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CBWD7 Gene

protein-coding   GIFtS: 26
GCID: GC09P042945          (predicted)

COBW Domain Containing 7

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
COBW Domain Containing 71 2
Putative Cobalamin Synthase W Domain-Containing Protein 72 3
Putative COBW Domain-Containing Protein 72

External Ids:    HGNC: 319771   Entrez Gene: 7280132   Ensembl: ENSG000002151267   UniProtKB: A6NM153   

Export aliases for CBWD7 gene to outside databases

Previous GC identifers: GC09U900750 GC09P042661 GC09P042662 GC09P042667 GC09P042658 GC09P042671 GC09P042836


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CBWD7 Gene:
CBWD7 (COBW domain containing 7) is a protein-coding gene. An important paralog of this gene is CBWD2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CBWD7 gene promoter:
         AML1a   Nkx2-5   MIF-1   LCR-F1   Evi-1   C/EBPalpha   POU2F1   POU2F1a   Sox9   Chx10   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CBWD7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CBWD7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p12   Ensembl cytogenetic band:  9p12   HGNC cytogenetic band: 9p12

CBWD7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CBWD7 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P042945:  view genomic region     (about GC identifiers)

Start:
42,668,608 bp from pter      End:
42,714,962 bp from pter
Size:
46,355 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CBWD7_HUMAN, A6NM15 (See protein sequence)
Recommended Name: Putative COBW domain-containing protein 7  
Size: 247 amino acids; 28232 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for CBWD7: NX_A6NM15

Explore proteomics data for CBWD7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CBWD7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000401079   ENSP00000366608   ENSP00000402214  

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    antibodies-online kits for CBWD7 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011629 Cbl_biosynth_CobW-like_C
     IPR027417 P-loop_NTPase
     IPR003495 CobW/HypB/UreG_dom

    Graphical View of Domain Structure for InterPro Entry A6NM15

    ProtoNet protein and cluster: A6NM15

    UniProtKB/Swiss-Prot: CBWD7_HUMAN, A6NM15
    Similarity: Belongs to the CobW family
    Similarity: Contains 1 cobW C-terminal domain


    Find genes that share domains with CBWD7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with CBWD7           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CBWD7

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion1
    nucleus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CBWD7
    Interactions:

        Search GeneGlobe Interaction Network for CBWD7

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CBWD7 (ENSP000003666084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2E1ENSP000002838754STRING: ENSP00000283875
    TTC39AENSP000004061444STRING: ENSP00000406144
    TTC39BENSP000003479204STRING: ENSP00000347920
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CBWD7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467192 ENST00000460896(uc004ack.3) ENST00000467791 ENST00000496146
    ENST00000486387 ENST00000456520 ENST00000377391 ENST00000489423 ENST00000382436
    ENST00000494538 ENST00000490294 ENST00000466582 ENST00000496513(uc004acm.3)
    ENST00000457288 ENST00000478448 ENST00000462573
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CBWD7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CBWD7 Expression
    About this image

    CBWD7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CBWD7 Protein Expression
        Custom PCR Arrays for CBWD7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBWD7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CBWD7 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CBWD16
    COBW domain-containing protein 1
    44(a)
    1 → many
    Z(25552426-25574010)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    43(a)
    1 → many
    2(49999445-50023007)
    zebrafish
    (Danio rerio)
    Actinopterygii cbwd6
    COBW domain containing
    42(a)
    1 → many
    8(31273742-31298114) ENSDARG00000004318
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    Putative protein of unknown function, deletion con...
    18(a)
    1 → many
    XIV(677199-678488) YNR029C
            Species with no ortholog for CBWD7

    ENSEMBL Gene Tree for CBWD7 (if available)
    TreeFam Gene Tree for CBWD7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CBWD7 gene
    CBWD22  CBWD62  CBWD32  CBWD12  CBWD52  
    5 SIMAP similar genes for CBWD7 using alignment to 3 protein entries:     CBWD7_HUMAN (see all proteins):
    CBWD2    CBWD5    CBWD6    CBWD3    CBWD1

    Find genes that share paralogs with CBWD7           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CBWD7
    PGOHUM00000240466


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CBWD7 (see all 12)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1997744711,2
    --42685216(+) ACATT-/TCTA  
            
    ACTTT
    1 -- int10--------
    rs2011308481,2
    ----42702461(+) ATGGCA/GTCAAC 1 -- int10--------
    rs2016716191,2
    ----42691805(+) AATTGC/TGTGAA 1 -- int10--------
    rs3724776651,2
    ----42669148(+) TAATT-/ATTA  
            
    ATTAA
    1 -- us2k10--------
    rs1900631971,2
    ----42709068(+) GATCAG/TTGGGT 1 -- int10--------
    rs3775094481,2
    ----42674802(+) TTTGC-/TTTTTT 1 -- int10--------
    rs3718117481,2
    ----42713631(+) GTGAT-/AAAAAA 1 -- int10--------
    rs3748287691,2
    ----42707408(+) GATAT-/TAAAAAA 1 -- int10--------
    rs3710148491,2
    ----42669382(+) TCTTT-/GCCATTTG 1 -- us2k10--------
    rs2021931021,2
    ----42706409(+) TAGACA/TCCTGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for CBWD7 (42668608 - 42714962 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CBWD7: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CBWD7
    DNA2.0 Custom Variant and Variant Library Synthesis for CBWD7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CBWD7 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CBWD7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    3. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Toward a complete human genome sequence. (PubMed id 9847074)1 Sulston J.E. and Waterston R. (Genome Res. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 728013 HGNC: 31977 Ensembl:ENSG00000215126 euGenes: HUgn728013 ECgene: CBWD7
    H-InvDB: CBWD7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CBWD7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CBWD7 gene:
    Search GeneIP for patents involving CBWD7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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      Search eBioscience for elisas for CBWD7
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CBWD7
      Search antibodies-online for antibodies for CBWD7
     antibodies-online kits for CBWD7 (2 products)
      Search antibodies-online for peptides for CBWD7
     antibodies-online proteins for CBWD7
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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