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Aliases for CBWD6 Gene

Aliases for CBWD6 Gene

  • COBW Domain Containing 6 2 3
  • Cobalamin Synthase W Domain-Containing Protein 6 4

External Ids for CBWD6 Gene

Previous GeneCards Identifiers for CBWD6 Gene

  • GC09P042659
  • GC09M068495
  • GC09M069204

Summaries for CBWD6 Gene

GeneCards Summary for CBWD6 Gene

CBWD6 (COBW Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is CBWD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBWD6 Gene

Genomics for CBWD6 Gene

Regulatory Elements for CBWD6 Gene

Genomic Location for CBWD6 Gene

41,131,309 bp from pter
41,189,364 bp from pter
58,056 bases
Minus strand

Genomic View for CBWD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CBWD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBWD6 Gene

Proteins for CBWD6 Gene

  • Protein details for CBWD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COBW domain-containing protein 6
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CBWD6 Gene

    395 amino acids
    Molecular mass:
    43964 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CBWD6 Gene

Proteomics data for CBWD6 Gene at MOPED

Post-translational modifications for CBWD6 Gene

  • Ubiquitination at Lys55, Lys69, Lys113, Lys176, Lys306, and Lys370
  • Modification sites at PhosphoSitePlus

Other Protein References for CBWD6 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for CBWD6 Gene

Domains for CBWD6 Gene

Suggested Antigen Peptide Sequences for CBWD6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 cobW C-terminal domain.
  • Belongs to the CobW family.
  • Contains 1 cobW C-terminal domain.
  • Belongs to the CobW family.
genes like me logo Genes that share domains with CBWD6: view

No data available for Gene Families for CBWD6 Gene

Function for CBWD6 Gene

Gene Ontology (GO) - Molecular Function for CBWD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CBWD6: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CBWD6 Gene

Localization for CBWD6 Gene

Subcellular locations from

Jensen Localization Image for CBWD6 Gene COMPARTMENTS Subcellular localization image for CBWD6 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CBWD6 Gene

Pathways for CBWD6 Gene

SuperPathways for CBWD6 Gene

No Data Available

Interacting Proteins for CBWD6 Gene

Gene Ontology (GO) - Biological Process for CBWD6 Gene


No data available for Pathways by source for CBWD6 Gene

Transcripts for CBWD6 Gene

mRNA/cDNA for CBWD6 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CBWD6 Gene

COBW domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CBWD6 Gene

No ASD Table

Relevant External Links for CBWD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CBWD6 Gene

mRNA expression in normal human tissues for CBWD6 Gene

SOURCE GeneReport for Unigene cluster for CBWD6 Gene Hs.597638

genes like me logo Genes that share expressions with CBWD6: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for CBWD6 Gene

Orthologs for CBWD6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CBWD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 87 (a)
(Canis familiaris)
Mammalia -- 36
  • 90 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
(Mus musculus)
Mammalia Cbwd1 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
(Pan troglodytes)
Mammalia CBWD2 36
  • 98 (a)
(Gallus gallus)
Aves CBWD1 36
  • 72 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
(Danio rerio)
Actinopterygii cbwd 36
  • 71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 32 (a)
Species with no ortholog for CBWD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBWD6 Gene

Gene Tree for CBWD6 (if available)
Gene Tree for CBWD6 (if available)

Paralogs for CBWD6 Gene

Paralogs for CBWD6 Gene

(5) SIMAP similar genes for CBWD6 Gene using alignment to 6 proteins: Pseudogenes for CBWD6 Gene

genes like me logo Genes that share paralogs with CBWD6: view

Variants for CBWD6 Gene

Sequence variations from dbSNP and Humsavar for CBWD6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2482131 -- 41,147,379(+) AATAT(A/G)AAAAA intron-variant
rs2482154 -- 41,167,229(+) AAAAA(A/G)GATAA intron-variant
rs4097585 -- 41,173,676(-) TTAAT(A/G)TAATG intron-variant, upstream-variant-2KB
rs62548577 -- 41,157,726(-) GTTGA(G/T)AATAA intron-variant, upstream-variant-2KB
rs62548651 -- 41,140,052(-) ACTGT(A/C)TGTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CBWD6 Gene

Variant ID Type Subtype PubMed ID
dgv2381e1 CNV Complex 17122850
dgv135n16 CNV Deletion 17901297
esv33449 CNV Loss 17666407
essv17250 CNV CNV 17122850

Relevant External Links for CBWD6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBWD6 Gene

Disorders for CBWD6 Gene

No disorders were found for CBWD6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CBWD6 Gene

Publications for CBWD6 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  4. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3

Products for CBWD6 Gene

Sources for CBWD6 Gene

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