Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CBX1 Gene

protein-coding   GIFtS: 59
GCID: GC17M046147

Chromobox Homolog 1

(Previous name: chromobox homolog 1 (Drosophila HP1 beta))
  See CBX1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Chromobox Homolog 11 2     HP1Hs-beta2
Heterochromatin Protein 1 Homolog Beta2 3     MOD12
Modifier 1 Protein2 3     Chromobox Homolog 1 (HP1 Beta Homolog Drosophila )2
CBX2 3     Chromobox Protein Homolog 12
HP1Hsbeta2 3     Heterochromatin Protein 1-Beta2
M312 3     Heterochromatin Protein P25 Beta2
p25beta2 3     HP1 Beta Homolog2
Chromobox Homolog 1 (Drosophila HP1 Beta)1     Heterochromatin Protein P253
HP1 Beta Homolog (Drosophila )1     HP1 Beta3
HP1-BETA2     

External Ids:    HGNC: 15511   Entrez Gene: 109512   Ensembl: ENSG000001084687   OMIM: 6045115   UniProtKB: P839163   

Export aliases for CBX1 gene to outside databases

Previous GC identifers: GC17M045852 GC17M048627 GC17M046489 GC17M046622 GC17M043502 GC17M041515


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CBX1 Gene:
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family .
The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single
N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal
chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of
chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of
chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X.
Multiple alternatively spliced variants, encoding the same protein, have been identified. (provided by RefSeq,
Jul 2008)

GeneCards Summary for CBX1 Gene:
CBX1 (chromobox homolog 1) is a protein-coding gene. Diseases associated with CBX1 include mandibuloacral dysplasia. GO annotations related to this gene include enzyme binding and identical protein binding. An important paralog of this gene is CBX3.

UniProtKB/Swiss-Prot: CBX1_HUMAN, P83916
Function: Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to
epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the
heterochromatin with the inner nuclear membrane

Gene Wiki entry for CBX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CBX1 gene promoter:
         CREB   deltaCREB   NF-kappaB1   NF-kappaB   Pax-4a   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCBX1 promoter sequence
   Search Chromatin IP Primers for CBX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CBX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

CBX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBX1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046147:  view genomic region     (about GC identifiers)

Start:
46,147,414 bp from pter      End:
46,178,883 bp from pter
Size:
31,470 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CBX1_HUMAN, P83916 (See protein sequence)
Recommended Name: Chromobox protein homolog 1  
Size: 185 amino acids; 21418 Da
Subunit: Homodimer. Interacts directly with CHAF1A, EMSY, LBR, TIF1/TIF1A and TRIM28/TIF1B PXVXL motif via the
chromoshadow domain. Interacts directly with histone H3 methylated at 'Lys-9' via the chromo domain. Interacts
with SUV39H1 and SETDB1, SUV420H1 and SUV420H2. Interacts with PRDM6. Interacts with POGZ. Interacts with CHAMP1.
Interacts with ASXL1
3 PDB 3D structures from and Proteopedia for CBX1:
2FMM (3D)        3F2U (3D)        3Q6S (3D)    
Secondary accessions: P23197

Explore the universe of human proteins at neXtProt for CBX1: NX_P83916

Explore proteomics data for CBX1 at MOPED

Post-translational modifications: 

  • Not phosphorylated1
  • Ubiquitinated1
  • Ubiquitination2 at Lys25, Lys41, Lys43, Lys139, Lys150
  • Modification sites at PhosphoSitePlus

  • See CBX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001120700.1  NP_006798.1  

    ENSEMBL proteins: 
     ENSP00000377060   ENSP00000225603   ENSP00000462242   ENSP00000385413   ENSP00000465985  
     ENSP00000393179  

    CBX1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CBX1
    OriGene Protein Over-expression Lysate for CBX1
    OriGene MassSpec for CBX1
    OriGene Custom Protein Services for CBX1
    GenScript Custom Purified and Recombinant Proteins Services for CBX1
    Novus Biologicals CBX1 Proteins
    Novus Biologicals CBX1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CBX1
    Cloud-Clone Corp. Proteins for CBX1

     
    Search eBioscience for Proteins for CBX1 

    CBX1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CBX1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CBX1 
    OriGene Antibodies for CBX1
    OriGene Custom Antibody Services for CBX1
    Novus Biologicals CBX1 Antibodies
    Abcam antibodies for CBX1
    Cloud-Clone Corp. Antibodies for CBX1
    ThermoFisher Antibody for CBX1
    LSBio Antibodies in human, mouse, rat for CBX1

    CBX1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CBX1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CBX1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CBX1
    Cloud-Clone Corp. CLIAs for CBX1
    Search eBioscience for ELISAs for CBX1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 6):
     IPR000953 Chromo_domain/shadow
     IPR023780 Chromo_domain
     IPR016197 Chromodomain-like
     IPR023779 Chromodomain_CS
     IPR017984 Chromo_dom_subgr

    Graphical View of Domain Structure for InterPro Entry P83916

    ProtoNet protein and cluster: P83916

    1 Blocks protein domain: IPB008251 Chromo shadow

    UniProtKB/Swiss-Prot: CBX1_HUMAN, P83916
    Similarity: Contains 2 chromo domains


    Find genes that share domains with CBX1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBX1_HUMAN, P83916
    Function: Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to
    epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the
    heterochromatin with the inner nuclear membrane

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding TAS9169582
    GO:0005515protein binding IPI16415788
    GO:0019899enzyme binding IPI19486527
    GO:0042802identical protein binding IEA--
    GO:1990226histone methyltransferase binding IPI19486527
         
    Find genes that share ontologies with CBX1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CBX1:
     Decreased G3BP1 protein expres  Decreased Hepatitis C virus re  Decreased number of cells in m 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cbx1):
     homeostasis/metabolism  immune system  mortality/aging  normal 

    Find genes that share phenotypes with CBX1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CBX1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CBX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CBX1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CBX1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CBX1:
    hsa-mir-877-3p (MIRT037076), hsa-mir-590-3p (MIRT016166), hsa-mir-210-3p (MIRT003170), hsa-mir-342-3p (MIRT043713), hsa-mir-186-5p (MIRT021150), hsa-mir-193b-3p (MIRT016475)

    Block miRNA regulation of human, mouse, rat CBX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CBX1 (see all 42):
    hsa-miR-3678-3p hsa-miR-3607-3p hsa-miR-376b hsa-miR-29a hsa-miR-200a hsa-miR-139-5p hsa-miR-218 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidCBX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CBX1
    Predesigned siRNA for gene silencing in human, mouse, rat CBX1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CBX1

    Clone
    Products:
         
    OriGene clones in human, mouse for CBX1 (see all 11)
    OriGene ORF clones in mouse, rat for CBX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CBX1 (NM_001127228)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBX1
    Addgene plasmids for CBX1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CBX1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CBX1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CBX1_HUMAN, P83916: Nucleus. Note=Unassociated with chromosomes during mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IDA8287692
    GO:0000785chromatin IDA11101528
    GO:0001939female pronucleus IEA--
    GO:0001940male pronucleus IEA--
    GO:0005634nucleus ----

    Find genes that share ontologies with CBX1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CBX1 About    
    See pathways by source

    SuperPathContained pathways About
    1Packaging Of Telomere Ends
    Histone modification0.31
    2Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with CBX1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CBX1
        Chromatin Regulation / Acetylation


