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Aliases for CBWD3 Gene

Aliases for CBWD3 Gene

  • COBW Domain Containing 3 2 3 5
  • Cobalamin Synthase W Domain-Containing Protein 3 3 4
  • Cobalamin Synthetase W Domain-Containing Protein 3 3
  • COBW Domain-Containing Protein 3 3
  • BA561O23.1 3

External Ids for CBWD3 Gene

Previous GeneCards Identifiers for CBWD3 Gene

  • GC00U921005
  • GC09U900666
  • GC09P068087
  • GC09P070046
  • GC09P070849

Summaries for CBWD3 Gene

GeneCards Summary for CBWD3 Gene

CBWD3 (COBW Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is CBWD6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBWD3 Gene

Genomics for CBWD3 Gene

Regulatory Elements for CBWD3 Gene

Enhancers for CBWD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F069044 1.2 Ensembl ENCODE 4.5 +812.8 812808 1.6 ARID1B RFX1 NCOR1 SCRT2 TAL1 ID3 PRKACG FXN TJP2 CBWD3 GC09P069043 GC09P069088 PIR41938
GH09F068234 0.5 Ensembl 0.8 +4.2 4198 2.8 CBWD3 ENSG00000279706
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CBWD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CBWD3 Gene

68,232,003 bp from pter
68,300,035 bp from pter
68,033 bases
Plus strand

Genomic View for CBWD3 Gene

Genes around CBWD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBWD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBWD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBWD3 Gene

Proteins for CBWD3 Gene

  • Protein details for CBWD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COBW domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • B4DNG9
    • Q6VB91

    Protein attributes for CBWD3 Gene

    395 amino acids
    Molecular mass:
    44038 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CBWD3 Gene


neXtProt entry for CBWD3 Gene

Post-translational modifications for CBWD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CBWD3 Gene

Domains & Families for CBWD3 Gene

Suggested Antigen Peptide Sequences for CBWD3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 cobW C-terminal domain.
  • Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
  • Contains 1 cobW C-terminal domain.
  • Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
genes like me logo Genes that share domains with CBWD3: view

No data available for Gene Families for CBWD3 Gene

Function for CBWD3 Gene

Gene Ontology (GO) - Molecular Function for CBWD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CBWD3: view

Animal Model Products

miRNA for CBWD3 Gene

miRTarBase miRNAs that target CBWD3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CBWD3 Gene

Localization for CBWD3 Gene

Subcellular locations from

Jensen Localization Image for CBWD3 Gene COMPARTMENTS Subcellular localization image for CBWD3 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CBWD3 Gene

Pathways & Interactions for CBWD3 Gene

SuperPathways for CBWD3 Gene

No Data Available

Interacting Proteins for CBWD3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)
Selected Interacting proteins: ENSP00000353295 Q5JTY5-CBWD3_HUMAN for CBWD3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CBWD3 Gene


No data available for Pathways by source and SIGNOR curated interactions for CBWD3 Gene

Transcripts for CBWD3 Gene

mRNA/cDNA for CBWD3 Gene

(11) REFSEQ mRNAs :
(19) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CBWD3 Gene

No ASD Table

Relevant External Links for CBWD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CBWD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CBWD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of CBWD3 Gene:

genes like me logo Genes that share expression patterns with CBWD3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CBWD3 Gene

Orthologs for CBWD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CBWD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CBWD2 35
  • 98 (a)
(Canis familiaris)
Mammalia -- 35
  • 90 (a)
(Bos Taurus)
Mammalia -- 35
  • 88 (a)
(Mus musculus)
Mammalia Cbwd1 35
  • 81 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 76 (a)
(Gallus gallus)
Aves CBWD1 35
  • 73 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 72 (a)
(Danio rerio)
Actinopterygii cbwd 35
  • 72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 32 (a)
Species where no ortholog for CBWD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBWD3 Gene

Gene Tree for CBWD3 (if available)
Gene Tree for CBWD3 (if available)

Paralogs for CBWD3 Gene

Paralogs for CBWD3 Gene

(5) SIMAP similar genes for CBWD3 Gene using alignment to 8 proteins: Pseudogenes for CBWD3 Gene

genes like me logo Genes that share paralogs with CBWD3: view

Variants for CBWD3 Gene

Sequence variations from dbSNP and Humsavar for CBWD3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10083632 -- 68,277,578(+) TTTGT(C/G)TTTGG intron-variant
rs10114848 -- 68,276,781(+) TTGGC(A/G)ATGCG intron-variant
rs10115438 -- 68,250,261(+) AAAGT(A/T)ATCAT intron-variant
rs10115441 -- 68,250,290(+) AAGTA(A/G)Gggct intron-variant
rs10117536 -- 68,250,374(+) ttcaa(A/G)accag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CBWD3 Gene

Variant ID Type Subtype PubMed ID
dgv4061n106 CNV duplication 24896259
dgv4438e59 CNV duplication 20981092
esv3400365 CNV duplication 20981092
esv992234 CNV gain 20482838
nsv1078088 CNV duplication 25765185
nsv1110576 CNV duplication 24896259
nsv1115837 CNV duplication 24896259
nsv1119313 CNV duplication 24896259
nsv1146589 CNV duplication 26484159
nsv1150027 CNV duplication 26484159
nsv1152669 CNV duplication 26484159
nsv428218 CNV loss 18775914
nsv6547 CNV insertion 18451855
nsv831608 CNV loss 17160897
nsv831609 CNV gain 17160897
nsv951521 CNV duplication 24416366
nsv969692 CNV duplication 23825009
nsv972754 CNV duplication 23825009
nsv982301 CNV duplication 23825009
nsv982302 CNV duplication 23825009
nsv982540 CNV duplication 23825009

Variation tolerance for CBWD3 Gene

Gene Damage Index Score: 18.22; 98.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CBWD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBWD3 Gene

Disorders for CBWD3 Gene

Relevant External Links for CBWD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CBWD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBWD3 Gene

Publications for CBWD3 Gene

  1. Diverse fates of paralogs following segmental duplication of telomeric genes. (PMID: 15233989) Wong A. … Ledbetter D.H. (Genomics 2004) 2 3 4 64
  2. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PMID: 12421752) Fan Y. … Trask B.J. (Genome Res. 2002) 2 3 4 64
  3. FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development. (PMID: 26124079) Nishiyama M. … Nakayama K.I. (Stem Cells 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3 64

Products for CBWD3 Gene

Sources for CBWD3 Gene

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