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Aliases for CBWD3 Gene

Aliases for CBWD3 Gene

  • COBW Domain Containing 3 2 3 5
  • Cobalamin Synthase W Domain-Containing Protein 3 3 4
  • Cobalamin Synthetase W Domain-Containing Protein 3 3
  • COBW Domain-Containing Protein 3 3
  • BA561O23.1 3

External Ids for CBWD3 Gene

Previous GeneCards Identifiers for CBWD3 Gene

  • GC00U921005
  • GC09U900666
  • GC09P068087
  • GC09P070046
  • GC09P070849

Summaries for CBWD3 Gene

GeneCards Summary for CBWD3 Gene

CBWD3 (COBW Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is CBWD5.

Additional gene information for CBWD3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBWD3 Gene

Genomics for CBWD3 Gene

Regulatory Elements for CBWD3 Gene

Enhancers for CBWD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H069044 0.8 Ensembl ENCODE 4.5 +812.8 812808 1.6 TCF12 RFX1 NCOR1 TAL1 SCRT2 ID3 PRKACG FXN TJP2 CBWD3 GC09P069043 PIR41938 GC09P069094
GH09H068234 0.2 Ensembl 0.7 +4.0 3998 2.4 CBWD3 ENSG00000279706
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CBWD3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CBWD3 Gene

Genomic Locations for CBWD3 Gene
68,033 bases
Plus strand

Genomic View for CBWD3 Gene

Genes around CBWD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBWD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBWD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBWD3 Gene

Proteins for CBWD3 Gene

  • Protein details for CBWD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COBW domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • B4DNG9
    • Q6VB91

    Protein attributes for CBWD3 Gene

    395 amino acids
    Molecular mass:
    44038 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CBWD3 Gene


neXtProt entry for CBWD3 Gene

Post-translational modifications for CBWD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CBWD3 Gene

Domains & Families for CBWD3 Gene

Gene Families for CBWD3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CBWD3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
  • Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
genes like me logo Genes that share domains with CBWD3: view

Function for CBWD3 Gene

Gene Ontology (GO) - Molecular Function for CBWD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CBWD3: view

miRNA for CBWD3 Gene

miRTarBase miRNAs that target CBWD3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CBWD3 Gene

Localization for CBWD3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CBWD3 gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CBWD3 Gene

Pathways & Interactions for CBWD3 Gene

SuperPathways for CBWD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CBWD3 Gene


No data available for Pathways by source and SIGNOR curated interactions for CBWD3 Gene

Drugs & Compounds for CBWD3 Gene

No Compound Related Data Available

Transcripts for CBWD3 Gene

mRNA/cDNA for CBWD3 Gene

(11) REFSEQ mRNAs :
(19) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CBWD3 Gene

No ASD Table

Relevant External Links for CBWD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CBWD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CBWD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of CBWD3 Gene:

genes like me logo Genes that share expression patterns with CBWD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBWD3 Gene

Orthologs for CBWD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CBWD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CBWD2 34
  • 98 (a)
(Canis familiaris)
Mammalia -- 34
  • 90 (a)
(Bos Taurus)
Mammalia -- 34
  • 88 (a)
(Mus musculus)
Mammalia Cbwd1 34
  • 81 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 76 (a)
(Gallus gallus)
Aves CBWD1 34
  • 73 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 72 (a)
(Danio rerio)
Actinopterygii cbwd 34
  • 72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 32 (a)
Species where no ortholog for CBWD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBWD3 Gene

Gene Tree for CBWD3 (if available)
Gene Tree for CBWD3 (if available)

Paralogs for CBWD3 Gene

Paralogs for CBWD3 Gene

(5) SIMAP similar genes for CBWD3 Gene using alignment to 8 proteins: Pseudogenes for CBWD3 Gene

genes like me logo Genes that share paralogs with CBWD3: view

Variants for CBWD3 Gene

Sequence variations from dbSNP and Humsavar for CBWD3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10083632 -- 68,277,578(+) TTTGT(C/G)TTTGG intron-variant
rs10114848 -- 68,276,781(+) TTGGC(A/G)ATGCG intron-variant
rs10115438 -- 68,250,261(+) AAAGT(A/T)ATCAT intron-variant
rs10115441 -- 68,250,290(+) AAGTA(A/G)Gggct intron-variant
rs10117536 -- 68,250,374(+) ttcaa(A/G)accag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CBWD3 Gene

Variant ID Type Subtype PubMed ID
nsv982540 CNV duplication 23825009
nsv982302 CNV duplication 23825009
nsv982301 CNV duplication 23825009
nsv972754 CNV duplication 23825009
nsv969692 CNV duplication 23825009
nsv951521 CNV duplication 24416366
nsv831609 CNV gain 17160897
nsv831608 CNV loss 17160897
nsv6547 CNV insertion 18451855
nsv428218 CNV loss 18775914
nsv1152669 CNV duplication 26484159
nsv1150027 CNV duplication 26484159
nsv1146589 CNV duplication 26484159
nsv1119313 CNV duplication 24896259
nsv1115837 CNV duplication 24896259
nsv1110576 CNV duplication 24896259
nsv1078088 CNV duplication 25765185
esv992234 CNV gain 20482838
esv3400365 CNV duplication 20981092
dgv4438e59 CNV duplication 20981092
dgv4061n106 CNV duplication 24896259

Variation tolerance for CBWD3 Gene

Gene Damage Index Score: 18.22; 98.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CBWD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBWD3 Gene

Disorders for CBWD3 Gene

Relevant External Links for CBWD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CBWD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBWD3 Gene

Publications for CBWD3 Gene

  1. Diverse fates of paralogs following segmental duplication of telomeric genes. (PMID: 15233989) Wong A … Ledbetter DH (Genomics 2004) 2 3 4 60
  2. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PMID: 12421752) Fan Y … Trask BJ (Genome research 2002) 2 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development. (PMID: 26124079) Nishiyama M … Nakayama KI (Stem cells (Dayton, Ohio) 2015) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for CBWD3 Gene

Sources for CBWD3 Gene

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