        Pathway & Disease-focused RT2 Profiler PCR Arrays including CBX1: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CBX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CBX1 (P839161, 2, 3 ENSP000002256034) via UniProtKB, MINT, STRING, and/or I2D (see all 168)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3CP684311, 2, 3EBI-78129,EBI-79722 MINT-2830869 MINT-2830755 MINT-2829009 MINT-8087334 MINT-2829033 MINT-2828976 MINT-2829858 MINT-8087351 MINT-2830731 I2D: score=8 
    HIST1H3DP684311, 2, 3EBI-78129,EBI-79722 MINT-2830869 MINT-2830755 MINT-2829009 MINT-8087334 MINT-2829033 MINT-2828976 MINT-2829858 MINT-8087351 MINT-2830731 I2D: score=8 
    HIST1H3EP684311, 2, 3EBI-78129,EBI-79722 MINT-2830869 MINT-2830755 MINT-2829009 MINT-8087334 MINT-2829033 MINT-2828976 MINT-2829858 MINT-8087351 MINT-2830731 I2D: score=8 
    HIST1H3FP684311, 2, 3EBI-78129,EBI-79722 MINT-2830869 MINT-2830755 MINT-2829009 MINT-8087334 MINT-2829033 MINT-2828976 MINT-2829858 MINT-8087351 MINT-2830731 I2D: score=8 
    HIST1H3GP684311, 2, 3EBI-78129,EBI-79722 MINT-2830869 MINT-2830755 MINT-2829009 MINT-8087334 MINT-2829033 MINT-2828976 MINT-2829858 MINT-8087351 MINT-2830731 I2D: score=8 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045892negative regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with CBX1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CBX1

    1 Novoseek inferred chemical compound relationship for CBX1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 13.7 1 17038565 (1)



    Find genes that share compounds with CBX1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CBX1 gene (2 alternative transcripts): 
    NM_001127228.1  NM_006807.4  

    Unigene Cluster for CBX1:

    Chromobox homolog 1
    Hs.77254  [show with all ESTs]
    Unigene Representative Sequence: NM_006807
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393408(uc002ind.4) ENST00000225603(uc002ine.4) ENST00000581003
    ENST00000402583 ENST00000495350 ENST00000444685
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CBX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CBX1 (see all 42):
    hsa-miR-3678-3p hsa-miR-3607-3p hsa-miR-376b hsa-miR-29a hsa-miR-200a hsa-miR-139-5p hsa-miR-218 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidCBX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CBX1
    Predesigned siRNA for gene silencing in human, mouse, rat CBX1
    Clone
    Products:
         
    OriGene clones in human, mouse for CBX1 (see all 11)
    OriGene ORF clones in mouse, rat for CBX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CBX1 (NM_001127228)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CBX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBX1
    Addgene plasmids for CBX1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CBX1
    OriGene qSTAR qPCR primer pairs in human, mouse for CBX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBX1
      QuantiTect SYBR Green Assays in human, mouse, rat CBX1
      QuantiFast Probe-based Assays in human, mouse, rat CBX1

    Additional mRNA sequence: 

    AK312615.1 BC002609.1 BC021302.2 CR456766.1 U35451.1 

    10 DOTS entries:

    DT.100792093  DT.119761  DT.100792090  DT.91763852  DT.91763848  DT.100044420  DT.121004469  DT.95218046 
    DT.121004449  DT.121004466 

    Selected AceView cDNA sequences (see all 507):

    AA447594 AI263947 BE742645 BM126689 AA988657 AI363231 NM_006807 T89291 
    AI185431 BE810322 BI493221 W42735 BU625204 AW769024 BU553842 BU684554 
    BU950954 T35919 AA771867 AI370840 AI359573 AA614830 AA136464 BE731753 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CBX1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6
    SP1:                                                      
    SP2:              -                                       
    SP3:              -                                       
    SP4:                                                      


    ECgene alternative splicing isoforms for CBX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CBX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTAGATTT
    CBX1 Expression
    About this image


    CBX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Thymus (Hematopoietic System)
             Thymus
    CBX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CBX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.77254

