Aliases for CBWD3 Gene
Aliases for CBWD3 Gene
External Ids for CBWD3 Gene
- HGNC: 18519
- Entrez Gene: 445571
- Ensembl: ENSG00000196873
- OMIM: 611080
- UniProtKB: Q5JTY5
Previous GeneCards Identifiers for CBWD3 Gene
- GC00U921005
- GC09U900666
- GC09P068087
- GC09P070046
- GC09P070849
Summaries for CBWD3 Gene
GeneCards Summary for CBWD3 Gene
CBWD3 (COBW Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is CBWD6.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBWD3 Gene
Genomics for CBWD3 Gene
Regulatory Elements for CBWD3 Gene
Enhancers for CBWD3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH09G069044 | 0.8 | Ensembl ENCODE | 4.5 | +812.8 | 812808 | 1.6 | ARID1B TCF12 RFX1 NCOR1 TAL1 SCRT2 ID3 | PRKACG FXN TJP2 CBWD3 GC09P069043 PIR41938 GC09P069091 |
| GH09G068234 | 0.2 | Ensembl | 0.7 | +4.0 | 3998 | 2.4 | CBWD3 ENSG00000279706 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CBWD3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CBWD3 gene promoter:
Regulatory Element Products
Genomic Location for CBWD3 Gene
- Chromosome:
- 9
- Start:
- 68,232,003 bp from pter
- End:
- 68,300,035 bp from pter
- Size:
- 68,033 bases
- Orientation:
- Plus strand
Genomic View for CBWD3 Gene
Genes around CBWD3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q21.11 by Ensembl
- 9q21.11 by Entrez Gene
- 9q21.11 by HGNC
CBWD3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBWD3 Gene
Proteins for CBWD3 Gene
-
Protein details for CBWD3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5JTY5-CBWD3_HUMAN
- Recommended name:
- COBW domain-containing protein 3
- Protein Accession:
- Q5JTY5
- B4DNG9
- Q6VB91
Protein attributes for CBWD3 Gene
- Size:
- 395 amino acids
- Molecular mass:
- 44038 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for CBWD3 Gene
Other Protein References for CBWD3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CBWD3
- Search GeneTex for Antibodies for CBWD3
Protein Products
-
OriGene Purified Proteins for CBWD3
- Search Origene for MassSpec and Protein Over-expression Lysates for CBWD3
- Origene Custom Protein Services for CBWD3
- Search GeneTex for Proteins for CBWD3
-
ProSci Proteins for CBWD3
Assay Products
No data available for DME Specific Peptides for CBWD3 Gene
Domains & Families for CBWD3 Gene
Protein Domains for CBWD3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CBWD3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5JTY5- Family:
-
- Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
No data available for Gene Families for CBWD3 Gene
Function for CBWD3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005524 | ATP binding | IEA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBWD3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CBWD3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CBWD3 gene
- Search ViGene Biosciences for CBWD3
CRISPR Products
-
OriGene CRISPR knockouts for CBWD3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBWD3
- GenScript: Design CRISPR guide RNA sequences for CBWD3
miRNA for CBWD3 Gene
- miRTarBase miRNAs that target CBWD3
miRNA Products
- Search ViGene Biosciences for CBWD3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBWD3
- Browse OriGene Inhibitory RNA Products For CBWD3
-
ViGene Biosciences ready-to-package AAV shRNAs for CBWD3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CBWD3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBWD3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CBWD3
-
ViGene Biosciences adenoviral particle packaged cDNA for CBWD3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CBWD3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CBWD3 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CBWD3 Gene
Localization for CBWD3 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| cytosol | 2 |
| peroxisome | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CBWD3 Gene
Pathways & Interactions for CBWD3 Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for CBWD3 Gene
Transcripts for CBWD3 Gene
mRNA/cDNA for CBWD3 Gene
- (11) REFSEQ mRNAs :
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CBWD3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBWD3
- GenScript: Design CRISPR guide RNA sequences for CBWD3
miRNA Products
- Search ViGene Biosciences for CBWD3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBWD3
- Browse OriGene Inhibitory RNA Products For CBWD3
-
ViGene Biosciences ready-to-package AAV shRNAs for CBWD3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CBWD3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBWD3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CBWD3 Gene
NURSA nuclear receptor signaling pathways regulating expression of CBWD3 Gene:
CBWD3Primer Products
-
OriGene qPCR primer pairs for CBWD3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBWD3 Gene
