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Aliases for CBWD3 Gene

Aliases for CBWD3 Gene

  • COBW Domain Containing 3 2 3
  • Cobalamin Synthase W Domain-Containing Protein 3 3 4
  • Cobalamin Synthetase W Domain-Containing Protein 3 3
  • BA561O23.1 3

External Ids for CBWD3 Gene

Previous GeneCards Identifiers for CBWD3 Gene

  • GC00U921005
  • GC09U900666
  • GC09P068087
  • GC09P070046
  • GC09P070849

Summaries for CBWD3 Gene

GeneCards Summary for CBWD3 Gene

CBWD3 (COBW Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is CBWD6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBWD3 Gene

Genomics for CBWD3 Gene

Regulatory Elements for CBWD3 Gene

Genomic Location for CBWD3 Gene

Chromosome:
9
Start:
68,232,003 bp from pter
End:
68,300,035 bp from pter
Size:
68,033 bases
Orientation:
Plus strand

Genomic View for CBWD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CBWD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBWD3 Gene

Proteins for CBWD3 Gene

  • Protein details for CBWD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JTY5-CBWD3_HUMAN
    Recommended name:
    COBW domain-containing protein 3
    Protein Accession:
    Q5JTY5
    Secondary Accessions:
    • B4DNG9
    • Q6VB91

    Protein attributes for CBWD3 Gene

    Size:
    395 amino acids
    Molecular mass:
    44038 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CBWD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CBWD3 Gene

Proteomics data for CBWD3 Gene at MOPED

Post-translational modifications for CBWD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CBWD3 Gene

Domains & Families for CBWD3 Gene

Suggested Antigen Peptide Sequences for CBWD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q5JTY5

UniProtKB/Swiss-Prot:

CBWD3_HUMAN :
  • Contains 1 cobW C-terminal domain.
  • Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
Domain:
  • Contains 1 cobW C-terminal domain.
Family:
  • Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
genes like me logo Genes that share domains with CBWD3: view

No data available for Gene Families for CBWD3 Gene

Function for CBWD3 Gene

Gene Ontology (GO) - Molecular Function for CBWD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CBWD3: view

Animal Model Products

CRISPR Products

miRNA for CBWD3 Gene

miRTarBase miRNAs that target CBWD3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CBWD3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for CBWD3 Gene

Localization for CBWD3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CBWD3 Gene

Pathways & Interactions for CBWD3 Gene

SuperPathways for CBWD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CBWD3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CBWD3 Gene

Drugs & Compounds for CBWD3 Gene

No Compound Related Data Available

Transcripts for CBWD3 Gene

mRNA/cDNA for CBWD3 Gene

(7) REFSEQ mRNAs :
(19) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CBWD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CBWD3 Gene

No ASD Table

Relevant External Links for CBWD3 Gene

GeneLoc Exon Structure for
CBWD3
ECgene alternative splicing isoforms for
CBWD3

Expression for CBWD3 Gene

mRNA expression in normal human tissues for CBWD3 Gene

genes like me logo Genes that share expression patterns with CBWD3: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CBWD3 Gene

Orthologs for CBWD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CBWD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 90 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cbwd1 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CBWD2 36
  • 98 (a)
OneToMany
chicken
(Gallus gallus)
Aves CBWD1 36
  • 73 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii cbwd 36
  • 72 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 32 (a)
OneToMany
Species with no ortholog for CBWD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBWD3 Gene

ENSEMBL:
Gene Tree for CBWD3 (if available)
TreeFam:
Gene Tree for CBWD3 (if available)

Paralogs for CBWD3 Gene

Paralogs for CBWD3 Gene

(5) SIMAP similar genes for CBWD3 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for CBWD3 Gene

genes like me logo Genes that share paralogs with CBWD3: view

Variants for CBWD3 Gene

Sequence variations from dbSNP and Humsavar for CBWD3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs707729 -- 68,269,936(+) CCTGC(A/G)TTTCA intron-variant
rs987600 -- 68,254,523(+) ATACA(A/T)GTTTC intron-variant
rs1043609 -- 68,299,025(+) GCTCT(A/G)TGATC reference, missense, intron-variant
rs1127332 -- 68,297,603(+) TTTGA(A/C)GTACC reference, missense
rs1331406 -- 68,253,162(-) gtgag(A/G)aagtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CBWD3 Gene

Variant ID Type Subtype PubMed ID
dgv2381e1 CNV Complex 17122850
dgv135n16 CNV Deletion 17901297
esv33449 CNV Loss 17666407
essv2899 CNV CNV 17122850
nsv469665 CNV Complex 16826518
dgv2383e1 CNV Complex 17122850
nsv8518 CNV Gain+Loss 18304495
dgv8238n71 CNV Gain 21882294
esv992234 CNV Gain 20482838
dgv2384e1 CNV Complex 17122850
dgv2385e1 CNV Complex 17122850
nsv428218 CNV Loss 18775914
nsv6547 CNV Insertion 18451855
nsv831608 CNV Loss 17160897
dgv8240n71 CNV Gain 21882294
nsv893404 CNV Gain 21882294
nsv831609 CNV Gain 17160897

Variation tolerance for CBWD3 Gene

Gene Damage Index Score: 18.22; 98.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CBWD3 Gene

HapMap Linkage Disequilibrium report
CBWD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBWD3 Gene

Disorders for CBWD3 Gene

Relevant External Links for CBWD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CBWD3
genes like me logo Genes that share disorders with CBWD3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBWD3 Gene

Publications for CBWD3 Gene

  1. Diverse fates of paralogs following segmental duplication of telomeric genes. (PMID: 15233989) Wong A. … Ledbetter D.H. (Genomics 2004) 2 67
  2. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PMID: 12421752) Fan Y. … Trask B.J. (Genome Res. 2002) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 67
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 67

Products for CBWD3 Gene

Sources for CBWD3 Gene

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