chromatin

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI16189514
    GO:0035064methylated histone residue binding IEA--
         
    CBX2 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cbx2):
     cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland  growth/size 
     hematopoietic system  immune system  mortality/aging  reproductive system  skeleton 

    CBX2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CBX2: Cbx2tm1Cim Cbx2tm1Ykf

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CBX2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CBX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CBX2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CBX2 

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    SwitchGear 3'UTR luciferase reporter plasmidCBX2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CBX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/90 Interacting proteins for CBX2 (Q147811, 2, 3 ENSP000003087504) via UniProtKB, MINT, STRING, and/or I2D (see all 90)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235107Q065872, 3, ENSP000003964394MINT-8010325 MINT-8010390 I2D: score=3 STRING: ENSP00000396439
    ENSG00000206287Q065872, 3MINT-8010325 MINT-8010390 I2D: score=3 
    ENSG00000226788Q065872, 3MINT-8010325 MINT-8010390 I2D: score=3 
    ENSG00000228520Q065872, 3MINT-8010325 MINT-8010390 I2D: score=3 
    ENSG00000231115Q065872, 3MINT-8010325 MINT-8010390 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0016568chromatin modification NAS--
    GO:0030154cell differentiation IEA--
    GO:0045137development of primary sexual characteristics IMP19361780

    CBX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CBX2

    Search CenterWatch for drugs/clinical trials and news about CBX2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CBX2 gene (2 alternative transcripts): 
    NM_005189.2  NM_032647.3  

    Unigene Cluster for CBX2:

    Chromobox homolog 2
    Hs.368410  [show with all ESTs]
    Unigene Representative Sequence: NM_005189
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310942(uc002jxc.3) ENST00000571484 ENST00000269399(uc002jxb.2)

    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate CBX2 (see all 43):
    hsa-miR-596 hsa-miR-1321 hsa-let-7d hsa-miR-15a hsa-miR-503 hsa-miR-29a hsa-miR-30d hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmidCBX2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBX2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBX2

    Additional mRNA sequence: 

    AL157459.1 BC004252.1 BC119759.1 BC119760.1 

    7 DOTS entries:

    DT.451987  DT.40130210  DT.40130211  DT.100748381  DT.102826918  DT.91687342  DT.91880477 

    24/90 AceView cDNA sequences (see all 90):

    BM988729 AI361622 BE267375 NM_032647 CB053187 BF510073 CB410567 AL521369 
    AL157459 BQ428097 AI417551 BM473885 AW197075 AA347010 BM679787 AA378873 
    BF513841 BM831545 BQ069799 BM839724 AW771437 BU845448 AI680512 BQ881757 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CBX2 expression in normal human tissues (normalized intensities)      CBX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCAGCCCG
    CBX2 Expression
    About this image


    CBX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 5 entries
             ESI-049   
     
     Epithelium (Reproductive System)    fully expand to see all 4 entries
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             PureStem endothelial progenitor 30-MV2-12
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Human Cerebellar Astrocytes   
             brain/midbrain   

    See CBX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CBX2

    SOURCE GeneReport for Unigene cluster: Hs.368410
        SABiosciences Expression via Pathway-Focused PCR Arrays including CBX2: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CBX2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cbx21 , 5 chromobox homolog 2 (Drosophila Pc class)5
    chromobox 21
    83.3(n)1
    85.49(a)1
      11 (83.33 cM)5
    124161  NM_007623.21  NP_031649.21 
     1190229625 
    chicken
    (Gallus gallus)
    Aves CBX21 chromobox homolog 2 67.97(n)
    65.5(a)
      426248  XM_423911.3  XP_423911.3 
    lizard
    (Anolis carolinensis)
    Reptilia CBX26
    Uncharacterized protein
    60(a)
    1 ↔ 1
    2(100970557-100980317)
    African clawed frog
    (Xenopus laevis)
    Amphibia Pc12 Polycomb homolog Pc1 80.84(n)    AF101438.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cbx22 chromobox homolog 2 (Drosophila Pc class) 78.92(n)   327291  AB074154.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pc6
    Polycomb
    18(a)
    1 → many
    3L(21299238-21311120)


    ENSEMBL Gene Tree for CBX2 (if available)
    TreeFam Gene Tree for CBX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CBX2 gene
    CBX82  CBX62  CBX42  CBX72  
    3 SIMAP similar genes for CBX2 using alignment to 1 protein entry:     CBX2_HUMAN:
    CBX5    CBX1    CBX7

