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CBWD6 Gene(Protein Coding)

COBW Domain Containing 6

GCID:
GC09M041132
GIFtS:
36
Genes Participants
UDN Logo

Aliases for CBWD6 Gene

Aliases for CBWD6 Gene

  • COBW Domain Containing 6 2 3
  • COBW Domain Containing 7 2 3 5
  • Cobalamin Synthase W Domain-Containing Protein 6 3 4
  • CBWD7 3 5
  • Putative Cobalamin Synthase W Domain-Containing Protein 7 3
  • Cobalamin Synthetase W Domain-Containing Protein 6 3
  • Putative COBW Domain-Containing Protein 7 3
  • COBW Domain-Containing Protein 6 3

External Ids for CBWD6 Gene

Previous HGNC Symbols for CBWD6 Gene

  • CBWD7

Previous GeneCards Identifiers for CBWD6 Gene

  • GC09P042659
  • GC09M068495
  • GC09M069204

Summaries for CBWD6 Gene

GeneCards Summary for CBWD6 Gene

CBWD6 (COBW Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is CBWD3.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBWD6 Gene

Genomics for CBWD6 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CBWD6 Gene

Enhancers for CBWD6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G041194 0.2 Ensembl 0.7 +3.9 3861 2.4 CBWD6 FOXD4L6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CBWD6 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CBWD6 gene promoter:

Genomic Location for CBWD6 Gene

Chromosome:
9
Start:
41,131,306 bp from pter
End:
41,199,261 bp from pter
Size:
67,956 bases
Orientation:
Minus strand

Genomic View for CBWD6 Gene

Genes around CBWD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBWD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBWD6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CBWD6 Gene

Proteins for CBWD6 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CBWD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4V339-CBWD6_HUMAN
    Recommended name:
    COBW domain-containing protein 6
    Protein Accession:
    Q4V339

    Protein attributes for CBWD6 Gene

    Size:
    395 amino acids
    Molecular mass:
    43964 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CBWD6 Gene

Post-translational modifications for CBWD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CBWD6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CBWD6 Gene

Domains & Families for CBWD6 Gene

Protein Domains for CBWD6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CBWD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4V339

UniProtKB/Swiss-Prot:

CBWD6_HUMAN :
  • Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
Family:
  • Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
genes like me logo Genes that share domains with CBWD6: view

No data available for Gene Families for CBWD6 Gene

Function for CBWD6 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Gene Ontology (GO) - Molecular Function for CBWD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CBWD6: view

Phenotypes for CBWD6 Gene

GenomeRNAi human phenotypes for CBWD6:
genes like me logo Genes that share phenotypes with CBWD6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CBWD6 Gene

Localization for CBWD6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CBWD6 gene
Compartment Confidence
cytosol 2
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CBWD6 Gene

Pathways & Interactions for CBWD6 Gene

SuperPathways for CBWD6 Gene

PathCards logo More details on SuperPathways for CBWD6
No Data Available

Gene Ontology (GO) - Biological Process for CBWD6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CBWD6 Gene

Drugs & Compounds for CBWD6 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CBWD6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CBWD6 Gene

(36) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(18) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CBWD6 Gene

COBW domain containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CBWD6 Gene

No ASD Table

Relevant External Links for CBWD6 Gene

GeneLoc Exon Structure for
CBWD6
ECgene alternative splicing isoforms for
CBWD6

Expression for CBWD6 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CBWD6 Gene

mRNA expression in normal human tissues for CBWD6 Gene
mRNA expression by BioGPS for CBWD6 GenemRNA expression by GTEx for CBWD6 Gene

NURSA nuclear receptor signaling pathways regulating expression of CBWD6 Gene:

CBWD6

SOURCE GeneReport for Unigene cluster for CBWD6 Gene:

Hs.597638
genes like me logo Genes that share expression patterns with CBWD6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBWD6 Gene

Orthologs for CBWD6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CBWD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CBWD2 35
  • 63 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia -- 35
  • 56 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia -- 35
  • 56 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Cbwd1 35
  • 51 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 49 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 47 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves CBWD1 35
  • 44 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 43 (a)
 OneToMany
zebrafish
(Danio rerio)
 Actinopterygii cbwd 35
  • 42 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes -- 35
  • 18 (a)
 OneToMany
Species where no ortholog for CBWD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBWD6 Gene

ENSEMBL:
Gene Tree for CBWD6 (if available)
TreeFam:
Gene Tree for CBWD6 (if available)

Paralogs for CBWD6 Gene

Paralogs for CBWD6 Gene

(5) SIMAP similar genes for CBWD6 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CBWD6: view

Variants for CBWD6 Gene

Sequence variations from dbSNP and Humsavar for CBWD6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000201935 -- 41,145,888(+) ACATT(A/G)TTCTG intron-variant
rs1000453851 -- 41,184,651(+) ACTTA(C/T)ATATT intron-variant
rs1000506989 -- 41,150,829(+) CATCA(C/T)CATCA intron-variant
rs1000535819 -- 41,150,449(+) GGAAG(A/C)TCCAA intron-variant
rs1000659552 -- 41,169,468(+) ACTAT(A/G)GCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CBWD6 Gene

Variant ID Type Subtype PubMed ID
esv3346588 CNV duplication 20981092
esv3395969 CNV duplication 20981092
esv3416825 CNV duplication 20981092
nsv1110568 CNV duplication 24896259
nsv1125055 CNV duplication 24896259
nsv1151480 CNV duplication 26484159
nsv951495 CNV duplication 24416366
nsv972389 CNV duplication 23825009

Variation tolerance for CBWD6 Gene

Gene Damage Index Score: 6.31; 76.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CBWD6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CBWD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBWD6 Gene

Disorders for CBWD6 Gene

Relevant External Links for CBWD6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CBWD6

No disorders were found for CBWD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBWD6 Gene

Publications for CBWD6 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 3 64

Products for CBWD6 Gene

Sources for CBWD6 Gene

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