    UniProtKB/Swiss-Prot: CBX1_HUMAN, P83916
    Tissue specificity: Expressed in all adult and embryonic tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CBX1: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CBX1
    OriGene qSTAR qPCR primer pairs in human, mouse for CBX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBX1
    QuantiTect SYBR Green Assays in human, mouse, rat CBX1
    QuantiFast Probe-based Assays in human, mouse, rat CBX1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CBX1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cbx11 , 5 chromobox homolog 1 (Drosophila HP1 beta)5
    chromobox 11
    94.59(n)1
    100(a)1
      11 (60.11 cM)5
    124121  NM_007622.31  NP_031648.11 
     967891275 
    chicken
    (Gallus gallus)
    Aves CBX11 chromobox homolog 1 84.47(n)
    96.02(a)
      374237  NM_204332.1  NP_989663.1 
    lizard
    (Anolis carolinensis)
    Reptilia CBX16
    chromobox homolog 1
    93(a)
    1 ↔ 1
    6(74984824-74996671)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA973688.12   -- 79.42(n)    CA973688.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045443.12   -- 79.56(n)   326746  BC045443.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta HP1b1 , 3 chromatin binding3
    Heterochromatin Protein 1b1
    58(a)3
    56.74(n)1
    58.87(a)1
      8C73
    318341  NM_001169242.11  NP_001162713.11 
    worm
    (Caenorhabditis elegans)
    Secernentea hpl-16
    Protein HPL-1 (hpl-1) mRNA, complete cds
    32(a)
    1 → many
    X(13245390-13247044) WBGene00001995


    ENSEMBL Gene Tree for CBX1 (if available)
    TreeFam Gene Tree for CBX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CBX1 gene
    CBX32  CBX52  
    10 SIMAP similar genes for CBX1 using alignment to 7 protein entries:     CBX1_HUMAN (see all proteins):
    CBX3    CBX5    CBX4    CBX7    MPHOSPH8    CBX2
    CBX6    CDYL    SUV39H2    CDYL2

    Find genes that share paralogs with CBX1           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for CBX1
    PGOHUM00000245170 PGOHUM00000238256 PGOHUM00000241201 PGOHUM00000241348 PGOHUM00000241655


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CBX1 (see all 702)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1484358571,2
    --41550741(+) ACCACA/GAACCC 1 -- int10--------
    rs116499951,2
    C,F,A,H--46146955(+) ACTCCA/GTCTCA 2 -- ds50015Minor allele frequency- G:0.36NA WA 14
    rs1431665511,2
    --46147011(+) AGTGCA/GCAAAC 2 -- ds50010--------
    rs116510971,2
    C,F,H--46147039(+) GAAAAT/CTTTGG 2 -- ds500129Minor allele frequency- C:0.29NS EA NA WA 2856
    rs1883473951,2
    --46147136(+) ATACCA/GTAGTT 2 -- ds50010--------
    rs1912627611,2
    --46147214(+) ATCTTC/TACAAC 2 -- ds50010--------
    rs10634881,2
    C--46147476(-) TTAAAT/CGTAAA 2 -- ut312Minor allele frequency- C:0.00NA 4
    rs1855645781,2
    --46147577(+) TTCTCA/GTGACT 2 -- ut310--------
    rs115549261,2
    F--46147724(+) TCACTA/CAACTC 2 -- ut31 ese33Minor allele frequency- C:0.04NA 124
    rs68471,2
    C,F,A,H--46147807(-) CGTTTA/TCTTTG 2 -- ut3132Minor allele frequency- T:0.29MN NA NS EA WA 3292

    HapMap Linkage Disequilibrium report for CBX1 (46147414 - 46178883 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CBX1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716011CNV Deletion23290073
    esv2663382CNV Deletion23128226
    esv2582446CNV Deletion19546169
    esv1003767CNV Insertion20482838
    nsv513477CNV Insertion21212237
    nsv908576CNV Gain21882294
    nsv469808CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CBX1
    DNA2.0 Custom Variant and Variant Library Synthesis for CBX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604511    OMIM disorders: --

    1 disease for CBX1:    
    About MalaCards
    mandibuloacral dysplasia


    Find genes that share disorders with CBX1           About GenesLikeMe


    Export disorders for CBX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CBX1 gene, integrated from 10 sources (see all 129):
    (articles sorted by number of sources associating them with CBX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Heterochromatin protein HP1Hsbeta (p25beta) and its localization with centromeres in mitosis. (PubMed id 9169582)1, 2, 3, 9 Furuta K....Tan E.M. (Chromosoma 1997)
    2. Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69. (PubMed id 15947784)1, 2, 9 Ekblad C.M.S.... Itzhaki L.S. (EMBO Rep. 2005)
    3. Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells. (PubMed id 10460410)1, 2, 9 Minc E.... Buendia B. (Chromosoma 1999)
    4. In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation. (PubMed id 15899859)1, 2, 9 Verschure P.J.... van Driel R. (Mol. Cell. Biol. 2005)
    5. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PubMed id 20562864)1, 2 Nozawa R.S.... Obuse C. (Nat. Cell Biol. 2010)
    6. Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10. (PubMed id 20498703)1, 2 Chaturvedi P. and Parnaik V.K. (PLoS ONE 2010)
    7. Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding. (PubMed id 16615912)1, 2 Huang Y.... Xu R.-M. (Structure 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. (PubMed id 14651845)1, 2 Hughes-Davies L.... Kouzarides T. (Cell 2003)
    10. Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. (PubMed id 10202156)1, 2 Aagaard L....Jenuwein T. (EMBO J. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10951 HGNC: 1551 AceView: CBX1 Ensembl:ENSG00000108468 euGenes: HUgn10951
    ECgene: CBX1 H-InvDB: CBX1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CBX1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Heterochromatin_Protein_1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CBX1 gene:
    Search GeneIP for patents involving CBX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CBX1
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CBX1   OriGene RNAi products in human, mouse, rat for CBX1  
     OriGene qPCR primer pairs and template standards for CBX1   OriGene Protein Over-expression Lysate for CBX1  
     OriGene MassSpec something-or-other for CBX1   OriGene clones in human, mouse for CBX1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CBX1   OriGene Purified Protein for CBX1  
     OriGene ORF clones in mouse, rat for CBX1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CBX1   OriGene Custom Protein Services for CBX1  

     
     
     Block miRNA regulation of human, mouse, rat CBX1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CBX1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CBX1 Predesigned siRNA for gene silencing in human, mouse, rat CBX1
     QuantiFast Probe-based Assays in human, mouse, rat CBX1 QuantiTect SYBR Green Assays in human, mouse, rat CBX1
     PCR Arrays including human, mouse, rat CBX1 Search Chromatin IP Primers for CBX1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CBX1  GeneGlobe Interaction Network for CBX1
     Regulatory tfbs in CBX1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CBX1 GenScript cDNA clones with any tag delivered in your preferred vector for CBX1
     GenScript Custom Assay Services for CBX1 GenScript Custom overexpressing Cell Line Services for CBX1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for CBX1 

     Search Tocris compounds for CBX1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CBX1 antibodies
     CBX1 proteins
     CBX1 lysates
     Antibodies for CBX1
     See all of Abcam's Antibodies, Kits and Proteins for CBX1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CBX1
     Proteins for CBX1
     Antibodies for CBX1
     ELISAs for CBX1
     CLIAs for CBX1



     Browse ESI BIO Cell Lines and PureStem Progenitors for CBX1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBX1
     SwitchGear 3'UTR luciferase reporter plasmids for CBX1
     SwitchGear Promoter luciferase reporter plasmids for CBX1
     ThermoFisher Antibody for CBX1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBX1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CBX1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CBX1
     LSBio Antibodies in human, mouse, rat for CBX1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for CBX1
      Search eBioscience for proteins for CBX1
      Search eBioscience for elisas for CBX1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CBX1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4