Aliases for CBWD2 Gene
Aliases for CBWD2 Gene
External Ids for CBWD2 Gene
- HGNC: 17907
- Entrez Gene: 150472
- Ensembl: ENSG00000136682
- OMIM: 611079
- UniProtKB: Q8IUF1
Previous GeneCards Identifiers for CBWD2 Gene
- GC00U991146
- GC02U900009
- GC02P114102
- GC02P114290
- GC02P113912
- GC02P114188
- GC02P114196
Summaries for CBWD2 Gene
GeneCards Summary for CBWD2 Gene
CBWD2 (COBW Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is CBWD1.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBWD2 Gene
Genomics for CBWD2 Gene
Regulatory Elements for CBWD2 Gene
Enhancers for CBWD2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CBWD2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CBWD2 gene promoter:
Regulatory Element Products
Genomic Location for CBWD2 Gene
- Chromosome:
- 2
- Start:
- 113,437,691 bp from pter
- End:
- 113,496,204 bp from pter
- Size:
- 58,514 bases
- Orientation:
- Plus strand
Genomic View for CBWD2 Gene
Genes around CBWD2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q14.1 by Ensembl
- 2q14.1 by Entrez Gene
- 2q14.1 by HGNC
CBWD2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBWD2 Gene
Proteins for CBWD2 Gene
-
Protein details for CBWD2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IUF1-CBWD2_HUMAN
- Recommended name:
- COBW domain-containing protein 2
- Protein Accession:
- Q8IUF1
- Q0VAN3
Protein attributes for CBWD2 Gene
- Size:
- 395 amino acids
- Molecular mass:
- 44034 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for CBWD2 Gene
Other Protein References for CBWD2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CBWD2
- Invitrogen Antibodies for CBWD2
- GeneTex CBWD2 antibody for CBWD2
Protein Products
-
OriGene Purified Proteins for CBWD2
- Search Origene for MassSpec and Protein Over-expression Lysates for CBWD2
- Origene Custom Protein Services for CBWD2
- Search GeneTex for Proteins for CBWD2
Assay Products
No data available for DME Specific Peptides for CBWD2 Gene
Domains & Families for CBWD2 Gene
Protein Domains for CBWD2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CBWD2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IUF1- Family:
-
- Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
No data available for Gene Families for CBWD2 Gene
Function for CBWD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005524 | ATP binding | IEA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBWD2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CBWD2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CBWD2 gene
- Search ViGene Biosciences for CBWD2
CRISPR Products
-
OriGene CRISPR knockouts for CBWD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBWD2
- GenScript: Design CRISPR guide RNA sequences for CBWD2
miRNA for CBWD2 Gene
- miRTarBase miRNAs that target CBWD2
miRNA Products
- Search ViGene Biosciences for CBWD2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBWD2
- Browse OriGene Inhibitory RNA Products For CBWD2
-
ViGene Biosciences ready-to-package AAV shRNAs for CBWD2 gene
Clone Products
-
OriGene ORF clones in human for CBWD2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CBWD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBWD2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CBWD2
-
ViGene Biosciences adenoviral particle packaged cDNA for CBWD2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CBWD2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CBWD2 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CBWD2 Gene
Localization for CBWD2 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| cytosol | 2 |
| peroxisome | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CBWD2 Gene
Pathways & Interactions for CBWD2 Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for CBWD2 Gene
Transcripts for CBWD2 Gene
mRNA/cDNA for CBWD2 Gene
- (16) REFSEQ mRNAs :
- (301) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CBWD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBWD2
- GenScript: Design CRISPR guide RNA sequences for CBWD2
miRNA Products
- Search ViGene Biosciences for CBWD2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBWD2
- Browse OriGene Inhibitory RNA Products For CBWD2
-
ViGene Biosciences ready-to-package AAV shRNAs for CBWD2 gene
Clone Products
-
OriGene ORF clones in human for CBWD2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CBWD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBWD2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CBWD2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
NURSA nuclear receptor signaling pathways regulating expression of CBWD2 Gene:
CBWD2Evidence on tissue expression from TISSUES for CBWD2 Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs for CBWD2
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBWD2 Gene
Orthologs for CBWD2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Cbwd1 35 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | CBWD1 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | cbwd 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 35 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G15730 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0599700 34 |
|
- Species where no ortholog for CBWD2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CBWD2 Gene
(5) SIMAP similar genes for CBWD2 Gene using alignment to 5 proteins:
Variants for CBWD2 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000045085 | -- | 113,476,621(+) | TTCTG(C/T)TCTGT | intron-variant | |
| rs1000184934 | -- | 113,440,587(+) | ATTAA(C/T)ACCCT | intron-variant | |
| rs1000251478 | -- | 113,487,235(+) | GGAGC(A/C)ACAGG | intron-variant | |
| rs1000468439 | -- | 113,441,096(+) | AGGGA(A/G)GGTTA | intron-variant | |
| rs1000522571 | -- | 113,439,132(+) | TAGAT(C/G)ACTGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759085 | CNV | gain+loss | 17122850 |
| esv28287 | CNV | gain | 19812545 |
| esv3559956 | CNV | deletion | 23714750 |
| esv3592016 | CNV | gain | 21293372 |
| nsv1002255 | CNV | gain | 25217958 |
| nsv10130 | CNV | gain | 18304495 |
| nsv834334 | CNV | gain | 17160897 |
| nsv954794 | CNV | duplication | 24416366 |
| nsv961492 | CNV | duplication | 23825009 |
| nsv961999 | CNV | duplication | 23825009 |
| nsv963707 | CNV | duplication | 23825009 |
| nsv979106 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.00;
60.21% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CBWD2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CBWD2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBWD2 Gene
Disorders for CBWD2 Gene
Relevant External Links for CBWD2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CBWD2
No disorders were found for CBWD2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBWD2 Gene
Publications for CBWD2 Gene
- Diverse fates of paralogs following segmental duplication of telomeric genes. (PMID: 15233989) Wong A. … Ledbetter D.H. (Genomics 2004) 2 3 4 64
- Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PMID: 12421752) Fan Y. … Trask B.J. (Genome Res. 2002) 2 3 4 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
- Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3 64
Products for CBWD2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CBWD2
- Search Origene for MassSpec and Protein Over-expression Lysates for CBWD2
- Origene Custom Protein Services for CBWD2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CBWD2
- Browse OriGene Inhibitory RNA Products For CBWD2
- OriGene qPCR primer pairs for CBWD2
- OriGene CRISPR knockouts for CBWD2
- OriGene ORF clones in human for CBWD2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CBWD2
- GenScript: Next-day shipping cDNA ORF clone for CBWD2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CBWD2
- GenScript Custom Assay Services for CBWD2
- GenScript Custom overexpressing Cell Line Services for CBWD2
- GenScript: Design CRISPR guide RNA sequences for CBWD2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CBWD2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CBWD2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for CBWD2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CBWD2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CBWD2 gene
- Search ViGene Biosciences for CBWD2
- Horizon Cell Lines for CBWD2
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBWD2
- VectorBuilder custom plasmid, inducible vectors for CBWD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBWD2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CBWD2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer