CBWD5 Gene
protein-coding GIFtS: 43
GCID: GC09M070432
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|
COBW domain containing 5
| |
Aliases
for CBWD5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| COBW Domain Containing 51 2 | | COBW Domain-Containing Protein 52 | | Cobalamin Synthase W Domain-Containing Protein 52 3 | | COBW-Like Placental Protein2 | | DC362 | | Dopamine Responsive Protein2 | | Cobalamin Synthetase W Domain-Containing Protein 52 | | |
Export aliases for CBWD5 gene to outside databasesPrevious GC identifers: GC09P068088 GC09M069672 |
Summaries
for CBWD5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CBWD5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_113816.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CBWD5 gene promoter:
GR Pax-6 ATF-2 GR-beta POU3F2 Cdc5 GATA-1 GR-alpha MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CBWD5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBWD5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q21.11 Ensembl cytogenetic band: 9q21.11 HGNC cytogenetic band: 9q13CBWD5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M070432: view genomic region
(about GC identifiers)
Start:
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70,432,004 bp from pter |
End:
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70,497,240 bp from pter |
Size:
|
65,237 bases |
Orientation:
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minus strand |
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Proteins
for CBWD5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CBWD5_HUMAN, Q5RIA9 (See
protein sequence)Recommended Name: COBW domain-containing protein 5 Size: 395 amino acids; 44068 Da
Secondary accessions: Q8N7U8Alternative splicing: 3 isoforms: Q5RIA9-1 Q5RIA9-2 Q5RIA9-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CBWD5: NX_Q5RIA9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5RIA9
CBWD5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001020087.2
ENSEMBL proteins: ENSP00000371842 ENSP00000418163 ENSP00000366612 ENSP00000397999 ENSP00000405076 ENSP00000366606 ENSP00000420326 ENSP00000417466 ENSP00000419839 ENSP00000420033 ENSP00000417957 ENSP00000420334 ENSP00000366601 ENSP00000366609
Human Recombinant Protein Products:
CBWD5 Antibody Products:
Assay Products for CBWD5: |
Protein
Domains /
Families
for CBWD5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CBWD5 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5RIA9ProtoNet protein and cluster: Q5RIA9 2 Blocks protein families: IPB003495 Cobalamin synthesis protein/P47K IPB011629 Cobalamin synthesis CobW
UniProtKB/Swiss-Prot: CBWD5_HUMAN, Q5RIA9Similarity: Belongs to the CobW familySimilarity: Contains 1 cobW C-terminal domain |
Function
for CBWD5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBWD5
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CBWD5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CBWD5 (NM_001024916) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CBWD5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBWD5 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- |
CBWD5 for ontologies About GeneDecksing
|
Pathways & Interactions
for CBWD5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CBWD5
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for CBWD5 (Q5RIA93 ENSP000003666124) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CBWD5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CBWD5
Search CenterWatch for drugs/clinical trials and news about CBWD5
|
Transcripts
for CBWD5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CBWD5 gene: NM_001024916.2 Unigene Clusters for CBWD5: COBW domain containing 5 Hs.355950 [show with all ESTs], Hs.635227 [show with all ESTs], Hs.645504 [show with all ESTs]Unigene Representative Sequences: AK097639, BC043420, BI25682218/34 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34): ENST00000382405(uc004aga.4 uc004agb.4 uc004agc.4 uc004afy.4 uc011lrm.2)
ENST00000461932 ENST00000485088 ENST00000480229(uc011lrn.2) ENST00000377395
ENST00000491485 ENST00000430059 ENST00000429800 ENST00000476797(uc004afz.4)
ENST00000377389 ENST00000486221(uc010moe.1) ENST00000463075 ENST00000480819
ENST00000489273 ENST00000497250(uc004agd.1) ENST00000468497 ENST00000486191
ENST00000468066
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBWD5
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CBWD5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CBWD5 (NM_001024916) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CBWD5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBWD5 |
Additional cDNA sequence: AF065414.1 24/56 DOTS entries (see all 56): DT.100038778 DT.99947945 DT.121202301 DT.100890097 DT.318244 DT.121166890 DT.121202407 DT.99992243 DT.97801554 DT.121156666 DT.95318807 DT.100890111 DT.121202221 DT.121156658 DT.121202492 DT.318240 DT.100038781 DT.121156677 DT.92460277 DT.95175866 DT.95361228 DT.121156661 DT.121156708 DT.121202224 24/320 AceView cDNA sequences (see all 320): BM784929 BC067803 CB266974 H26334 AI140353 BF173972 AI074452 AA485713 BM977399 AI935941 Z41806 AI932337 BE042747 BM797966 BI256822 W23781 N33387 Z46181 BQ020384 H20934 AW189867 AI886537 AI360580 BM711778
GeneLoc Exon Structure
|
Expression
for CBWD5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CBWD5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGTTTATA
About this image
See CBWD5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CBWD5
SOURCE GeneReport for Unigene clusters: Hs.355950 Hs.635227 Hs.645504
SABiosciences Custom PCR Arrays for CBWD5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CBWD5
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CBWD5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBWD5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBWD5 |
Orthologs
for CBWD5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for CBWD5 gene from 8/21 species (see all 21) About this table
ENSEMBL Gene Tree for CBWD5 (if available)
TreeFam Gene Tree for CBWD5 (if available) |
Paralogs
for CBWD5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CBWD5 gene
- CBWD22 CBWD62 CBWD32 CBWD12 CBWD72
5 SIMAP similar genes for CBWD5 using alignment to 10 protein entries: CBWD5_HUMAN (see all proteins):CBWD7 CBWD3 CBWD6 CBWD2 CBWD1
CBWD5 for paralogs About GeneDecksing
|
Genomic Variants
for CBWD5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CBWD5 (70432004 - 70497240 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for CBWD5
7 CNVs: 33131 7748 3770 23255 31515 22958 2819
1 Inversion: 37337 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CBWD5 |
|
Disorders
/ Diseases
for CBWD5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CBWD5 for disorders About GeneDecksing
2  diseases for CBWD5: About MalaCardsmalaria neuronitis
Export disorders for CBWD5 gene to outside databases
|
Publications
for CBWD5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CBWD5 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with CBWD5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PubMed id 12421752)1 Fan Y.... Trask B.J. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The development of a genetic profile of placental gene expression during the first trimester of pregnancy: a potential tool for identifying novel secreted markers. (PubMed id 10867487)1 Page N.M.... Lowry P.J. (2000)
|
External Searches for CBWD5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CBWD5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CBWD5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CBWD5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CBWD5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CBWD5 gene:
Search GeneIP for patents involving CBWD5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CBWD5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CBWD5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CBWD5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CBWD5 | | | OriGene Protein Over-expression Lysate for CBWD5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CBWD5 | | OriGene 3'-UTR Clone for CBWD5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CBWD5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBWD5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | CBWD5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for CBWD5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBWD5 |
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