    CBX2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/390 SNPs in CBX2 are shown (see all 390)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219082561,2,4
    C46,XY sex reversal 5 (SRXY5)4 pathogenic173676593(+) GAGCCC/GCACAG 2 P R mis10--------
    rs1219082551,2,4
    C46,XY sex reversal 5 (SRXY5)4 pathogenic173677628(+) GGAACC/TCGATG 2 P L mis10--------
    rs759221501,2
    F--73190920(+) TTGGGC/TAGATG 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs734202831,2
    C,F--73191188(+) CAATAA/TATACA 2 -- us2k12Minor allele frequency- T:0.12WA 120
    rs1922016841,2
    --73191358(+) TTCCCC/TCCAAG 2 -- us2k10--------
    rs1431639541,2
    --73191437(+) AATGAA/GTGTAA 2 -- us2k10--------
    rs1837447351,2
    --73191497(+) TTCCTA/GCAGTT 2 -- us2k10--------
    rs1466781131,2
    --73191535(+) TAAAAA/CCAAAA 2 -- us2k10--------
    rs1417830161,2
    C--73191613(+) CTCCT-/ACAACAAG 2 -- us2k10--------
    rs612849991,2
    C,F--73191743(+) GGCTCA/GGGTCT 2 -- us2k14Minor allele frequency- G:0.10WA CSA 124

    HapMap Linkage Disequilibrium report for CBX2 (77751931 - 77761782 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for CBX2 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv828116CNV Loss20364138
    nsv469865CNV Loss16826518
    nsv908957CNV Loss21882294
    nsv483050CNV Loss15286789
    nsv908947CNV Loss21882294
    nsv908951CNV Loss21882294
    nsv908956CNV Loss21882294
    nsv908948CNV Loss21882294
    dgv3292n71CNV Loss21882294
    dgv3294n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): CBX2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CBX2
    DNA2.0 Custom Variant and Variant Library Synthesis for CBX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602770   
    OMIM disorders: 613080  
    UniProtKB/Swiss-Prot: CBX2_HUMAN, Q14781
  • 46,XY sex reversal 5 (SRXY5) [MIM:613080]: A disorder of sex development. Affected individuals have a
    46,XY karyotype but present as phenotypically normal females. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 6 diseases for CBX2:    About MalaCards
    46xy gonadal dysgenesis, complete, cbs2-related    gonadal dysgenesis    46 xy gonadal dysgenesis    disorders of sex development
    prostate cancer    prostatitis


    CBX2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CBX2

    Export disorders for CBX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CBX2 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with CBX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25. (PubMed id 7782071)1, 2, 3, 9 Gecz J.... Fontes M. (1995)
    2. Ovaries and female phenotype in a girl with 46,XY kar yotype and mutations in the CBX2 gene. (PubMed id 19361780)1, 2, 9 Biason-Lauber A....Schoenle E.J. (2009)
    3. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PubMed id 21282530)1, 2 Vandamme J.... Angrand P.O. (2011)
    4. Several distinct polycomb complexes regulate and co-l ocalize on the INK4a tumor suppressor locus. (PubMed id 19636380)1, 2 Maertens G.N....Peters G. (2009)
    5. The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. (PubMed id 12167701)1, 2 Levine S.S....Kingston R.E. (2002)
    6. Early detection and screening for prostatic cancer. (PubMed id 2477932)1, 3 Chodak G.W. (1989)
    7. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    8. CBX2 gene analysis in patients with 46,XY and 46,XX go nadal disorders of sex development. (PubMed id 23219007)1 Norling A....Barbaro M. (2013)
    9. A human Polycomb isoform lacking the Pc box does not p articipate to PRC1 complexes but forms protein assemblies and represses transcri ption. (PubMed id 22419124)1 Volkel P....Angrand P.O. (2012)
    10. PCGF homologs, CBX proteins, and RYBP define functiona lly distinct PRC1 family complexes. (PubMed id 22325352)1 Gao Z....Reinberg D. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84733 HGNC: 1552 AceView: MGC10561 Ensembl:ENSG00000173894 euGenes: HUgn84733
    ECgene: CBX2 H-InvDB: CBX2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CBX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CBX2 gene:
    Search GeneIP for patents involving CBX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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