CBWD6 Gene
protein-coding GIFtS: 38
GCID: GC09M069204
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COBW domain containing 6
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Aliases for CBWD6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| COBW Domain Containing 61 2 | | Cobalamin Synthase W Domain-Containing Protein 62 3 | | OTTHUMG000000668201 | | Cobalamin Synthetase W Domain-Containing Protein 62 | | COBW Domain-Containing Protein 62 |
Export aliases for CBWD6 gene to outside databasesPrevious GC identifers: GC09P042659 GC09M068495 |
Summaries for CBWD6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Views for CBWD6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_078070.3
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CBWD6 gene promoter: GR Pax-6 ATF-2 GR-beta HNF-4alpha2 POU3F2 Cdc5 GATA-1 GR-alpha Other transcription factors
Search SABiosciences Chromatin IP Primers for CBWD6
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBWD6 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q21.11 Ensembl cytogenetic band: 9q21.11 HGNC cytogenetic band: 9q13CBWD6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M069204: view genomic region
(about GC identifiers)
Start:
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69,204,538 bp from pter |
End:
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69,272,478 bp from pter |
Size:
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67,941 bases |
Orientation:
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minus strand |
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Proteins for CBWD6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: CBWD6_HUMAN, Q4V339 (See
protein sequence)Recommended Name: COBW domain-containing protein 6 Size: 395 amino acids; 43964 DaExplore the universe of human proteins at neXtProt for CBWD6: NX_Q4V339
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q4V339 CBWD6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001078926.1 ENSEMBL proteins: ENSP00000408279 ENSP00000366677 ENSP00000366668 ENSP00000366664 ENSP00000366660 ENSP00000366658 ENSP00000371836 Human Recombinant Protein Products:
CBWD6 Antibody Products: Assay Products for CBWD6: |
Protein
Domains / Families for CBWD6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CBWD6 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q4V339ProtoNet protein and cluster: Q4V339 2 Blocks protein families: IPB003495 Cobalamin synthesis protein/P47K IPB011629 Cobalamin synthesis CobW
UniProtKB/Swiss-Prot: CBWD6_HUMAN, Q4V339Similarity: Belongs to the CobW familySimilarity: Contains 1 cobW C-terminal domain |
Function for CBWD6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBWD6 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CBWD6 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CBWD6 (NM_001085457) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CBWD6 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CBWD6  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBWD6 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- |
CBWD6 for ontologies About GeneDecksing
|
Pathways & Interactions for CBWD6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CBWD6
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
 1 Interacting protein for CBWD6 (ENSP000003666774) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds for CBWD6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for CBWD6 Search CenterWatch for drugs/clinical trials and news about CBWD6 
|
Transcripts for CBWD6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for CBWD6 gene: NM_001085457.1 Unigene Cluster for CBWD6: COBW domain containing 6 Hs.597638 [show with all ESTs]Unigene Representative Sequence: BM47087218/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21): ENST00000416428 ENST00000377457(uc004afj.4 uc011lrf.2) ENST00000377449 ENST00000477430 ENST00000466320(uc004afk.4) ENST00000468061 ENST00000468763 ENST00000473839 ENST00000498101 ENST00000495626 ENST00000461037 ENST00000485382 ENST00000494632 ENST00000461834 ENST00000377445 ENST00000476973 ENST00000377441(uc004afl.3) ENST00000470192
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBWD6 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CBWD6 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CBWD6 (NM_001085457) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CBWD6 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CBWD6  |
Additional cDNA sequence: AF293368.1 24 DOTS entries: DT.121166890 DT.92460248 DT.121202301 DT.100890111 DT.121202364 DT.121202400 DT.121166875 DT.121166893 DT.92460230 DT.95095701 DT.95140938 DT.100038781 DT.100890115 DT.102843376 DT.121166896 DT.92460241 DT.92460279 DT.99947945 DT.100890095 DT.121166882 DT.121202224 DT.121202276 DT.318244 DT.95115608 GeneLoc Exon Structure
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Expression for CBWD6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CBWD6 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AGCTCTGTGA
About this image See CBWD6 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CBWD6
SOURCE GeneReport for Unigene cluster: Hs.597638 SABiosciences Custom PCR Arrays for CBWD6
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CBWD6 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CBWD6 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBWD6 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBWD6 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBWD6 |
Orthologs for CBWD6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for CBWD6 gene from 8/23 species (see all 23) About this table
ENSEMBL Gene Tree for CBWD6 (if available) TreeFam Gene Tree for CBWD6 (if available)  |
Paralogs for CBWD6 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for CBWD6 gene
- CBWD31 2 CBWD22 CBWD12 CBWD72 CBWD52
5 SIMAP similar genes for CBWD6 using alignment to 6 protein entries: CBWD6_HUMAN (see all proteins):CBWD3 CBWD7 CBWD5 CBWD2 CBWD1
CBWD6 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CBWD6 PGOHUM00000236194
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Genomic Variants for CBWD6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 9 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for CBWD6 (69204538 - 69272478 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 12 variations for CBWD6 11 CNVs: 83041 7748 23255 96094 83042 83040 3770 2144 96093 2819 22958 1 Inversion: 37337  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CBWD6 |
|
Disorders
/ Diseases for CBWD6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CBWD6 for disorders About GeneDecksing
1 disease for CBWD6: About MalaCardsmalaria Export disorders for CBWD6 gene to outside databases
|
Publications for CBWD6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CBWD6 gene integrated from 9 sources: (articles sorted by number of sources associating them with CBWD6) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CBWD6 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing CBWD6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CBWD6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CBWD6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for CBWD6 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CBWD6 gene: Search GeneIP for patents involving CBWD6
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products for CBWD6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for CBWD6 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CBWD6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CBWD6 | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for CBWD6 | | OriGene 3'-UTR Clone for CBWD6 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CBWD6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBWD6 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for CBWD6 | | OriGene Custom Protein Services for CBWD6 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CBWD6 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CBWD6 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBWD6 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CBWD6 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBWD6 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBWD6 |
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| | | Search Tocris compounds for CBWD6 |
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 | | CBWD6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBWD6 |
|  |  |  | | | Search ThermoFisher Antibodies for CBWD6 |
| | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CBWD6 |
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