CBWD2 Gene
protein-coding GIFtS: 40
GCID: GC02P114188
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COBW domain containing 2
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Aliases
for CBWD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| COBW Domain Containing 21 2 | | Cobalamin Synthase W Domain-Containing Protein 22 3 | | Cobalamin Synthetase W Domain-Containing Protein 22 | | COBW Domain-Containing Protein 22 |
Export aliases for CBWD2 gene to outside databasesPrevious GC identifers: GC00U991146 GC02U900009 GC02P114102 GC02P114290 GC02P113912 |
Summaries
for CBWD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CBWD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CBWD2 gene promoter:
Pax-6 GCNF ATF-2 HNF-4alpha2 Cdc5 GATA-1 HNF-4alpha1 GCNF-1 MRF-2 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CBWD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBWD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q13 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q14.1CBWD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P114188: view genomic region
(about GC identifiers)
Start:
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114,195,268 bp from pter |
End:
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114,253,781 bp from pter |
Size:
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58,514 bases |
Orientation:
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plus strand |
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Proteins
for CBWD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CBWD2_HUMAN, Q8IUF1 (See
protein sequence)Recommended Name: COBW domain-containing protein 2 Size: 395 amino acids; 44034 Da
Secondary accessions: Q0VAN3Explore the universe of human proteins at neXtProt for CBWD2: NX_Q8IUF1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IUF1
CBWD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_742000.1
ENSEMBL proteins: ENSP00000259199 ENSP00000351418 ENSP00000393105 ENSP00000411906 ENSP00000401945
Human Recombinant Protein Products:
CBWD2 Antibody Products:
Assay Products for CBWD2: |
Protein
Domains /
Families
for CBWD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CBWD2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IUF1ProtoNet protein and cluster: Q8IUF1 2 Blocks protein families: IPB003495 Cobalamin synthesis protein/P47K IPB011629 Cobalamin synthesis CobW
UniProtKB/Swiss-Prot: CBWD2_HUMAN, Q8IUF1Similarity: Belongs to the CobW familySimilarity: Contains 1 cobW C-terminal domain |
Function
for CBWD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBWD2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CBWD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CBWD2 (NM_172003) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CBWD2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBWD2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBWD2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- |
CBWD2 for ontologies About GeneDecksing
|
Pathways & Interactions
for CBWD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CBWD2
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/7 Interacting proteins for CBWD2 (Q8IUF11, 2, 3 ENSP000002591994) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
|
Drugs & Compounds
for CBWD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CBWD2
Search CenterWatch for drugs/clinical trials and news about CBWD2
|
Transcripts
for CBWD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CBWD2 gene: NM_172003.3 11 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000259199(uc002tju.3 uc010fkv.3) ENST00000358604 ENST00000463627
ENST00000456188 ENST00000490323(uc002tjt.2) ENST00000492566 ENST00000490446
ENST00000479583 ENST00000468417 ENST00000416503 ENST00000433343(uc010yxw.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBWD2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CBWD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CBWD2 (NM_172003) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CBWD2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBWD2 |
24/301 AceView cDNA sequences (see all 301): CA306465 BQ775348 AA508679 AI382135 AA917470 AA807492 AA724156 BM452484 T25769 R28638 BI480763 BM785604 BQ959562 CR621231 AF452722 BX436906 BI711184 AY343910 BU508138 N34152 W02142 AW102714 T30462 BM826452
GeneLoc Exon Structure
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Expression
for CBWD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CBWD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CBWD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CBWD2
SABiosciences Custom PCR Arrays for CBWD2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CBWD2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CBWD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBWD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBWD2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBWD2 |
Orthologs
for CBWD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for CBWD2 gene from 7/21 species (see all 21) About this table
ENSEMBL Gene Tree for CBWD2 (if available)
TreeFam Gene Tree for CBWD2 (if available) |
Paralogs
for CBWD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CBWD2 gene
- CBWD62 CBWD32 CBWD12 CBWD72 CBWD52
5 SIMAP similar genes for CBWD2 using alignment to 5 protein entries: CBWD2_HUMAN (see all proteins):CBWD7 CBWD3 CBWD1 CBWD6 CBWD5
CBWD2 for paralogs About GeneDecksing
|
Genomic Variants
for CBWD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CBWD2 (114195268 - 114253781 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for CBWD2
7 CNVs: 3385 78713 89901 30998 78714 3386 68130 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CBWD2 |
|
Disorders
/ Diseases
for CBWD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CBWD2 for disorders About GeneDecksing
OMIM gene information: 611079
OMIM disorders: --
1  disease for CBWD2: About MalaCardsmalaria
Export disorders for CBWD2 gene to outside databases
|
Publications
for CBWD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CBWD2 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with CBWD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Diverse fates of paralogs following segmental duplication of telomeric genes. (PubMed id 15233989)1, 2, 3 Wong A....Ledbetter D.H. (2004)
- Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PubMed id 12421752)1, 2, 3 Fan Y.... Trask B.J. (2002)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
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External Searches for CBWD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CBWD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CBWD2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CBWD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CBWD2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CBWD2 gene:
Search GeneIP for patents involving CBWD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CBWD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CBWD2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CBWD2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CBWD2 | | | OriGene Protein Over-expression Lysate for CBWD2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CBWD2 | | OriGene 3'-UTR Clone for CBWD2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CBWD2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CBWD2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CBWD2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CBWD2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CBWD2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CBWD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CBWD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CBWD2 |
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 | | | CBWD2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CBWD2 |
|  |  |  | | | | Search ThermoFisher Antibodies for CBWD2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CBWD2 |
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