Aliases for CBWD5 Gene
Aliases for CBWD5 Gene
External Ids for CBWD5 Gene
- HGNC: 24584
- Entrez Gene: 220869
- Ensembl: ENSG00000147996
- UniProtKB: Q5RIA9
Previous GeneCards Identifiers for CBWD5 Gene
- GC09P068088
- GC09M069672
- GC09M070432
Summaries for CBWD5 Gene
GeneCards Summary for CBWD5 Gene
CBWD5 (COBW Domain Containing 5) is a Protein Coding gene. An important paralog of this gene is CBWD3.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBWD5 Gene
Genomics for CBWD5 Gene
Regulatory Elements for CBWD5 Gene
Enhancers for CBWD5 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CBWD5 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for CBWD5 Gene
- Chromosome:
- 9
- Start:
- 65,668,805 bp from pter
- End:
- 65,734,041 bp from pter
- Size:
- 65,237 bases
- Orientation:
- Plus strand
Genomic View for CBWD5 Gene
Genes around CBWD5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q21.11 by Ensembl
- 9q21.11 by Entrez Gene
- 9q21.11 by HGNC
CBWD5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBWD5 Gene
Proteins for CBWD5 Gene
-
Protein details for CBWD5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5RIA9-CBWD5_HUMAN
- Recommended name:
- COBW domain-containing protein 5
- Protein Accession:
- Q5RIA9
- Q8N7U8
Protein attributes for CBWD5 Gene
- Size:
- 395 amino acids
- Molecular mass:
- 44068 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for CBWD5 Gene
Other Protein References for CBWD5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for CBWD5
Protein Products
-
OriGene Purified Proteins for CBWD5
- Search Origene for MassSpec and Protein Over-expression Lysates for CBWD5
- Origene Custom Protein Services for CBWD5
- Search GeneTex for Proteins for CBWD5
Assay Products
No data available for DME Specific Peptides for CBWD5 Gene
Domains & Families for CBWD5 Gene
Protein Domains for CBWD5 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CBWD5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5RIA9- Family:
-
- Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
No data available for Gene Families for CBWD5 Gene
Function for CBWD5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for CBWD5 Gene
- GenomeRNAi human phenotypes for CBWD5:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBWD5
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CBWD5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CBWD5 gene
- Search ViGene Biosciences for CBWD5
CRISPR Products
-
OriGene CRISPR knockouts for CBWD5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBWD5
- GenScript: Design CRISPR guide RNA sequences for CBWD5
miRNA for CBWD5 Gene
- miRTarBase miRNAs that target CBWD5
-
- hsa-mir-5089-3p (MIRT499115)
- hsa-mir-8081 (MIRT499116)
- hsa-mir-6790-5p (MIRT499117)
- hsa-mir-4658 (MIRT499118)
- hsa-mir-4758-5p (MIRT499119)
- hsa-mir-1238-5p (MIRT499120)
- hsa-mir-421 (MIRT499121)
- hsa-mir-505-3p (MIRT499122)
- hsa-mir-7159-5p (MIRT499123)
- hsa-mir-1909-5p (MIRT499124)
- hsa-mir-3065-5p (MIRT499125)
- hsa-mir-511-3p (MIRT499126)
- hsa-mir-7-2-3p (MIRT499127)
- hsa-mir-7-1-3p (MIRT499128)
- hsa-mir-4272 (MIRT504072)
miRNA Products
- Search ViGene Biosciences for CBWD5
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CBWD5
- Browse OriGene Inhibitory RNA Products For CBWD5
-
ViGene Biosciences ready-to-package AAV shRNAs for CBWD5 gene
Clone Products
- Sino Biological Human cDNA Clone for CBWD5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CBWD5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBWD5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CBWD5
-
ViGene Biosciences adenoviral particle packaged cDNA for CBWD5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CBWD5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CBWD5 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CBWD5 Gene
Localization for CBWD5 Gene
| Compartment | Confidence |
|---|---|
| peroxisome | 2 |
| nucleus | 2 |
| cytosol | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CBWD5 Gene
Pathways & Interactions for CBWD5 Gene
No Data Available
Interacting Proteins for CBWD5 Gene
No data available for Pathways by source and SIGNOR curated interactions for CBWD5 Gene
Transcripts for CBWD5 Gene
mRNA/cDNA for CBWD5 Gene
- (16) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (347) Selected AceView cDNA sequences:
- (33) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CBWD5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CBWD5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBWD5
- GenScript: Design CRISPR guide RNA sequences for CBWD5
miRNA Products
- Search ViGene Biosciences for CBWD5
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CBWD5
- Browse OriGene Inhibitory RNA Products For CBWD5
-
ViGene Biosciences ready-to-package AAV shRNAs for CBWD5 gene
Clone Products
- Sino Biological Human cDNA Clone for CBWD5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CBWD5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBWD5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CBWD5 Gene
NURSA nuclear receptor signaling pathways regulating expression of CBWD5 Gene:
CBWD5SOURCE GeneReport for Unigene cluster for CBWD5 Gene:
Hs.355950Primer Products
-
OriGene qPCR primer pairs for CBWD5
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBWD5 Gene
Orthologs for CBWD5 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CBWD2 35 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Cbwd1 35 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | CBWD1 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.12250 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cbwd 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 35 |
|
OneToMany |
- Species where no ortholog for CBWD5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CBWD5 Gene
(5) SIMAP similar genes for CBWD5 Gene using alignment to 8 proteins:
Pseudogenes.org Pseudogenes for CBWD5 Gene
Variants for CBWD5 Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000645646 | -- | 65,687,839(-) | CAAAA(A/C)TAAAG | intron-variant | |
| rs1000676818 | -- | 65,682,095(-) | TCTAG(A/G)GTCTA | intron-variant | |
| rs1002905309 | -- | 65,678,626(-) | CTAAA(A/G)TTCAT | intron-variant | |
| rs1003209341 | -- | 65,675,630(-) | GGTAG(A/G)GCTGA | intron-variant, upstream-variant-2KB | |
| rs1003651170 | -- | 65,671,026(-) | AACTT(C/G)ATATG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4057n106 | CNV | duplication | 24896259 |
| dgv4429e59 | CNV | duplication | 20981092 |
| dgv4438e59 | CNV | duplication | 20981092 |
| esv3346588 | CNV | duplication | 20981092 |
| esv3382518 | CNV | duplication | 20981092 |
| esv3395969 | CNV | duplication | 20981092 |
| esv3400365 | CNV | duplication | 20981092 |
| esv3416825 | CNV | duplication | 20981092 |
| esv3446582 | CNV | duplication | 20981092 |
| esv992234 | CNV | gain | 20482838 |
| nsv1075625 | CNV | deletion | 25765185 |
| nsv1077151 | CNV | deletion | 25765185 |
| nsv1077557 | CNV | duplication | 25765185 |
| nsv1078088 | CNV | duplication | 25765185 |
| nsv1110533 | CNV | duplication | 24896259 |
| nsv1110576 | CNV | duplication | 24896259 |
| nsv1115837 | CNV | duplication | 24896259 |
| nsv1125055 | CNV | duplication | 24896259 |
| nsv1147212 | CNV | duplication | 26484159 |
| nsv1151480 | CNV | duplication | 26484159 |
| nsv1152669 | CNV | duplication | 26484159 |
| nsv428218 | CNV | loss | 18775914 |
| nsv6547 | CNV | insertion | 18451855 |
| nsv951495 | CNV | duplication | 24416366 |
| nsv951514 | CNV | duplication | 24416366 |
| nsv951521 | CNV | duplication | 24416366 |
| nsv968698 | CNV | duplication | 23825009 |
| nsv969691 | CNV | duplication | 23825009 |
| nsv982299 | CNV | duplication | 23825009 |
| nsv982301 | CNV | duplication | 23825009 |
Gene Damage Index Score:
0.31;
6.94% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CBWD5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CBWD5
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBWD5 Gene
Disorders for CBWD5 Gene
Relevant External Links for CBWD5
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CBWD5
No disorders were found for CBWD5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBWD5 Gene
Publications for CBWD5 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Is DARPP-32 a potential therapeutic target? (PMID: 18020984) Reis H.J. … Romano-Silva M.A. (Expert Opin. Ther. Targets 2007) 22 64
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
- A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3 64
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4 64
Products for CBWD5 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Custom Antibody Services
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- OriGene Purified Proteins for CBWD5
- Search Origene for MassSpec and Protein Over-expression Lysates for CBWD5
- Origene Custom Protein Services for CBWD5
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBWD5
- Browse OriGene Inhibitory RNA Products For CBWD5
- OriGene qPCR primer pairs for CBWD5
- OriGene CRISPR knockouts for CBWD5
- OriGene ORF clones in human for CBWD5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CBWD5
- GenScript: Next-day shipping cDNA ORF clone for CBWD5 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CBWD5
- GenScript Custom Assay Services for CBWD5
- GenScript Custom overexpressing Cell Line Services for CBWD5
- GenScript: Design CRISPR guide RNA sequences for CBWD5
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Sino Biological Human cDNA Clone for CBWD5
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for CBWD5 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CBWD5 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CBWD5 gene
- Search ViGene Biosciences for CBWD5
- Horizon Cell Lines for CBWD5
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBWD5
- VectorBuilder custom plasmid, inducible vectors for CBWD5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBWD5
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CBWD5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer