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Aliases for CBWD5 Gene

Aliases for CBWD5 Gene

  • COBW Domain Containing 5 2 3 5
  • Cobalamin Synthase W Domain-Containing Protein 5 3 4
  • Dopamine Responsive Protein 2 3
  • Cobalamin Synthetase W Domain-Containing Protein 5 3
  • COBW Domain-Containing Protein 5 3
  • COBW-Like Placental Protein 3
  • DC36 3

External Ids for CBWD5 Gene

Previous GeneCards Identifiers for CBWD5 Gene

  • GC09P068088
  • GC09M069672
  • GC09M070432

Summaries for CBWD5 Gene

GeneCards Summary for CBWD5 Gene

CBWD5 (COBW Domain Containing 5) is a Protein Coding gene. An important paralog of this gene is CBWD6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBWD5 Gene

Genomics for CBWD5 Gene

Regulatory Elements for CBWD5 Gene


Promoters for CBWD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001909104 1295 201

Genomic Location for CBWD5 Gene

Chromosome:
9
Start:
65,668,805 bp from pter
End:
65,734,041 bp from pter
Size:
65,237 bases
Orientation:
Plus strand

Genomic View for CBWD5 Gene

Genes around CBWD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBWD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBWD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBWD5 Gene

Proteins for CBWD5 Gene

  • Protein details for CBWD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5RIA9-CBWD5_HUMAN
    Recommended name:
    COBW domain-containing protein 5
    Protein Accession:
    Q5RIA9
    Secondary Accessions:
    • Q8N7U8

    Protein attributes for CBWD5 Gene

    Size:
    395 amino acids
    Molecular mass:
    44068 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CBWD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CBWD5 Gene

Post-translational modifications for CBWD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CBWD5 Gene

Domains & Families for CBWD5 Gene

Graphical View of Domain Structure for InterPro Entry

Q5RIA9

UniProtKB/Swiss-Prot:

CBWD5_HUMAN :
  • Contains 1 cobW C-terminal domain.
  • Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
Domain:
  • Contains 1 cobW C-terminal domain.
Family:
  • Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
genes like me logo Genes that share domains with CBWD5: view

No data available for Gene Families for CBWD5 Gene

Function for CBWD5 Gene

Gene Ontology (GO) - Molecular Function for CBWD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CBWD5: view

Phenotypes for CBWD5 Gene

genes like me logo Genes that share phenotypes with CBWD5: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CBWD5 Gene

Localization for CBWD5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CBWD5 Gene COMPARTMENTS Subcellular localization image for CBWD5 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CBWD5 Gene

Pathways & Interactions for CBWD5 Gene

SuperPathways for CBWD5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CBWD5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CBWD5 Gene

Transcripts for CBWD5 Gene

Unigene Clusters for CBWD5 Gene

COBW domain containing 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CBWD5 Gene

No ASD Table

Relevant External Links for CBWD5 Gene

GeneLoc Exon Structure for
CBWD5
ECgene alternative splicing isoforms for
CBWD5

Expression for CBWD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CBWD5 Gene

NURSA nuclear receptor signaling pathways regulating expression of CBWD5 Gene:

CBWD5

SOURCE GeneReport for Unigene cluster for CBWD5 Gene:

Hs.355950
genes like me logo Genes that share expression patterns with CBWD5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CBWD5 Gene

Orthologs for CBWD5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CBWD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CBWD2 35
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 79 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cbwd1 35
  • 71 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 69 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves CBWD1 35
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 64 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.12250 34
zebrafish
(Danio rerio)
Actinopterygii cbwd 35
  • 63 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 27 (a)
OneToMany
Species where no ortholog for CBWD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBWD5 Gene

ENSEMBL:
Gene Tree for CBWD5 (if available)
TreeFam:
Gene Tree for CBWD5 (if available)

Paralogs for CBWD5 Gene

Paralogs for CBWD5 Gene

(5) SIMAP similar genes for CBWD5 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for CBWD5 Gene

genes like me logo Genes that share paralogs with CBWD5: view

Variants for CBWD5 Gene

Sequence variations from dbSNP and Humsavar for CBWD5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10114440 -- 65,705,748(-) TCTCT(A/G)TCTCT intron-variant, nc-transcript-variant
rs10115527 -- 65,689,491(-) GAATG(A/G)ACAAA intron-variant
rs10115528 -- 65,721,922(-) atagg(C/T)gagga intron-variant, nc-transcript-variant
rs10116928 -- 65,682,596(-) ACCAG(G/T)GAGAA intron-variant
rs10120265 -- 65,711,565(-) acaac(C/G)cgtca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CBWD5 Gene

Variant ID Type Subtype PubMed ID
dgv4057n106 CNV duplication 24896259
dgv4429e59 CNV duplication 20981092
dgv4438e59 CNV duplication 20981092
esv3346588 CNV duplication 20981092
esv3382518 CNV duplication 20981092
esv3395969 CNV duplication 20981092
esv3400365 CNV duplication 20981092
esv3416825 CNV duplication 20981092
esv3446582 CNV duplication 20981092
esv992234 CNV gain 20482838
nsv1075625 CNV deletion 25765185
nsv1077151 CNV deletion 25765185
nsv1077557 CNV duplication 25765185
nsv1078088 CNV duplication 25765185
nsv1110533 CNV duplication 24896259
nsv1110576 CNV duplication 24896259
nsv1115837 CNV duplication 24896259
nsv1125055 CNV duplication 24896259
nsv1147212 CNV duplication 26484159
nsv1151480 CNV duplication 26484159
nsv1152669 CNV duplication 26484159
nsv428218 CNV loss 18775914
nsv6547 CNV insertion 18451855
nsv951495 CNV duplication 24416366
nsv951514 CNV duplication 24416366
nsv951521 CNV duplication 24416366
nsv968698 CNV duplication 23825009
nsv969691 CNV duplication 23825009
nsv982299 CNV duplication 23825009
nsv982301 CNV duplication 23825009

Variation tolerance for CBWD5 Gene

Gene Damage Index Score: 0.31; 6.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CBWD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CBWD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBWD5 Gene

Disorders for CBWD5 Gene

Relevant External Links for CBWD5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CBWD5

No disorders were found for CBWD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBWD5 Gene

Publications for CBWD5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Is DARPP-32 a potential therapeutic target? (PMID: 18020984) Reis H.J. … Romano-Silva M.A. (Expert Opin. Ther. Targets 2007) 22 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3 64
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4 64

Products for CBWD5 Gene

Sources for CBWD5 Gene

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