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Aliases for CBWD5 Gene

Aliases for CBWD5 Gene

  • COBW Domain Containing 5 2 3 5
  • Cobalamin Synthase W Domain-Containing Protein 5 3 4
  • Dopamine Responsive Protein 2 3
  • Cobalamin Synthetase W Domain-Containing Protein 5 3
  • COBW-Like Placental Protein 3
  • DC36 3

External Ids for CBWD5 Gene

Previous GeneCards Identifiers for CBWD5 Gene

  • GC09P068088
  • GC09M069672
  • GC09M070432

Summaries for CBWD5 Gene

GeneCards Summary for CBWD5 Gene

CBWD5 (COBW Domain Containing 5) is a Protein Coding gene. An important paralog of this gene is CBWD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBWD5 Gene

Genomics for CBWD5 Gene

Regulatory Elements for CBWD5 Gene

Enhancers for CBWD5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CBWD5 on UCSC Golden Path with GeneCards custom track

Promoters for CBWD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CBWD5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CBWD5 Gene

65,668,805 bp from pter
65,734,041 bp from pter
65,237 bases
Plus strand

Genomic View for CBWD5 Gene

Genes around CBWD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBWD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBWD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBWD5 Gene

Proteins for CBWD5 Gene

  • Protein details for CBWD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COBW domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • Q8N7U8

    Protein attributes for CBWD5 Gene

    395 amino acids
    Molecular mass:
    44068 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CBWD5 Gene


neXtProt entry for CBWD5 Gene

Proteomics data for CBWD5 Gene at MOPED

Post-translational modifications for CBWD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CBWD5 Gene

Domains & Families for CBWD5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 cobW C-terminal domain.
  • Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
  • Contains 1 cobW C-terminal domain.
  • Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
genes like me logo Genes that share domains with CBWD5: view

No data available for Gene Families for CBWD5 Gene

Function for CBWD5 Gene

Phenotypes for CBWD5 Gene

GenomeRNAi human phenotypes for CBWD5:
genes like me logo Genes that share phenotypes with CBWD5: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CBWD5 Gene

Localization for CBWD5 Gene

Subcellular locations from

Jensen Localization Image for CBWD5 Gene COMPARTMENTS Subcellular localization image for CBWD5 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CBWD5 Gene

Pathways & Interactions for CBWD5 Gene

SuperPathways for CBWD5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CBWD5 Gene


No data available for Pathways by source and SIGNOR curated interactions for CBWD5 Gene

Drugs & Compounds for CBWD5 Gene

No Compound Related Data Available

Transcripts for CBWD5 Gene

Unigene Clusters for CBWD5 Gene

COBW domain containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CBWD5 Gene

No ASD Table

Relevant External Links for CBWD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CBWD5 Gene

mRNA expression in normal human tissues for CBWD5 Gene

SOURCE GeneReport for Unigene cluster for CBWD5 Gene Hs.355950

genes like me logo Genes that share expression patterns with CBWD5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CBWD5 Gene

Orthologs for CBWD5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CBWD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 77 (a)
(Canis familiaris)
Mammalia -- 36
  • 79 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
(Mus musculus)
Mammalia Cbwd1 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
(Pan troglodytes)
Mammalia CBWD2 36
  • 86 (a)
(Gallus gallus)
Aves CBWD1 36
  • 63 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12250 35
(Danio rerio)
Actinopterygii cbwd 36
  • 63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 27 (a)
Species with no ortholog for CBWD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBWD5 Gene

Gene Tree for CBWD5 (if available)
Gene Tree for CBWD5 (if available)

Paralogs for CBWD5 Gene

Paralogs for CBWD5 Gene

(5) SIMAP similar genes for CBWD5 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CBWD5: view

Variants for CBWD5 Gene

Sequence variations from dbSNP and Humsavar for CBWD5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_067710 -
VAR_067711 -
VAR_067712 -
VAR_067713 -
VAR_067714 -

Structural Variations from Database of Genomic Variants (DGV) for CBWD5 Gene

Variant ID Type Subtype PubMed ID
dgv2381e1 CNV Complex 17122850
dgv135n16 CNV Deletion 17901297
esv33449 CNV Loss 17666407
essv2899 CNV CNV 17122850
nsv469665 CNV Complex 16826518
dgv2383e1 CNV Complex 17122850
nsv8518 CNV Gain+Loss 18304495

Variation tolerance for CBWD5 Gene

Gene Damage Index Score: 0.31; 6.94% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CBWD5 Gene

Disorders for CBWD5 Gene

Relevant External Links for CBWD5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CBWD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBWD5 Gene

Publications for CBWD5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Is DARPP-32 a potential therapeutic target? (PMID: 18020984) Reis H.J. … Romano-Silva M.A. (Expert Opin. Ther. Targets 2007) 23
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PMID: 12421752) Fan Y. … Trask B.J. (Genome Res. 2002) 3

Products for CBWD5 Gene

Sources for CBWD5 Gene