Orthologs for CBWD3 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CBWD2 35 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Cbwd1 35 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | CBWD1 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | cbwd 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 35 |
|
OneToMany |
- Species where no ortholog for CBWD3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CBWD3 Gene
(5) SIMAP similar genes for CBWD3 Gene using alignment to 8 proteins:
Pseudogenes.org Pseudogenes for CBWD3 Gene
Variants for CBWD3 Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10083632 | -- | 68,277,578(+) | TTTGT(C/G)TTTGG | intron-variant | |
| rs10114848 | -- | 68,276,781(+) | TTGGC(A/G)ATGCG | intron-variant | |
| rs10115438 | -- | 68,250,261(+) | AAAGT(A/T)ATCAT | intron-variant | |
| rs10115441 | -- | 68,250,290(+) | AAGTA(A/G)Gggct | intron-variant | |
| rs10117536 | -- | 68,250,374(+) | ttcaa(A/G)accag | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4061n106 | CNV | duplication | 24896259 |
| dgv4438e59 | CNV | duplication | 20981092 |
| esv3400365 | CNV | duplication | 20981092 |
| esv992234 | CNV | gain | 20482838 |
| nsv1078088 | CNV | duplication | 25765185 |
| nsv1110576 | CNV | duplication | 24896259 |
| nsv1115837 | CNV | duplication | 24896259 |
| nsv1119313 | CNV | duplication | 24896259 |
| nsv1146589 | CNV | duplication | 26484159 |
| nsv1150027 | CNV | duplication | 26484159 |
| nsv1152669 | CNV | duplication | 26484159 |
| nsv428218 | CNV | loss | 18775914 |
| nsv6547 | CNV | insertion | 18451855 |
| nsv831608 | CNV | loss | 17160897 |
| nsv831609 | CNV | gain | 17160897 |
| nsv951521 | CNV | duplication | 24416366 |
| nsv969692 | CNV | duplication | 23825009 |
| nsv972754 | CNV | duplication | 23825009 |
| nsv982301 | CNV | duplication | 23825009 |
| nsv982302 | CNV | duplication | 23825009 |
| nsv982540 | CNV | duplication | 23825009 |
Gene Damage Index Score:
18.22;
98.49% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CBWD3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CBWD3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBWD3 Gene
Disorders for CBWD3 Gene
Relevant External Links for CBWD3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CBWD3
No disorders were found for CBWD3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBWD3 Gene
Publications for CBWD3 Gene
- Diverse fates of paralogs following segmental duplication of telomeric genes. (PMID: 15233989) Wong A. … Ledbetter D.H. (Genomics 2004) 2 3 4 64
- Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PMID: 12421752) Fan Y. … Trask B.J. (Genome Res. 2002) 2 3 4 64
- FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development. (PMID: 26124079) Nishiyama M. … Nakayama K.I. (Stem Cells 2015) 3 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3 64
Products for CBWD3 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
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- Browse Cell Culture Products
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- Browse Immunoprecipitation Assays
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CBWD3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CBWD3
- Search Origene for MassSpec and Protein Over-expression Lysates for CBWD3
- Origene Custom Protein Services for CBWD3
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBWD3
- Browse OriGene Inhibitory RNA Products For CBWD3
- OriGene qPCR primer pairs for CBWD3
- OriGene CRISPR knockouts for CBWD3
- OriGene ORF clones in human for CBWD3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CBWD3
- GenScript: Next-day shipping cDNA ORF clone for CBWD3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CBWD3
- GenScript Custom Assay Services for CBWD3
- GenScript Custom overexpressing Cell Line Services for CBWD3
- GenScript: Design CRISPR guide RNA sequences for CBWD3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Plasmid Preparation
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- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
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- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for CBWD3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CBWD3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CBWD3 gene
- Search ViGene Biosciences for CBWD3
- Search for CBWD3 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for CBWD3
- Horizon Cell Lines for CBWD3
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBWD3
- VectorBuilder custom plasmid, inducible vectors for CBWD3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBWD3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CBWD3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
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- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
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- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer