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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CBX2 Gene

protein-coding GIFtS: 53
GCID: GC17P077751

chromobox homolog 2

(Previous names: chromobox homolog 2 (Drosophila Pc class), cell division...)
(Previous symbol: CDCA6)

Explore 7 diseases affiliated with
CBX2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromobox Homolog 2¹ ²		SRXY5²
CDCA6¹ ²		Chromobox Homolog 2 (Pc Class Homolog, Drosophila)²
Cell Division Cycle Associated 6¹ ²		Chromobox Protein Homolog 2²
M33² ⁵		Modifier 3²
MGC10561¹		Pc Class Homolog²
Chromobox Homolog 2 (Drosophila Pc Class)¹

External Ids:	HGNC: 1552¹	Entrez Gene: 84733²	Ensembl: ENSG00000173894⁷	OMIM: 602770⁵	UniProtKB: Q14781³

Export aliases for CBX2 gene to outside databases

Previous GC identifers: GC17U990011 GC17M081046 GC17P078322 GC17P078458 GC17P075373 GC17P073192

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CBX2:

This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally

repressive state of many genes throughout development via chromatin remodeling and modification of histones.

Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also

associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms

have been noted for this gene.(provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: CBX2_HUMAN, Q14781

Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the

transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts

via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119',

rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of

NR5A1 expression

Gene Wiki entry for CBX2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CBX2 gene promoter:
CREB deltaCREB NF-kappaB NF-kappaB1 YY1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CBX2 promoter sequence

Search SABiosciences Chromatin IP Primers for CBX2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBX2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3

CBX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBX2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P077751: view genomic region (about GC identifiers)

Start:	77,751,931 bp from pter	End:	77,761,782 bp from pter
Size:	9,852 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CBX2_HUMAN, Q14781 (See protein sequence)

Recommended Name: Chromobox protein homolog 2

Size: 532 amino acids; 56081 Da

Subunit: Component of a PRC1-like complex

Subcellular location: Nucleus

Miscellaneous: The human orthologuous proteins of Drosphila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8,

show distinct nulear localizations, contribute differently to transcriptional repression, and appear to be part of

distinct PRC1-like protein complexes. The hPRC-H complex purification reported by PubMed:12167701 probably presents a

mixture of different complexes

2 PDB 3D structures from and Proteopedia for CBX2:

2D9U (3D)

3H91 (3D)

Secondary accessions: Q0VDA5 Q9BTB1

Alternative splicing: 2 isoforms: Q14781-1 Q14781-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CBX2: NX_Q14781

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14781

CBX2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_005180.1 NP_116036.1

ENSEMBL proteins:

ENSP00000308750 ENSP00000269399

Human Recombinant Protein Products:

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	Novus Biologicals CBX2 Proteins Novus Biologicals CBX2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CBX2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000792	heterochromatin	IEA	--
GO:0005634	nucleus	NAS	--
GO:0031519	PcG protein complex	IDA	--
GO:0035102	PRC1 complex	IDA	19636380

CBX2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CBX2 for domains About GeneDecksing

5 InterPro domains/families:

IPR017956 AT_hook_DNA-bd_motif

IPR000953 Chromo_domain/shadow

IPR023780 Chromo_domain

IPR016197 Chromodomain-like

IPR023779 Chromodomain_CS

Graphical View of Domain Structure for InterPro Entry Q14781

ProtoNet protein and cluster: Q14781

1 Blocks protein family: IPB000953 Chromo domain

UniProtKB/Swiss-Prot: CBX2_HUMAN, Q14781

Similarity: Contains 1 A.T hook DNA-binding domain

Similarity: Contains 1 chromo domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CBX2_HUMAN, Q14781

Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the

transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts

via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119',

rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of

NR5A1 expression

Genatlas biochemistry entry for CBX2:

Drosophila polycomb-like (PcG) chromobox homolog 2,involved in the compaction of chromatin

miRNA Products:		OriGene 3'-UTR Clone: CBX2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CBX2
		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate CBX2 (see all 43):
		hsa-miR-596 hsa-miR-1321 hsa-let-7d hsa-miR-15a hsa-miR-503 hsa-miR-29a hsa-miR-30d hsa-miR-219-5p

		SwitchGear 3'UTR luciferase reporter plasmid: CBX2 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003682	chromatin binding	IEA	--
GO:0005515	protein binding	IPI	19060904
GO:0035064	methylated histone residue binding	IEA	--

CBX2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for CBX2: Cbx2^tm1Cim Cbx2^tm1Ykf
     10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cbx2):

cellular	craniofacial	digestive/alimentary	endocrine/exocrine gland	growth/size
hematopoietic system	immune system	mortality/aging	reproductive system	skeleton

CBX2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CBX2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/85 Interacting proteins for CBX2 (Q14781^{1, 2, 3} ENSP00000308750⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 85)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RNF2	Q99496²^,³, ENSP00000356480⁴	MINT-8010325 MINT-8010390 I2D: score=2 STRING: ENSP00000356480
RYBP	Q8N488²^,³, ENSP00000419494⁴	MINT-8010325 I2D: score=4 STRING: ENSP00000419494
BMI1	P35226²^,³, ENSP00000365851⁴	MINT-8010325 I2D: score=2 STRING: ENSP00000365851
PHC3	Q8NDX5²^,³	MINT-8010325 MINT-8010390 I2D: score=1
USP11	P51784²^,³, ENSP00000218348⁴	MINT-8010325 MINT-8010390 MINT-8013034 I2D: score=1 STRING: ENSP00000218348

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0016568	chromatin modification	NAS	--
GO:0030154	cell differentiation	IEA	--
GO:0045137	development of primary sexual characteristics	IMP	19361780

CBX2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CBX2
Search CenterWatch for drugs/clinical trials and news about CBX2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CBX2 gene (2 alternative transcripts):

NM_005189.2 NM_032647.3

Unigene Cluster for CBX2:

Chromobox homolog 2

Hs.368410 [show with all ESTs]

Unigene Representative Sequence: NM_005189

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000310942(uc002jxc.3) ENST00000571484 ENST00000269399(uc002jxb.2)

miRNA Products:		OriGene 3'-UTR Clone: CBX2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CBX2
		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate CBX2 (see all 43):
		hsa-miR-596 hsa-miR-1321 hsa-let-7d hsa-miR-15a hsa-miR-503 hsa-miR-29a hsa-miR-30d hsa-miR-219-5p

		SwitchGear 3'UTR luciferase reporter plasmid: CBX2 3' UTR sequence

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBX2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBX2

Additional cDNA sequence:

AL157459.1 BC004252.1 BC119759.1 BC119760.1

7 DOTS entries:

DT.451987 DT.40130210 DT.40130211 DT.100748381 DT.102826918 DT.91687342 DT.91880477

24/90 AceView cDNA sequences (see all 90):

BE267375 AL157459 CB053187 BF513841 AI417551 NM_032647 BM717764 BM473885

AA378873 AI885164 AA347010 AI680512 CB410567 BM831545 BU845448 BM679787

AI361622 BM988729 BF510073 BQ069799 BE393424 BQ881757 BM839724 BQ428097

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CBX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCAGCCCG

About this image

CBX2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary, Testis

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

See CBX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CBX2

SOURCE GeneReport for Unigene cluster: Hs.368410

SABiosciences Expression via Pathway-Focused PCR Arrays including CBX2:

Polycomb & Trithorax Complexes in human mouse rat

Epigenetic Chromatin Remodeling Factors in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBX2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CBX2 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CBX2¹	chromobox homolog 2	67.97(n) 65.5(a)		426248 XM_423911.3 XP_423911.3
lizard (Anolis carolinensis)	Reptilia	CBX2⁶	--	52(a)	1 ↔ 1	2(100970557-100980085)
African clawed frog (Xenopus laevis)	Amphibia	Pc1²	Polycomb homolog Pc1	80.84(n)		AF101438.1
zebrafish (Danio rerio)	Actinopterygii	cbx2²	chromobox homolog 2 (Drosophila Pc class)	78.92(n)		327291 AB074154.1
fruit fly (Drosophila melanogaster)	Insecta	Pc⁶	Polycomb	16(a)	1 → many	3L(21299238-21311120)

ENSEMBL Gene Tree for CBX2 (if available)
TreeFam Gene Tree for CBX2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CBX2 gene

CBX8² CBX4² CBX7²

3 SIMAP similar genes for CBX2 using alignment to 1 protein entry: CBX2_HUMAN:

CBX5 CBX1 CBX7

CBX2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121908255^1,2	C	pathogenic	73677628(+)	`GGAACC/TCGATG`	2	P L	mis¹		0	--	--	--	--
rs75922150^1,2		--	73190920(+)	`TTGGGC/TAGATG`	2	--	us2k¹		1		CSA	2
rs73420283^1,2	C,	--	73191188(+)	`CAATAA/TATACA`	2	--	us2k¹		2		WA	120
rs61284999^1,2	C,F,	--	73191743(+)	`GGCTCA/GGGTCT`	2	--	us2k¹		4		WA CSA	124
rs113822583^1,2		--	73191820(+)	`AATTCA/C/GAATCT`	2	--	us2k¹		1		CSA	2
rs61130343^1,2		--	73191824(+)	`CGAATC/ATTAAC`	2	--	us2k¹		2		CSA WA	120
rs57158368^1,2		--	73191844(+)	`AAAGGG/ATAGCC`	2	--	us2k¹		2		CSA WA	120
rs74851309^1,2		--	73192187(+)	`GTTAAA/TGCATT`	2	--	us2k¹		2		CSA WA	120
rs111795035^1,2	C,	--	73193268(+)	`CGCCCA/GGCCCG`	2	--	int¹		0	--	--	--	--
rs3833851^1,2	C	--	73194121(+)	`CACTGTG/-GGGAG`	2	--	int¹		2		CSA	4

HapMap Linkage Disequilibrium report for CBX2 (77751931 - 77761782 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CBX2
3 CNVs: 7173 0213 2234
Human Gene Mutation Database (HGMD): CBX2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CBX2

DNA2.0 Custom Variant and Variant Library Synthesis for CBX2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CBX2 for disorders           About GeneDecksing

OMIM gene information: 602770
OMIM disorders: 613080
UniProtKB/Swiss-Prot: CBX2_HUMAN, Q14781

Defects in CBX2 are the cause of 46,XY sex reversal type 5 (SRXY5) [MIM:613080]. It is a disorder of sex

development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females

7 diseases for CBX2: About MalaCards

gonadal dysgenesis sex reversal 46 xy gonadal dysgenesis xy sex reversal

disorders of sex development prostate cancer prostatitis

Export disorders for CBX2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CBX2 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with CBX2)

Utopia: connect your pdf to the dynamic
world of online information

Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25. (PubMed id 7782071)^{1, 2, 3, 9} Gecz J.... Fontes M. (1995)
Ovaries and female phenotype in a girl with 46,XY kar yotype and mutations in the CBX2 gene. (PubMed id 19361780)^{1, 2, 9} Biason-Lauber A....Schoenle E.J. (2009)
Several distinct polycomb complexes regulate and co-l ocalize on the INK4a tumor suppressor locus. (PubMed id 19636380)^{1, 2} Maertens G.N....Peters G. (2009)
The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. (PubMed id 12167701)^{1, 2} Levine S.S....Kingston R.E. (2002)
Early detection and screening for prostatic cancer. (PubMed id 2477932)^{1, 3} Chodak G.W. (1989)
A human Polycomb isoform lacking the Pc box does not p articipate to PRC1 complexes but forms protein assemblies and represses transcri ption. (PubMed id 22419124)¹ Volkel P....Angrand P.O. (2012)
PCGF homologs, CBX proteins, and RYBP define functiona lly distinct PRC1 family complexes. (PubMed id 22325352)¹ Gao Z....Reinberg D. (2012)
The global gene-expression profiles of U-937 human mac rophages treated with Tat peptide and Tat-FITC conjugate. (PubMed id 22632162)¹ Lin C.W....Jan M.S. (2012)
BMI1 is recruited to DNA breaks and contributes to DN A damage-induced H2A ubiquitination and repair. (PubMed id 21383063)¹ Ginjala V....Ganesan S. (2011)
Recognition and specificity determinants of the human cbx chromodomains. (PubMed id 21047797)¹ Kaustov L.... Arrowsmith C.H. (2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84733	HGNC: 1552	AceView: MGC10561	Ensembl:ENSG00000173894	euGenes: HUgn84733
ECgene: CBX2	H-InvDB: CBX2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CBX2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CBX2 gene
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Patent Information for CBX2 gene:
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chromobox homolog 2

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chromobox homolog 2

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