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Aliases for CBWD2 Gene

Aliases for CBWD2 Gene

  • COBW Domain Containing 2 2 3 5
  • Cobalamin Synthase W Domain-Containing Protein 2 4

External Ids for CBWD2 Gene

Previous GeneCards Identifiers for CBWD2 Gene

  • GC00U991146
  • GC02U900009
  • GC02P114102
  • GC02P114290
  • GC02P113912
  • GC02P114188
  • GC02P114196

Summaries for CBWD2 Gene

GeneCards Summary for CBWD2 Gene

CBWD2 (COBW Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is CBWD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBWD2 Gene

Genomics for CBWD2 Gene

Regulatory Elements for CBWD2 Gene

Enhancers for CBWD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CBWD2 on UCSC Golden Path with GeneCards custom track

Promoters for CBWD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CBWD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CBWD2 Gene

113,437,691 bp from pter
113,496,204 bp from pter
58,514 bases
Plus strand

Genomic View for CBWD2 Gene

Genes around CBWD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBWD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBWD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBWD2 Gene

Proteins for CBWD2 Gene

  • Protein details for CBWD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COBW domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q0VAN3

    Protein attributes for CBWD2 Gene

    395 amino acids
    Molecular mass:
    44034 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CBWD2 Gene

Proteomics data for CBWD2 Gene at MOPED

Post-translational modifications for CBWD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CBWD2 Gene

No data available for DME Specific Peptides for CBWD2 Gene

Domains & Families for CBWD2 Gene

Suggested Antigen Peptide Sequences for CBWD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 cobW C-terminal domain.
  • Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
  • Contains 1 cobW C-terminal domain.
  • Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
genes like me logo Genes that share domains with CBWD2: view

No data available for Gene Families for CBWD2 Gene

Function for CBWD2 Gene

Animal Model Products

CRISPR Products

miRNA for CBWD2 Gene

miRTarBase miRNAs that target CBWD2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CBWD2 Gene

Localization for CBWD2 Gene

Subcellular locations from

Jensen Localization Image for CBWD2 Gene COMPARTMENTS Subcellular localization image for CBWD2 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CBWD2 Gene

Pathways & Interactions for CBWD2 Gene

SuperPathways for CBWD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CBWD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for CBWD2 Gene

Drugs & Compounds for CBWD2 Gene

No Compound Related Data Available

Transcripts for CBWD2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CBWD2 Gene

No ASD Table

Relevant External Links for CBWD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CBWD2 Gene

mRNA expression in normal human tissues for CBWD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expression patterns with CBWD2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CBWD2 Gene

Orthologs for CBWD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CBWD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 88 (a)
(Canis familiaris)
Mammalia -- 36
  • 90 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
(Mus musculus)
Mammalia Cbwd1 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
(Pan troglodytes)
Mammalia -- 36
  • 98 (a)
-- 36
  • 96 (a)
(Gallus gallus)
Aves CBWD1 36
  • 73 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
(Danio rerio)
Actinopterygii cbwd 36
  • 72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G15730 35
  • 52.12 (n)
  • 42.11 (a)
(Oryza sativa)
Liliopsida Os04g0599700 35
  • 51.02 (n)
  • 40.55 (a)
Species with no ortholog for CBWD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBWD2 Gene

Gene Tree for CBWD2 (if available)
Gene Tree for CBWD2 (if available)

Paralogs for CBWD2 Gene

Paralogs for CBWD2 Gene

(5) SIMAP similar genes for CBWD2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CBWD2: view

Variants for CBWD2 Gene

Sequence variations from dbSNP and Humsavar for CBWD2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1756507 -- 113,447,615(+) tttac(C/T)cacag intron-variant, upstream-variant-2KB
rs1830616 -- 113,453,363(-) AGGCA(A/C/G)GAGAA intron-variant
rs1831503 -- 113,453,315(-) agatc(A/T)tgcca intron-variant
rs1853235 -- 113,437,109(-) CTAAC(A/C/G)TAAAA upstream-variant-2KB
rs2757914 -- 113,441,984(+) ccacc(C/T)gcctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CBWD2 Gene

Variant ID Type Subtype PubMed ID
dgv1240e1 CNV Complex 17122850
esv380 CNV CNV 17122850
esv28287 CNV Gain 19812545
nsv10130 CNV Gain 18304495
nsv834334 CNV Gain 17160897
nsv874902 CNV Gain 21882294
nsv874903 CNV Gain 21882294
essv901 CNV CNV 17122850

Variation tolerance for CBWD2 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CBWD2 Gene

Disorders for CBWD2 Gene

Relevant External Links for CBWD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CBWD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBWD2 Gene

Publications for CBWD2 Gene

  1. Diverse fates of paralogs following segmental duplication of telomeric genes. (PMID: 15233989) Wong A. … Ledbetter D.H. (Genomics 2004) 2 3 4 67
  2. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PMID: 12421752) Fan Y. … Trask B.J. (Genome Res. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for CBWD2 Gene

Sources for CBWD2 Gene